Artikel ; Online: Monitoring of hepatitis E virus in wastewater can identify clinically relevant variants.
Liver international : official journal of the International Association for the Study of the Liver
2024 Band 44, Heft 3, Seite(n) 637–643
Abstract: Hepatitis E virus (HEV) is prevalent worldwide and can cause persistent infection with severe morbidity. Antiviral treatment approaches can lead to the emergence of viral variants encoding escape mutations that may impede viral clearance. The frequency ... ...
| Abstract | Hepatitis E virus (HEV) is prevalent worldwide and can cause persistent infection with severe morbidity. Antiviral treatment approaches can lead to the emergence of viral variants encoding escape mutations that may impede viral clearance. The frequency of these variants remains unknown in the human population as well as environment due to limited comprehensive data on HEV diversity. In this study, we investigated the HEV prevalence and diversity of circulating variants in environmental samples, that is, wastewater and rivers from North-Rhine Westphalia, Germany. HEV prevalence could be determined with 73% of samples tested positive for viral RNA via qRT-PCR. Using high-throughput sequencing, we were able to assess the overall genetic diversity in these samples and identified the presence of clinically relevant variants associated with drug resistance. In summary, monitoring variants from environmental samples could provide valuable insights into estimating HEV prevalence and identifying circulating variants that can impact treatment outcome. |
|||||
|---|---|---|---|---|---|---|
| Mesh-Begriff(e) | Humans ; Hepatitis E virus/genetics ; Wastewater ; Hepatitis E/diagnosis ; Hepatitis E/drug therapy ; Hepatitis E/epidemiology ; Phylogeny ; Prevalence ; RNA, Viral/genetics | |||||
| Chemische Substanzen | Wastewater ; RNA, Viral | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2024-01-30 | |||||
| Erscheinungsland | United States | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 2102783-3 | |||||
| ISSN | 1478-3231 ; 1478-3223 | |||||
| ISSN (online) | 1478-3231 | |||||
| ISSN | 1478-3223 | |||||
| DOI | 10.1111/liv.15842 | |||||
| Signatur |
|
|||||
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Zs.A 1632: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.