Article ; Online: In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract.
2008 Volume 22, Issue 3, Page(s) 376–383
Abstract: The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. ... ...
| Abstract | The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. The effect on antioxidant status and protection against induced oxidative stress were also investigated using primary rat hepatocytes. A RR fruit extract containing 45 g/L total ascorbic acid and 65 g/L total polyphenols was used in this study. Dilutions up to 0.08% (v/v) increased significantly the antioxidant status in primary rat hepatocytes. The glutathione redox state was decreased with RR treatment but was increased in Chang liver cells and MT-2 lymphoblast. No cyto- or genotoxicity were observed at levels of up to 5% (v/v) of the fruit extract. In addition, a significant protection against t-BHP induced oxidative stress was observed in primary rat hepatocytes. The Ames test revealed no mutagenic activity using the Salmonella typhimurium strains TA98, TA100 and TA102. A significant antimutagenic effect of the extract was observed against the metabolic activated mutagens 2-acetylaminofluorene and aflatoxin B1 and to a lesser extent against methyl methanesulfonate. It is concluded that these results support the associated health promoting potential of Rosa Roxburghii fruit and in particular against oxidative stress. |
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| MeSH term(s) | Animals ; Antimutagenic Agents/pharmacology ; Antioxidants/pharmacology ; Carcinogens/pharmacology ; Cells, Cultured ; Comet Assay ; DNA Damage/drug effects ; Fruit/chemistry ; Glutathione/analysis ; Glutathione/drug effects ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Male ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Plant Extracts/pharmacology ; Plant Extracts/toxicity ; Rats ; Rats, Sprague-Dawley ; Rosa/chemistry ; Salmonella typhimurium/drug effects ; tert-Butylhydroperoxide/pharmacology |
| Chemical Substances | Antimutagenic Agents ; Antioxidants ; Carcinogens ; Plant Extracts ; tert-Butylhydroperoxide (955VYL842B) ; Glutathione (GAN16C9B8O) |
| Language | English |
| Publishing date | 2008-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 639136-9 |
| ISSN | 1099-1573 ; 0951-418X |
| ISSN (online) | 1099-1573 |
| ISSN | 0951-418X |
| DOI | 10.1002/ptr.2330 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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