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  1. Article ; Online: Atypical Presentation of Pseudoxanthoma Elasticum in Two Siblings from North India

    Sunayana Misra / Ravindra Kumar Saran

    Acta Medica, Vol 63, Iss 4, Pp 198-

    2020  Volume 201

    Abstract: Pseudoxanthoma elasticum (PXE) is a rare hereditary disorder occurring due to metabolic defect in the liver and manifesting predominantly in the skin, eyes and arteries. It shows characteristic yellowish papules on the skin around the nape of neck along ... ...

    Abstract Pseudoxanthoma elasticum (PXE) is a rare hereditary disorder occurring due to metabolic defect in the liver and manifesting predominantly in the skin, eyes and arteries. It shows characteristic yellowish papules on the skin around the nape of neck along with looseness of skin over flexural surfaces. PXE shows marked phenotypic heterogeneity. Complications related to arterial wall and retinal Bruchs’ membrane calcification occur later in life; early diagnosis therefore helps keep patient on follow up for development of the same. In Indian patients, classic skin changes may be missed clinically making histopathology pivotal in diagnosis and patient management.
    Keywords pseudoxanthoma elasticum ; hereditary ; metabolic defect ; ectopic calcification ; Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Karolinum Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Adrenal myelolipoma

    Ashish Sachan / Hirdaya Hulas Nag / Sandip Barmann / Ravindra Kumar Saran

    Apollo Medicine, Vol 15, Iss 1, Pp 44-

    Radiologic-pathologic correlation

    2018  Volume 46

    Abstract: Myelolipomas are rare, benign tumors of adrenal gland. These tumors are generally asymptomatic and are diagnosed incidentally. Differentiating the tumor from other adrenal tumors such as liposarcoma, pheochromocytoma is important for management. We ... ...

    Abstract Myelolipomas are rare, benign tumors of adrenal gland. These tumors are generally asymptomatic and are diagnosed incidentally. Differentiating the tumor from other adrenal tumors such as liposarcoma, pheochromocytoma is important for management. We hereby describe the case of adrenal myelolipoma we recently managed, with emphasis on the radiologic and pathologic correlation of this rare disease.
    Keywords adrenal gland ; adrenal incidentaloma ; adrenal myelolipoma ; Medicine ; R
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Aspergillus growth within ventriculoperitoneal shunt tube

    Vikas Kumar / Poonam Sood Loomba / Daljit Singh / Ravindra Kumar Saran

    Journal of Pediatric Neurosciences, Vol 12, Iss 1, Pp 83-

    2017  Volume 84

    Abstract: Cerebrospinal fluid (CSF) shunt failure is commonly associated with infection or mechanical obstruction of the shunt system. A 4-year-old male child who had undergone multiple shunt revisions at another hospital for congenital hydrocephalus and later for ...

    Abstract Cerebrospinal fluid (CSF) shunt failure is commonly associated with infection or mechanical obstruction of the shunt system. A 4-year-old male child who had undergone multiple shunt revisions at another hospital for congenital hydrocephalus and later for shunt obstruction, presented with exposed shunt at the supraclavicular region. Shunt revision was performed. The CSF culture showed no growth; however, the histopathological examination of shunt tube showed Aspergillus growth inside the lumen of silicone tube well away from the tip of ventriculoperitoneal shunt. The skin biopsy from the exposed site revealed foreign body giant cell granulomatous reaction. The patient was discharged on postoperative day 6 without any complications. At 3 months follow-up, the patient is doing well. A growth of Aspergillus within the shunt tube prompted us to think of how the hardware can get infected and may remain a source of constant infection.
    Keywords Aspergillus ; hydrocephalus ; infection ; ventriculoperitoneal shunt ; Pediatrics ; RJ1-570 ; Medicine ; R ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Atypical presentation of cystic schwannoma of the sphenoid sinus

    Gautam Dutta / Daljit Singh / Hukum Singh / Ghanshyam Singhal / Ravindra Kumar Saran

    The Pan African Medical Journal, Vol 31, Iss

    a nonsolitary mass with osseous, intracranial and cavernous sinus invasion

    2018  Volume 233

    Abstract: Although nearly half of all schwannomas involve the head and neck region, nasal and paranasal sinus presentations are quite rarely seen. Cystic schwannoma, characterized by cyst formation lined by S-100 protein positive membrane-like structures is very ... ...

    Abstract Although nearly half of all schwannomas involve the head and neck region, nasal and paranasal sinus presentations are quite rarely seen. Cystic schwannoma, characterized by cyst formation lined by S-100 protein positive membrane-like structures is very uncommonly seen in sphenoid sinus with only a single previously reported case. Here we report a young patient of cystic schwannoma of the paranasal sinuses having epicenter in the sphenoid sinus. The tumor had caused extensive erosion of the skull base and paranasal sinuses and extended intracranially that radiologically mimicked as infected mucocele causing loss of vision. This case denotes the aggressive behavior of such uncommon tumors.
    Keywords cystic schwannoma ; sphenoid sinus ; paranasal sinus ; mucocele ; Medicine ; R
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher The Pan African Medical Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Extra-axial dural cavernous hemangioma with dural tail sign, masquerading as meningioma

    Rakesh Kumar Gupta / Ravindra Kumar Saran / Anita Jagetia / Poonam Narang

    Journal of Neurosciences in Rural Practice, Vol 7, Iss 4, Pp 615-

    2016  Volume 616

    Keywords Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Reversible cerebral and brain stem dysfunction in n

    Vinod Puri / Abhijit Das Gupta / Neera Chaudhry / Ravindra Kumar Saran

    Annals of Indian Academy of Neurology, Vol 18, Iss 4, Pp 464-

    Hexane neuropathy

    2015  Volume 467

    Abstract: A 18-year-old male, screen printer by profession developed sensory motor polyneuropathy, change in his behavior, bilateral 6 th and 7 th cranial nerve palsies, down beat nystagmus and cerebellar dysarthria. He had bilaterally prolonged P100 latency; left: ...

    Abstract A 18-year-old male, screen printer by profession developed sensory motor polyneuropathy, change in his behavior, bilateral 6 th and 7 th cranial nerve palsies, down beat nystagmus and cerebellar dysarthria. He had bilaterally prolonged P100 latency; left: 137 ms; right: 144 ms. P 37 was not recordable on either side while N 20 was normal. The inter latency difference between Ipsilateral R2 and Contralateral R2 was 6.15 ms, on the left side and normal on the right side. In the follow-up, there was normalization of the blink reflex study, improvement in P100 latency [left: 114 ms; right: 120 ms.] but worsening of peripheral nerve conductions. The sequential clinical recovery was of the behavioral dysfunction, down beat nystagmus, 6 th nerve, 7 th nerve involvement and ataxia, in that order. Sural nerve biopsy showed loss of large diameter myelinated fibers.
    Keywords 6 th and 7 th nerve palsy ; blink reflex ; central nervous system involvement ; down beat nystagmus ; n- Hexane neuropathy ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A case report of pontine glioblastoma presenting as subcutaneous metastasis in nape of neck in a child

    Vikas Kumar / Daljit Singh / Hukum Singh / Ravindra Kumar Saran

    Journal of Pediatric Neurosciences, Vol 10, Iss 4, Pp 386-

    2015  Volume 388

    Abstract: Glioblastoma (GBM) is the most common malignant tumor in adults. Extracranial metastasis of GBM is very rare. The incidence of brainstem glioblastoma is not known due to low biopsy and resection rates. In this case report, we experienced an 11-year-old ... ...

    Abstract Glioblastoma (GBM) is the most common malignant tumor in adults. Extracranial metastasis of GBM is very rare. The incidence of brainstem glioblastoma is not known due to low biopsy and resection rates. In this case report, we experienced an 11-year-old male who was diagnosed as a case of pontine GBM after biopsy of lesion and underwent radiotherapy with adjuvant chemotherapy. He presented with a subcutaneous swelling in the nape of neck 1 year after the first procedure. Swelling was excised. Pathological examination and immunohistochemical staining confirmed it as GBM. This case shows us that GBM can at times present as a swelling in soft tissue.
    Keywords Brainstem glioblastoma ; glioblastoma metastasis ; pediatric glioblastoma ; pontine glioblastoma ; subcutaneous metastasis ; Pediatrics ; RJ1-570 ; Medicine ; R ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Parasellar chondrosarcoma in three young patients

    Rakesh Kumar Gupta / Latika Gupta / Ravindra Kumar Saran / Anita Jagetia / Lalit Garg

    Journal of Neurosciences in Rural Practice, Vol 8, Iss 5, Pp 130-

    A diagnosis of caution

    2017  Volume 132

    Abstract: Parasellar chondrosarcoma is rare slowly growing intracranial tumors. A correct diagnosis of these tumors is challenging for clinician due to overlapping location and simulation of clinical presentations with much common pituitary adenomas. We are ... ...

    Abstract Parasellar chondrosarcoma is rare slowly growing intracranial tumors. A correct diagnosis of these tumors is challenging for clinician due to overlapping location and simulation of clinical presentations with much common pituitary adenomas. We are reporting three young patients diagnosed to have parasellar chondrosarcoma highlighting the pathological features of importance required for confirm diagnosis.
    Keywords Chondrosarcoma ; chordoma ; parasellar ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Necrotizing autoimmune myopathy

    Sachin Suresh Babu / Laxmi Khanna / Ravindra Kumar Saran / Gaurav Mittal / Sudhir Peter / Ivy Sebastian

    Annals of Indian Academy of Neurology, Vol 19, Iss 2, Pp 288-

    2016  Volume 290

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Is histopathology informative for further characterization of DOTANOC-proven islet cell lesions in infancy?

    Rakesh Kumar Gupta / Ravindra Kumar Saran / Pinaki Ranjan Debnath / Rajiv Chadha

    Indian Journal of Pathology and Microbiology, Vol 58, Iss 3, Pp 410-

    2015  Volume 412

    Keywords Pathology ; RB1-214 ; Medicine ; R ; Microbiology ; QR1-502 ; Science ; Q
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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