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  1. Article ; Online: Initial Experience with Apixaban for Extended Venous Thromboembolism Prophylaxis After Radical Cystectomy.

    Rosen, Geoffrey / Anwar, Taha / Syed, Johar / Weinstein, David / Ravichandran, Sandhiya / Bailey, Jacob / Hamilton, Zachary / Murray, Katie S

    European urology focus

    2021  Volume 8, Issue 2, Page(s) 480–482

    Abstract: Patients who undergo radical cystectomy (RC) are at elevated risk of venous thromboembolism and associated morbidity and mortality. Guidelines recommend extended thromboprophylaxis (ETP), typically with heparins, but adherence is low. Outside urology, ... ...

    Abstract Patients who undergo radical cystectomy (RC) are at elevated risk of venous thromboembolism and associated morbidity and mortality. Guidelines recommend extended thromboprophylaxis (ETP), typically with heparins, but adherence is low. Outside urology, low-dose apixaban has been used for postoperative ETP with success. We describe our first experiences with low-dose apixaban for ETP after RC for bladder cancer. In our sample of 72 patients who underwent RC for cancer and subsequently received apixaban 2.5 mg twice daily for ETP, there were no symptomatic thromboembolic events and no major bleeding events. Other complication rates were in line with historical reports. Our experience with apixaban 2.5 mg twice daily for ETP after RC demonstrates safety and potential efficacy. A transition from injectable to oral thromboprophylaxis has the potential to improve adherence and patient satisfaction, while allowing the possibility of further extending prophylaxis beyond 28 d, which may be beneficial in selected patients. Further evaluation of apixaban for thromboprophylaxis in urologic cancer surgery is warranted. PATIENT SUMMARY: Home injectable heparin is used for 4 weeks after bladder removal surgery to prevent blood clots. We evaluated our use of the oral medication apixaban for prevention of blood clots after bladder removal surgery and found that none of our patients had major bleeding events or symptomatic blood clots. We conclude that there should be further evaluation of the use of oral instead of injectable medication to prevent blood clots after urology surgery.
    MeSH term(s) Anticoagulants/adverse effects ; Cystectomy/adverse effects ; Hemorrhage/chemically induced ; Humans ; Pyrazoles ; Pyridones ; Urinary Bladder ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/surgery ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J)
    Language English
    Publishing date 2021-03-15
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2021.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Multicomponent Library Resource Model to Enhance Academic Global Health Education Among Residency Programs.

    Patel, Rupa R / Ravichandran, Sandhiya / Doering, Michelle M / Hardi, Angela C

    Medical reference services quarterly

    2017  Volume 36, Issue 2, Page(s) 120–128

    Abstract: Global health is becoming an increasingly important component of medical education. Medical libraries have an opportunity to assist global health residents with their information needs, but first it is important to identify what those needs are and how ... ...

    Abstract Global health is becoming an increasingly important component of medical education. Medical libraries have an opportunity to assist global health residents with their information needs, but first it is important to identify what those needs are and how best they can be addressed. This article reports a collaboration between global health faculty and an academic medical librarian to assess the information needs of global health pathway residents and how assessment data are used to create a multicomponent program designed to enhance global health education.
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605941-7
    ISSN 1540-9597 ; 0276-3869
    ISSN (online) 1540-9597
    ISSN 0276-3869
    DOI 10.1080/02763869.2017.1293971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2751: Show issues Location:
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  3. Article: Prognostic significance of pulmonary function tests in dyskeratosis congenita, a telomere biology disorder.

    Giri, Neelam / Ravichandran, Sandhiya / Wang, Youjin / Gadalla, Shahinaz M / Alter, Blanche P / Fontana, Joseph / Savage, Sharon A

    ERJ open research

    2019  Volume 5, Issue 4

    Abstract: Pulmonary fibrosis and pulmonary arteriovenous malformations are known manifestations of dyskeratosis congenita (DC), a telomere biology disorder (TBD) and inherited bone marrow failure syndrome caused by germline mutations in telomere maintenance genes ... ...

    Abstract Pulmonary fibrosis and pulmonary arteriovenous malformations are known manifestations of dyskeratosis congenita (DC), a telomere biology disorder (TBD) and inherited bone marrow failure syndrome caused by germline mutations in telomere maintenance genes resulting in very short telomeres. Baseline pulmonary function tests (PFTs) and long-term clinical outcomes have not been thoroughly studied in DC/TBDs. In this retrospective study, 43 patients with DC and 67 unaffected relatives underwent baseline PFTs and were followed for a median of 8 years (range 1-14). Logistic regression and competing risk models were used to compare PFT results in relation to clinical and genetic characteristics, and patient outcomes. Restrictive abnormalities on spirometry and moderate-to-severe reduction in diffusing capacity of the lung for carbon monoxide were significantly more frequent in patients with DC than relatives (42%
    Language English
    Publishing date 2019-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00209-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-κB.

    Soh, Hendrick / Venkatesan, Natarajan / Veena, Mysore S / Ravichandran, Sandhiya / Zinabadi, Alborz / Basak, Saroj K / Parvatiyar, Kislay / Srivastava, Meera / Liang, Li-Jung / Gjertson, David W / Torres, Jorge Z / Moatamed, Neda A / Srivatsan, Eri S

    Molecular and cellular biology

    2016  Volume 36, Issue 12, Page(s) 1776–1792

    Abstract: We and others have shown that the cystatin E/M gene is inactivated in primary human tumors, pointing to its role as a tumor suppressor gene. However, the molecular mechanism of tumor suppression is not yet understood. Using plasmid-directed cystatin E/M ... ...

    Abstract We and others have shown that the cystatin E/M gene is inactivated in primary human tumors, pointing to its role as a tumor suppressor gene. However, the molecular mechanism of tumor suppression is not yet understood. Using plasmid-directed cystatin E/M gene overexpression, a lentivirus-mediated tetracycline-inducible vector system, and human papillomavirus 16 (HPV 16) E6 and E7 gene-immortalized normal human epidermal keratinocytes, we demonstrated intracellular and non-cell-autonomous apoptotic growth inhibition of tumor cell lines and that growth inhibition is associated with cytoplasmic retention of NF-κB. We further demonstrated decreased phosphorylation of IκB kinase (IKKβ) and IκBα in the presence of tumor necrosis factor alpha (TNF-α), confirming the role of cystatin E/M in the regulation of the NF-κB signaling pathway. Growth suppression of nude mouse xenograft tumors carrying a tetracycline-inducible vector system was observed with the addition of doxycycline in drinking water, confirming that the cystatin E/M gene is a tumor suppressor gene. Finally, immunohistochemical analyses of cervical carcinoma in situ and primary tumors have shown a statistically significant inverse relationship between the expression of cystatin E/M and cathepsin L and a direct relationship between the loss of cystatin E/M expression and nuclear expression of NF-κB. We therefore propose that the cystatin E/M suppressor gene plays an important role in the regulation of NF-κB.
    MeSH term(s) Animals ; Cathepsin L/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Cystatin M/genetics ; Cystatin M/metabolism ; Cytoplasm/metabolism ; Doxycycline/administration & dosage ; Female ; Gene Expression Regulation, Neoplastic ; Genetic Vectors/pharmacology ; HeLa Cells ; Humans ; I-kappa B Proteins/metabolism ; Lentivirus/genetics ; Mice ; Mice, Nude ; NF-kappa B/metabolism ; Neoplasm Transplantation ; Phosphorylation ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
    Chemical Substances CST6 protein, human ; Cystatin M ; I-kappa B Proteins ; NF-kappa B ; TNF protein, human ; Tumor Necrosis Factor-alpha ; CTSL protein, human (EC 3.4.22.15) ; Cathepsin L (EC 3.4.22.15) ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2016-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00878-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-κB

    Soh, Hendrick / Venkatesan, Natarajan / Veena, Mysore S. / Ravichandran, Sandhiya / Zinabadi, Alborz / Basak, Saroj K. / Parvatiyar, Kislay / Srivastava, Meera / Liang, Li-Jung / Gjertson, David W. / Torres, Jorge Z. / Moatamed, Neda A. / Srivatsan, Eri S.

    Molecular and Cellular Biology. 2016 June 1, v. 36, no. 12 p.1776-1792

    2016  

    Abstract: We and others have shown that the cystatin E/M gene is inactivated in primary human tumors, pointing to its role as a tumor suppressor gene. However, the molecular mechanism of tumor suppression is not yet understood. Using plasmid-directed cystatin E/M ... ...

    Abstract We and others have shown that the cystatin E/M gene is inactivated in primary human tumors, pointing to its role as a tumor suppressor gene. However, the molecular mechanism of tumor suppression is not yet understood. Using plasmid-directed cystatin E/M gene overexpression, a lentivirus-mediated tetracycline-inducible vector system, and human papillomavirus 16 (HPV 16) E6 and E7 gene-immortalized normal human epidermal keratinocytes, we demonstrated intracellular and non-cell-autonomous apoptotic growth inhibition of tumor cell lines and that growth inhibition is associated with cytoplasmic retention of NF-κB. We further demonstrated decreased phosphorylation of IκB kinase (IKKβ) and IκBα in the presence of tumor necrosis factor alpha (TNF-α), confirming the role of cystatin E/M in the regulation of the NF-κB signaling pathway. Growth suppression of nude mouse xenograft tumors carrying a tetracycline-inducible vector system was observed with the addition of doxycycline in drinking water, confirming that the cystatin E/M gene is a tumor suppressor gene. Finally, immunohistochemical analyses of cervical carcinoma in situ and primary tumors have shown a statistically significant inverse relationship between the expression of cystatin E/M and cathepsin L and a direct relationship between the loss of cystatin E/M expression and nuclear expression of NF-κB. We therefore propose that the cystatin E/M suppressor gene plays an important role in the regulation of NF-κB.
    Keywords Human papillomavirus type 16 ; apoptosis ; cathepsin L ; cell growth ; doxycycline ; gene overexpression ; growth retardation ; humans ; immunohistochemistry ; keratinocytes ; mice ; neoplasm cells ; phosphorylation ; suppressor genes ; tumor necrosis factor-alpha ; tumor suppressor genes ; uterine cervical neoplasms ; xenotransplantation
    Language English
    Dates of publication 2016-0601
    Size p. 1776-1792.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00878-15
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

    Veena, Mysore S / Wilken, Reason / Zheng, Jun-Ying / Gholkar, Ankur / Venkatesan, Natarajan / Vira, Darshni / Ahmed, Sameer / Basak, Saroj K / Dalgard, Clifton L / Ravichandran, Sandhiya / Batra, Raj K / Kasahara, Noriyuki / Elashoff, David / Fishbein, Michael C / Whitelegge, Julian P / Torres, Jorge Z / Wang, Marilene B / Srivatsan, Eri S

    The Journal of biological chemistry

    2014  Volume 289, Issue 50, Page(s) 34921–34937

    Abstract: The molecular mechanism of p16-mediated senescence in cisplatin-treated cancer cells is not fully understood. Here we show that cisplatin treatment of head and neck cancer cells results in nuclear transport of p16 leading to a molecular modification of ... ...

    Abstract The molecular mechanism of p16-mediated senescence in cisplatin-treated cancer cells is not fully understood. Here we show that cisplatin treatment of head and neck cancer cells results in nuclear transport of p16 leading to a molecular modification of NFκB. Chromatin immunoprecipitation assays show that this modification is associated with the inhibition of NFκB interacting with its DNA binding sequences, leading to decreased expression of NFκB-transcribed proteins. LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetracycline-inducible GFP-S peptide-NFκB expression system identified gigaxonin, an ubiquitin E3 ligase adaptor, as an NFκB-interacting protein. Immunoblotting and siRNA studies confirmed the NFκB-gigaxonin interaction and the dependence of this binding on p16-NFκB binding. Using gel shift assays, we have confirmed p16-NFκB and gigaxonin-NFκB interactions. Furthermore, we have observed increased NFκB ubiquitination with cisplatin treatment that is abolished in the absence of p16 and gigaxonin expression. Analysis of 103 primary tumors has shown that increased nuclear p16 expression correlates with enhanced survival of head and neck cancer patients (p < 0.0000542), indicating the importance of nuclear p16 expression in prognosis. Finally, p16 expression is associated with reduced cytokine expression and the presence of human papilloma virus in chemoradiation-sensitive basaloid tumors. However, the absence of p16 expression is associated with enhanced cytokine expression and the absence of human papilloma virus in aggressive tumors. These results clearly demonstrate that nuclear p16 and gigaxonin play an important role in chemosensitivity of head and neck cancers through ubiquitination of NFκB.
    MeSH term(s) Active Transport, Cell Nucleus/drug effects ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cellular Senescence/drug effects ; Cisplatin/pharmacology ; Cyclin D1/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cytoskeletal Proteins/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/virology ; Human papillomavirus 16/physiology ; Humans ; NF-kappa B/metabolism ; Prognosis ; Ubiquitination/drug effects
    Chemical Substances Antineoplastic Agents ; Cyclin-Dependent Kinase Inhibitor p16 ; Cytoskeletal Proteins ; GAN protein, human ; NF-kappa B ; Cyclin D1 (136601-57-5) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2014-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M114.568543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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