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  1. Book: Medical treatment of pituitary tumours

    Raverot, Gérald

    (Best practice & research. Clinical endocrinology & metabolism ; volume 36, issue 6 (December 2022))

    2022  

    Author's details Gérald Raverot and Fréderic Castinetti guest editors
    Series title Best practice & research. Clinical endocrinology & metabolism ; volume 36, issue 6 (December 2022)
    Best practice & research
    Collection Best practice & research
    Language English
    Size ca. 109 Seiten in verschiedenen Seitenzählungen, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT021695606
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 1075 -36,6- not available for loan Lesesaal EG

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  2. Book ; Online ; E-Book: Adult Craniopharyngiomas

    Jouanneau, Emmanuel / Raverot, Gérald

    Differences and Lessons from Paediatrics

    2020  

    Abstract: This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and ... ...

    Author's details edited by Emmanuel Jouanneau, Gérald Raverot
    Abstract This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.
    Keywords Neurosurgery ; Endocrinology  ; Pediatrics ; Radiology ; Oncology   ; Endocrinology ; Imaging / Radiology ; Oncology ; Tumors cerebrals ; Cirurgia endoscòpica ; Malalties dels infants ; Adults ; Pediatria ; Endocrinologia ; Oncologia
    Subject code 616.99481
    Language English
    Size 1 online resource (xii, 231 pages) :, illustrations
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-41176-1 ; 3-030-41175-3 ; 978-3-030-41176-3 ; 978-3-030-41175-6
    DOI 10.1007/978-3-030-41176-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Oxytocin deficiency in patients with arginine vasopressin deficiency (central diabetes insipidus).

    Ilie, Mirela Diana / Raverot, Gérald

    The lancet. Diabetes & endocrinology

    2023  Volume 11, Issue 7, Page(s) 442–443

    MeSH term(s) Humans ; Diabetes Insipidus, Neurogenic ; Oxytocin ; Diabetes Insipidus/complications ; Deamino Arginine Vasopressin ; Arginine ; Diabetes Mellitus
    Chemical Substances Oxytocin (50-56-6) ; Deamino Arginine Vasopressin (ENR1LLB0FP) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2023-05-13
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(23)00126-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Letter to the Editor from Salle et al.: "A prospective multi-center observational study of surgical versus non-surgical management for pituitary apoplexy".

    Salle, Laurence / Raverot, Gerald / Salle, Henri

    The Journal of clinical endocrinology and metabolism

    2024  

    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Immunotherapy in pituitary carcinomas and aggressive pituitary tumors.

    Raverot, Gérald / Ilie, Mirela Diana

    Best practice & research. Clinical endocrinology & metabolism

    2022  Volume 36, Issue 6, Page(s) 101712

    Abstract: After temozolomide failure, no evidence-based treatment option is currently available for aggressive pituitary tumors (APTs) and pituitary carcinomas (PCs). Moreover, once temozolomide has failed, the survival of these patients is very poor. The use of ... ...

    Abstract After temozolomide failure, no evidence-based treatment option is currently available for aggressive pituitary tumors (APTs) and pituitary carcinomas (PCs). Moreover, once temozolomide has failed, the survival of these patients is very poor. The use of immune-checkpoint inhibitors (ICIs) has been so far reported in a large cohort, a small phase 2 clinical trial, and in another five isolated cases (24 cases in total). Here, we review the available evidence on the efficacy and potential predictors of response to ICIs in PCs and APTs, namely the histological type (corticotroph versus lactotroph), the tumor type (PC versus APT), the presence of uncontrolled endogenous hypercortisolism, the type of protocol (combined ICIs versus monotherapy), programmed death-ligand 1 (PD-L1) expression, CD8+ cell infiltration, tumor mutational burden (TMB), microsatellite instability (MSI), and mismatch repair (MMR) status. We also discuss key clinical aspects that can already be implemented in the everyday practice and identify future research needs.
    Language English
    Publishing date 2022-10-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2022.101712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pituitary neuroendocrine tumors: from old treatments to innovations, from efficacy to tolerance, from benignity to carcinomas, where do we stand now?

    Castinetti, Frederic / Raverot, Gerald

    Best practice & research. Clinical endocrinology & metabolism

    2022  Volume 36, Issue 6, Page(s) 101717

    Language English
    Publishing date 2022-11-12
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2022.101717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1075: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Outcome and prognostic factors for pituitary carcinomas: lessons from a systematic review.

    Raymond, Perrine / Raverot, Gérald / Ilie, Mirela-Diana

    Endocrine-related cancer

    2023  Volume 30, Issue 5

    Abstract: Purpose: The purpose of this work was toinvestigate the clinicopathological characteristics at the initial diagnosis of the pituitary tumor and at pituitary carcinoma (PC) diagnosis, alongside with the management and outcomes of PCs, and identify ... ...

    Abstract Purpose: The purpose of this work was toinvestigate the clinicopathological characteristics at the initial diagnosis of the pituitary tumor and at pituitary carcinoma (PC) diagnosis, alongside with the management and outcomes of PCs, and identify potential prognostic factors and therapeutic strategies associated with the clinical outcome.
    Methods: PubMed was searched in May 2021 for articles in English and French reporting PCs, the diagnosis of which was made on the presence of metastases. The cases without histological proof and with either another cancer present or an atypical history for a pituitary tumor were excluded.
    Results: One hundred and eighty-one articles reporting 207 cases were included, which included 38% corticotroph and 29% lactotroph carcinomas. An initial Ki67 index ≥10% was associated with shorter survival after the initial diagnosis (P = 0.01). Cases with early metastases were associated with both higher initial Ki67 index (P = 0.01) and shorter survival after PC diagnosis (P = 0.001). Interestingly, cases with short survival after PC diagnosis were associated with shorter time between the initial diagnosis and PC diagnosis (P = 0.0006) and had both higher initial Ki67 index (P = 0.003) and higher Ki67 index of the metastasis (P = 0.03). In addition, cases with long survival after PC diagnosis had received more frequently both systemic treatment after PC diagnosis (P = 0.0005) and local treatment for metastases (P < 0.0001).
    Conclusions: An initial Ki67 index ≥10% is associated with worse outcome and appears as a promising early marker of future metastasis. Its presence should lead to an intensified surveillance and to a more timely management. Clinicians should not hesitate to use local treatment, independent of whether systemic treatment is used.
    MeSH term(s) Humans ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/therapy ; Pituitary Neoplasms/pathology ; Prognosis ; Ki-67 Antigen
    Chemical Substances Ki-67 Antigen
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-22-0338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Letter to the Editor From Helene Lasolle and Gérald Raverot: "USP8 and TP53 Drivers Are Associated With CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors".

    Lasolle, Hélène / Raverot, Gérald

    The Journal of clinical endocrinology and metabolism

    2021  Volume 106, Issue 8, Page(s) e3285–e3286

    MeSH term(s) ACTH-Secreting Pituitary Adenoma ; Adenoma ; Cohort Studies ; Endopeptidases ; Endosomal Sorting Complexes Required for Transport ; Humans ; Pituitary ACTH Hypersecretion ; Pituitary Neoplasms ; Tumor Suppressor Protein p53/genetics ; Ubiquitin Thiolesterase
    Chemical Substances Endosomal Sorting Complexes Required for Transport ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Endopeptidases (EC 3.4.-) ; USP8 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgab217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.134: Show issues Location:
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  9. Article ; Online: Aggressive pituitary tumors and carcinomas: medical treatment beyond temozolomide.

    DE Alcubierre, Dario / Carretti, Anna L / Ducray, François / Jouanneau, Emmanuel / Raverot, Gérald / Ilie, Mirela D

    Minerva endocrinology

    2024  

    Abstract: Aggressive pituitary tumors are a subset of pituitary neoplasms, characterized by unusually fast growth rate, invasiveness and overall resistance to optimized standard treatment. When metastases are present, the term pituitary carcinoma is employed. ... ...

    Abstract Aggressive pituitary tumors are a subset of pituitary neoplasms, characterized by unusually fast growth rate, invasiveness and overall resistance to optimized standard treatment. When metastases are present, the term pituitary carcinoma is employed. After failure of standard treatments, current guidelines recommend first-line temozolomide monotherapy. However, a significant number of patients do not respond to temozolomide, or experience disease progression following its discontinuation; in these latter cases, re-challenge with temozolomide is generally advised, although the reported outcomes have been less satisfactory. Although no alternative therapies have been formally recommended after temozolomide failure, growing evidence regarding potential second- or third-line therapeutic strategies has emerged. In the present work, we reviewed the available evidence published up to April 2023 involving the most relevant therapies employed so far, namely immune checkpoint inhibitors, bevacizumab, peptide radionuclide receptor therapy, tyrosine kinase inhibitors and mTOR inhibitors. For each treatment, we report efficacy and safety outcomes, along with data regarding potential predictors of response. Overall, immune checkpoint inhibitors and bevacizumab are showing the most promise as therapeutic options after temozolomide failure. The former showed better responses in pituitary carcinomas. Peptide radionuclide receptor therapy has also showed some efficacy in these tumors, while tyrosine kinase inhibitors and mTOR inhibitors have exhibited so far limited or no efficacy. Further studies, as well as an individualized, patient-tailored approach, are clearly needed. In addition, we report an unpublished case of a silent corticotroph pituitary carcinoma that progressed under dual immunotherapy, and then showed stable disease under a combination of lomustine and bevacizumab.
    Language English
    Publishing date 2024-01-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.23.04058-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2105: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Current Advances in Papillary Craniopharyngioma: State-Of-The-Art Therapies and Overview of the Literature.

    Jannelli, Gianpaolo / Calvanese, Francesco / Paun, Luca / Raverot, Gerald / Jouanneau, Emmanuel

    Brain sciences

    2023  Volume 13, Issue 3

    Abstract: Craniopharyngiomas are commonly classified as low-grade tumors, although they may harbor a malignant behavior due to their high rate of recurrence and long-term morbidity. Craniopharyngiomas are classically distinguished into two histological types ( ... ...

    Abstract Craniopharyngiomas are commonly classified as low-grade tumors, although they may harbor a malignant behavior due to their high rate of recurrence and long-term morbidity. Craniopharyngiomas are classically distinguished into two histological types (adamantinomatous and papillary), which have been recently considered by the WHO classification of CNS tumors as two independent entities, due to different epidemiological, radiological, histopathological, and genetic patterns. With regard to papillary craniopharyngioma, a BRAF V600 mutation is detected in 95% of cases. This genetic feature is opening new frontiers in the treatment of these tumors using an adjuvant or, in selected cases, a neo-adjuvant approach. In this article, we present an overview of the more recent literature, focusing on the specificities and the role of oncological treatment in the management of papillary craniopharyngiomas. Based on our research and experience, we strongly suggest a multimodal approach combining clinical, endocrinological, radiological, histological, and oncological findings in both preoperative workup and postoperative follow up to define a roadmap integrating every aspect of this challenging condition.
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13030515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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