LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China.

    Rautenberg, Tamlyn A / Ng, Shu Kay Angus / Downes, Martin

    BMC women's health

    2023  Volume 23, Issue 1, Page(s) 563

    Abstract: Objective: To measure symptoms and health-related quality of life in a cross-sectional cohort of menopausal-aged women in China.: Method: A cross-sectional survey was conducted in a general population cohort of 2,000 Chinese females over the age of ... ...

    Abstract Objective: To measure symptoms and health-related quality of life in a cross-sectional cohort of menopausal-aged women in China.
    Method: A cross-sectional survey was conducted in a general population cohort of 2,000 Chinese females over the age of 45 years. Patients completed the Chinese version of the EuroQol-5D five level (EQ5D5L) health-related quality of life instrument via Personal Digital Assistant. Raw scores were converted to utility tariffs using value sets for China. Statistical analysis included Pearson's chi-square test, z test for multiple comparisons with adjustment by the Bonferroni method, independent-sample t-test, ANOVA, and adjustment by the Tukey method for multiple comparison. Results were considered statistically significant when p < 0.05 and the study was reported according to the STROBE recommendations.
    Results: In a cohort of 2000 women, 732 (37%) were premenopausal, 798 (40%) were perimenopausal and 470 (23%) were postmenopausal. Perimenopausal women reported significantly more symptoms (91%) compared to premenopausal (77%) and postmenopausal (81%) women. Health-related quality of life was significantly lower in symptomatic perimenopausal women compared to premenopausal (0.919, p < 0.05) and postmenopausal (0.877, p < 0.05) women. Within each group there was a statistically significant difference between the health-related quality of life of women with symptoms compared to without symptoms.
    Conclusion: The perimenopausal phase of menopause is associated with significantly more symptoms and significantly lower HRQoL compared to premenopausal and postmenopausal phases.
    MeSH term(s) Humans ; Female ; Aged ; Middle Aged ; Male ; Cross-Sectional Studies ; Perimenopause ; Quality of Life ; Menopause ; Premenopause
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050444-5
    ISSN 1472-6874 ; 1472-6874
    ISSN (online) 1472-6874
    ISSN 1472-6874
    DOI 10.1186/s12905-023-02728-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa.

    Rautenberg, Tamlyn A / Ng, Shu Kay / George, Gavin / Moosa, Mahomed-Yunus S / McCluskey, Suzanne M / Gilbert, Rebecca F / Pillay, Selvan / Aturinda, Isaac / Ard, Kevin L / Muyindike, Winnie R / Musinguzi, Nicholas / Masette, Godfrey / Pillay, Melendhran / Moodley, Pravi / Brijkumar, Jaysingh / Gandhi, Rajesh T / Johnson, Brent / Sunpath, Henry / Bwana, Mwebesa B /
    Marconi, Vincent C / Siedner, Mark J

    Health and quality of life outcomes

    2023  Volume 21, Issue 1, Page(s) 94

    Abstract: Background: Antiretroviral treatment improves health related quality of life (HRQoL) of people with human immunodeficiency virus (PWH). However, one third initiating first-line treatment experience virological failure and the determinants of HRQoL in ... ...

    Abstract Background: Antiretroviral treatment improves health related quality of life (HRQoL) of people with human immunodeficiency virus (PWH). However, one third initiating first-line treatment experience virological failure and the determinants of HRQoL in this key population are unknown. Our study aims to identify determinants of among PWH failing antiretroviral treatment in sub-Saharan Africa.
    Methods: We analysed data from a cohort of PWH having virological failure (> 1,000 copies/mL) on first-line ART in South Africa and Uganda. We measured HRQoL using the EuroQOL EQ-5D-3L and used a two-part regression model to obtain by-country analyses for South Africa and Uganda. The first part identifies risk factors that were associated with the likelihood of participants reporting perfect health (utility = 1) versus non-perfect health (utility < 1). The second part identifies risk factors that were associated with the EQ-5 L-3L utility scores for participants reporting non-perfect health. We performed sensitivity analyses to compare the results between the two-part model using tobit models and ordinary least squares regression.
    Results: In both countries, males were more likely to report perfect health and participants with at least one comorbidity were less likely to report perfect health. In South Africa, participants with side effects and in Uganda those with opportunistic infections were also less likely to report perfect health. In Uganda, participants with 100% ART adherence were more likely to report perfect health. In South Africa, high HIV viral load, experiencing ART side effects, and the presence of opportunistic infections were each associated with lower HRQoL, whereas participants with 100% ART adherence reported higher HRQoL. In Uganda participants with lower CD4 count had lower HRQoL.
    Conclusion: Markers of advanced disease (opportunistic infection, high viral load, low CD4), side effects, comorbidities and lack of ART adherence negatively impacted HRQoL for PWH experiencing virological failure.
    Trial registration: ClinicalTrials.gov: NCT02787499.
    MeSH term(s) Male ; Humans ; HIV ; Quality of Life ; South Africa/epidemiology ; Anti-Retroviral Agents ; Opportunistic Infections ; HIV Infections/drug therapy ; HIV Infections/epidemiology
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2098765-1
    ISSN 1477-7525 ; 1477-7525
    ISSN (online) 1477-7525
    ISSN 1477-7525
    DOI 10.1186/s12955-023-02179-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Seemingly Unrelated Regression Analysis of the Cost and Health-Related Quality of Life Outcomes of the REVAMP Randomized Clinical Trial.

    Rautenberg, Tamlyn A / Ng, Shu Kay / George, Gavin / Moosa, Mahomed-Yunus S / McCluskey, Suzanne M / Gilbert, Rebecca F / Pillay, Selvan / Aturinda, Isaac / Ard, Kevin L / Muyindike, Winnie / Musinguzi, Nicholas / Masette, Godfrey / Pillay, Melendhran / Moodley, Pravi / Brijkumar, Jaysingh / Gandhi, Rajesh T / Johnson, Brent / Sunpath, Henry / Bwana, Mwebesa B /
    Marconi, Vincent C / Siedner, Mark J

    Value in health regional issues

    2023  Volume 35, Page(s) 42–47

    Abstract: Objective: This study aimed to evaluate the 9-month cost and health-related quality of life (HRQOL) outcomes of resistance versus viral load testing strategies to manage virological failure in low-middle income countries.: Methods: We analyzed ... ...

    Abstract Objective: This study aimed to evaluate the 9-month cost and health-related quality of life (HRQOL) outcomes of resistance versus viral load testing strategies to manage virological failure in low-middle income countries.
    Methods: We analyzed secondary outcomes from the REVAMP clinical trial: a pragmatic, open label, parallel-arm randomized trial investigating resistance versus viral load testing for individuals failing first-line treatment in South Africa and Uganda. We collected resource data, valued according to local cost data and used the 3-level version of EQ-5D to measure HRQOL at baseline and 9 months. We applied seemingly unrelated regression equations to account for the correlation between cost and HRQOL. We conducted intention-to-treat analyses with multiple imputation using chained equations for missing data and performed sensitivity analyses using complete cases.
    Results: For South Africa, resistance testing and opportunistic infections were associated with statistically significantly higher total costs, and virological suppression was associated with lower total cost. Higher baseline utility, higher cluster of differentiation 4 (CD4) count, and virological suppression were associated with better HRQOL. For Uganda, resistance testing and switching to second-line treatment were associated with higher total cost, and higher CD4 was associated with lower total cost. Higher baseline utility, higher CD4 count, and virological suppression were associated with better HRQOL. Sensitivity analyses of the complete-case analysis confirmed the overall results.
    Conclusion: Resistance testing showed no cost or HRQOL advantage in South Africa or Uganda over the 9-month REVAMP clinical trial.
    MeSH term(s) Humans ; Anti-HIV Agents/therapeutic use ; Quality of Life ; South Africa
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2679127-4
    ISSN 2212-1102 ; 2212-1099
    ISSN (online) 2212-1102
    ISSN 2212-1099
    DOI 10.1016/j.vhri.2022.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6969: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top