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  1. Article: Oesophagectomy in End-Stage Achalasia.

    Butt, W T / Donlon, N E / Guiney, M / Ravi, N / Reynolds, J V

    Irish medical journal

    2024  Volume 117, Issue 4, Page(s) 949

    MeSH term(s) Humans ; Esophageal Achalasia/surgery ; Esophagectomy/methods ; Male ; Female
    Language English
    Publishing date 2024-04-25
    Publishing country Ireland
    Document type Letter ; Case Reports ; Journal Article
    ZDB-ID 193134-9
    ISSN 0332-3102 ; 0021-129X
    ISSN 0332-3102 ; 0021-129X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 148: Show issues Location:
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  2. Article ; Online: How to reload and upgrade digital health to serve the healthcare needs of Nigerians.

    Ravi, Nirmal / Thomas, Christy / Odogwu, Juliet

    Frontiers in digital health

    2024  Volume 5, Page(s) 1225092

    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-253X
    ISSN (online) 2673-253X
    DOI 10.3389/fdgth.2023.1225092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial: Legacy and the Future.

    Samy, Ravi N

    Current opinion in otolaryngology & head and neck surgery

    2020  Volume 28, Issue 5, Page(s) 273

    MeSH term(s) Humans ; Otolaryngology
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Book: Common tropical and sub-tropical sedges and grasses

    Ravi, N. / Mohanan, N.

    an illustrated account

    2002  

    Author's details N. Ravi ; N. Mohanan
    Keywords Tropen ; Riedgräser ; Systematik ; Gräser ; Subtropen
    Subject Klassifikation ; Taxonomie ; Biosystematik ; Echte Gräser ; Gramineae ; Gras ; Poaceae ; Süßgräser ; Poales ; Graminales ; Cyperaceae ; Rietgräser ; Sauergräser ; Zyperazeen ; Sauergrasgewächse ; Riedgrasgewächse
    Language English
    Size VII, 219 S. : Ill.
    Publisher Science Publ
    Publishing place Enfield, NH u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014290485
    ISBN 1-57808-227-7 ; 978-1-57808-227-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    058/670 available for loan (reading room) Freihandmagazin (U1)

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  5. Article ; Online: Representation from India in multinational, interventional, phase 2 or 3 trials registered in Clinical Trials Registry-India

    Jaishree Mendiratta / Ravi N. Vaswani / Gayatri Saberwal

    PLoS ONE, Vol 18, Iss

    A cross-sectional study

    2023  Volume 9

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cochlear implantation: an effective modality for hearing restoration following vestibular schwannoma resection.

    Doyle, Edward J / Samy, Ravi N

    Current opinion in otolaryngology & head and neck surgery

    2022  Volume 30, Issue 5, Page(s) 309–313

    Abstract: Purpose of review: Preservation of hearing is one of the tenets of vestibular schwannoma management. In recent years, cochlear implants have been employed with increasing use in patients who have suffered profound sensorineural hearing loss due to the ... ...

    Abstract Purpose of review: Preservation of hearing is one of the tenets of vestibular schwannoma management. In recent years, cochlear implants have been employed with increasing use in patients who have suffered profound sensorineural hearing loss due to the natural history of vestibular schwannoma or due to injury to neurovascular anatomy at time of surgical resection.
    Recent findings: Cochlear implantation has been found to be an effective modality for hearing restoration following vestibular schwannoma. Simultaneous cochlear implantation has been employed by an increased number of centers around the world and has been shown to provide restoration of open set speech perception and return of binaural hearing. Ongoing use of electrically evoked auditory brainstem response (ABR) has improved our detection of viable cochlear nerves and provided insight into those who would benefit from this procedure. Finally, minimally invasive approaches to the internal auditory canal and intralabyrinthine tumors have been described. These methods frequently employ simultaneous cochlear implantation and have emphasized that hearing preservation remains possible with surgical excision despite the location of the tumor.
    Summary: Cochlear implantation is an effective modality for hearing restoration following vestibular schwannoma excision.
    MeSH term(s) Cochlear Implantation ; Cochlear Implants ; Cochlear Nerve ; Hearing ; Hearing Loss, Sensorineural ; Humans ; Neuroma, Acoustic
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Influences of polycyclic aromatic hydrocarbon on the epigenome toxicity and its applicability in human health risk assessment.

    Das, Durgesh Nandini / Ravi, Nathan

    Environmental research

    2022  Volume 213, Page(s) 113677

    Abstract: The existence of polycyclic aromatic hydrocarbons (PAHs) in ambient air is an escalating concern worldwide because of their ability to cause cancer and induce permanent changes in the genetic material. Growing evidence implies that during early life- ... ...

    Abstract The existence of polycyclic aromatic hydrocarbons (PAHs) in ambient air is an escalating concern worldwide because of their ability to cause cancer and induce permanent changes in the genetic material. Growing evidence implies that during early life-sensitive stages, the risk of progression of acute and chronic diseases depends on epigenetic changes initiated by the influence of environmental cues. Several reports deciphered the relationship between exposure to environmental chemicals and epigenetics, and have known toxicants that alter the epigenetic states. Amongst PAHs, benzo[a]pyrene (B[a]P) is accepted as a group 1 cancer-causing agent by the International Agency for the Research on Cancer (IARC). B[a]P is a well-studied pro-carcinogen that is metabolically activated by the aryl hydrocarbon receptor (AhR)/cytochrome P450 pathway. Cytochrome P450 plays a pivotal role in the stimulation step, which is essential for DNA adduct formation. Accruing evidence suggests that epigenetic alterations assume a fundamental part in PAH-promoted carcinogenesis. This interaction between PAHs and epigenetic factors results in an altered profile of these marks, globally and locus-specific. Some of the epigenetic changes due to exposure to PAHs lead to increased disease susceptibility and progression. It is well understood that exposure to environmental carcinogens, such as PAH triggers disease pathways through changes in the genome. Several evidence reported due to the epigenome-wide association studies, that early life adverse environmental events may trigger widespread and persistent variations in transcriptional profiling. Moreover, these variations respond to DNA damage and/or a consequence of epigenetic modifications that need further investigation. Growing evidence has associated PAHs with epigenetic variations involving alterations in DNA methylation, histone modification, and micro RNA (miRNA) regulation. Epigenetic alterations to PAH exposure were related to chronic diseases, such as pulmonary disease, cardiovascular disease, endocrine disruptor, nervous system disorder, and cancer. This hormetic response gives a novel perception concerning the toxicity of PAHs and the biological reaction that may be a distinct reliance on exposure. This review sheds light on understanding the latest evidence about how PAHs can alter epigenetic patterns and human health. In conclusion, as several epigenetic change mechanisms remain unclear yet, further analyses derived from PAHs exposure must be performed to find new targets and disease biomarkers. In spite of the current limitations, numerous evidence supports the perception that epigenetics grips substantial potential for advancing our knowledge about the molecular mechanisms of environmental toxicants, also for predicting health-associated risks due to environmental circumstances exposure and individual susceptibility.
    MeSH term(s) Cytochrome P-450 Enzyme System ; Epigenome ; Humans ; Neoplasms/chemically induced ; Neoplasms/genetics ; Polycyclic Aromatic Hydrocarbons/metabolism ; Polycyclic Aromatic Hydrocarbons/toxicity ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Risk Assessment
    Chemical Substances Polycyclic Aromatic Hydrocarbons ; Receptors, Aryl Hydrocarbon ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2022-06-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.113677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
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  8. Article ; Online: Editorial: Cerebrospinal fluid physiology.

    Samy, Ravi N

    Current opinion in otolaryngology & head and neck surgery

    2019  Volume 27, Issue 5, Page(s) 325

    MeSH term(s) Brain Diseases/physiopathology ; Cerebrospinal Fluid/physiology ; Cerebrospinal Fluid Leak/physiopathology ; Ear Diseases/physiopathology ; Humans
    Language English
    Publishing date 2019-08-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [AUDITORY OUTCOMES OF COCHLEAR IMPLANTATION IN MENIERE'S DISEASE].

    Lipschitz, Noga / Kohlberg, Gavriel D / Samy, Ravi N

    Harefuah

    2023  Volume 162, Issue 7, Page(s) 424–427

    Abstract: Background: Cochlear implants are valuable in the auditory rehabilitation of patients with severe to profound hearing loss. However, there is limited data on the outcomes of cochlear implantation in patients with Meniere's disease (MD).: Objectives: ... ...

    Abstract Background: Cochlear implants are valuable in the auditory rehabilitation of patients with severe to profound hearing loss. However, there is limited data on the outcomes of cochlear implantation in patients with Meniere's disease (MD).
    Objectives: In this study, we aim to evaluate the auditory outcomes of cochlear implantation in patients with MD.
    Methods: A retrospective case series of patients with MD and severe to profound sensorineural hearing loss (SNHL), who underwent cochlear implantation at a tertiary academic center between 2006-2017. Patient's clinical characteristics and audiometric data were reviewed.
    Results: The study included 20 ears in 19 patients with MD who underwent cochlear implantation with available pre- and postoperative audiometric data. There were 10 males and 9 females with a mean age of 63 years and a mean follow-up duration of 70.8 months. Pre- and post-implant CNC word recognition scores were 18.31% and 66.89%, respectively (p<0.001). Pre- and post-implant AzBio and/or HINT sentence recognition scores were 12.25% and 68.28% in quiet, respectively (p<0.001), and 18.25% and 63.43% in noise, respectively (p<0.001).
    Conclusions: Cochlear implantation resulted in an improvement of word and sentence recognition scores in MD patients. These results support the role of cochlear implants in the auditory rehabilitation of MD.
    Discussion: Dr. Samy received research support from Cochlear Corporation.
    MeSH term(s) Male ; Female ; Humans ; Middle Aged ; Cochlear Implantation/methods ; Meniere Disease/complications ; Meniere Disease/surgery ; Retrospective Studies ; Speech Perception ; Treatment Outcome ; Cochlear Implants
    Language Hebrew
    Publishing date 2023-08-07
    Publishing country Israel
    Document type English Abstract ; Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exploring features in chromatographic profiles as a tool for monitoring column performance.

    Ravi, Nivetita / Malmquist, Gunnar / Stanev, Valentin / Ferreira, Gisela

    Journal of chromatography. A

    2023  Volume 1698, Page(s) 463982

    Abstract: In the biopharmaceutical industry, chromatography resins have a finite number of uses before they start to age and degrade, typically due to losses of ligand integrity and/or density. The "health" of a column is predicted and validated by running ... ...

    Abstract In the biopharmaceutical industry, chromatography resins have a finite number of uses before they start to age and degrade, typically due to losses of ligand integrity and/or density. The "health" of a column is predicted and validated by running multiple cycles on representative scale-down models and can be followed by real-time on-going validation during commercial production. Principal Component Analysis (PCA), Partial Least Square (PLS), Similarity Scores and Single One Point-MultiParameter Technique (SOP-MPT) along with machine learning principles were applied to explore the hypothesis that there is predictive capability of latent variables in chromatography absorbance profiles for process performance (step yield) and product quality (aggregates, fragments, host cell proteins (HCP) and DNA, and Protein A ligand). The first stage of this study is described in this paper: a MabSelect SuRe™ chromatography column was cycled with a method to establish the "normal" baseline for process performance and product quality, followed by runs using a harsher NaOH Cleaning in Place (CIP) procedure (with a higher NaOH concentration than that recommended by the vendor) to accelerate resin degradation. The different mathematical analytical tools correlated with resin degradation of the column (reflected in decreasing step yield and binding capacity with increasing running cycle), specifically when using the Wash, Elution and Strip phases of the chromatography method. Monomer, HCP and DNA content were not significantly impacted and therefore a correlation with product quality was inconsequential. Importantly, this work shows proof-of-concept that while more traditional methods of measuring resin integrity such as the height equivalent to a theoretical place (HETP) and Asymmetry (As) measurements could not detect changes in the integrity of the resin, PCA, PLS, Similarity Scores and SOP-MPT (to a lesser extent) applied to the absorbance data were capable of anticipating issues in the chromatography bed by identifying atypical outcomes.
    MeSH term(s) Chromatography, Affinity/instrumentation ; Chromatography, Affinity/methods ; Proteins ; Sodium Hydroxide/chemistry ; DNA/chemistry ; Models, Chemical
    Chemical Substances Proteins ; Sodium Hydroxide (55X04QC32I) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2023.463982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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