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Article: Oral potentially malignant disorders: Revisited.

Ray, Jay Gopal

Journal of oral and maxillofacial pathology : JOMFP

2017 Volume 21, Issue 3, Page(s) 326–327

Language	English
Publishing date	2017-12-29
Publishing country	India
Document type	Editorial
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.JOMFP_224_17
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Article ; Online: A unique case of epithelioid sarcoma involving the mandibular alveolar mucosa.

Ray, Debarati / Sarangi, Snehanjan / Ghose, Sandip / Ray, Jay Gopal

Oral surgery, oral medicine, oral pathology and oral radiology

2023 Volume 137, Issue 2, Page(s) e16–e21

Abstract: Epithelioid sarcoma (ES) is an infrequent, malignant, mesenchymal, soft-tissue neoplasm of uncertain histogenesis characterized by epithelioid cytomorphology. The lack of SMARCB1/INI1 (Integrase interactor 1) expression typifies this pathology. It ... ...

Abstract	Epithelioid sarcoma (ES) is an infrequent, malignant, mesenchymal, soft-tissue neoplasm of uncertain histogenesis characterized by epithelioid cytomorphology. The lack of SMARCB1/INI1 (Integrase interactor 1) expression typifies this pathology. It usually presents as a painless, indolent, slowly enlarging lesion or rarely as an aggressive growth. Epithelioid sarcoma affects mostly pediatric patients or young adults. It recurs quite frequently and possesses a high degree of metastatic potential. Two predominant histomorphologic patterns include classic/conventional type and proximal types. Epithelioid sarcoma immunohistochemically shows vimentin, cytokeratin, epithelial membrane antigen, CD34 positivity, and negative staining with S100 and desmin. Management is generally multimodal, including wide surgical resection, radiotherapy, and chemotherapy. To date, to our knowledge, only 11 instances of head and neck ES have been reported in the literature. Our case deals with the diagnosis of intraoral ES in a 55-year-old female patient, probably the first one to involve the mandibular mucosa, based on relevant clinical-radiologic-pathologic-immunohistochemical findings.
MeSH term(s)	Female ; Young Adult ; Humans ; Child ; Middle Aged ; Biomarkers, Tumor/metabolism ; Neoplasm Recurrence, Local ; Sarcoma/diagnosis ; Soft Tissue Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2650843-6
ISSN	2212-4411 ; 2212-4403
ISSN (online)	2212-4411
ISSN	2212-4403
DOI	10.1016/j.oooo.2023.09.007
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Article ; Online: MiRNAs as non-invasive biomarkers in the serum of Oral Squamous Cell Carcinoma (OSCC) and Oral Potentially Malignant Disorder (OPMD) patients.

Mazumder, Sayani / Basu, Baidehi / Ray, Jay Gopal / Chatterjee, Raghunath

Archives of oral biology

2023 Volume 147, Page(s) 105627

Abstract: Objective: Cell-free microRNAs have shown differential levels in the serum of individuals under disease conditions suggesting its potential to act as biomarkers. A population specific miRNA signature in oral cancer is reported in different studies. We ... ...

Abstract	Objective: Cell-free microRNAs have shown differential levels in the serum of individuals under disease conditions suggesting its potential to act as biomarkers. A population specific miRNA signature in oral cancer is reported in different studies. We aim to identify a set of serum specific miRNAs that may differentiate oral cancer, oral pre-malignant conditions from the healthy individuals. Design: We investigated the levels of 24 miRNAs in the serum of 47 Oral squamous cell carcinoma (OSCC) patients, 20 patients with Oral potentially malignant disorders (OPMD) and 42 healthy controls from Eastern India. Small RNAs were isolated from serum samples followed by cDNA synthesis. Levels of miRNAs were determined using qRT-PCR. The sources of serum specific miRNAs were evaluated using GTEx-RNAseq and TCGA-HNSCC database. Results: Five miRNAs, miR-483-5p, miR-31-5p, Let-7b-5p, miR-486-5p and miR-30e-5p showed significant elevation in OSCC patients. An Elastic-Net model with 4 miRNAs classified OSCC from healthy controls with 80 % sensitivity, 64.3 % specificity, and 72.4 % accuracy. Mir-483-5p and miR-31-5p was significantly overexpressed in OSCC tissues as well as significantly higher in the serum of Leukoplakia and Verrucous carcinoma patients suggesting their potential as early disease markers. MiR-483-5p showed a consistent elevated level in the serum/plasma of oral cancer patients across different population and was found to be tumour specific while, the rest of the miRNAs showed variable results across different studies. Conclusions: Our study suggested that the serum miRNAs in oral cancer and pre-malignant disorder conditions can be used as a non-invasive marker for screening of these oral conditions.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Carcinoma, Squamous Cell/pathology ; Squamous Cell Carcinoma of Head and Neck ; Mouth Neoplasms/pathology ; Biomarkers, Tumor/genetics ; Head and Neck Neoplasms
Chemical Substances	MicroRNAs ; Biomarkers, Tumor
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	80227-x
ISSN	1879-1506 ; 0003-9969
ISSN (online)	1879-1506
ISSN	0003-9969
DOI	10.1016/j.archoralbio.2023.105627
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Ul III Zs.151: Show issues

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Article: Oral submucous fibrosis: An update.

Ray, Jay Gopal / Smitha, T

Journal of oral and maxillofacial pathology : JOMFP

2017 Volume 21, Issue 3, Page(s) 330–331

Language	English
Publishing date	2017-12-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.JOMFP_230_17
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Article ; Online: Oral submucous fibrosis: A global challenge. Rising incidence, risk factors, management, and research priorities.

Ray, Jay Gopal / Chatterjee, Raghunath / Chaudhuri, Keya

Periodontology 2000

2019 Volume 80, Issue 1, Page(s) 200–212

Abstract: Oral submucous fibrosis is a potentially malignant disorder of the oral cavity, with a high rate of malignant transformation. It is very common among habitual areca nut chewers. The pathogenesis of oral submucous fibrosis is not well established, but it ... ...

Abstract	Oral submucous fibrosis is a potentially malignant disorder of the oral cavity, with a high rate of malignant transformation. It is very common among habitual areca nut chewers. The pathogenesis of oral submucous fibrosis is not well established, but it is believed to be a disease of multifactorial origin, including areca nut chewing, ingestion of chilies, genetic factors, immunologic processes and nutritional deficiencies. Genetically susceptible individuals when exposed to areca nut chewing develop this disease over a variable period of time. Oral submucous fibrosis is considered to be a disease of collagen metabolism. Several genetic factors are reported but there is no consensus about the exact mechanism of disease initiation. Variations in histopathological presentation are noted among oral submucous fibrosis patients with habitual areca nut chewing in different forms and other additive agents, eg betel quid, pan masala and gutkha, together with a variety of tobacco habits. The role of epigenetic modifications, such as miRNA regulation, and DNA methylation is also being reported as part of the pathogenesis of oral submucous fibrosis. A combined approach, including analysis of genetic and epigenetic regulations with different habits, might be helpful to better understand the contributory factors and pathogenesis of this serious disorder.
MeSH term(s)	Areca ; Humans ; Incidence ; Mouth Neoplasms ; Oral Submucous Fibrosis ; Risk Factors
Language	English
Publishing date	2019-05-14
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1200504-6
ISSN	1600-0757 ; 0906-6713
ISSN (online)	1600-0757
ISSN	0906-6713
DOI	10.1111/prd.12277
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Zs.A 4046: Show issues

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Article ; Online: Molecular Pathology of Malignant Transformation of Oral Submucous Fibrosis.

Chattopadhyay, Amit / Ray, Jay Gopal

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer

2016 Volume 35, Issue 3, Page(s) 193–205

Abstract: Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, ... ...

Abstract	Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Transformation of OSF to squamous cell carcinoma (SCC) is variable, but up to 13% conversion of OSF to SCC has been reported. Various genetic and molecular mechanisms impact the malignant transformation of OSF, causing changes in the cell cycle, DNA, keratinocytes, and keratin; tumor-cell proliferation and survival; angiogenesis; fibrosis through epithelial-mesenchymal transitions (EMTs), and tissue hypoxia. All are reviewed here, including potential biomarkers for malignant transformation of OSF. These interactions are not fully understood, but a critical mass of knowledge is building up to ultimately allow the understanding of all mechanisms involved.
MeSH term(s)	Areca/adverse effects ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/pathology ; Cell Transformation, Neoplastic/pathology ; Humans ; Oral Submucous Fibrosis/etiology ; Oral Submucous Fibrosis/pathology
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441790-2
ISSN	2162-6537 ; 0731-8898 ; 0146-4779
ISSN (online)	2162-6537
ISSN	0731-8898 ; 0146-4779
DOI	10.1615/JEnvironPatholToxicolOncol.2016014024
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Zs.A 1472: Show issues

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Article: Dysbiosis of Oral Microbiota During Oral Squamous Cell Carcinoma Development.

Sarkar, Purandar / Malik, Samaresh / Laha, Sayantan / Das, Shantanab / Bunk, Soumya / Ray, Jay Gopal / Chatterjee, Raghunath / Saha, Abhik

Frontiers in oncology

2021 Volume 11, Page(s) 614448

Abstract: Infection with specific pathogens and alterations in tissue commensal microbial composition are intricately associated with the development of many human cancers. Likewise, dysbiosis of oral microbiome was also shown to play critical role in the ... ...

Abstract	Infection with specific pathogens and alterations in tissue commensal microbial composition are intricately associated with the development of many human cancers. Likewise, dysbiosis of oral microbiome was also shown to play critical role in the initiation as well as progression of oral cancer. However, there are no reports portraying changes in oral microbial community in the patients of Indian subcontinent, which has the highest incidence of oral cancer per year, globally. To establish the association of bacterial dysbiosis and oral squamous cell carcinoma (OSCC) among the Indian population, malignant lesions and anatomically matched adjacent normal tissues were obtained from fifty well-differentiated OSCC patients and analyzed using 16S rRNA V3-V4 amplicon based sequencing on the MiSeq platform. Interestingly, in contrast to the previous studies, a significantly lower bacterial diversity was observed in the malignant samples as compared to the normal counterpart. Overall our study identified
Language	English
Publishing date	2021-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.614448
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Article ; Online: Effect of Lysyl Oxidase G473 A Polymorphism on Lysyl Oxidase and Total Soluble Collagen Expression in Oral Submucous Fibrosis.

Mukherjee, Sanjit / Katarkar, Atul / Dhariwal, Richa / Mohanty, Sweta / Mahato, Basudev / Ray, Jay Gopal / Chaudhuri, Keya

Asian Pacific journal of cancer prevention : APJCP

2021 Volume 22, Issue 8, Page(s) 2493–2499

Abstract: Background: Oral submucous fibrosis (OSF) is a debilitating collagen-metabolic disorder leading to submucosal fibrosis and trismus. Lysyl oxidase (LOX), a critical collagen biosynthetic enzyme, is up-regulated in OSF. Polymorphisms in the Lysyl oxidase ... ...

Abstract	Background: Oral submucous fibrosis (OSF) is a debilitating collagen-metabolic disorder leading to submucosal fibrosis and trismus. Lysyl oxidase (LOX), a critical collagen biosynthetic enzyme, is up-regulated in OSF. Polymorphisms in the Lysyl oxidase gene have been associated with increased risk of OSF and might affect normal collagen synthesis, accumulation, or degradation, crucial in determining fibrosis severity. Methods: One hundred OSF cases and 100 controls were genotyped for LOX G473A(Arg158Gln) polymorphism by polymerase chain reaction-restriction fragment length polymorphism. The expression of LOX was estimated both by quantitative mRNA analysis and western blot. Total soluble collagen was evaluated from mucosal tissue obtained from OSF cases. Immunohistochemical (IHC) localization of type 1 collagen was performed in mucosal tissue obtained from patients carrying various genotypes. Results: Heterozygous G473A genotype was significantly higher in OSF cases [2.063(95% CI =1.059-4.016)], among 26-40 years age-group [4.375(95% CI=1.323-14.267),p=0.029] and in male patients [2.38 (95% CI= 1.107-5.121), p= 0.042]. LOX expression was significantly higher in cases of the heterozygous or homozygous carrier (p <0.001). We found the total soluble collagen level significantly (p <0.001) higher among patients carrying GA or AA genotype. IHC revealed focal deposition of type1 collagen in the submucosal tissue; comparatively higher deposition was evident in mucosal tissue of OSF patients carrying AA genotype. Conclusions: These findings suggest LOX G473A polymorphism confers an increased risk of OSF and may affect collagen accumulation in OSF cases.
MeSH term(s)	Adolescent ; Adult ; Case-Control Studies ; Child ; Child, Preschool ; Collagen/metabolism ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Humans ; India/epidemiology ; Infant ; Infant, Newborn ; Male ; Oral Submucous Fibrosis/epidemiology ; Oral Submucous Fibrosis/genetics ; Oral Submucous Fibrosis/metabolism ; Oral Submucous Fibrosis/pathology ; Polymorphism, Single Nucleotide ; Prognosis ; Protein-Lysine 6-Oxidase/genetics ; Risk Factors ; Young Adult
Chemical Substances	Collagen (9007-34-5) ; LOX protein, human (EC 1.4.3.13) ; Protein-Lysine 6-Oxidase (EC 1.4.3.13)
Language	English
Publishing date	2021-08-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2021.22.8.2493
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Article ; Online: Malignant transformation of oral submucous fibrosis: overview of histopathological aspects.

Ray, Jay Gopal / Ranganathan, Kannan / Chattopadhyay, Amit

Oral surgery, oral medicine, oral pathology and oral radiology

2016 Volume 122, Issue 2, Page(s) 200–209

Abstract: Oral submucous fibrosis (OSF), first described in 1952, is a potentially malignant disorder associated with betel quid and areca nut chewing, mostly prevalent in the population of the Indian subcontinent and South East Asia. Malignant transformation of ... ...

Abstract	Oral submucous fibrosis (OSF), first described in 1952, is a potentially malignant disorder associated with betel quid and areca nut chewing, mostly prevalent in the population of the Indian subcontinent and South East Asia. Malignant transformation of OSF to squamous cell carcinoma (SCC) has been estimated to be between 2% and 8%. Our study aimed to review the histopathologic changes that contribute to the understanding of the malignant transformation of OSF. Changes in epithelial thickness and dysplasia characterized by micronuclei, altered AgNOR counts and distribution, keratin protein alteration, and alteration of P63 and E-cadherin characterize the epithelial changes during the transformation of OSF to SCC. Common mechanisms have been proposed to be involved in OSF and SCC, through collagen maturation and their interaction with myofibroblasts and mast cells. Fibrosis-driven vascular constriction that results in epithelial hypoxia has also been proposed as an important mechanism for the malignant transformation of OSF. However, reassessment of the classical view is required, because with demonstration of large blood vasculature in the connective tissue stroma of OSF, the hypothesis associated with tissue hypoxia-induced malignant transformation of OSF can be questioned.
MeSH term(s)	Areca/adverse effects ; Carcinoma, Squamous Cell/pathology ; Cell Transformation, Neoplastic/pathology ; Humans ; Mouth Neoplasms/pathology ; Oral Submucous Fibrosis/pathology ; Risk Factors
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2650843-6
ISSN	2212-4411 ; 2212-4403
ISSN (online)	2212-4411
ISSN	2212-4403
DOI	10.1016/j.oooo.2015.11.024
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Ul III Zs.121: Show issues

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Article: Quantitative assessment of silver-stained nucleolar organizer region in odontogenic cysts to correlate the growth and malignant potentiality.

Biswas, Sailendra Nath / Paul, R R / Ray, Jay Gopal / Majumdar, Sumit / Uppala, Divya

Journal of oral and maxillofacial pathology : JOMFP

2018 Volume 21, Issue 3, Page(s) 460–461

Abstract: Context: The most common and important odontogenic cyst involving jaws is the odontogenic keratocyst (OKC) or primordial cyst, the dentigerous cyst and the radicular cyst. These cysts all though do not show similar behavior, they all have the ... ...

Abstract	Context: The most common and important odontogenic cyst involving jaws is the odontogenic keratocyst (OKC) or primordial cyst, the dentigerous cyst and the radicular cyst. These cysts all though do not show similar behavior, they all have the potentiality to recur. Silver nitrate staining of the nucleolar organizer regions (AgNORs) of the benign and malignant lesions is becoming very useful as a diagnostic indicator. Thus, the aim of this study is to assess the diagnostic potential of AgNORs in the cystic epithelium of common odontogenic cysts. Materials and methods: Archived specimens of odontogenic cysts were stained with hematoxylin and eosin stain and AgNOR stain. Results: The comparative evaluation of the AgNOR counts was done among the three varieties of odontogenic cysts, i.e., radicular cysts, dentigerous cysts and OKC and were observed that the mean for OKC was significantly higher than that of radicular cyst. Conclusion: Therefore, AgNor could be used as an efficient tool for comparative evaluation of microscopic features such as epithelial thickness, surface keratinization and mural proliferation in dentigerous cyst to that of the AgNOR count.
Language	English
Publishing date	2018-01-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.JOMFP_181_15
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