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  1. AU="Raval, Urdhva"
  2. AU="Senn, L Kirsten"
  3. AU="Matsutani, Noriyuki"
  4. AU="Bernstein, Herbert J"
  5. AU="Elisa Impresari"
  6. AU="Feldman, Noa"
  7. AU="Dhingra, Mandeep Singh"

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  1. Artikel ; Online: Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies.

    Naughton, Sean X / Raval, Urdhva / Pasinetti, Giulio M

    Journal of Alzheimer's disease : JAD

    2020  Band 76, Heft 1, Seite(n) 21–25

    Abstract: There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune ...

    Abstract There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune response and excessive inflammation in COVID-19 may also accelerate the progression of brain inflammatory neurodegeneration, and elderly individuals are more susceptible to severe outcomes after SARS-CoV-2 infection. Individuals with type 2 diabetes (T2D) are at an increased risk for AD as well as severe outcomes after SARS-CoV-2 infection. Genetic and socioeconomic factors influencing the rates of T2D, AD, and COVID-19 severity may create an exceptionally high-risk profile for certain demographics such as African Americans and Hispanic Americans. Type I interferon response plays an important role in both host response to viral infection, as well as AD pathology and may be a sensible therapeutic target in both AD and COVID-19.
    Mesh-Begriff(e) Aged ; Alzheimer Disease ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus, Type 2 ; Humans ; Interferon Type I ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Synapses
    Chemische Substanzen Interferon Type I
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-200537
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The Viral Hypothesis in Alzheimer's Disease: Novel Insights and Pathogen-Based Biomarkers.

    Naughton, Sean X / Raval, Urdhva / Pasinetti, Giulio M

    Journal of personalized medicine

    2020  Band 10, Heft 3

    Abstract: Early diagnosis of Alzheimer's disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a ... ...

    Abstract Early diagnosis of Alzheimer's disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a critical need to establish biomarkers which can predict the risk of developing AD before the onset of cognitive decline. A number of studies have indicated that exposure to various microbial pathogens can accelerate AD pathology. Additionally, several studies have indicated that amyloid-β possess antimicrobial properties and may act in response to infection as a part of the innate immune system. These findings have led some to speculate that certain types of infections may play a significant role in AD pathogenesis. In this review, we will provide an overview of studies which suggest pathogen involvement in AD. Additionally, we will discuss a number of pathogen-associated biomarkers which may be effective in establishing AD risk. Infections that increase the risk of AD represent a modifiable risk factor which can be treated with therapeutic intervention. Pathogen-based biomarkers may thus be a valuable tool for evaluating and decreasing AD risk across the population.
    Sprache Englisch
    Erscheinungsdatum 2020-07-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm10030074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection.

    Naughton, Sean X / Raval, Urdhva / Harary, Joyce M / Pasinetti, Giulio M

    Journal of exposure science & environmental epidemiology

    2020  Band 30, Heft 5, Seite(n) 776–777

    Mesh-Begriff(e) Air Pollution ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Exposome ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-12
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-020-0232-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The dichotomous role of the gut microbiome in exacerbating and ameliorating neurodegenerative disorders.

    Raval, Urdhva / Harary, Joyce M / Zeng, Emma / Pasinetti, Giulio M

    Expert review of neurotherapeutics

    2020  Band 20, Heft 7, Seite(n) 673–686

    Abstract: Introduction: Age related neurodegenerative disorders affect millions of people around the world. The role of the gut microbiome (GM) in neurodegenerative disorders has been elucidated over the past few years. Dysbiosis of the gut microbiome ultimately ... ...

    Abstract Introduction: Age related neurodegenerative disorders affect millions of people around the world. The role of the gut microbiome (GM) in neurodegenerative disorders has been elucidated over the past few years. Dysbiosis of the gut microbiome ultimately results in neurodegeneration. However, the gut microbiome can be modulated to promote neuro-resilience.
    Areas covered: This review is focused on demonstrating the role of the gut microbiome in host physiology in Parkinson's disease (PD) and other neurodegenerative disorders. We will discuss how the microbiome will impact neurodegeneration in PD, Alzheimer's Disease (AD), Multiple sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and finally discuss how the gut microbiome can be influenced through diet and lifestyle.
    Expert opinion: Currently, much of the focus has been to study the mechanisms by which the microbiome induces neuroinflammation and neurodegeneration in PD, AD, MS, ALS. In particular, the role of certain dietary flavonoids in regulation of gut microbiome to promote neuro-resilience. Polyphenol prebiotics delivered in combination with probiotics (synbiotics) present an exciting new avenue to harness the microbiome to attenuate immune inflammatory responses which ultimately may influence brain cascades associated with promotion of neurodegeneration across the lifespan.
    Mesh-Begriff(e) Dysbiosis/complications ; Dysbiosis/diet therapy ; Dysbiosis/microbiology ; Gastrointestinal Microbiome ; Humans ; Neurodegenerative Diseases/diet therapy ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/microbiology ; Probiotics/therapeutic use
    Sprache Englisch
    Erscheinungsdatum 2020-06-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2020.1775585
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies

    Naughton, Sean X / Raval, Urdhva / Pasinetti, Giulio M

    J Alzheimers Dis

    Abstract: There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune ...

    Abstract There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune response and excessive inflammation in COVID-19 may also accelerate the progression of brain inflammatory neurodegeneration, and elderly individuals are more susceptible to severe outcomes after SARS-CoV-2 infection. Individuals with type 2 diabetes (T2D) are at an increased risk for AD as well as severe outcomes after SARS-CoV-2 infection. Genetic and socioeconomic factors influencing the rates of T2D, AD, and COVID-19 severity may create an exceptionally high-risk profile for certain demographics such as African Americans and Hispanic Americans. Type I interferon response plays an important role in both host response to viral infection, as well as AD pathology and may be a sensible therapeutic target in both AD and COVID-19.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #601164
    Datenquelle COVID19

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  6. Artikel: The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection

    Naughton, Sean X / Raval, Urdhva / Harary, Joyce M / Pasinetti, Giulio M

    J Expo Sci Environ Epidemiol

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #244484
    Datenquelle COVID19

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  7. Artikel ; Online: The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection

    Naughton, Sean X. / Raval, Urdhva / Harary, Joyce M. / Pasinetti, Giulio M.

    Journal of Exposure Science & Environmental Epidemiology

    2020  Band 30, Heft 5, Seite(n) 776–777

    Schlagwörter Toxicology ; Public Health, Environmental and Occupational Health ; Epidemiology ; Pollution ; covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-020-0232-4
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Inflammasome-Mediated Neuronal-Microglial Crosstalk: a Therapeutic Substrate for the Familial C9orf72 Variant of Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.

    Trageser, Kyle J / Yang, Eun-Jeong / Smith, Chad / Iban-Arias, Ruth / Oguchi, Tatsunori / Sebastian-Valverde, Maria / Iqbal, Umar Haris / Wu, Henry / Estill, Molly / Al Rahim, Md / Raval, Urdhva / Herman, Francis J / Zhang, Yong Jie / Petrucelli, Leonard / Pasinetti, Giulio Maria

    Molecular neurobiology

    2023  Band 60, Heft 7, Seite(n) 4004–4016

    Abstract: ... Intronic ... ...

    Abstract Intronic G
    Mesh-Begriff(e) Animals ; Mice ; Amyotrophic Lateral Sclerosis/metabolism ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/pathology ; Microglia/metabolism ; Inflammasomes ; C9orf72 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Neuroinflammatory Diseases ; DNA Repeat Expansion/genetics ; Dipeptides
    Chemische Substanzen Inflammasomes ; C9orf72 Protein ; NLR Family, Pyrin Domain-Containing 3 Protein ; Dipeptides
    Sprache Englisch
    Erscheinungsdatum 2023-04-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03315-w
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  9. Artikel ; Online: Exposure to World Trade Center Dust Exacerbates Cognitive Impairment and Evokes a Central and Peripheral Pro-Inflammatory Transcriptional Profile in an Animal Model of Alzheimer's Disease.

    Iban-Arias, Ruth / Trageser, Kyle J / Yang, Eun-Jeong / Griggs, Elizabeth / Radu, Aurelian / Naughton, Sean / Al Rahim, Md / Tatsunori, Oguchi / Raval, Urdhva / Palmieri, Joshua / Huang, Zerlina / Chen, Lung-Chi / Pasinetti, Giulio Maria

    Journal of Alzheimer's disease : JAD

    2022  Band 91, Heft 2, Seite(n) 779–794

    Abstract: Background: The terrorist attacks on September 11, 2001, on the World Trade Center (WTC) led to intense fires and a massive dense cloud of toxic gases and suspended pulverized debris. In the subsequent years, following the attack and cleanup efforts, a ... ...

    Abstract Background: The terrorist attacks on September 11, 2001, on the World Trade Center (WTC) led to intense fires and a massive dense cloud of toxic gases and suspended pulverized debris. In the subsequent years, following the attack and cleanup efforts, a cluster of chronic health conditions emerged among First Responders (FR) who were at Ground Zero for prolonged periods and were repeatedly exposed to high levels of WTC particulate matter (WTCPM). Among those are neurological complications which may increase the risk for the development of Alzheimer's disease (AD) later in life.
    Objective: We hypothesize that WTCPM dust exposure affects the immune cross-talking between the periphery and central nervous systems that may induce brain permeability ultimately promoting AD-type phenotype.
    Methods: 5XFAD and wild-type mice were intranasally administered with WTCPM dust collected at Ground Zero within 72 h after the attacks. Y-maze assay and novel object recognition behavioral tests were performed for working memory deficits and learning and recognition memory, respectively. Transcriptomic analysis in the blood and hippocampus was performed and confirmed by RT qPCR.
    Results: Mice exposed to WTCPM dust exhibited a significant impairment in spatial and recognition short and long-term memory. Furthermore, the transcriptomic analysis in the hippocampal formation and blood revealed significant changes in genes related to immune-inflammatory responses, and blood-brain barrier disruption.
    Conclusion: These studies suggest a putative peripheral-brain immune inflammatory cross-talking that may potentiate cognitive decline, identifying for the first time key steps which may be therapeutically targetable in future studies in WTC FR.
    Mesh-Begriff(e) Mice ; Animals ; Dust/analysis ; Alzheimer Disease/genetics ; September 11 Terrorist Attacks ; Models, Animal ; Cognitive Dysfunction/genetics
    Chemische Substanzen Dust
    Sprache Englisch
    Erscheinungsdatum 2022-12-25
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-221046
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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