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  1. Article ; Online: COVID-19 and Co-infection in Children: The Indian Perspectives.

    Raychaudhuri, Dibyendu / Sarkar, Mihir / Roy, Aniket / Roy, Debapriya / Datta, Kalpana / Sengupta, Tapti / Hazra, Avijit / Mondal, Rakesh

    Journal of tropical pediatrics

    2021  Volume 67, Issue 4

    Abstract: Background and objectives: Assessing the co-infections with COVID-19 is crucial to delineate its true clinical impact. Pediatric information in this aspect is limited. Our study aims to analyze the spectrum of co-infections in pediatric COVID-19 ... ...

    Abstract Background and objectives: Assessing the co-infections with COVID-19 is crucial to delineate its true clinical impact. Pediatric information in this aspect is limited. Our study aims to analyze the spectrum of co-infections in pediatric COVID-19 patients and determine the clinical as well as laboratory parameters predicting co-infection.
    Methodology: In this prospective observational study conducted from June to December 2020 in a single tertiary care institution, data pertaining to demographic, illness and treatment-related variables were analyzed among two subsets of pediatric patients of age 1 month-12 years with RT-PCR-confirmed COVID-19 infection-Group A: those with confirmed co-infection and Group B: moderate to severe disease without co-infection. Among Group A, etiology of co-infection was characterized through relevant microbiological examination within 48 h admission.
    Result: Among our study population, 15.03% and 20.6% had co-infections and moderate to severe disease respectively. Among those with confirmed co-infection, 32.5%, 11.6% and 6.97% recorded blood culture, respiratory secretion and CSF growth, respectively, the picture being dominated by Methicillin resistant and sensitive Staphylococcus aureus. Serum serology demonstrated Scrub typhus infection to be most prevalent. Concurrent respiratory viral infections were seen in 11.6%. Children with co-infection had significantly higher morbidity and need for supportive therapy. Predictors of co-infection were localization of infection, Neutrophil count ≥10×109, age-specific lymphopenia, CRP > 100 mg/dl and hyperferritinemia.
    Conclusion: Co-infections are an important factor prognosticating pediatric COVID infection. Their early detection, prompt and appropriate treatment is of paramount importance.
    MeSH term(s) COVID-19 ; Child ; Coinfection/epidemiology ; Humans ; Prospective Studies ; SARS-CoV-2 ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/epidemiology
    Language English
    Publishing date 2021-09-03
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 800065-7
    ISSN 1465-3664 ; 0449-3281 ; 0142-6338
    ISSN (online) 1465-3664
    ISSN 0449-3281 ; 0142-6338
    DOI 10.1093/tropej/fmab073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PIMS-TS vs. MIS-C: Diagnostic Criteria in COVID-19-Associated Hyperinflammation in Children.

    Sarkar, Mihir / Pal, Priyankar / Raychaudhuri, Dibyendu / Sen, Bonny / Roychowdhoury, Satyabrata / Chattopadhyay, Amitabha / Hazra, Avijit / Mondal, Rakesh

    Indian journal of pediatrics

    2021  Volume 88, Issue 11, Page(s) 1149–1150

    MeSH term(s) COVID-19 ; Child ; Humans ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-08-09
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-021-03908-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Animal Bites and Rabies Prophylaxis in Rural Children: Indian Perspective.

    Samanta, Moumita / Mondal, Rakesh / Shah, Ankit / Hazra, Avijit / Ray, Somosri / Dhar, Goutam / Biswas, Rupa / Sabui, Tapas Kumar / Raychaudhuri, Dibyendu / Chatterjee, Kaushani / Kundu, Chanchal / Sarkar, Sumantra

    Journal of tropical pediatrics

    2016  Volume 62, Issue 1, Page(s) 55–62

    Abstract: A prospective observational study was conducted in a tertiary care hospital to study clinicoepidemiological profile of potentially rabid animal bite cases from rural India. Total of 308 children (median age 6 years) admitted to hospital, were recruited ... ...

    Abstract A prospective observational study was conducted in a tertiary care hospital to study clinicoepidemiological profile of potentially rabid animal bite cases from rural India. Total of 308 children (median age 6 years) admitted to hospital, were recruited over 1 year and followed up till completion of antirabies vaccine course. Dog was the commonest (77.27%) offending animal. Of the exposures, 66.88% were scratches, 88.96% were unprovoked and 27.27% were categorized as Class III. The median times to wound toileting and reporting to health facility were 1 and 6 h, respectively. Majority received prompt PEP in hospital, and RIG was administered in 34.55% of Class II and 90.48% of Class III exposures. Compared with their older counterparts, children aged <5 years suffered more bites on face and trunk and more Class III exposures. The rabies prophylaxis scenario is encouraging, when compared with earlier studies, but there are gaps to be addressed.
    MeSH term(s) Animals ; Bites and Stings/complications ; Bites and Stings/epidemiology ; Child ; Child, Preschool ; Dogs ; Female ; Health Facilities ; Humans ; Incidence ; India/epidemiology ; Infant ; Infant, Newborn ; Male ; Post-Exposure Prophylaxis ; Prevalence ; Prospective Studies ; Rabies/diagnosis ; Rabies/epidemiology ; Rural Population ; Socioeconomic Factors
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 800065-7
    ISSN 1465-3664 ; 0449-3281 ; 0142-6338
    ISSN (online) 1465-3664
    ISSN 0449-3281 ; 0142-6338
    DOI 10.1093/tropej/fmv072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of malnutrition as a predictor of adverse outcomes in febrile neutropenia associated with paediatric haematological malignancies.

    Chaudhuri, Jasodhara / Biswas, Tamoghna / Datta, Jyotishka / Sabui, Tapas Kumar / Chatterjee, Sukanta / Ray, Somosri / Raychaudhuri, Dibyendu / Mandal, Kalyanbrata / Chatterjee, Kaushani / Chakraborty, Swapna

    Journal of paediatrics and child health

    2016  Volume 52, Issue 7, Page(s) 704–709

    Abstract: Aim: Malnutrition has been reported in the literature to be adversely associated with outcomes in paediatric malignancies. Our objective in this paper was to evaluate malnutrition as a potential predictor for adverse outcomes in febrile neutropenia ... ...

    Abstract Aim: Malnutrition has been reported in the literature to be adversely associated with outcomes in paediatric malignancies. Our objective in this paper was to evaluate malnutrition as a potential predictor for adverse outcomes in febrile neutropenia associated with haematological malignancies.
    Methods: A prospective observational study was performed in a tertiary care teaching hospital of Kolkata, India. Forty-eight participants, suffering from haematological malignancy, were included. Participants were included if they experienced at least one episode of febrile neutropenia. For children aged <5 years, weight for height, height for age and weight for age were used as criteria for defining malnutrition, while body mass index for age was used in children ≥5 years. A total of 162 episodes of febrile neutropenia were studied.
    Results: Thirty patients (30/48, 62.5%) included in the study had malnutrition. In bivariate analyses at patient level, there is a strong association between malnutrition and death (odds ratio (OR) 7.286, 95% confidence interval (CI) 0.838-63.345, one-tailed P = 0.044), and life-threatening complications show a moderate trend towards significance (OR 3.333, 95% CI 0.791-14.052, one-tailed P = 0.084). Survival functions were significantly different between malnourished and non-malnourished children (log rank test χ(2)  = 4.609, degree of freedom = 1, P = 0.032). Wasting was associated with life-threatening complications in children aged <5 years (OR 14, 95% CI 1.135-172.642, one-tailed P = 0.036). Logistic regression analyses at episode level revealed that phase of treatment and respiratory system involvement were significant predictors of death, while malnutrition was not.
    Conclusion: Malnutrition may be a potential predictor of mortality in febrile neutropenia.
    MeSH term(s) Child ; Child, Preschool ; Female ; Fever ; Forecasting ; Hematologic Neoplasms/complications ; Humans ; Male ; Malnutrition ; Neutropenia/etiology ; Outcome Assessment (Health Care) ; Pediatrics ; Prospective Studies
    Language English
    Publishing date 2016-07
    Publishing country Australia
    Document type Journal Article ; Observational Study
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.13233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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