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  1. AU="Ravender, Raja"
  2. AU="Sheng, Honghao"
  3. AU="Bezler, Valerie"
  4. AU="Kevin Rostásy"
  5. AU=van Helden Mary J.
  6. AU="Grzegorz Adamczyk"
  7. AU="Longo, M"
  8. AU="Debarnot, Cecilé"
  9. AU="Thomas, Sophie"
  10. AU=Steyer Terence E AU=Steyer Terence E
  11. AU="Retrouvey, Jean-Marc"
  12. AU="Crecchio, Carmine"
  13. AU=Moll Philip J. W.
  14. AU="Coombs, Catherine C"
  15. AU="Safaei, Naser"
  16. AU="Bachouche, Imene"
  17. AU="Roignant, Jean-Yves"
  18. AU="Thabet, Nagwa"
  19. AU="Asor, Eyal"
  20. AU="Rahaman, Md Hasibur"
  21. AU="Angela Di Capua"
  22. AU=De Vitis R
  23. AU="Young, Kaelin C"

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  1. Artikel: Abiraterone-Associated Mineralocorticoid Excess: A Case Report.

    Shaffi, Saeed K / Ravender, Raja / Kodavanti, Chandra Kumar Mallick / Wagner, Brent / Soleimani, Manoocher

    Cureus

    2024  Band 16, Heft 1, Seite(n) e51757

    Abstract: Abiraterone acetate causes an adrenocorticotropic hormone (ACTH)-mediated mineralocorticoid excess. We present a 77-year-old man with prostate adenocarcinoma who developed signs and symptoms of mineralocorticoid excess while on abiraterone and discuss ... ...

    Abstract Abiraterone acetate causes an adrenocorticotropic hormone (ACTH)-mediated mineralocorticoid excess. We present a 77-year-old man with prostate adenocarcinoma who developed signs and symptoms of mineralocorticoid excess while on abiraterone and discuss its pathophysiology and treatment options. The patient developed hypokalemia, metabolic alkalosis, and hypertension, indicative of increased mineralocorticoid activity, confirmed by elevated ACTH, corticosterone, and deoxycorticosterone levels. Abiraterone inhibits cytochrome P450c17 (CYP17A1), thus inhibiting testosterone and cortisol synthesis. Diminished cortisol synthesis, in turn, leads to excessive mineralocorticoid precursor production mediated by ACTH, leading to enhanced sodium absorption and potassium excretion. Abiraterone is often prescribed with low-dose prednisone to suppress ACTH; however, this strategy may not provide physiological glucocorticoid levels, resulting in ACTH-mediated mineralocorticoid excess in some patients. High-dose steroids or mineralocorticoid antagonists may activate mutant androgen receptors in prostate cancer tissue; therefore, amiloride is suggested for managing residual mineralocorticoid activity. This case highlights the importance of being vigilant for the signs and symptoms of mineralocorticoid excess in patients on abiraterone.
    Sprache Englisch
    Erscheinungsdatum 2024-01-06
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.51757
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Chronic Kidney Disease in the Older Adult Patient with Diabetes.

    Ravender, Raja / Roumelioti, Maria-Eleni / Schmidt, Darren W / Unruh, Mark L / Argyropoulos, Christos

    Journal of clinical medicine

    2024  Band 13, Heft 2

    Abstract: Diabetes mellitus (DM) and chronic kidney disease (CKD) are common in middle aged and older adult individuals. DM may accelerate the aging process, and the age-related declines in the estimated glomerular filtration rate (eGFR) can pose a challenge to ... ...

    Abstract Diabetes mellitus (DM) and chronic kidney disease (CKD) are common in middle aged and older adult individuals. DM may accelerate the aging process, and the age-related declines in the estimated glomerular filtration rate (eGFR) can pose a challenge to diagnosing diabetic kidney disease (DKD) using standard diagnostic criteria especially with the absence of severe albuminuria among older adults. In the presence of CKD and DM, older adult patients may need multidisciplinary care due to susceptibility to various health issues, e.g., cognitive decline, auditory or visual impairment, various comorbidities, complex medical regimens, and increased sensitivity to medication adverse effects. As a result, it can be challenging to apply recent therapeutic advancements for the general population to older adults. We review the evidence that the benefits from these newer therapies apply equally to older and younger patients with CKD and diabetes type 2 and propose a comprehensive management. This framework will address nonpharmacological measures and pharmacological management with renin angiotensin system inhibitors (RASi), sodium glucose co-transporter 2 inhibitors (SGLT2i), non-steroidal mineralocorticoids receptor antagonists (MRAs), and glucagon like peptide 1 receptor agonists (GLP1-RAs).
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020348
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: Diabetic Kidney Disease in Post-Kidney Transplant Patients.

    Pham, Ngoc-Yen T / Cruz, Diego / Madera-Marin, Luis / Ravender, Raja / Garcia, Pablo

    Journal of clinical medicine

    2024  Band 13, Heft 3

    Abstract: Post-transplant diabetes mellitus (PTDM) is a common occurrence in post-kidney transplantation and is associated with greater mortality, allograft failure, and increased risk of infections. The primary goal in the management of PTDM is to achieve ... ...

    Abstract Post-transplant diabetes mellitus (PTDM) is a common occurrence in post-kidney transplantation and is associated with greater mortality, allograft failure, and increased risk of infections. The primary goal in the management of PTDM is to achieve glycemic control to minimize the risk of complications while balancing the need for immunosuppression to maintain the health of the transplanted kidney. This review summarizes the effects of maintenance immunosuppression and therapeutic options among kidney transplant recipients. Patients with PTDM are at increased risk of diabetic kidney disease development; therefore, in this review, we focus on evidence supporting the use of novel antidiabetic agents and discuss their benefits and potential side effects in detail.
    Sprache Englisch
    Erscheinungsdatum 2024-01-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030793
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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