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Article ; Online: New-onset systemic lupus erythematosus following BNT162b2 mRNA COVID-19 vaccine: a case series and literature review.

Sagy, Iftach / Zeller, Lior / Raviv, Yael / Porges, Tzvika / Bieber, Amir / Abu-Shakra, Mahmoud

2022 Volume 42, Issue 12, Page(s) 2261–2266

Abstract: Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases ... ...

Abstract	Emerging data evaluated the possible link between the Coronavirus 19 (COVID-19) vaccine and acute flares of rheumatic autoimmune diseases. However, the association between the COVID-19 vaccine and the development of de-novo rheumatic autoimmune diseases remained unclear. We report the first case series of three male patients who developed new-onset systemic lupus erythematosus following receiving Pfizer BNT162b2 mRNA vaccination. The clinical characteristics share some similarities with drug-induced lupus. More patients with SLE following COVID-19 may be diagnosed in the future. Additional studies will provide more significant insights into the possible immunogenic influence of the COVID-19 vaccine.
MeSH term(s)	Autoimmune Diseases ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Male ; RNA, Messenger ; Vaccination
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-09-13
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-022-05203-3
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Article: A Case Report of Lifesaving in Life-threatening Pulmonary Mucormycosis.

Shalata, Walid / Abo Abod, Motaz / Boehm Cohen, Liora / Kassirer, Michael / Raviv, Yael / Potashner, Dana

The Israel Medical Association journal : IMAJ

2022 Volume 24, Issue 10, Page(s) 682–684

MeSH term(s)	Humans ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Lung ; Respiration, Artificial/adverse effects
Language	English
Publishing date	2022-12-13
Publishing country	Israel
Document type	Case Reports ; Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article: Cannabis Vaping-induced Lung Injury.

Shalata, Walid / Abo Abod, Motaz / Golosky, Mitchell / Boehm Cohen, Liora / Kassirer, Michael / Kamenev, Iris / Raviv, Yael

The Israel Medical Association journal : IMAJ

2023 Volume 25, Issue 5, Page(s) 360–361

MeSH term(s)	Humans ; Cannabis/adverse effects ; Lung Injury/chemically induced ; Vaping/adverse effects
Language	English
Publishing date	2023-05-25
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article: Novel Bronchoscopic Drainage Technique in Multiple Drug Resistant Acinetobacter Lung Abscess: A Case Report.

Shalata, Walid / Abo Abod, Motaz / Tsaregorodtsev, Sergei / Abu Hamid-Salama, Reem / Boehm Cohen, Liora / Kassirer, Michael / Raviv, Yael / Potashner, Dana

The Israel Medical Association journal : IMAJ

2022 Volume 24, Issue 10, Page(s) 679–681

MeSH term(s)	Humans ; Lung Abscess/surgery ; Acinetobacter ; Drainage/methods ; Bronchoscopy/methods
Language	English
Publishing date	2022-10-30
Publishing country	Israel
Document type	Case Reports ; Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article: First Presentation of Systemic Lupus Erythematosus in a 24-Year-Old Male following mRNA COVID-19 Vaccine.

Raviv, Yael / Betesh-Abay, Batya / Valdman-Grinshpoun, Yuliya / Boehm-Cohen, Liora / Kassirer, Michael / Sagy, Iftach

Case reports in rheumatology

2022 Volume 2022, Page(s) 9698138

Abstract: The SARS-CoV-2 viral pandemic has had an immeasurable global impact, resulting in over 5 million deaths worldwide. Numerous vaccines were developed in an attempt to quell viral dissemination and reduce symptom severity among those infected. Systemic ... ...

Abstract	The SARS-CoV-2 viral pandemic has had an immeasurable global impact, resulting in over 5 million deaths worldwide. Numerous vaccines were developed in an attempt to quell viral dissemination and reduce symptom severity among those infected. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of antinuclear autoantibodies (ANAs) with heterogenic clinical manifestations, secondary to immune complex deposition in a multitude of organ systems. There are scarcely reported cases of SLE development following COVID-19 mRNA vaccination. We present a case of a 24-year-old male without preexisting conditions or family history of autoimmune disorders, presenting with SLE following the first dose of the SARS-CoV-2 Pfizer-BioNTech mRNA vaccine.
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2666708-3
ISSN	2090-6897 ; 2090-6889
ISSN (online)	2090-6897
ISSN	2090-6889
DOI	10.1155/2022/9698138
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Article ; Online: Personalizing non-small cell lung cancer treatment through patient-derived xenograft models: preclinical and clinical factors for consideration.

Fuchs, Vered / Sobarzo, Ariel / Msamra, Maha / Kezerle, Yarden / Linde, Liat / Sevillya, Gur / Anoze, Alaa / Refaely, Yael / Cohen, Ahron Yehonatan / Melamed, Israel / Azriel, Amit / Shoukrun, Rami / Raviv, Yael / Porgador, Angel / Peled, Nir / Roisman, Laila Catalina

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2024

Abstract: Purpose: In the pursuit of creating personalized and more effective treatment strategies for lung cancer patients, Patient-Derived Xenografts (PDXs) have been introduced as preclinical platforms that can recapitulate the specific patient's tumor in an ... ...

Abstract	Purpose: In the pursuit of creating personalized and more effective treatment strategies for lung cancer patients, Patient-Derived Xenografts (PDXs) have been introduced as preclinical platforms that can recapitulate the specific patient's tumor in an in vivo model. We investigated how well PDX models can preserve the tumor's clinical and molecular characteristics across different generations. Methods: A Non-Small Cell Lung Cancer (NSCLC) PDX model was established in NSG-SGM3 mice and clinical and preclinical factors were assessed throughout subsequent passages. Our cohort consisted of 40 NSCLC patients, which were used to create 20 patient-specific PDX models in NSG-SGM3 mice. Histopathological staining and Whole Exome Sequencing (WES) analysis were preformed to understand tumor heterogeneity throughout serial passages. Results: The main factors that contributed to the growth of the engrafted PDX in mice were a higher grade or stage of disease, in contrast to the long duration of chemotherapy treatment, which was negatively correlated with PDX propagation. Successful PDX growth was also linked to poorer prognosis and overall survival, while growth pattern variability was affected by the tumor aggressiveness, primarily affecting the first passage. Pathology analysis showed preservation of the histological type and grade; however, WES analysis revealed genomic instability in advanced passages, leading to the inconsistencies in clinically relevant alterations between the PDXs and biopsies. Conclusions: Our study highlights the impact of multiple clinical and preclinical factors on the engraftment success, growth kinetics, and tumor stability of patient-specific NSCLC PDXs, and underscores the importance of considering these factors when guiding and evaluating prolonged personalized treatment studies for NSCLC patients in these models, as well as signaling the imperative for additional investigations to determine the full clinical potential of this technique.
Language	English
Publishing date	2024-03-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-024-03450-3
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Article ; Online: SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera.

Kuzmina, Alona / Khalaila, Yara / Voloshin, Olga / Keren-Naus, Ayelet / Boehm-Cohen, Liora / Raviv, Yael / Shemer-Avni, Yonat / Rosenberg, Elli / Taube, Ran

Cell host & microbe

2021 Volume 29, Issue 4, Page(s) 522–528.e2

Abstract: Toward eradicating the COVID-19 pandemic, vaccines that induce high humoral and cellular immune responses are essential. However, SARS-CoV-2 variants have begun to emerge and raise concerns, as they may potentially compromise vaccine efficiency. Here, we ...

Abstract	Toward eradicating the COVID-19 pandemic, vaccines that induce high humoral and cellular immune responses are essential. However, SARS-CoV-2 variants have begun to emerge and raise concerns, as they may potentially compromise vaccine efficiency. Here, we monitored neutralization potency of convalescent or Pfizer-BTN162b2 post-vaccination sera against pseudoviruses displaying spike proteins derived from wild-type SARS-CoV-2, or its UK-B.1.1.7 and SA-B.1.351 variants. Compared to convalescent sera, vaccination induces high titers of neutralizing antibodies, which exhibit efficient neutralization potential against pseudovirus carrying wild-type SARS-CoV-2. However, while wild-type and UK-N501Y pseudoviruses were similarly neutralized, those displaying SA-N501Y/K417N/E484K spike mutations moderately resist neutralization. Contribution of single or combined spike mutations to neutralization and infectivity were monitored, highlighting mechanisms by which viral infectivity and neutralization resistance are enhanced by N501Y or E484K/K417N mutations. Our study validates the importance of the Pfizer vaccine but raises concerns regarding its efficacy against specific SARS-CoV-2 circulating variants.
MeSH term(s)	Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; BNT162 Vaccine ; COVID-19 Vaccines/immunology ; Convalescence ; Humans ; Mutation ; Neutralization Tests ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/genetics ; Vaccination
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2021.03.008
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Article ; Online: SARS CoV-2 escape variants exhibit differential infectivity and neutralization sensitivity to convalescent or post-vaccination sera

Kuzmina, Alona / Khalaila, Yara / Voloshin, Olga / Keren-Naus, Ayelet / Bohehm, Liora / Raviv, Yael / Shemer-Avni, Yonat / Rosenberg, Elli / Taube, Ran

medRxiv

Abstract: Towards eradicating COVID19, developing vaccines that induce high levels of neutralizing antibodies is a main goal. As counter measurements, viral escape mutants rapidly emerge and potentially compromise vaccine efficiency. Herein we monitored ability of ...

Abstract	Towards eradicating COVID19, developing vaccines that induce high levels of neutralizing antibodies is a main goal. As counter measurements, viral escape mutants rapidly emerge and potentially compromise vaccine efficiency. Herein we monitored ability of convalescent or Pfizer-BTN162b2 post-vaccination sera to neutralize wide-type SARS- CoV2 or its UK-B.1.1.7 and SA-B.1.351 variants. Relative to convalescent sera, post- vaccination sera exhibited higher levels of neutralizing antibodies against wild-type or mutated viruses. However, while SARS-CoV2 wild-type and UK-N501Y were similarly neutralized by tested sera, the SA-N501Y/K417N/E484K variant moderately escaped neutralization. Significant contribution to infectivity and sensitivity to neutralization was attributed to each of the variants and their single or combined mutations, highlighting alternative mechanisms by which prevalent variants with either N501Y or E484K/K417N mutations spread. Our study validates the clinical significance of currently administered vaccines, but emphasizes that their efficacy may be compromised by circulated variants, urging the development of new ones with broader neutralization functions.
Keywords	covid19
Language	English
Publishing date	2021-02-24
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.02.22.21252002
Database	COVID19

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Article ; Online: Pulmonary Langerhans cell histiocytosis and diabetes insipidus in pregnant women: our experience.

Fuks, Leonardo / Kramer, Mordechai R / Shitrit, David / Raviv, Yael

Lung

2014 Volume 192, Issue 2, Page(s) 285–287

Abstract: Pulmonary Langerhans cell histiocytosis (PLCH) occurs predominantly in young adult smokers. Diabetes insipidus occurs in up to 15 % patients with PLCH. Information on PLCH in pregnancy is sparse, especially associated with diabetes insipidus. We report ... ...

Abstract	Pulmonary Langerhans cell histiocytosis (PLCH) occurs predominantly in young adult smokers. Diabetes insipidus occurs in up to 15 % patients with PLCH. Information on PLCH in pregnancy is sparse, especially associated with diabetes insipidus. We report three patients with these conditions and describe the disease history and pregnancy outcomes.
MeSH term(s)	Adult ; Diabetes Insipidus/complications ; Diabetes Insipidus/diagnosis ; Diabetes Insipidus/therapy ; Female ; Histiocytosis, Langerhans-Cell/diagnosis ; Histiocytosis, Langerhans-Cell/etiology ; Histiocytosis, Langerhans-Cell/therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Live Birth ; Pregnancy ; Pregnancy in Diabetics ; Risk Factors ; Smoking/adverse effects ; Smoking Cessation ; Smoking Prevention ; Treatment Outcome
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2014-02-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	6165-7
ISSN	1432-1750 ; 0341-2040
ISSN (online)	1432-1750
ISSN	0341-2040
DOI	10.1007/s00408-014-9559-8
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Article ; Online: Routine comprehensive Aspergillus screening of bronchoalveolar lavage samples in lung transplant recipients.

Unterman, Avraham / Izhakian, Shimon / Geffen, Yuval / Rosengarten, Dror / Shtraichman, Osnat / Pertzov, Barak / Vainshelboim, Baruch / Alon, Hagar / Raviv, Yael / Kramer, Mordechai R

Clinical transplantation

2020 Volume 34, Issue 3, Page(s) e13811

Abstract: Background: Invasive aspergillosis is a significant cause of morbidity and mortality in lung transplant recipients (LTRs). Early diagnosis may improve outcome, yet is challenging. We assessed the diagnostic yield of a routine, comprehensive, ... ...

Abstract	Background: Invasive aspergillosis is a significant cause of morbidity and mortality in lung transplant recipients (LTRs). Early diagnosis may improve outcome, yet is challenging. We assessed the diagnostic yield of a routine, comprehensive, prospectively employed Aspergillus screening strategy in LTRs. Methods: During a 6-month period, all bronchoalveolar lavage (BAL) samples (including post-transplant surveillance) obtained from LTRs at our center were routinely tested for Aspergillus PCR, galactomannan (GM), and fungal culture. Invasive aspergillosis (IA) was defined using EORTC/MSG and ISHLT criteria for proven and probable aspergillosis. Results: Ninety-five consecutive BAL samples were tested. PCR, GM, and fungal culture were positive in 28.4%, 30.6%, and 7.4%, respectively. Five cases of IA (two proven, three probable) were identified. Fungal culture failed to detect 40% of IA cases, which were detected by a positive PCR and/or GM. However, the majority of positive PCR samples represented colonization (59.3%). Sensitivity of PCR, GM, and culture for IA was 80%, 60%, and 60%, respectively, and specificity was 74%, 71%, and 96%. Conclusions: In LTRs, a routine prospectively employed screening strategy in which all BAL samples were screened for Aspergillus PCR and GM, detected aspergillosis cases that were otherwise missed by a false-negative fungal culture, but resulted in more cases of colonization being detected. Clinical judgment is thus warranted to avoid unnecessary treatment of colonization.
MeSH term(s)	Aspergillus/genetics ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid ; Humans ; Lung ; Sensitivity and Specificity ; Transplant Recipients
Language	English
Publishing date	2020-02-20
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.13811
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