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  1. Article: The use of mechanical circulatory support in post-acute myocardial infarction mechanical complications.

    Lorusso, Roberto / Lo Coco, Valeria / Ravaux, Justine M / Mariani, Silvia

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 3, Page(s) 325–327

    Language English
    Publishing date 2022-06-13
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-ami-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Left ventricular assist devices and right ventricular failure prediction: Quo Vadis?

    Lorusso, Roberto / Ravaux, Justine M / Mariani, Silvia

    Interactive cardiovascular and thoracic surgery

    2021  Volume 33, Issue 5, Page(s) 793–794

    MeSH term(s) Heart Failure/therapy ; Heart-Assist Devices ; Humans ; Ventricular Dysfunction, Right/etiology
    Language English
    Publishing date 2021-08-17
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivab208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gently handling the acutely failing right ventricle … at last!

    Lorusso, Roberto / Mariani, Silvia / Ravaux, Justine M

    Interactive cardiovascular and thoracic surgery

    2021  Volume 33, Issue 5, Page(s) 801–802

    MeSH term(s) Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery ; Heart-Assist Devices ; Humans ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/etiology
    Language English
    Publishing date 2021-09-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivab248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Predictors of permanent pacemaker implantation following surgical aortic valve replacement: Letter to the editor-Reply.

    Ravaux, Justine M / Mariani, Silvia / Lorusso, Roberto

    Journal of cardiac surgery

    2021  Volume 36, Issue 11, Page(s) 4444

    MeSH term(s) Aortic Valve/surgery ; Heart Valve Prosthesis ; Humans ; Pacemaker, Artificial ; Transcatheter Aortic Valve Replacement
    Language English
    Publishing date 2021-08-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.15899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effects of concomitant coronary artery bypass grafting on early and late mortality in the treatment of post-infarction mechanical complications: a systematic review and meta-analysis.

    Ronco, Daniele / Corazzari, Claudio / Matteucci, Matteo / Massimi, Giulio / Di Mauro, Michele / Ravaux, Justine M / Beghi, Cesare / Lorusso, Roberto

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 3, Page(s) 210–225

    Abstract: Background: Mechanical complications of acute myocardial infarction represent life-threatening events, including ventricular septal rupture (VSR), left ventricular free-wall rupture (LVFWR) and papillary muscle rupture (PMR). In-hospital mortality is ... ...

    Abstract Background: Mechanical complications of acute myocardial infarction represent life-threatening events, including ventricular septal rupture (VSR), left ventricular free-wall rupture (LVFWR) and papillary muscle rupture (PMR). In-hospital mortality is high, even when prompt surgery can be offered. The role of concomitant coronary artery bypass grafting (CABG) in the surgical treatment of these conditions is still debated.
    Methods: A systematic review of the literature, from 2000 onwards, about these complications was performed, analyzing data of subjects receiving versus not-receiving concomitant CABG. Primary outcome was early mortality. Secondary outcome was late mortality for hospital survivors. Subgroup analysis for VSR, LVFWR and PMR was also performed.
    Results: Thirty-six studies were identified, including 4,321 patients (mostly VSR-related). Preoperative coronarography was performed in 92.2% of the cases, showing single-vessel disease in 54.3% of patients. Concomitant CABG rate was 49.0%. Early mortality was 32.6% and late mortality was 40.0% with 5.2 years of mean follow-up. The analysis showed no difference in early (OR 0.96; P=0.60) or late mortality (RR 0.91; P=0.49) between CABG and non-CABG group. In subgroup analysis, concomitant CABG was associated with significantly lower mortality at long term for PMR (RR 0.42; P=0.001), although it showed a higher, but not significant, mortality in VSR (RR 1.24; P=0.20).
    Conclusions: Concomitant CABG in the treatment for post-infarction mechanical complications showed no significant impact on both early and late mortality, although deserving some distinctions among different types of complication and single versus multiple vessel disease. However, larger, dedicated studies are required to provide more consistent data and evidence.
    Language English
    Publishing date 2022-06-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-ami-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Apical versus subclavian transcatheter aortic valve implantation: An 8-year United Kingdom analysis.

    D'Auria, Francesca / Santo, Danilo F / Myat, Aung / Lorusso, Roberto / Ravaux, Justine M / Trivedi, Uday / Hildick-Smith, David

    Journal of cardiac surgery

    2022  Volume 37, Issue 4, Page(s) 978–984

    Abstract: Objectives: Subclavian (SC) and transapical (TA) approaches are the main alternatives to the default femoral delivery for transcatheter aortic valve implantation (TAVI). The aim of this study was to compare complications and morbidity/mortality ... ...

    Abstract Objectives: Subclavian (SC) and transapical (TA) approaches are the main alternatives to the default femoral delivery for transcatheter aortic valve implantation (TAVI). The aim of this study was to compare complications and morbidity/mortality associated with SC and TA in a long-term time frame.
    Methods: From January 2007 to July 2015, 1506 patients underwent TAVI surgery in 36 United Kingdom TAVI centers. Primary outcomes were complications according to VARC-2 criteria. The secondary outcome was long-term survival.
    Results: The enrolled patients were distributed as follows: 1216 in the TA group and 290 in the SC group. There were no differences in the rates of acute myocardial infarction, emergency valve-in-valve, paravalvular leak, balloon post dilatation, cardiac tamponade, stroke, renal replacement therapy, vascular injuries, and 30-day mortality among the groups. Conversely, the rate of permanent pacemaker implantation (p = .02), the procedural time duration (p = .04), and the 12-month mortality (p = .03) was higher in SC than in TA, while in-hospital length of stay was reduced in SC than in TA (p = .01). Up to 8 years, the long-term mortality was not different among groups (p = .77), and no difference in long-term survival between self- versus balloon-expandable devices was found (p = .26).
    Conclusions: According to our results, TA provided the best 12-month survival compared to SC, while the long-term survival up to 2900 days is not significantly different between groups, so SC and TA may both represent a safe non-femoral access if femoral is precluded.
    MeSH term(s) Aortic Valve/surgery ; Aortic Valve Stenosis ; Fluoroscopy ; Humans ; Risk Factors ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The best approach for functional tricuspid regurgitation: A network meta-analysis.

    Di Mauro, Michele / Lorusso, Roberto / Parolari, Alessandro / Ravaux, Justine M / Bonalumi, Giorgia / Guarracini, Stefano / Ricci, Fabrizio / Benedetto, Umberto / Calafiore, Antonio M

    Journal of cardiac surgery

    2021  Volume 36, Issue 6, Page(s) 2072–2080

    Abstract: Objective: For many years, functional tricuspid regurgitation (FTR) was considered negligible after treatment of left-sided heart valve surgery. The aim of the present network meta-analysis is to summarize the results of four approaches to establish the ...

    Abstract Objective: For many years, functional tricuspid regurgitation (FTR) was considered negligible after treatment of left-sided heart valve surgery. The aim of the present network meta-analysis is to summarize the results of four approaches to establish the possible gold standard.
    Methods: A systematic search was performed to identify all publications reporting the outcomes of four approaches for FTR, not tricuspid annuloplasty (no TA), suture annuloplasty (SA), flexible (FRA), rigid rings (RRA). All studies reporting at least one the four endpoints (early and late mortality, early and late moderate or more TFR) were included in a Bayesian network meta-analysis.
    Results: There were 31 included studies with 9663 patients. Aggregate early mortality was 5.3% no TA, 7.2% SA, 6.6% FRA, and 6.4% RRA; early TR moderate-or-more was 9.6%, 4.8%, 4.6%, and 3.8%; late mortality was 22.5%, 18.2%, 11.9%, and 11.9%; late TR moderate-or-more was 27.9%, 18.3%, 14.3%, and 6.4%. Rigid or semirigid ring annuloplasty was the most effective approach for decreasing the risk of late moderate or more FTR (-85% vs. no TA; -64% vs. SA; -32% vs. FRA). Concerning late mortality, no significant differences were found among different surgical approaches; however, flexible or rigid rings reduced significantly the risk of late mortality (78% and 47%, respectively) compared with not performing TA mortality. No differences were found for early outcomes.
    Conclusions: Ring annuloplasty seems to offer better late outcomes compare to either suture annuloplasty or not performing TA. In particular rigid or semirigid rings provide more stable FTR across time.
    MeSH term(s) Bayes Theorem ; Cardiac Valve Annuloplasty ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation ; Humans ; Network Meta-Analysis ; Treatment Outcome ; Tricuspid Valve Insufficiency/surgery
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.15378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel cannulation strategy with a bidirectional cannula for distal limb perfusion during peripheral veno-arterial extracorporeal life support: A preliminary, single-centre study.

    Simons, Jorik / Doddema, Arne R / Körver, Erik Pj / di Mauro, Michele / Agricola, Sandra / Smets, Jeroen / Metz, Renske / Mariani, Silvia / De Piero, Maria Elena / Matteucci, Matteo / Romeo, Jamie / Ravaux, Justine M / van Mook, Walther Nka / Mees, Barend Me / Lorusso, Roberto

    Perfusion

    2023  Volume 38, Issue 1_suppl, Page(s) 44–53

    Abstract: Introduction: Limb ischemia is a severe complication of peripheral veno-arterial extracorporeal life support (V-A ECLS). Several techniques have been developed to prevent this, but it remains a major and frequent adverse event (incidence: 10-30%). In ... ...

    Abstract Introduction: Limb ischemia is a severe complication of peripheral veno-arterial extracorporeal life support (V-A ECLS). Several techniques have been developed to prevent this, but it remains a major and frequent adverse event (incidence: 10-30%). In 2019, a new cannula with bidirectional flow (retrograde towards the heart and antegrade towards the distal limb) has been introduced. A single-centre experience with this cannula in patients undergoing peripheral V-A ECLS is herewith reported.
    Methods: This prospective observational study included adults (≥18 years) undergoing V-A ECLS from January 2021 to October 2022 with the use of a bidirectional femoral artery cannula. Primary outcome was limb ischemia requiring intervention during cardio-circulatory support. Secondary outcomes were compartment syndrome, limb amputation, cannulation site bleeding, need for other surgical intervention due to cannula related complications, duplex ultrasound parameters from the femoral vessels, and in-hospital survival.
    Results: Twenty-two consecutive patients were included. During extracorporeal life support (ECLS) support, limb ischemia requiring intervention occurred in one patient (4.5%) and no patients developed a compartment syndrome, or required a fasciotomy or amputation. Significant bleeding was reported in two patients (9%) due to slight cannula dislodgement, easily solved with cannula repositioning. In-hospital survival was 63.6%.
    Conclusions: The bidirectional cannula is associated with a low risk for limb ischemia-related complications compared to current literature, and apparently represents a safe alternative to dedicated distal perfusion cannula. Further studies are warranted to confirm these preliminary findings.
    MeSH term(s) Adult ; Humans ; Cannula ; Catheterization, Peripheral/adverse effects ; Catheterization, Peripheral/methods ; Perfusion/adverse effects ; Lower Extremity/blood supply ; Femoral Artery/surgery ; Ischemia ; Retrospective Studies
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 645038-6
    ISSN 1477-111X ; 0267-6591
    ISSN (online) 1477-111X
    ISSN 0267-6591
    DOI 10.1177/02676591231159565
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  9. Article: Surgical repair of post-infarction ventricular free-wall rupture in the Netherlands: data from a nationwide registry.

    Matteucci, Matteo / Ronco, Daniele / Ravaux, Justine M / Massimi, Giulio / Di Mauro, Michele / Houterman, Saskia / Maessen, Jos / Beghi, Cesare / Severgnini, Paolo / Lorusso, Roberto

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 3, Page(s) 310–318

    Abstract: Background: Ventricular free-wall rupture (VFWR) is an infrequent but catastrophic complication of acute myocardial infarction (AMI). Most reports about outcome after surgical treatment are single-center experiences. We examined the early and mid-term ... ...

    Abstract Background: Ventricular free-wall rupture (VFWR) is an infrequent but catastrophic complication of acute myocardial infarction (AMI). Most reports about outcome after surgical treatment are single-center experiences. We examined the early and mid-term outcomes after surgical repair of post-AMI VFWR using the Netherlands Heart Registration (NHR) database.
    Methods: We included data from NHR patients (>18 years old) who underwent surgery for post-AMI VFWR between 2014 and 2019. The primary end-point was in-hospital mortality. Secondary outcomes included postoperative complications and mid-term survival.
    Results: The study included 148 patients (54.7% male, mean age 66.5±11.1 years). Critical preoperative status was found in 62.6% of subjects. In-hospital mortality was 31.1% (46 of 148). Multivariable analysis identified female sex [odds ratio (OR), 5.49; 95% confidence interval (CI): 2.24-13.46] and critical preoperative status (OR, 4.06; 95% CI: 1.36-12.13) as independent predictors of in-hospital mortality. The overall median postoperative follow-up was 2.2 (interquartile range, 0.7-3.8) years. Overall survival rates at three and five years were 58.9% and 55.7%, respectively. Among hospital survivors, only 15 (14.7%) patients died during follow-up, with a five-year survival rate of 80.8%.
    Conclusions: In-hospital mortality after surgical repair of post-AMI VFWR is considerable. Female sex and preoperative critical status are independent predictors of early postoperative (in-hospital) death. Logistic EuroSCORE I can reliably predict in-hospital mortality (optimal cut-off >33%). Mid-term follow-up of patients surviving in-hospital course shows excellent results.
    Language English
    Publishing date 2022-05-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-ami-10
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  10. Article ; Online: Awake extracorporeal life support and physiotherapy in adult patients: A systematic review of the literature.

    Cucchi, Marta / Mariani, Silvia / De Piero, Maria E / Ravaux, Justine M / Kawczynski, Michal J / Di Mauro, Michele / Shkurka, Emma / Hoskote, Aparna / Lorusso, Roberto

    Perfusion

    2022  Volume 38, Issue 5, Page(s) 939–958

    Abstract: Objective: The Awake Extracorporeal Life Support (ECLS) practice combined with physiotherapy is increasing. However, available evidence for this approach is limited, with unclear indications on timing, management, and protocols. This review summarizes ... ...

    Abstract Objective: The Awake Extracorporeal Life Support (ECLS) practice combined with physiotherapy is increasing. However, available evidence for this approach is limited, with unclear indications on timing, management, and protocols. This review summarizes available literature regarding Awake ECLS and physiotherapy application rates, practices, and outcomes in adults, providing indications for future investigations.
    Methods: Four databases were screened from inception to February 2021, for studies reporting adult Awake ECLS with/without physiotherapy. Primary outcome was hospital discharge survival, followed by Extracorporeal Membrane Oxygenation (ECMO) duration, extubation, Intensive Care Unit stay.
    Results: Twenty-nine observational studies and one randomized study were selected, including 1,157 patients (males
    Conclusion: Awake ECLS strategy associated with physiotherapy is performed regardless of cannulation approach. Ambulation, as main objective, is achieved in almost half the population examined. Prospective studies are needed to evaluate safety and efficacy of physiotherapy during Awake ECLS, and suitable patient selection. Guidelines are required to identify appropriate assessment/evaluation tools for Awake ECLS patients monitoring.
    MeSH term(s) Male ; Humans ; Adult ; Female ; Extracorporeal Membrane Oxygenation/methods ; Wakefulness ; Physical Therapy Modalities ; Patient Discharge ; Airway Extubation ; Retrospective Studies
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 645038-6
    ISSN 1477-111X ; 0267-6591
    ISSN (online) 1477-111X
    ISSN 0267-6591
    DOI 10.1177/02676591221096078
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