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  1. Article: Potential therapeutics against neurological disorders: Natural products-based drugs.

    Rauf, Abdur / Rahman, Md Mominur

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 950457

    Abstract: Neurodegenerative disorders, which are defined by the breakdown of neurons over time, are affecting an increasing number of people. Stroke, Alzheimer's, Parkinson's, Multiple Sclerosis, Migraine, and Amyotrophic Lateral Sclerosis are just a few examples ... ...

    Abstract Neurodegenerative disorders, which are defined by the breakdown of neurons over time, are affecting an increasing number of people. Stroke, Alzheimer's, Parkinson's, Multiple Sclerosis, Migraine, and Amyotrophic Lateral Sclerosis are just a few examples of brain disorders that have no cure. Besides, there is a huge demand for drugs that can cure the diseases mentioned above because the majority of the medications we use to treat them only alleviate diseases. Different neurological disorders have responded satisfactorily to the pharmacological effects of medicinal plants. Despite the numerous multiple types of plants in the world, only a small number of them have been investigated for neurological disorders. As a result, there are many opportunities in this area for further research on plants and their bioactive chemicals. The search for natural therapeutic alternatives that promote faster healing and adverse effects avoidance has gained popularity in recent years. The aim of this mini-review is to explore some natural products that have strong therapeutic effects on neurodegenerative disorders such as Stroke, Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Migraine, Amyotrophic Lateral Sclerosis, and others. We have also shown the safety of natural products to improve their appropriate usage in neurological disorders from recent literature.
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.950457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Malathion-resistant Tribolium castaneum has enhanced response to oxidative stress, immunity, and fitness.

    Rauf, Abdur / Wilkins, Richard M

    Pesticide biochemistry and physiology

    2022  Volume 184, Page(s) 105128

    Abstract: Many cases of insecticide resistance in insect pests give resulting no-cost strains that retain the resistance genes even in the absence of the toxic stressor. Malathion (rac-diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]succinate) has been widely used ... ...

    Abstract Many cases of insecticide resistance in insect pests give resulting no-cost strains that retain the resistance genes even in the absence of the toxic stressor. Malathion (rac-diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]succinate) has been widely used against the red flour beetle, Tribolium castaneum Herbst. in stored products although no longer used. Malathion specific resistance in this pest is long lasting and widely distributed. A malathion resistant strain was challenged with a range of stressors including starvation, hyperoxia, malathion and a pathogen to determine the antioxidant responses and changes to some lifecycle parameters. Adult life span of the malathion-specific resistant strain of T. castaneum was significantly shorter than that of the susceptible. Starvation and/or high oxygen reduced adult life span of both strains. Starving, with and without 100% oxygen, gave longer lifespan for the resistant strain, but for oxygen alone there was a small extension. Under oxygen the proportional survival of the resistant strain to the adult stage was significantly higher, for both larvae and pupae, than the susceptible. The resistant strain when stressed with malathion and oxygen significantly increased catalase activity, but the susceptible did not. The resistant strain stressed with Paranosema whitei infection had significantly higher survival compared to the susceptible, and with low mortality. The malathion resistant strain of T. castaneum showed greater vigour than the susceptible in oxidative stress situations and especially where stressors were combined. The induction of the antioxidant enzyme catalase could have helped the resistant strain to withstand oxidative stresses, including insecticidal and importantly those from pathogens. These adaptations, in the absence of insecticide, seem to support the increased immunity of the insecticide resistant host to pathogens seen in other insect species, such as mosquitoes. By increasing the responses to a range of stressors the resistant strain could be considered as having enhanced fitness, compared to the susceptible.
    MeSH term(s) Animals ; Antioxidants ; Catalase ; Insecticides/pharmacology ; Malathion/pharmacology ; Oxidative Stress ; Oxygen ; Tribolium
    Chemical Substances Antioxidants ; Insecticides ; Catalase (EC 1.11.1.6) ; Oxygen (S88TT14065) ; Malathion (U5N7SU872W)
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184819-7
    ISSN 1095-9939 ; 0048-3583 ; 0048-3575
    ISSN (online) 1095-9939
    ISSN 0048-3583 ; 0048-3575
    DOI 10.1016/j.pestbp.2022.105128
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  3. Article: Malathion-resistant Tribolium castaneum has enhanced response to oxidative stress, immunity, and fitness

    Rauf, Abdur / Wilkins, Richard M.

    Pesticide biochemistry and physiology. 2022 June, v. 184

    2022  

    Abstract: Many cases of insecticide resistance in insect pests give resulting no-cost strains that retain the resistance genes even in the absence of the toxic stressor. Malathion (rac-diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]succinate) has been widely used ... ...

    Abstract Many cases of insecticide resistance in insect pests give resulting no-cost strains that retain the resistance genes even in the absence of the toxic stressor. Malathion (rac-diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]succinate) has been widely used against the red flour beetle, Tribolium castaneum Herbst. in stored products although no longer used. Malathion specific resistance in this pest is long lasting and widely distributed. A malathion resistant strain was challenged with a range of stressors including starvation, hyperoxia, malathion and a pathogen to determine the antioxidant responses and changes to some lifecycle parameters. Adult life span of the malathion-specific resistant strain of T. castaneum was significantly shorter than that of the susceptible. Starvation and/or high oxygen reduced adult life span of both strains. Starving, with and without 100% oxygen, gave longer lifespan for the resistant strain, but for oxygen alone there was a small extension. Under oxygen the proportional survival of the resistant strain to the adult stage was significantly higher, for both larvae and pupae, than the susceptible. The resistant strain when stressed with malathion and oxygen significantly increased catalase activity, but the susceptible did not. The resistant strain stressed with Paranosema whitei infection had significantly higher survival compared to the susceptible, and with low mortality. The malathion resistant strain of T. castaneum showed greater vigour than the susceptible in oxidative stress situations and especially where stressors were combined. The induction of the antioxidant enzyme catalase could have helped the resistant strain to withstand oxidative stresses, including insecticidal and importantly those from pathogens. These adaptations, in the absence of insecticide, seem to support the increased immunity of the insecticide resistant host to pathogens seen in other insect species, such as mosquitoes. By increasing the responses to a range of stressors the resistant strain could be considered as having enhanced fitness, compared to the susceptible.
    Keywords Tribolium castaneum ; adults ; antioxidant enzymes ; catalase ; hyperoxia ; immunity ; insecticide resistance ; longevity ; malathion ; mortality ; oxidative stress ; oxygen ; pathogens ; starvation ; succinic acid ; toxicity ; vigor
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 184819-7
    ISSN 1095-9939 ; 0048-3583 ; 0048-3575
    ISSN (online) 1095-9939
    ISSN 0048-3583 ; 0048-3575
    DOI 10.1016/j.pestbp.2022.105128
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    In stock of ZB MED Bonn / Germany

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  4. Article: Editorial: High altitude medicinal plants and their bioactive compounds for the prevention of oxidative stress-induced diseases and disorders.

    Semwal, Prabhakar / Rauf, Abdur / Simal-Gandara, Jesus

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1257018

    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1257018
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  5. Article ; Online: Genetic control of generative cell shape by DUO1 in Arabidopsis.

    Rauf, Abdur / Khatab, Hoda / Borg, Michael / Twell, David

    Plant reproduction

    2023  Volume 36, Issue 3, Page(s) 243–254

    Abstract: Key message: The main features of generative cell morphogenesis, formation of a cytoplasmic projection and elongation of the GC body, operate through independent genetic pathways. Male gametogenesis in developing angiosperm pollen involves distinctive ... ...

    Abstract Key message: The main features of generative cell morphogenesis, formation of a cytoplasmic projection and elongation of the GC body, operate through independent genetic pathways. Male gametogenesis in developing angiosperm pollen involves distinctive changes in cell morphogenesis. Re-shaping and elongation of the generative cell (GC) are linked to the formation of a GC cytoplasmic projection connected to the vegetative cell nucleus. Although genetic control of GC morphogenesis is unknown, we suspected the involvement of the germline-specific MYB transcription factor DUO POLLEN1 (DUO1). We used light and fluorescence microscopy to examine male germline development in pollen of wild-type Arabidopsis and in four allelic duo1 mutants expressing introduced cell markers. Our analysis shows that the undivided GC in duo1 pollen forms a cytoplasmic projection, but the cell body fails to elongate. In contrast GCs of cyclin-dependent kinase function mutants, which fail to divide like duo1 mutants, achieve normal morphogenesis. We conclude that DUO1 has an essential role in the elongation of the GC, but DUO1-independent pathways control the development of the GC cytoplasmic projection. The two main features of GC morphogenesis therefore operate through independently regulated genetic pathways.
    MeSH term(s) Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Shape ; Cell Nucleus/metabolism ; Pollen
    Chemical Substances Arabidopsis Proteins
    Language English
    Publishing date 2023-04-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2700598-7
    ISSN 2194-7961 ; 2194-7953
    ISSN (online) 2194-7961
    ISSN 2194-7953
    DOI 10.1007/s00497-023-00462-x
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  6. Article ; Online: In Vivo Anti-inflammatory, Analgesic, and Sedative Studies of the Extract and Naphthoquinone Isolated from

    Bawazeer, Saud / Rauf, Abdur

    ACS omega

    2021  Volume 6, Issue 14, Page(s) 9852–9856

    Abstract: Anti-inflammatory, analgesic, and sedative medicine is used with numerous side effects, including peptic ulcer, headache, addiction, and other complications. In this regard, discovery research is undergoing a process to discover effective, safe, and ... ...

    Abstract Anti-inflammatory, analgesic, and sedative medicine is used with numerous side effects, including peptic ulcer, headache, addiction, and other complications. In this regard, discovery research is undergoing a process to discover effective, safe, and economical drugs with no side effects. The aim of this study was to assess chloroform extracts and isolated compounds for anti-inflammatory, analgesic, and sedative activities in animal models. The anti-inflammatory potential was measured by using the carrageenan-induced and histamine-induced paw edema procedure, while the analgesic potential was determined using a hot plate analgesiometer. The sedative effect was observed in an animal model for screening of the locomotor effect of the extract and isolated compound
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c00537
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  7. Article ; Online: In Vitro Antibacterial and Antifungal Potential of Amyrin-Type Triterpenoid Isolated from

    Bawazeer, Sami / Rauf, Abdur

    BioMed research international

    2021  Volume 2021, Page(s) 1543574

    Abstract: The aim of the present investigation was to evaluate the effect of the combined crude extract, fractions, and compound 1 isolated from the fruits ... ...

    Abstract The aim of the present investigation was to evaluate the effect of the combined crude extract, fractions, and compound 1 isolated from the fruits of
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Bacteria/drug effects ; Crystallography, X-Ray ; Datura metel/chemistry ; Fungi/drug effects ; Microbial Sensitivity Tests ; Plant Extracts/pharmacology ; Triterpenes/chemistry ; Triterpenes/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents ; Plant Extracts ; Triterpenes ; daturaolone (41498-80-0)
    Language English
    Publishing date 2021-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2021/1543574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: In vitro antiglycation and lipoxygenase inhibition of naphthoquinones isolated from Diospyros lotus Linn

    Bawazeer, Saud / Rauf, Abdur

    SAAB South African journal of botany. 2021 Mar. 07,

    2021  

    Abstract: Medicinal plants are a key source of important natural products, which are used for discovery of new drugs. The aim of this work was to explore the natural compounds having in vitro antiglycation and lipoxygenase inhibition potential. Consequently, ... ...

    Abstract Medicinal plants are a key source of important natural products, which are used for discovery of new drugs. The aim of this work was to explore the natural compounds having in vitro antiglycation and lipoxygenase inhibition potential. Consequently, compounds such as di-naphthodiospyrols A (1), di-naphthodiospyrols B (2), di-naphthodiospyrols C (3), di-naphthodiospyrols D (4), di-naphthodiospyrols E (5), di-naphthodiospyrols F (6), di-naphthodiospyrols g (7), 8-hydroxyisodiospyrin (8), and diospyrin (9) were isolated for the first time from Diospyros lotus Linn. In vitro antiglycation and lipoxygenase inhibitory activity results indicated that compound 4 exhibits the highest antiglycation activity with inhibition IC₅₀ = 287.45 ± 1.60 μM), followed by compound 5 with an IC₅₀ value of 248.72 ± 2.09 μM respectively. Similarly, compounds 7 and 8 showed moderate activity with IC₅₀ values of 234.87 ± 2.00 , and 228.98 ± 1.98 μM, respectively, when compared with rutin (IC₅₀ = 295.22 ± 1.55 μM). . The isolated compounds (1‒9) were also subjected to lipoxygenase inhibitory activity. Results revealed that secondary metabolites (1‒7) exhibit an excellent inhibitory effect against lipoxygenase, with IC₅₀ values of 90.35 ± 0.96, 87.09 ± 1.00, 84.01 ± 1.01, 40.49 ± 0.49, 44.70 ± 0.49, 79.04 ± 0.86, and 62.09 ± 0.18 μM, for compounds 1, 2, 3, 4, 5, 6, and 7, respectively. The standard drugs Baicalein and Tenidap sodium exhibited inhibitory effect with IC₅₀ values of 40.98 ± 0.08 μM and 23.00 ± 0.05 µM, respectively. Within this context, compounds with high inhibition potential against lioxygenase can be regarded as lead compounds in drug discovery. Furthermore, these compounds can be further studied as antiglycating agents to increase the chemical space for new chemical entities having drug-like properties.
    Keywords Diospyros lotus ; lipoxygenases ; naphthoquinones ; rutin ; secondary metabolites ; sodium
    Language English
    Dates of publication 2021-0307
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean ; Pre-press version
    ZDB-ID 2126918-X
    ISSN 0254-6299
    ISSN 0254-6299
    DOI 10.1016/j.sajb.2021.03.014
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  9. Article: Skin cancer from the perspective of public health concerns: etiology, transmission, diagnosis, treatment, and complications - correspondence.

    Islam, Md Rezaul / Akash, Shopnil / Rauf, Abdur / Sharma, Rohit

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 5, Page(s) 2266–2267

    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000662
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  10. Article: The recent outbreak of Iatrogenic botulism: point of view from the present world: editorial.

    Islam, Md Rezaul / Akash, Shopnil / Emran, Talha Bin / Rauf, Abdur

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 6, Page(s) 2289–2290

    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000711
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