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Article ; Online: The added value of radiomics in determining patient responsiveness to laryngeal preservation strategies.

Ravanelli, Marco / Rondi, Paolo / Di Meo, Nunzia / Farina, Davide

Current opinion in otolaryngology & head and neck surgery

2024 Volume 32, Issue 2, Page(s) 134–137

Abstract: Purpose of review: Laryngeal cancer (LC) is a highly aggressive malignancy of the head and neck and represents about 1-2% of cancer worldwide.Treatment strategies for LC aim both to complete cancer removal and to preserve laryngeal function or maximize ... ...

Abstract	Purpose of review: Laryngeal cancer (LC) is a highly aggressive malignancy of the head and neck and represents about 1-2% of cancer worldwide.Treatment strategies for LC aim both to complete cancer removal and to preserve laryngeal function or maximize larynx retention.Predicting with high precision response to induction chemotherapy (IC) is one of the main fields of research when considering LC, since this could guide treatment strategies in locally advanced LC. Recent findings: Radiomics is a noninvasive method to extract quantitative data from the whole tumor using medical imaging. This signature could represent the underlying tumor heterogeneity and phenotype.During the last five years, some studies have highlighted the potential of radiomics in the pretreatment assessment of LC, in the prediction of response to IC, and in the early assessment of response to radiation therapy. Although these represent promising results, larger multicentric studies are demanded to validate the value of radiomics in this field. Summary: The role of radiomics in laryngeal preservation strategies is still to be defined. There are some early promising studies, but the lack of validation and larger multicentric studies limit the value of the papers published in the literature and its application in clinical practice.
MeSH term(s)	Humans ; Radiomics ; Larynx/diagnostic imaging ; Laryngeal Neoplasms/diagnostic imaging ; Laryngeal Neoplasms/therapy ; Laryngeal Neoplasms/pathology ; Diagnostic Imaging
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000963
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Article: FREEZEit StarVIBE: Freezing the Moving Head and Neck at a Sub-Millimetric Scale

Ravanelli, Marco

Magnetom flash

2016 Volume -, Issue 3 = Nr. 66, Page(s) 92

Language	English
Document type	Article
ZDB-ID	2465783-9
Database	Current Contents Medicine

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Article ; Online: CT and MR anatomy of the larynx and hypopharynx.

Ravanelli, Marco / Rondi, Paolo / Ferrari, Marco / Lancini, Davide / Buffoli, Barbara / Borghesi, Andrea / Maroldi, Roberto / Farina, Davide

Neuroradiology

2024

Abstract: Imaging of the larynx and hypopharynx is frequently requested to assess the extent of neoplasms beyond the field of view of endoscopic evaluation. The combination of optical and cross-sectional imaging allows tumors to be classified according to AJCC/ ... ...

Abstract	Imaging of the larynx and hypopharynx is frequently requested to assess the extent of neoplasms beyond the field of view of endoscopic evaluation. The combination of optical and cross-sectional imaging allows tumors to be classified according to AJCC/UICC guidelines. A thorough understanding of laryngeal and hypopharyngeal anatomy is crucial to guide the radiological eye along the possible pathways of the spread of diseases and to guide differential diagnoses. Computed tomography (CT) has been the first cross-sectional imaging technique used to evaluate the larynx and hypopharynx; its spatial resolution combined with volumetric capability and the use of injectable contrast medium made CT the working horse in the assessment of neoplastic and inflammatory diseases. In the last two decades, magnetic resonance (MR) supported CT in the most challenging cases, when the optimal contrast resolution due to the multisequence portfolio is needed to assess the neoplastic involvement of laryngeal cartilages, paraglottic space(s), and extra laryngeal spread. The aim of this paper is to give a comprehensive radiological overview of larynx and hypopharynx complex anatomy, combining in vivo images, anatomical sections, and images of ex vivo specimens.
Language	English
Publishing date	2024-02-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-024-03320-3
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Article ; Online: MRI radiomics in head and neck cancer from reproducibility to combined approaches.

Corti, Anna / Cavalieri, Stefano / Calareso, Giuseppina / Mattavelli, Davide / Ravanelli, Marco / Poli, Tito / Licitra, Lisa / Corino, Valentina D A / Mainardi, Luca

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9451

Abstract: The clinical applicability of radiomics in oncology depends on its transferability to real-world settings. However, the absence of standardized radiomics pipelines combined with methodological variability and insufficient reporting may hamper the ... ...

Abstract	The clinical applicability of radiomics in oncology depends on its transferability to real-world settings. However, the absence of standardized radiomics pipelines combined with methodological variability and insufficient reporting may hamper the reproducibility of radiomic analyses, impeding its translation to clinics. This study aimed to identify and replicate published, reproducible radiomic signatures based on magnetic resonance imaging (MRI), for prognosis of overall survival in head and neck squamous cell carcinoma (HNSCC) patients. Seven signatures were identified and reproduced on 58 HNSCC patients from the DB2Decide Project. The analysis focused on: assessing the signatures' reproducibility and replicating them by addressing the insufficient reporting; evaluating their relationship and performances; and proposing a cluster-based approach to combine radiomic signatures, enhancing the prognostic performance. The analysis revealed key insights: (1) despite the signatures were based on different features, high correlations among signatures and features suggested consistency in the description of lesion properties; (2) although the uncertainties in reproducing the signatures, they exhibited a moderate prognostic capability on an external dataset; (3) clustering approaches improved prognostic performance compared to individual signatures. Thus, transparent methodology not only facilitates replication on external datasets but also advances the field, refining prognostic models for potential personalized medicine applications.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/pathology ; Female ; Male ; Reproducibility of Results ; Middle Aged ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging ; Squamous Cell Carcinoma of Head and Neck/pathology ; Aged ; Adult ; Radiomics
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60009-6
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Article ; Online: Software-based quantitative CT analysis to predict the growth trend of persistent nonsolid pulmonary nodules: a retrospective study.

Borghesi, Andrea / Coviello, Felice Leopoldo / Scrimieri, Alessandra / Ciolli, Pietro / Ravanelli, Marco / Farina, Davide

La Radiologia medica

2023 Volume 128, Issue 6, Page(s) 734–743

Abstract: Purpose: Persistent nonsolid nodules (NSNs) usually exhibit an indolent course and may remain stable for several years; however, some NSNs grow quickly and require surgical excision. Therefore, identifying quantitative features capable of early ... ...

Abstract	Purpose: Persistent nonsolid nodules (NSNs) usually exhibit an indolent course and may remain stable for several years; however, some NSNs grow quickly and require surgical excision. Therefore, identifying quantitative features capable of early discrimination between growing and nongrowing NSNs is becoming a crucial aspect of radiological analysis. The main purpose of this study was to evaluate the performance of an open-source software (ImageJ) to predict the future growth of NSNs detected in a Caucasian (Italian) population. Material and methods: We retrospectively selected 60 NSNs with an axial diameter of 6-30 mm scanned with the same acquisition-reconstruction parameters and the same computed tomography (CT) scanner. Software-based analysis was performed on thin-section CT images using ImageJ. For each NSNs, several quantitative features were extracted from the baseline CT images. The relationships of NSN growth with quantitative CT features and other categorical variables were analyzed using univariate and multivariable logistic regression analyses. Results: In multivariable analysis, only the skewness and linear mass density (LMD) were significantly associated with NSN growth, and the skewness was the strongest predictor of growth. In receiver operating characteristic curve analyses, the optimal cutoff values of skewness and LMD were 0.90 and 19.16 mg/mm, respectively. The two predictive models that included the skewness, with or without LMD, exhibited an excellent power for predicting NSN growth. Conclusion: According to our results, NSNs with a skewness value > 0.90, specifically those with a LMD > 19.16 mg/mm, should require closer follow-up due to their higher growth potential, and higher risk of becoming an active cancer.
MeSH term(s)	Humans ; Retrospective Studies ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Multiple Pulmonary Nodules/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Software ; Solitary Pulmonary Nodule/diagnostic imaging
Language	English
Publishing date	2023-05-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	205751-7
ISSN	1826-6983 ; 0033-8362
ISSN (online)	1826-6983
ISSN	0033-8362
DOI	10.1007/s11547-023-01648-z
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Article ; Online: Unilateral absence of the pulmonary artery: a one-stop-shop assessment with cardiac magnetic resonance imaging.

Vaccher, Filippo / Ravanelli, Marco / Farina, Davide

Kardiologia polska

2020 Volume 78, Issue 9, Page(s) 939–940

MeSH term(s)	Heart ; Humans ; Magnetic Resonance Imaging ; Pulmonary Artery/diagnostic imaging
Language	English
Publishing date	2020-06-17
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.15434
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Zs.B 598: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Longitudinal Body Composition Changes Detected by [

Albano, Domenico / Dondi, Francesco / Treglia, Giorgio / Tucci, Alessandra / Ravanelli, Marco / Farina, Davide / Bertagna, Francesco

Cancers

2022 Volume 14, Issue 20

Abstract: The aim of this retrospective study was to investigate the longitudinal body changes in terms of muscle and adipose areas and their prognostic role in elderly (>65 years) patients affected by Hodgkin lymphoma (HL). Skeletal muscle area (SMA), skeletal ... ...

Abstract	The aim of this retrospective study was to investigate the longitudinal body changes in terms of muscle and adipose areas and their prognostic role in elderly (>65 years) patients affected by Hodgkin lymphoma (HL). Skeletal muscle area (SMA), skeletal muscle index (SMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intramuscular adipose tissue (IMAT), and total dispose tissue (TAT) were measured using the computed tomography (CT) of fluorine-18-fluorodeoxyglucose positron emission tomography/CT ([18F]FDG PET/CT) in 88 patients who undertook baseline, interim (after two cycles of chemotherapy), and end-of-treatment (after 6 cycles of chemotherapy) PET/CT scans. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured at pre-treatment PET/CT. Metabolic response applying Deauville score was evaluated at interim and end-of-treatment PET/CT. Survival curves, such as progression free survival (PFS) and overall survival (OS), were calculated for the whole population. Fifty-eight (66%) patients had sarcopenia at baseline and sarcopenia rate increased at interim scan with 68 (77%) cases and at end-of-treatment scan with 73 (83%) cases. Muscular areas (SMA and SMI) declined significantly during the treatment (p < 0.001), decreasing from baseline by 5% and 7% at interim and end-of-treatment evaluation, respectively. Instead, VAT, SAT, IMAT, and TAT increased significantly over this time (p < 0.001). Sarcopenia was significantly related with comprehensive geriatric assessment. PET/CT response at interim and end-of-treatment, MTV, TLG, and baseline sarcopenia were independent prognostic factors for PFS. Instead, metabolic response at interim and end-of-treatment PET, baseline sarcopenia, ΔSMI at interim, and ΔSMI at end-of-treatment for OS were independent prognostic factors.
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14205147
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Article ; Online: Residual Lung Abnormalities in Survivors of Severe or Critical COVID-19 at One-Year Follow-Up Computed Tomography: A Narrative Review Comparing the European and East Asian Experiences.

Borghesi, Andrea / Ciolli, Pietro / Antonelli, Elisabetta / Monti, Alessandro / Scrimieri, Alessandra / Ravanelli, Marco / Maroldi, Roberto / Farina, Davide

Tomography (Ann Arbor, Mich.)

2023 Volume 10, Issue 1, Page(s) 25–36

Abstract: The literature reports that there was a significant difference in the medical impact of the coronavirus disease (COVID-19) pandemic between European and East Asian countries; specifically, the mortality rate of COVID-19 in Europe was significantly higher ...

Abstract	The literature reports that there was a significant difference in the medical impact of the coronavirus disease (COVID-19) pandemic between European and East Asian countries; specifically, the mortality rate of COVID-19 in Europe was significantly higher than that in East Asia. Considering such a difference, our narrative review aimed to compare the prevalence and characteristics of residual lung abnormalities at one-year follow-up computed tomography (CT) after severe or critical COVID-19 in survivors of European and East Asian countries. A literature search was performed to identify articles focusing on the prevalence and characteristics of CT lung abnormalities in survivors of severe or critical COVID-19. Database analysis identified 16 research articles, 9 from Europe and 7 from East Asia (all from China). Our analysis found a higher prevalence of CT lung abnormalities in European than in Chinese studies (82% vs. 52%). While the most prevalent lung abnormalities in Chinese studies were ground-glass opacities (35%), the most prevalent lung abnormalities in European studies were linear (59%) and reticular opacities (55%), followed by bronchiectasis (46%). Although our findings required confirmation, the higher prevalence and severity of lung abnormalities in European than in Chinese survivors of COVID-19 may reflect a greater architectural distortion due to a more severe lung damage.
MeSH term(s)	Humans ; COVID-19/complications ; COVID-19/diagnostic imaging ; East Asian People ; Follow-Up Studies ; Lung/diagnostic imaging ; Survivors ; Tomography, X-Ray Computed ; Europe ; Asia, Eastern ; European People ; Patient Acuity
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Review
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography10010003
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Article ; Online: Magnetic resonance diagnosis of laryngeal chondritis after transoral laser microsurgery for laryngeal cancer.

Cunha, Bruno / Lancini, Davide / Rondi, Paolo / Ravanelli, Marco / Maroldi, Roberto / Paderno, Alberto / Zigliani, Gabriele / Bertotto, Ilaria / Piazza, Cesare / Farina, Davide

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2023 Volume 43, Issue 1, Page(s) 32–41

Abstract: Objective: Laryngeal chondritis (LC) is a rare complication of carbon dioxide transoral laser microsurgery (CO: Methods: Clinical records and MR images of all patients presenting with LC after CO: Results: Seven patients were analysed. Timing of ... ...

Abstract	Objective: Laryngeal chondritis (LC) is a rare complication of carbon dioxide transoral laser microsurgery (CO Methods: Clinical records and MR images of all patients presenting with LC after CO Results: Seven patients were analysed. Timing of LC diagnosis ranged from 1 to 8 months after CO Conclusions: LC after CO
MeSH term(s)	Humans ; Laryngeal Neoplasms ; Carbon Dioxide ; Microsurgery ; Neoplasm Recurrence, Local ; Magnetic Resonance Spectroscopy ; Lasers
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-03-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N2262
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Article ; Online: A case of otoliquorrhoea secondary to immunotherapy response in head and neck cutaneous squamous cell carcinoma. When abrupt response may worry the physician.

Lorini, Luigi / Tomasoni, Michele / Rondi, Paolo / Esposito, Andrea / Ravanelli, Marco / Schreiber, Alberto / Biroli, Antonio / Bossi, Paolo

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2023

Language	English
Publishing date	2023-10-10
Publishing country	Italy
Document type	Letter
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-N2647
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