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Article ; Online: Venomics and antivenomics of Indian spectacled cobra (Naja naja) from the Western Ghats.

Vanuopadath, Muralidharan / Raveendran, Dileepkumar / Nair, Bipin Gopalakrishnan / Nair, Sudarslal Sadasivan

2022 Volume 228, Page(s) 106324

Abstract: Venom proteome profiling of Naja naja from the Western Ghats region in Kerala was achieved through SDS-PAGE and RP-HPLC followed by Q-TOF LC-MS/MS analysis, incorporating PEAKS and Novor assisted de novo sequencing methodologies. A total of 115 proteins ... ...

Abstract	Venom proteome profiling of Naja naja from the Western Ghats region in Kerala was achieved through SDS-PAGE and RP-HPLC followed by Q-TOF LC-MS/MS analysis, incorporating PEAKS and Novor assisted de novo sequencing methodologies. A total of 115 proteins distributed across 17 different enzymatic and non-enzymatic venom protein families were identified through conventional and 39 peptides through homology-driven proteomics approaches. Fourteen peptides derived through de novo complements the Mascot data indicating the importance of homology-driven approaches in improving protein sequence information. Among the protein families identified, glutathione peroxidase and endonuclease were reported for the first time in the Indian cobra venom. Immunological cross-reactivity assessed using Indian polyvalent antivenoms suggested that VINS showed better EC
MeSH term(s)	Animals ; Antivenins ; Chromatography, Liquid ; Elapid Venoms/analysis ; Naja naja/metabolism ; Proteome ; Tandem Mass Spectrometry
Chemical Substances	Antivenins ; Elapid Venoms ; Proteome
Language	English
Publishing date	2022-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2022.106324
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Article: Highlight on drying fruit slices with better retention of bioactive compounds

Raveendran, Dhivya / Bhagwat, Madhura / Chidanand, Duggonahally Veeresh / Anandakumar, Sugumar / Sunil, Chikkaballapur Krishnappa

Journal of food process engineering. 2022 Aug., v. 45, no. 8

2022

Abstract: In the human diet, bioactive compounds are additional nutrients that are available through fruits. They positively influence human health with their antioxidant activity. To extend shelf life and produce value‐added products, fruits are dried. However, ... ...

Abstract	In the human diet, bioactive compounds are additional nutrients that are available through fruits. They positively influence human health with their antioxidant activity. To extend shelf life and produce value‐added products, fruits are dried. However, in the process of drying, bioactive compounds are degraded and reduced. In the modern fruit drying facilities, fruits are dried as slices which find their market as snacks and as garnishes for ice creams, yoghurts, and cookies. Hence, it is essential to adopt drying methods that aim at maximum retention of bioactive compounds. Conventional drying methods poorly retain the bioactive constituents and have higher processing time. Potential drying systems that better retain the bioactive compounds include vacuum dryer, hybrid dryer, and freeze dryer. The review focus on different pretreatments and drying methods employed for drying fruit slices with a highlight to the retention of bioactive compounds such as phenols, flavonoids, carotenoids, anthocyanins, and ascorbic acid. The review also gives an outline of the latest techniques to process dried fruit slices with high retention of bioactive compounds. PRACTICAL APPLICATIONS: Dried fruit slices are valued products from fruits that, after drying, retain a high level of bioactive compounds, fetch a reasonable price in the market. Various drying means for drying fruit slices have been discoursed in the study. Dry fruit makers can choose from various procedures and pretreatments, depending on the costs involved and the technology available. Consumers are watching for healthy snacking options which dry fruit slices can fulfill.
Keywords	anthocyanins ; antioxidant activity ; ascorbic acid ; carotenoids ; dried fruit ; fruits ; human health ; ice ; markets ; prices ; shelf life ; value added
Language	English
Dates of publication	2022-08
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	REVIEW
ZDB-ID	752358-0
ISSN	0145-8876
ISSN	0145-8876
DOI	10.1111/jfpe.14048
Database	NAL-Catalogue (AGRICOLA)

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Article: Inhaled Corticosteroids and Risk of Cardiovascular Disease in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Regression.

Gadhvi, Krishna / Kandeil, Minnah / Raveendran, Dinushan / Choi, Jeewoo / Davies, Nia / Nanchahal, Sukanya / Wing, Oliva / Quint, Jennifer / Whittaker, Hannah

Chronic obstructive pulmonary diseases (Miami, Fla.)

2023 Volume 10, Issue 3, Page(s) 317–327

Abstract: Background: Previous studies have reported mixed associations between inhaled corticosteroids (ICSs) and cardiovascular disease (CVD) in people with chronic obstructive pulmonary disease (COPD). Using updated literature, we investigated the association ... ...

Abstract	Background: Previous studies have reported mixed associations between inhaled corticosteroids (ICSs) and cardiovascular disease (CVD) in people with chronic obstructive pulmonary disease (COPD). Using updated literature, we investigated the association between ICS-containing medications and CVD in COPD patients, stratified by study-related factors. Methods: We searched MEDLINE and EMBASE for studies that reported effect estimates for the association between ICS-containing medications and the risk of CVD in COPD patients. CVD outcomes specifically included heart failure, myocardial infarction, and stroke-related events. We conducted a random-effects meta-analysis and a meta-regression to identify effect-modifying study-related factors. Results: Fifteen studies met inclusion criteria and investigated the association between ICS-containing medications and the risk of CVD. Pooled results from our meta-analysis showed a significant association between ICS-containing medication and reduced risk of CVD (hazard ratio 0.87, 95% confidence intervals 0.78 to 0.97). Study follow-up time, non-ICS comparator, and exclusion of patients with previous CVD modified the association between ICS use and risk of CVD. Conclusions: Overall, we found an association between ICS-containing medications and reduced risk of CVD in COPD patients. Results from the meta-regression suggest that subgroups of COPD patients may benefit from ICS use more than others and further work is needed to determine this.
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2771715-X
ISSN	2372-952X
ISSN	2372-952X
DOI	10.15326/jcopdf.2022.0386
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Article ; Online: Biochemical Characterization of Nonamer Binding Domain of RAG1 Reveals its Thymine Preference with Respect to Length and Position.

Raveendran, Deepthi / Raghavan, Sathees C

Scientific reports

2016 Volume 6, Page(s) 19091

Abstract: RAG complex consisting of RAG1 and RAG2 is a site-specific endonuclease responsible for the generation of antigen receptor diversity. It cleaves recombination signal sequence (RSS), comprising of conserved heptamer and nonamer. Nonamer binding domain ( ... ...

Abstract	RAG complex consisting of RAG1 and RAG2 is a site-specific endonuclease responsible for the generation of antigen receptor diversity. It cleaves recombination signal sequence (RSS), comprising of conserved heptamer and nonamer. Nonamer binding domain (NBD) of RAG1 plays a central role in the recognition of RSS. To investigate the DNA binding properties of the domain, NBD of murine RAG1 was cloned, expressed and purified. Electrophoretic mobility shift assays showed that NBD binds with high affinity to nonamer in the context of 12/23 RSS or heteroduplex DNA. NBD binding was specific to thymines when single stranded DNA containing poly A, C, G or T were used. Biolayer interferometry studies showed that poly T binding to NBD was robust and comparable to that of 12RSS. More than 23 nt was essential for NBD binding at homothymidine stretches. On a double-stranded DNA, NBD could bind to A:T stretches, but not G:C or random sequences. Although NBD is indispensable for sequence specific activity of RAGs, external supplementation of purified nonamer binding domain to NBD deleted cRAG1/cRAG2 did not restore its activity, suggesting that the overall domain architecture of RAG1 is important. Therefore, we define the sequence requirements of NBD binding to DNA.
MeSH term(s)	Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Base Sequence ; Binding Sites ; Cloning, Molecular ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/genetics ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/genetics ; Mice ; Poly A/chemistry ; Poly C/chemistry ; Poly G/chemistry ; Poly T/chemistry ; Protein Binding ; Protein Domains ; Protein Sorting Signals ; Receptors, Antigen/chemistry ; Receptors, Antigen/genetics ; Receptors, Antigen/immunology ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; V(D)J Recombination
Chemical Substances	DNA, Single-Stranded ; DNA-Binding Proteins ; Homeodomain Proteins ; Protein Sorting Signals ; Rag2 protein, mouse ; Receptors, Antigen ; Recombinant Proteins ; RAG-1 protein (128559-51-3) ; Poly A (24937-83-5) ; Poly T (25086-81-1) ; Poly G (25191-14-4) ; Poly C (30811-80-4)
Language	English
Publishing date	2016-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep19091
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Article ; Online: The prognostic significance of postoperative hyperbilirubinemia in cardiac surgery: systematic review and meta-analysis.

Raveendran, Dev / Penny-Dimri, Jahan C / Segal, Reny / Smith, Julian A / Plummer, Mark / Liu, Zhengyang / Perry, Luke A

Journal of cardiothoracic surgery

2022 Volume 17, Issue 1, Page(s) 129

Abstract: Background: Hyperbilirubinemia following cardiac surgery is a common phenomenon and is of emerging interest in prognostic factor research. This systematic review and meta-analysis evaluated the association between post-operative hyperbilirubinemia (PH) ... ...

Abstract	Background: Hyperbilirubinemia following cardiac surgery is a common phenomenon and is of emerging interest in prognostic factor research. This systematic review and meta-analysis evaluated the association between post-operative hyperbilirubinemia (PH) and mortality and morbidity in cardiac surgery patients. Methods: Ovid Medline and Ovid Embase were searched from inception to July 2020 for studies evaluating the prognostic significance of PH following cardiac surgery. Maximally adjusted odds ratios (OR) with associated confidence intervals were obtained from each study and pooled using random effects inverse variance modelling to assess in-hospital mortality. Standardised mean differences were pooled to assess Intensive Care Unit (ICU) and hospital length of stay (LOS). Qualitative analysis was performed to assess ventilation requirements and long-term mortality. Meta-regression was used to assess inter- and intra-study heterogeneity. Results: 3251 studies satisfied the selection criteria, from which 12 studies incorporating 3876 participants were included. PH significantly predicted in-hospital mortality with a pooled OR of 7.29 (95% CI 3.53, 15.09). Multiple pre-defined covariates contributed to the prognostic significance of PH, however only aortic cross-clamp time (p < 0.0001) and number of transfusions (p = 0.0001) were significant effect modifiers. PH significantly predicted both ICU LOS (Mean difference 1.32 [95% CI 0.04-2.6]) and hospital LOS (Mean difference 1.79 [95% CI 0.36-3.21]). Qualitative analysis suggested PH is associated with increased post-operative ventilation requirements and reduced long-term survival rates. Conclusions: Hyperbilirubinemia is a cost-effective, widely available prognostic marker of adverse outcomes following cardiac surgery, albeit with residual sources of heterogeneity.
MeSH term(s)	Cardiac Surgical Procedures/adverse effects ; Hospital Mortality ; Humans ; Hyperbilirubinemia/etiology ; Length of Stay ; Prognosis
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-022-01870-2
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Article ; Online: Delineating the venom toxin arsenal of Malabar pit viper (Trimeresurus malabaricus) from the Western Ghats of India and evaluating its immunological cross-reactivity and in vitro cytotoxicity.

Vanuopadath, Muralidharan / Shaji, Sanu Korumadathil / Raveendran, Dileepkumar / Nair, Bipin Gopalakrishnan / Nair, Sudarslal Sadasivan

International journal of biological macromolecules

2020 Volume 148, Page(s) 1029–1045

Abstract: The venom protein components of Malabar pit viper (Trimeresurus malabaricus) were identified by combining SDS-PAGE and ion-exchange chromatography pre-fractionation techniques with LC-MS/MS incorporating Novor and PEAKS-assisted de novo sequencing ... ...

Abstract	The venom protein components of Malabar pit viper (Trimeresurus malabaricus) were identified by combining SDS-PAGE and ion-exchange chromatography pre-fractionation techniques with LC-MS/MS incorporating Novor and PEAKS-assisted de novo sequencing strategies. Total 97 proteins that belong to 16 protein families such as L-amino acid oxidase, metalloprotease, serine protease, phospholipase A
MeSH term(s)	5'-Nucleotidase/chemistry ; Animals ; Antivenins/chemistry ; Apoptosis/drug effects ; Cell Line ; Cell Survival/drug effects ; Chromatography, High Pressure Liquid ; Crotalid Venoms/analysis ; Crotalid Venoms/enzymology ; Crotalid Venoms/toxicity ; Humans ; India ; L-Amino Acid Oxidase/chemistry ; Lectins, C-Type/chemistry ; Metalloproteases/chemistry ; Mice ; Phospholipases A2/chemistry ; Proteome/chemistry ; Daboia ; Serine Proteases/chemistry ; Tandem Mass Spectrometry ; Trimeresurus
Chemical Substances	Antivenins ; Crotalid Venoms ; Lectins, C-Type ; Proteome ; L-Amino Acid Oxidase (EC 1.4.3.2) ; Phospholipases A2 (EC 3.1.1.4) ; 5'-Nucleotidase (EC 3.1.3.5) ; Metalloproteases (EC 3.4.-) ; Serine Proteases (EC 3.4.-)
Language	English
Publishing date	2020-01-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.01.226
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Article ; Online: The Prognostic Significance of Red Cell Distribution Width in Cardiac Surgery: A Systematic Review and Meta-Analysis.

Frentiu, Angela A / Mao, Kevin / Caruana, Carla Borg / Raveendran, Dev / Perry, Luke A / Penny-Dimri, Jahan C / Ramson, Dhruvesh M / Segal, Reny / Bellomo, Rinaldo / Smith, Julian A / Liu, Zhengyang

Journal of cardiothoracic and vascular anesthesia

2022 Volume 37, Issue 3, Page(s) 471–479

Abstract: RED CELL DISTRIBUTION WIDTH (RDW) is a routinely available biomarker of likely erythropoietic dysfunction, which may be associated with adverse outcomes after cardiac surgery. This systematic review and meta-analysis aimed to clarify the prognostic value ...

Abstract	RED CELL DISTRIBUTION WIDTH (RDW) is a routinely available biomarker of likely erythropoietic dysfunction, which may be associated with adverse outcomes after cardiac surgery. This systematic review and meta-analysis aimed to clarify the prognostic value of RDW in patients undergoing cardiac surgery. The authors searched MEDLINE, Embase, and the Cochrane Library from inception to May 10, 2022 for studies investigating the association between elevated RDW (as defined by the authors of included studies) and adverse outcomes after cardiac surgery. Herein, the authors extracted maximally adjusted hazard ratios (HRs) and odds ratios (ORs) with associated CIs, and pooled them using random-effects inverse- variance modeling. The authors explored interstudy heterogeneity using metaregression. The authors included 26 studies involving 48,092 patients who had undergone cardiac surgery. Elevated preoperative RDW was associated with long-term mortality (pooled HR 1.63, 95% CI 1.05-2.52), short-term mortality (pooled OR 2.16, 95% CI 1.21-3.87), acute kidney injury (AKI; pooled OR 1.30, 95% CI 1.19-1.41) and postoperative atrial fibrillation (POAF; pooled OR 1.44, 95% CI 1.05-1.96). Some studies suggested a significant association between preoperative RDW elevation and neurologic complications; however, their number was insufficient for meta-analysis. The postoperative RDW levels were less consistently reported and could not be meta-analyzed. In conclusion, the authors found that elevated preoperative RDW was associated with increased short- and long-term mortality, POAF, and AKI after cardiac surgery. Further research is needed to investigate its role in the risk stratification of patients undergoing cardiac surgery.
MeSH term(s)	Humans ; Erythrocyte Indices ; Prognosis ; Cardiac Surgical Procedures/adverse effects ; Biomarkers ; Acute Kidney Injury/etiology
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-11-20
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2022.11.015
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Article ; Online: The association of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with retinal vein occlusion: a systematic review and meta-analysis.

Liu, Zhengyang / Perry, Luke A / Penny-Dimri, Jahan C / Raveendran, Dev / Hu, Monica L / Arslan, Janan / Britten-Jones, Alexis Ceecee / O'Hare, Fleur / Ayton, Lauren N / Edwards, Thomas L

Acta ophthalmologica

2021 Volume 100, Issue 3, Page(s) e635–e647

Abstract: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are emerging haematological inflammatory biomarkers. However, their significance in retinal vein occlusion (RVO) and its subtypes, branch and central RVO (BRVO and CRVO, ... ...

Abstract	The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are emerging haematological inflammatory biomarkers. However, their significance in retinal vein occlusion (RVO) and its subtypes, branch and central RVO (BRVO and CRVO, respectively), is uncertain. This systematic review and meta-analysis aimed to clarify the association of NLR and PLR with RVO. We searched MEDLINE (Ovid), EMBASE (Ovid) and the Cochrane Library for studies investigating the association of NLR and PLR with RVO from inception to 2 December 2020. We used random-effects inverse-variance modelling to generate pooled effect measures. We used bivariate Bayesian modelling to meta-analyse the ability of NLR and PLR to differ between individuals with and without RVO and performed meta-regression and sensitivity analyses to explore inter-study heterogeneity. Eight studies published encompassing 1059 patients were included for analysis. Both NLR and PLR were significantly elevated in RVO, with pooled mean differences of 0.63 (95% confidence interval (CI) 0.31-0.95) and 21.49 (95% CI 10.03-32.95), respectively. The pooled sensitivity, specificity and area under the Bayesian summary receiver operating characteristic curve were, respectively, 0.629 (95% credible interval (CrI) 0.284-0.872), 0.731 (95% CrI 0.373-0.934) and 0.688 (95% CrI 0.358-0.872) for NLR; and 0.645 (95% CrI 0.456-0.779), 0.616 (95% CrI 0.428-0.761) and 0.621 (95% CrI 0.452-0.741) for PLR. Mean and variability of age and diabetes mellitus prevalence partially explained between-study heterogeneity. NLR and PLR are significantly elevated in RVO. Future research is needed to investigate the potential prognostic value and independence of these findings.
MeSH term(s)	Bayes Theorem ; Blood Platelets/cytology ; Humans ; Lymphocytes/cytology ; Neutrophils/cytology ; Prognosis ; Retinal Vein Occlusion/blood ; Retinal Vein Occlusion/diagnosis ; Retrospective Studies
Language	English
Publishing date	2021-07-04
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.14955
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Article: Ethnomedicinal plants used for snake envenomation by folk traditional practitioners from Kallar forest region of South Western Ghats, Kerala, India.

Sulochana, Anaswara Krishnan / Raveendran, Dileepkumar / Krishnamma, Anoop Pushkaran / Oommen, Oommen V

Journal of intercultural ethnopharmacology

2014 Volume 4, Issue 1, Page(s) 47–51

Abstract: Background: The traditional medicinal systems of Indian folklore abundantly use medicinal plants or its derivatives for the treatment of snakebites. However, this traditional knowledge is on the verge of extinction, and there is an immediate necessity ... ...

Abstract	Background: The traditional medicinal systems of Indian folklore abundantly use medicinal plants or its derivatives for the treatment of snakebites. However, this traditional knowledge is on the verge of extinction, and there is an immediate necessity to conserve this oral traditional knowledge primarily by proper documentation and scientific authentication. The present ethno botanical study carried out among the folk medicine practitioners in the rural settle mental areas of Kallar forest region of southern Kerala, aims to document the folk herbal knowledge particularly for snake envenomation. Materials and methods: The survey was conducted during the period of June 2012-July 2013 in the rural and forest settlement areas of Kallar in the Thiruvananthapuram district of Kerala. Direct observation and oral communications with local folk medicine practitioners in this region were adopted to collect valid information regarding the herbal formulations used to treat snake bite patients. Results: The study enumerates a list of 24 plant species belonging to seventeen families with anti-venomous potential. The scientific, vernacular and family names of these plants, along with the part used and their application modes are also enumerated in this communication. Conclusions: Plants are believed to be potent snake bite antidotes from centuries back, and knowledge about the use of plants is strictly conserved among tribes through generations without recorded data. It is the need of the hour to document these old drug formulations and is the cardinal responsibility of the scientific community to validate it and come up with new potent drug molecule for the benefit of snake bite victims.
Language	English
Publishing date	2014-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2721488-6
ISSN	2146-8397
ISSN	2146-8397
DOI	10.5455/jice.20141010122750
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Article ; Online: Mass spectrometry-assisted venom profiling of Hypnale hypnale found in the Western Ghats of India incorporating de novo sequencing approaches.

Vanuopadath, Muralidharan / Sajeev, Nithin / Murali, Athira Radhamony / Sudish, Nayana / Kangosseri, Nithya / Sebastian, Ivy Rose / Jain, Nidhi Dalpatraj / Pal, Amit / Raveendran, Dileepkumar / Nair, Bipin Gopalakrishnan / Nair, Sudarslal Sadasivan

International journal of biological macromolecules

2018 Volume 118, Issue Pt B, Page(s) 1736–1746

Abstract: Hypnale hypnale (hump-nosed pit viper) is considered to be one among the medically important venomous snake species of India and Sri Lanka. In the present study, venom proteome profiling of a single Hypnale hypnale from Western Ghats of India was ... ...

Abstract	Hypnale hypnale (hump-nosed pit viper) is considered to be one among the medically important venomous snake species of India and Sri Lanka. In the present study, venom proteome profiling of a single Hypnale hypnale from Western Ghats of India was achieved using SDS-PAGE based protein separation followed by LC-MS/MS analysis. The identities of the proteins that were not established using the Mascot search were determined through de novo sequencing tools such as Novor followed by MS-BLAST based sequence similarity search algorithm and PEAKS proteomics software. The combined proteomics analysis revealed a total of 37 proteins belonging to nine different snake venom families, in which 7 proteins were exclusively identified through de novo strategies. The enzymatic and non-enzymatic venom protein families identified include serine proteases, metalloproteases, phospholipase A
MeSH term(s)	Amino Acid Sequence ; Chromatography, Liquid ; India ; Proteome ; Proteomics/methods ; Snake Venoms/analysis ; Snake Venoms/chemistry ; Tandem Mass Spectrometry
Chemical Substances	Proteome ; Snake Venoms
Language	English
Publishing date	2018-07-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2018.07.016
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