Article ; Online: Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae.
2023 Volume 186, Issue 12, Page(s) 2690–2704.e20
Abstract: Biofilm formation is generally recognized as a bacterial defense mechanism against environmental threats, including antibiotics, bacteriophages, and leukocytes of the human immune system. Here, we show that for the human pathogen Vibrio cholerae, biofilm ...
| Abstract | Biofilm formation is generally recognized as a bacterial defense mechanism against environmental threats, including antibiotics, bacteriophages, and leukocytes of the human immune system. Here, we show that for the human pathogen Vibrio cholerae, biofilm formation is not only a protective trait but also an aggressive trait to collectively predate different immune cells. We find that V. cholerae forms biofilms on the eukaryotic cell surface using an extracellular matrix comprising primarily mannose-sensitive hemagglutinin pili, toxin-coregulated pili, and the secreted colonization factor TcpF, which differs from the matrix composition of biofilms on other surfaces. These biofilms encase immune cells and establish a high local concentration of a secreted hemolysin to kill the immune cells before the biofilms disperse in a c-di-GMP-dependent manner. Together, these results uncover how bacteria employ biofilm formation as a multicellular strategy to invert the typical relationship between human immune cells as the hunters and bacteria as the hunted. |
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| MeSH term(s) | Animals ; Humans ; Vibrio cholerae/metabolism ; Predatory Behavior ; Biofilms ; Fimbriae, Bacterial ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial | ||||||||||
| Chemical Substances | Bacterial Proteins | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2023-06-08 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 187009-9 | ||||||||||
| ISSN | 1097-4172 ; 0092-8674 | ||||||||||
| ISSN (online) | 1097-4172 | ||||||||||
| ISSN | 0092-8674 | ||||||||||
| DOI | 10.1016/j.cell.2023.05.008 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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