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  1. AU="Ravens, Sarina"
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  1. Article ; Online: αβ and γδ T-cell responses to Epstein-Barr Virus: insights in immunocompetence, immune failure and therapeutic augmentation in transplant patients.

    Eiz-Vesper, Britta / Ravens, Sarina / Maecker-Kolhoff, Britta

    Current opinion in immunology

    2023  Volume 82, Page(s) 102305

    Abstract: Epstein-Barr Virus (EBV) is a human gamma herpes virus, which causes several diseases in immunocompetent (mononucleosis, chronic fatigue syndrome, gastric cancer, endemic Burkitt's lymphoma, head and neck cancer) and immunosuppressed (post-transplant ... ...

    Abstract Epstein-Barr Virus (EBV) is a human gamma herpes virus, which causes several diseases in immunocompetent (mononucleosis, chronic fatigue syndrome, gastric cancer, endemic Burkitt's lymphoma, head and neck cancer) and immunosuppressed (post-transplant lymphoproliferative disease, EBV-associated soft tissue tumors) patients. It elicits a complex humoral and cellular immune response with both innate and adaptive immune components. Substantial progress has been made in understanding the interplay of immune cells in EBV-associated diseases in recent years, and several therapeutic approaches have been developed to augment cellular immunity toward EBV for control of EBV-associated malignancy. This review will focus on recent developments in immunosuppressed transplant recipients.
    MeSH term(s) Humans ; Herpesvirus 4, Human ; Epstein-Barr Virus Infections/therapy ; Immunocompromised Host ; Immunocompetence ; Lymphoproliferative Disorders/complications
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2023.102305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
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    Zs.MG 13: Show issues

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  2. Article ; Online: Corrigendum: Systematic pattern analyses of Vδ2

    Deng, Lihua / Harms, Anna / Ravens, Sarina / Prinz, Immo / Tan, Likai

    Frontiers in immunology

    2022  Volume 13, Page(s) 1055103

    Abstract: This corrects the article DOI: 10.3389/fimmu.2022.960920.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2022.960920.].
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1055103
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  3. Article ; Online: Systematic pattern analyses of Vδ2

    Deng, Lihua / Harms, Anna / Ravens, Sarina / Prinz, Immo / Tan, Likai

    Frontiers in immunology

    2022  Volume 13, Page(s) 960920

    Abstract: Background: Vγ9Vδ2: Methods: Shared "public" Vδ2: Results: Vδ2: Conclusion: To conclude, the heterogeneity of ... ...

    Abstract Background: Vγ9Vδ2
    Methods: Shared "public" Vδ2
    Results: Vδ2
    Conclusion: To conclude, the heterogeneity of Vδ2
    MeSH term(s) Adult ; Infant ; Infant, Newborn ; Humans ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; T-Lymphocyte Subsets ; Intraepithelial Lymphocytes ; Clone Cells ; Thymus Gland
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.960920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Human γδ TCR Repertoires in Health and Disease.

    Fichtner, Alina Suzann / Ravens, Sarina / Prinz, Immo

    Cells

    2020  Volume 9, Issue 4

    Abstract: The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more ...

    Abstract The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that discriminate between the two major subsets, namely Vδ2
    MeSH term(s) Disease ; Embryonic Development ; Health ; Humans ; Infections/immunology ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; T-Lymphocyte Subsets/immunology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2020-03-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9040800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High-throughput analysis of the human thymic Vδ1

    Di Lorenzo, Biagio / Ravens, Sarina / Silva-Santos, Bruno

    Scientific data

    2019  Volume 6, Issue 1, Page(s) 115

    Abstract: γδ T cells are a relatively rare subset of lymphocytes in the human peripheral blood, but they play important roles at the interface between the innate and the adaptive immune systems. The γδ T cell lineage is characterized by a signature γδ T cell ... ...

    Abstract γδ T cells are a relatively rare subset of lymphocytes in the human peripheral blood, but they play important roles at the interface between the innate and the adaptive immune systems. The γδ T cell lineage is characterized by a signature γδ T cell receptor (γδTCR) that displays extensive sequence variability originated by DNA rearrangement of the corresponding V(D)J loci. Human γδ T cells comprise Vγ9Vδ2 T cells, the major subset in the peripheral blood; and Vδ1
    MeSH term(s) High-Throughput Nucleotide Sequencing ; Humans ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; T-Lymphocyte Subsets/cytology ; Thymus Gland/cytology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2019-07-04
    Publishing country England
    Document type Dataset ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-019-0118-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages.

    Hahn, Anne M / Vogg, Lisa / Brey, Stefanie / Schneider, Andrea / Schäfer, Simon / Palmisano, Ralph / Pavlova, Anna / Sandrock, Inga / Tan, Likai / Fichtner, Alina S / Prinz, Immo / Ravens, Sarina / Winkler, Thomas H

    Cell reports

    2023  Volume 42, Issue 3, Page(s) 112253

    Abstract: The clonal selection theory describes key features of adaptive immune responses of B and T cells. For αβ T cells and B cells, antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor ... ...

    Abstract The clonal selection theory describes key features of adaptive immune responses of B and T cells. For αβ T cells and B cells, antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor in γδ T cells remains less well understood. To better understand the role of the γδ T cell receptor (TCR), we generate an orthotopic TCRδ transgenic mouse model. We demonstrate a multi-layered functionality of γδ TCRs and diverse roles of CDR3δ-mediated selection during γδ T cell development. Whereas epithelial populations using Vγ5 or Vγ7 chains are almost unaffected in their biology in the presence of the transgenic TCRδ chain, pairing with Vγ1 positively selects γδ T cell subpopulations with distinct programs in several organs, thereby distorting the repertoire. In conclusion, our data support dictation of developmental tropism together with adaptive-like recognition principles in a single antigen receptor.
    MeSH term(s) Mice ; Animals ; Cell Lineage ; Receptors, Antigen, T-Cell, gamma-delta ; Mice, Transgenic ; Intraepithelial Lymphocytes
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages.

    Hahn, Anne M / Vogg, Lisa / Brey, Stefanie / Schneider, Andrea / Schäfer, Simon / Palmisano, Ralph / Pavlova, Anna / Sandrock, Inga / Tan, Likai / Fichtner, Alina S / Prinz, Immo / Ravens, Sarina / Winkler, Thomas H

    Cell reports

    2023  Volume 42, Issue 5, Page(s) 112558

    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Expansion of memory Vδ2 T cells following SARS-CoV-2 vaccination revealed by temporal single-cell transcriptomics.

    Terzoli, Sara / Marzano, Paolo / Cazzetta, Valentina / Piazza, Rocco / Sandrock, Inga / Ravens, Sarina / Tan, Likai / Prinz, Immo / Balin, Simone / Calvi, Michela / Carletti, Anna / Cancellara, Assunta / Coianiz, Nicolò / Franzese, Sara / Frigo, Alessandro / Voza, Antonio / Calcaterra, Francesca / Di Vito, Clara / Della Bella, Silvia /
    Mikulak, Joanna / Mavilio, Domenico

    NPJ vaccines

    2024  Volume 9, Issue 1, Page(s) 63

    Abstract: γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-CoV-2 vaccination. ... ...

    Abstract γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-CoV-2 vaccination. While the first dose of vaccine primes Vδ2 T cells, it is the second administration that significantly boosts their immune response. Specifically, the second vaccination uncovers memory features of Vδ2 T cells, shaped by the induction of AP-1 family transcription factors and characterized by a convergent central memory signature, clonal expansion, and an enhanced effector potential. This temporally distinct effector response of Vδ2 T cells was also confirmed in vitro upon stimulation with SARS-CoV-2 spike-peptides. Indeed, the second challenge triggers a significantly higher production of IFNγ by Vδ2 T cells. Collectively, our findings suggest that mRNA SARS-CoV-2 vaccination might benefit from the establishment of long-lasting central memory Vδ2 T cells to confer protection against SARS-CoV-2 infection.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-024-00853-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis.

    León-Lara, Ximena / Fichtner, Alina S / Willers, Maike / Yang, Tao / Schaper, Katharina / Riemann, Lennart / Schöning, Jennifer / Harms, Anna / Almeida, Vicente / Schimrock, Anja / Janssen, Anika / Ospina-Quintero, Laura / von Kaisenberg, Constantin / Förster, Reinhold / Eberl, Matthias / Richter, Manuela F / Pirr, Sabine / Viemann, Dorothee / Ravens, Sarina

    The Journal of experimental medicine

    2024  Volume 221, Issue 7

    Abstract: Preterm infants are at high risk of developing neonatal sepsis. γδ T cells are thought to be an important set of effector cells in neonates. Here, γδ T cells were investigated in a longitudinal cohort of preterm neonates using next-generation sequencing, ...

    Abstract Preterm infants are at high risk of developing neonatal sepsis. γδ T cells are thought to be an important set of effector cells in neonates. Here, γδ T cells were investigated in a longitudinal cohort of preterm neonates using next-generation sequencing, flow cytometry, and functional assays. During the first year of life, the Vγ9Vδ2 T cell subset showed dynamic phenotypic changes and elevated levels of fetal-derived Vγ9Vδ2 T cells were evident in infants with sepsis. Single-cell transcriptomics identified HLA-DRhiCD83+ γδ T cells in neonatal sepsis, which expressed genes related to antigen presentation. In vitro assays showed that CD83 was expressed on activated Vγ9Vδ2 T cells in preterm and term neonates, but not in adults. In contrast, activation of adult Vγ9Vδ2 T cells enhanced CD86 expression, which was presumably the key receptor to induce CD4 T cell proliferation. Together, we provide a map of the maturation of γδ T cells after preterm birth and highlight their phenotypic diversity in infections.
    MeSH term(s) Humans ; Infant, Newborn ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Infant, Premature/immunology ; Antigens, CD/metabolism ; Antigens, CD/genetics ; CD83 Antigen ; Membrane Glycoproteins/metabolism ; Membrane Glycoproteins/genetics ; Female ; Male ; Sepsis/immunology ; Cohort Studies ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Adult ; Lymphocyte Activation/immunology ; Neonatal Sepsis/immunology ; Infant
    Language English
    Publishing date 2024-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20231987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.107: Show issues Location:
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  10. Article ; Online: RORγt

    Yang, Tao / Barros-Martins, Joana / Wang, Ziqing / Wencker, Melanie / Zhang, Jiang / Smout, Justine / Gambhir, Prerna / Janssen, Anika / Schimrock, Anja / Georgiev, Hristo / León-Lara, Ximena / Weiss, Siegfried / Huehn, Jochen / Prinz, Immo / Krueger, Andreas / Foerster, Reinhold / Walzer, Thierry / Ravens, Sarina

    Cell reports

    2023  Volume 42, Issue 10, Page(s) 113230

    Abstract: T cell receptor (TCR) Vγ4-expressing γδ T cells comprise interferon γ (IFNγ)- and interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate decisions during early ontogeny. The existence of adult-thymus-derived IL- ... ...

    Abstract T cell receptor (TCR) Vγ4-expressing γδ T cells comprise interferon γ (IFNγ)- and interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate decisions during early ontogeny. The existence of adult-thymus-derived IL-17
    MeSH term(s) Mice ; Animals ; Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Mice, Inbred C57BL ; T-Lymphocytes ; Thymus Gland ; T-Lymphocyte Subsets ; Proto-Oncogene Proteins c-maf
    Chemical Substances Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Maf protein, mouse ; Proto-Oncogene Proteins c-maf
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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