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Article: Influence of manmade effects on geomorphology, bathymetry and coastal dynamics in a monsoon-affected river outlet in Southwest coast of Sri Lanka

Gunasinghe, G. P / Ruhunage, Lilani / Ratnayake, N. P / Ratnayake, A. S / Samaradivakara, G. V. I / Jayaratne, Ravindra

Environmental earth sciences. 2021 Apr., v. 80, no. 7

2021

Abstract: A complex coastal environment with a river outlet, a sand spit barrier and an estuary of such coastal features is controlled by wave-induced hydrodynamics and sediment dynamics. The coastal dynamics patterns can be changed by natural or anthropogenic ... ...

Abstract	A complex coastal environment with a river outlet, a sand spit barrier and an estuary of such coastal features is controlled by wave-induced hydrodynamics and sediment dynamics. The coastal dynamics patterns can be changed by natural or anthropogenic activities. This study is mainly focused on understanding the significant changes of geomorphology, bathymetry, and the coastal dynamics originated due to human influences in a monsoon-affected Kalu Ganga (River) outlet in Sri Lanka. In this research project, bathymetric variations before and after the collapse of sand spit barrier were analysed to understand the extent of the erosional and depositional effects. High-resolution satellite images in Google Earth Pro were also used to qualitatively analyse beach boundary changes before the collapse of the sand spit barrier. Temporal and spatial changes of beach boundary positions after collapse of the sand spit barrier were measured using high precision GPS surveying in river outlet including the evolving sand spit barrier. Nested wave model (Delft3D modelling suite) was applied to understand the wave climate changes. The data obtained from all methods were analysed to understand the geomorphological, bathymetric and coastal dynamic changes of the study area. The results show significant and widespread deepening of bathymetry up to 1–2 m extending as far as 2 km offshore from the river outlet initiated after the collapse of the sand spit barrier. Further, the study shows separation from the mainland and buckling of the sand barrier was initiated by anthropogenic activity coupled with the release of riverine floodwater and strong waves during southwest monsoon season. The weakened and buckled sand spit barrier was migrated and welded to the mainland during calm weather of northeast monsoon. This has resulted complete change of coastal dynamics in the Kalu Ganga (River) outlet area. Since the sediment dynamics and hydrodynamics completely changed, even after 2 years, the sand spit barrier across the river outlet has not been recreated naturally. Therefore, important structures in Kalutara coastal area were threatened due to severe erosion. This study shows understanding such coastal morpho-dynamic and hydrodynamic changes are vital to implement proper coastal prevention management strategies.
Keywords	Internet ; anthropogenic activities ; climate ; coasts ; estuaries ; humans ; hydrodynamics ; models ; monsoon season ; riparian areas ; rivers ; sand ; satellites ; weather ; Sri Lanka
Language	English
Dates of publication	2021-04
Size	p. 238.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-021-09555-0
Database	NAL-Catalogue (AGRICOLA)

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Article: Nerve tube in peripheral nerve repair.

Perera, V A / Ratnayake, A S / Dissanayake, D A

The Ceylon medical journal

2011 Volume 56, Issue 2, Page(s) 83–84

MeSH term(s)	Fingers/innervation ; Humans ; Male ; Peripheral Nervous System Diseases/surgery ; Polyesters/therapeutic use ; Prostheses and Implants ; Young Adult
Chemical Substances	Polyesters ; lactide-caprolactone copolymer (70524-20-8)
Language	English
Publishing date	2011-07-15
Publishing country	Sri Lanka
Document type	Case Reports ; Letter
ZDB-ID	419365-9
ISSN	0009-0875
ISSN	0009-0875
DOI	10.4038/cmj.v56i2.3120
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Article: The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus.

Ratnayake, A S / Yoshida, W Y / Mooberry, S L / Hemscheidt, T

Organic letters

2001 Volume 3, Issue 22, Page(s) 3479–3481

Abstract: structure: see text]. A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting ... ...

Abstract	[structure: see text]. A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.
MeSH term(s)	Actin Cytoskeleton/drug effects ; Alkenes/chemical synthesis ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Cell Line ; Circular Dichroism ; Fungi/chemistry ; Humans ; Lactones/chemical synthesis ; Magnetic Resonance Spectroscopy ; Microscopy, Fluorescence ; Molecular Conformation ; Muscle, Smooth/cytology ; Muscle, Smooth/drug effects ; Rats ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet ; Stereoisomerism ; Tumor Cells, Cultured
Chemical Substances	Alkenes ; Antineoplastic Agents ; Lactones ; oximidine I ; oximidine II
Language	English
Publishing date	2001-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1523-7060
ISSN	1523-7060
DOI	10.1021/ol016515s
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Article: Nomofungin: a new microfilament disrupting agent.

Ratnayake, A S / Yoshida, W Y / Mooberry, S L / Hemscheidt, T K

The Journal of organic chemistry

2001 Volume 66, Issue 26, Page(s) 8717–8721

Abstract: A new alkaloid, nomofungin, has been isolated from the fermentation broth of an unidentified endophytic fungus obtained from the bark of Ficus microcarpa L. The structure of nomofungin was determined by application of spectroscopic methods. The absolute ... ...

Abstract	A new alkaloid, nomofungin, has been isolated from the fermentation broth of an unidentified endophytic fungus obtained from the bark of Ficus microcarpa L. The structure of nomofungin was determined by application of spectroscopic methods. The absolute stereochemistry of nomofungin was assigned by using the exciton chirality method. Nomofungin disrupts microfilaments in cultured mammalian cells and is moderately cytotoxic with minimum inhibitory concentrations (MICs) of 2 and 4.5 microg/mL against LoVo and KB cells, respectively. The ring system of nomofungin is unprecedented.
MeSH term(s)	Alkaloids/chemistry ; Alkaloids/pharmacology ; Animals ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/pharmacology ; Cells, Cultured ; Drug Screening Assays, Antitumor ; Epoxy Compounds/chemistry ; Epoxy Compounds/pharmacology ; Fermentation ; Ficus/microbiology ; Fluorescent Antibody Technique ; Fungi/chemistry ; Fungi/metabolism ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Microfilament Proteins/metabolism ; Models, Molecular ; Muscle, Smooth/cytology ; Muscle, Smooth/metabolism ; Plant Bark/microbiology ; Rats ; Tumor Cells, Cultured
Chemical Substances	Alkaloids ; Antibiotics, Antineoplastic ; Epoxy Compounds ; Microfilament Proteins ; nomofungin
Language	English
Publishing date	2001-12-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo010335e
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Article ; Audio / Video: Theopapuamide, a Cyclic Depsipeptide from a Papua New Guinea Lithistid Sponge Theonella swinhoei

Ratnayake, A.S / Bugni, T.S / Feng, X / Harper, M.K / Skalicky, J.J / Mohammed, K.A / Andjelic, C.D / Barrows, L.R / Ireland, C.M

Journal of natural products. 2006 Nov., v. 69, no. 11

2006

Keywords	Porifera ; cyclic peptides ; chemical structure ; spectral analysis ; stereochemistry ; cytotoxicity ; anticarcinogenic activity ; antiviral properties ; Human immunodeficiency virus 1 ; Papua New Guinea
Language	English
Dates of publication	2006-11
Size	p. 1582-1586.
Document type	Article ; Audio / Video
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np060229d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Expert assessment of future vulnerability of the global peatland carbon sink

Loisel, J. / Gallego-Sala, A. V. / Amesbury, M. J. / Magnan, G. / Anshari, G. / Beilman, D. W. / Benavides, J. C. / Blewett, J. / Camill, P. / Charman, D. J. / Chawchai, S. / Hedgpeth, A. / Kleinen, T. / Korhola, A. / Large, D. / Mansilla, C. A. / Müller, J. / van Bellen, S. / West, J. B. /

Yu, Z. / Bubier, J. L. / Garneau, M. / Moore, T. / Sannel, A. B. K. / Page, S. / Väliranta, M. / Bechtold, M. / Brovkin, V. / Cole, L. E. S. / Chanton, J. P. / Christensen, T. R. / Davies, M. A. / De Vleeschouwer, F. / Finkelstein, S. A. / Frolking, S. / Gałka, M. / Gandois, L. / Girkin, N. / Harris, L. I. / Heinemeyer, A. / Hoyt, A. M. / Jones, M. C. / Joos, F. / Juutinen, S. / Kaiser, K. / Lacourse, T. / Lamentowicz, M. / Larmola, T. / Leifeld, J. / Lohila, A. / Milner, A. M. / Minkkinen, K. / Moss, P. / Naafs, B. D. A. / Nichols, J. / O’Donnell, J. / Payne, R. / Philben, M. / Piilo, S. / Quillet, A. / Ratnayake, A. S. / Roland, T. P. / Sjögersten, S. / Sonnentag, O. / Swindles, G. T. / Swinnen, W. / Talbot, J. / Treat, C. / Valach, A. C. / Wu, J.

2021

Abstract: The carbon balance of peatlands is predicted to shift from a sink to a source this century. However, peatland ecosystems are still omitted from the main Earth system models that are used for future climate change projections, and they are not considered ... ...

Abstract	The carbon balance of peatlands is predicted to shift from a sink to a source this century. However, peatland ecosystems are still omitted from the main Earth system models that are used for future climate change projections, and they are not considered in integrated assessment models that are used in impact and mitigation studies. By using evidence synthesized from the literature and an expert elicitation, we define and quantify the leading drivers of change that have impacted peatland carbon stocks during the Holocene and predict their effect during this century and in the far future. We also identify uncertainties and knowledge gaps in the scientific community and provide insight towards better integration of peatlands into modelling frameworks. Given the importance of the contribution by peatlands to the global carbon cycle, this study shows that peatland science is a critical research area and that we still have a long way to go to fully understand the peatland–carbon–climate nexus.
Subject code	333 ; 550
Language	English
Publisher	Nature Research
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Global attitudes in the management of acute appendicitis during COVID-19 pandemic

Ielpo, B. / Podda, M. / Pellino, G. / Pata, F. / Caruso, R. / Gravante, G. / Di Saverio, S. / Gallo, G. / Lui, R. / Orengia, A. / Chowdary, A. / Kulkarni, A. / Kuvvetli, A. / Navarro, A. / Pisanu, A. / Smith, A. / Ibiricu, A. C. / Nacion, A. J. D. / Alsaleh, A. /

Alhazmi, A. / Elmabri, A. / Wani, A. / Rencuzogullari, A. / Lasarte, A. S. / Rubio, A. V. / Bavikatte, A. / Kumar, A. / Jamiri, A. -R. / Padilla, A. M. A. / Cacurri, A. / de San Ildefonso, A. / Porcu, A. / Sartori, A. / Rocca, A. / Yanez, A. P. / Becaria, A. / Solis-Pena, A. / Sretenovic, A. / Urbistondo, A. / Bandin, A. / Najar, A. / De Luca, A. / Boddy, A. / Charalabopoulos, A. / Tzivanakis, A. / Amendola, A. / de Velasco, A. R. -G. / Yildirim, A. C. / Frontali, A. / Toure, A. O. / Garcia-Granero, A. / Roldan, A. M. / Larrainzar, A. S. / Ratnayake, A. S. / Gonzalez-Ganso, A. M. / Minaya-Bravo, A. M. / Das, A. / Bondurri, A. / Costanzi, A. / Lucchi, A. / Mazzari, A. / Musig, A. / Peloso, A. / Piano, A. / Police, A. / Mihailescu, A. / Pouy, A. / Romano, A. / Iossa, A. / Leonetti, A. C. / Guariniello, A. / Isaac, A. / Bovi, A. P. D. / Chessa, A. / Tromba, A. / Martinez, A. A. / Brillantino, A. / Caira, A. / Castaldi, A. / Ferronetti, A. / Giuliani, A. / Prestera, A. / la Medina, A. R. -D. / Tarasconi, A. / Tornambe, A. / Picciariello, A. / Ioannidis, A. / Leppaniemi, A. / Khan, A. / Rashid, A. / Perez-Sanchez, A. L. E. / Mittal, A. / Mitul, A. R. / Mehraj, A. / Laharwal, A. / Dorisme, A. / Marinis, A. / Iqbal, A. / Moncada, A. / Braccio, B. / Alkhafaji, B. / de Andres Asenjo, B. / Martin-Perez, B. / Perez, B. S. / Creavin, B. / Cali, B. / Pascotto, B. / Stubbs, B. / Retes, B. Z. / Jovanovic, B. / Goh, B. K. P. / Sensi, B. / Biddau, C. / Gazia, C. / Vallicelli, C. / Fagundes, C. A. / Santacruz, C. C. / Chirico, C. / Diaz, C. J. G. / Petrola, C. / Rodriguez, C. S. / Benitez, C. Y. / Dammaro, C. / Faro, C. L. / Reinke, C. / Paez, C. D. / Oliva, C. / Paranjape, C. / Thomas, C. / Chia, C. F. / Kong, C. K. / De Lucia, C. / Chao, C. O. / Arcudi, C. / Guerci, C. / Chia, C. / Parise, C. / Folliero, C. / Varela, C. / Ferguson, D. M. / Camacho, D. / Popowich, D. / Lima, D. S. / Rega, D. / Delogu, D. / Zigiotto, D. / Vinci, D. / D'Antonio, D. / Parini, D. / Merlini, D. A. / Zimmerman, D. D. E. / Moro-Valdezate, D. / Pertile, D. / Giusti, D. M. / Keller, D. S. / Tarik, D. / Kalivaci, D. / Mazingi, D. / Maldonado-Pintado, D. G. / Sasia, D. / Linardoutsos, D. / Osilli, D. / Murrone, D. / Russello, D. / Rodas, E. / Roa, E. A. A. / Ricciardi, E. / Rosso, E. / Saladino, E. / Flores-Villalba, E. / Ajs, E. R. / Smith-Singares, E. / Baili, E. / Kouroumpas, E. / Bourmpouteli, E. / Douka, E. / Martin-Perez, E. / Guaitoli, E. / Samadov, E. / Francone, E. / Vaterlini, E. / Morales, E. / Pena, E. / Zhao, E. / Andres, E. D. P. / Benzoni, E. / Erdas, E. / Pinotti, E. / Colas-Ruiz, E. / Aytac, E. / Laterza, E. / Agastra, E. / Foianini, E. / Moscoso, E. / Laviano, E. / Marra, E. / Cardamone, E. / Licardie, E. / Mpaili, E. / Pinna, E. / Varo, E. / Navarro, F. M. / Marino, F. / Medas, F. / Romano, F. / Maraska, F. / Saliu, F. / Madrid, F. / Rosa, F. / Mastella, F. / Gheza, F. / Luvisetto, F. / Alconchel, F. / Vieira, F. M. / Pareja, F. / Agresta, F. / Luna, F. / Bonilla, F. / Cordera, F. / Burdio, F. / Mendoza-Moreno, F. / Flores, F. M. / Aranda, F. P. / Taylor, F. / Ramos, F. L. / Fernandes, F. / Tropeano, F. P. / Balestra, F. / Bianco, F. / Ceci, F. / Colombo, F. / Di Marzo, F. / Ferrara, F. / Lancellotti, F. / Lazzarin, F. / Litta, F. / Martini, F. / Pizza, F. / Roscio, F. / Virdis, F. / Antona, F. B. / Ramirez, F. C. / Fernandez, F. M. / Llinares, F. O. / Quezada, F. / Schlottmann, F. / Herrera-Almario, G. / Massaferro, G. / Bislenghi, G. / van Ramshorst, G. / Luglio, G. / Bointas, G. / Kampouroglou, G. / Papadopoulos, G. / Manrique, G. A. / Calini, G. / Nastri, G. / Formisano, G. / Galiffa, G. / Palini, G. M. / Colucci, G. / Pagano, G. / Vanni, G. / Pattacini, G. C. / De Paola, G. / Lisi, G. / Partida, G. / Bellanova, G. / De Nobili, G. / Necchi, G. S. / Sinibaldi, G. / Tebala, G. / Bagaglini, G. / Izzo, G. / Argenio, G. / Brisinda, G. / Candilio, G. / Di Grezia, G. / Esposito, G. / Faillace, G. / Frazzetta, G. / La Gumina, G. / Nigri, G. / Romeo, G. / Amatriain, G. C. / Ortega, G. / Martin-Martin, G. / Stavrou, G. A. / Gunadi, / Ugon, G. A. / Machain, G. / Marcucci, G. / Martinez-Mier, G. / Machain, G. M. / Nari, G. / Calvo, H. / Fathy, H. / Hamilto, / Ahmed, H. / Faraj, H. / Nava, H. / Macias, H. O. / Nikaj, H. / Solano, H. / Khan, H. A. / Alarcon, H. S. / Ebied, H. / Giani, I. / Ateca, I. V. / Neri, I. / Roman, I. A. S. / Fidoshev, I. / Rodriguez, I. M. / Negoi, I. / Ortega, I. / Bernescu, I. / Russo, I. S. / Rodriguez, I. V. / Palomares, I. / Baltazar, I. / Torrejimeno, I. J. / Jurado, I. M. C. / Reccia, I. / Hussain, I. / Toledo, I. B. / Mora-Guzman, I. / Dogaru, I. / Romic, I. / Balciscueta, I. / Kenington, J. C. / Sagolsem, J. / Jang, J. Y. / Olivier, J. / Lammel-Lindemann, J. / Dziakova, J. / Villavicencio, J. I. R. / Salinas, J. / Parreira, J. P. J. G. / Jovanovic, / Perez, J. R. / Reyes, J. A. S. / Luque, J. A. M. / Mak, J. / Rodriguez, J. S. / Kok, J. H. H. / Krook, J. / Diaz-Elizondo, J. A. / Castell, J. / Garcia-Flores, J. E. / Navalon, J. M. J. / Rodrigues, J. M. S. / Pereira, J. / Gomez, J. T. C. / Luque, J. B. / del Olmo, J. C. M. / Salamea, J. C. / Olivier, J. F. C. / Laina, J. L. B. / Ordonez, J. M. / Gutierrez, J. / Abba, J. / Sofi, J. A. / Sherafgan, K. / Sahnan, K. / Yanaga, K. / Beatson, K. / Asim, L. / Alvarez, L. / Siragusa, L. / Farber, L. / Ong, L. / Athanasios, L. / Garcia-Bruna, L. / De Martino, L. / Ferrario, L. / Giordano, L. / Gordini, L. / Pio, L. / Ponchietti, L. / Moletta, L. / Curella, L. / Poggi, L. / Taglietti, L. / Bonavina, L. / Conti, L. / Goffredi, L. / Ruiz, L. A. G. / Barrionuevo, L. / Fregoso, L. E. / Cabrera, L. F. / Rodriguez, L. G. / Grande, L. / Osoria, L. G. / Gonzalez, L. J. K. / Sanchez-Guillen, L. / Tallon-Aguilar, L. / Tresierra, L. / Giavarini, L. / Hasabelnabi, M. / Odovic, M. / Uemura, M. / Khan, M. / Artiles-Armas, M. / David, M. / Di Martino, M. / Spampinato, M. G. / Ribeiro, M. A. F. / Viola, M. / Angrisani, M. / Calussi, M. / Cannistra, M. / Catarci, M. / Cereda, M. / Conte, M. / Giordano, M. / Pellicciaro, M. / Marino, M. V. / Vaterlini, M. E. / Jimenez, M. F. / Lolli, M. G. / Bellini, M. I. / Lemma, M. / Chiarello, M. M. / Nicola, M. / Arrigo, M. / Mejia, M. C. / Manrique, M. M. / Rodriguez-Lopez, M. / Serradilla-Martin, M. / Lara, M. Z. / Martinez, M. / Bagnall, M. / Peter, M. / Lara, M. C. / Gomez, M. J. / Paniagua-Garcia-Senorans, M. / Gonzalez, M. P. / Rutegard, M. / Salo, M. / Franceschilli, M. / Silveri, M. / Veroux, M. / Pezzulo, M. / Nardi, M. / Rottoli, M. / Tolonen, M. / Ciro, M. P. / Zuluagua, M. / Cannavo, M. / Cervellera, M. / Iacobone, M. / Montuori, M. / Dominguez, M. G. / Bingol-Kologlu, M. / Tahir, M. / Lim, M. / Wilson, M. S. / Wilson, M. / Campanelli, M. / Bisaccia, M. / De Rosa, M. / Maruccia, M. / Paterno, M. / Pisano, M. / Torre, M. / Trevino, M. / Zuolo, M. / Hernandez Bartolome, M. A. / Farina, M. / Pera, M. / Calvo, M. P. / Sotelo, M. / Thway, M. M. / Hassan, M. / Hassan, M. S. E. / Azfar, M. / Bouhuwaish, M. / Taha, M. / Zaieem, M. / Korkoman, M. / Guraieb, M. / Shalaby, M. / Raza, M. A. / Younis, M. U. / Elhadi, M. / Ali, M. Z. / Quazi, N. / Dudi-Venkata, N. N. / Alselaim, N. / Loria, N. / Ramirez, N. V. / Than, N. W. / Smart, N. / Trelles, N. / Pinto, N. / Allievi, N. / Petrucciani, N. / Antonacci, N. / Cillara, N. / Gica, N. / Cristiana, N. D. / Krystek, N. / Falco, N. / Pecorelli, N. / Tamini, N. / Dallas, N. A. / Machairas, N. / Brito, N. / Fieturi, N. A. / Ortega, N. / Mercado, O. A. / Irkorucu, O. / Alsherif, O. / Valles, O. / Ioannidis, O. / Palmas, O. H. / Palmas, O. I. H. / Guadarrama, O. S. / Bozbiyik, O. / Omelanczuk, P. / Ottolino, P. / Rodrigues, P. / Ruiz, P. / Campenni, P. / Chiarade, P. / Olivares, P. P. / Baroffio, P. / Panaccio, P. / Wintringer, P. / Di Fronzo, P. / Talento, P. / Favoriti, P. / Sendino, P. / Marsanic, P. / Mifsut, P. / Andrade, P. / Ajawin, P. / Abadia-Barno, P. / Castaneda, P. A. N. / Arevalos, P. O. S. / Bellver, P. P. / Koh, P. S. / Souza, P. / Major, P. / Bali, R. S. / Khattar, R. M. / Melo, R. B. / Ebrahiminia, R. / Azar, R. / Murga, R. L. / Pirolo, R. / Brady, R. / Davies, R. J. / Dholakia, R. / Rattan, R. / Singhal, R. / Lim, R. / Angelico, R. / Isernia, R. M. / Tutino, R. / Faccincani, R. / Peltrini, R. / Carrera-Ceron, R. / Tejos, R. / Kashyap, R. / Fajardo, R. / Lozito, R. / Pareja, R. M. / Garbarino, S. / Morales-Conde, S. / Benli, S. / Mansour, S. / Flores, S. / Suarez, S. L. / Ben, S. L. / Fuentes, S. / Napetti, S. / de Guzman, S. O. / Awad, S. / Weckmann Lujan, S. A. / Gentilli, S. / Grimaldi, S. / Pizarro, S. 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ACIE Appy Study

2020

Abstract: Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a ... ...

Abstract	Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis. Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic. Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19·8 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6·6 and 2·4 per cent respectively before, but 23·7 and 5·3 per cent, during the pandemic (both P < 0·001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe. Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2.
Keywords	covid19
Subject code	610
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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