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  1. Article ; Online: Gastroenteropankreatische neuroendokrine Tumoren.

    Rayes, Nada / Denecke, Timm

    Der Radiologe

    2021  Volume 61, Issue 12, Page(s) 1129–1138

    Abstract: Neuroendocrine tumors (NET), or more generally neuroendocrine neoplasms (NEN), represent a very heterogeneous group of rare tumors with varying location which are only defined by their endocrine biology and secretion of synaptophysin and chromogranin A. ... ...

    Title translation Gastroenteropancreatic neuroendocrine tumors.
    Abstract Neuroendocrine tumors (NET), or more generally neuroendocrine neoplasms (NEN), represent a very heterogeneous group of rare tumors with varying location which are only defined by their endocrine biology and secretion of synaptophysin and chromogranin A. They originate from mesoderm-derived stem cells. In the last few years, the incidence and prevalence of NEN have been steadily increasing. Classification is based on the affected organ, the proliferation rate and presence or absence of hormone production with typical symptoms. Diagnosis and treatment of these tumors is therefore very specific and requires an interdisciplinary approach. Treatment options include endoscopic or surgical resection, drug therapy for control of symptoms and proliferation, locoregional therapy and radionuclide therapy. Guidelines with algorithms for diagnostic workup and treatment are constantly updated.
    MeSH term(s) Humans ; Intestinal Neoplasms/diagnostic imaging ; Intestinal Neoplasms/therapy ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/therapy ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/therapy ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/therapy
    Language German
    Publishing date 2021-11-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 505520-9
    ISSN 1432-2102 ; 0033-832X
    ISSN (online) 1432-2102
    ISSN 0033-832X
    DOI 10.1007/s00117-021-00929-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MG 106: Show issues

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  2. Book ; Thesis: Nachuntersuchungsergebnisse bei operativ und konservativ behandelten Radiusköpfchenfrakturen

    Rayes, Nada

    1993  

    Author's details vorgelegt von Nada Rayes
    Language German
    Size 107 S. : Ill.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1993
    HBZ-ID HT006260201
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    94 D 1055 order for loan Magazin

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  3. Article: Endokrine Hypertonie

    Rayes, Nada / Seidemann, Lena / Lange, Undine

    Allgemein- und Viszeralchirurgie up2date

    2023  Volume 17, Issue 03, Page(s) 249–263

    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2317051-7
    ISSN 1611-6461 ; 1611-6437
    ISSN (online) 1611-6461
    ISSN 1611-6437
    DOI 10.1055/a-2046-0051
    Database Thieme publisher's database

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  4. Article ; Online: False-positive results for pheochromocytoma associated with norepinephrine reuptake blockade.

    Schürfeld, Robin / Pamporaki, Christina / Peitzsch, Mirko / Rayes, Nada / Sabri, Osama / Rohm, Silvio / Biemann, Ronald / Sandner, Benjamin / Tönjes, Anke / Eisenhofer, Graeme

    Endocrine-related cancer

    2023  Volume 31, Issue 1

    Abstract: Measurements of plasma metanephrines and methoxytyramine provide a sensitive test for diagnosis of pheochromocytoma/paraganglioma. False-positive results remain a problem, particularly in patients taking norepinephrine reuptake-blocking drugs. Therefore, ...

    Abstract Measurements of plasma metanephrines and methoxytyramine provide a sensitive test for diagnosis of pheochromocytoma/paraganglioma. False-positive results remain a problem, particularly in patients taking norepinephrine reuptake-blocking drugs. Therefore, in this retrospective observational study, we measured plasma metanephrines and methoxytyramine in 61 patients taking norepinephrine reuptake blockers (tricyclic antidepressants or serotonin-norepinephrine reuptake inhibitors) and 17 others taking selective serotonin reuptake inhibitors, all without pheochromocytoma/paraganglioma. We highlight a singular case with strongly elevated plasma normetanephrine and methoxytyramine concentrations associated with norepinephrine reuptake blockade. Data were compared to results from 252 and 1804 respective patients with and without tumors. Plasma normetanephrine was 40% higher (P < 0.0001) in patients on norepinephrine reuptake blockers and methoxytyramine was 127% higher (P = 0.0062) in patients taking tricyclic antidepressants compared to patients not taking uptake blockers and without tumors. The corresponding false-positive rates rose (P < 0.0001) from 4.8% to 23.0% for normetanephrine and from 0.9% to 28.6% for methoxytyramine. Selective serotonin reuptake inhibitors did not increase plasma concentrations of metabolites. In the highlighted case, plasma normetanephrine and methoxytyramine were elevated more than six times above upper reference limits. A pheochromocytoma/paraganglioma, however, was excluded by functional imaging. All biochemical test results normalized after discontinuation of norepinephrine reuptake blockers. These findings clarify that norepinephrine reuptake blockers usually result in mild elevations of normetanephrine and methoxytyramine that, nevertheless, significantly increase the number of false-positive results. There can, however, be exceptions where increases in normetanephrine and methoxytyramine reach pathological levels. Such exceptions may reflect failure of centrally mediated sympathoinhibition that normally occurs with the norepinephrine reuptake blockade.
    MeSH term(s) Humans ; Pheochromocytoma/drug therapy ; Pheochromocytoma/diagnosis ; Normetanephrine ; Antidepressive Agents, Tricyclic ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Metanephrine ; Paraganglioma/drug therapy ; Paraganglioma/diagnosis ; Norepinephrine ; Adrenal Gland Neoplasms/drug therapy ; Adrenal Gland Neoplasms/diagnosis
    Chemical Substances Normetanephrine (0J45DE6B88) ; 3-methoxytyramine (JCH2767EDP) ; Antidepressive Agents, Tricyclic ; Selective Serotonin Reuptake Inhibitors ; Metanephrine (5001-33-2) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-23-0063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4192: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Correction: Adrenal Crisis - Definition, Prevention and Treatment: Results from a Delphi Survey.

    Kienitz, Tina / Bechmann, Nicole / Deutschbein, Timo / Hahner, Stefanie / Honegger, Jürgen / Kroiss, Matthias / Quinkler, Marcus / Rayes, Nada / Reisch, Nicole / Willenberg, Holger Sven / Meyer, Gesine

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2023  

    Language English
    Publishing date 2023-08-25
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-2157-2308
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    Zs.A 681: Show issues Location:
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  6. Article: Spectral Similarity Measures for In Vivo Human Tissue Discrimination Based on Hyperspectral Imaging.

    Pathak, Priya / Chalopin, Claire / Zick, Laura / Köhler, Hannes / Pfahl, Annekatrin / Rayes, Nada / Gockel, Ines / Neumuth, Thomas / Melzer, Andreas / Jansen-Winkeln, Boris / Maktabi, Marianne

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Problem: Similarity measures are widely used as an approved method for spectral discrimination or identification with their applications in different areas of scientific research. Even though a range of works have been presented, only a few showed ... ...

    Abstract Problem: Similarity measures are widely used as an approved method for spectral discrimination or identification with their applications in different areas of scientific research. Even though a range of works have been presented, only a few showed slightly promising results for human tissue, and these were mostly focused on pathological and non-pathological tissue classification.
    Methods: In this work, several spectral similarity measures on hyperspectral (HS) images of in vivo human tissue were evaluated for tissue discrimination purposes. Moreover, we introduced two new hybrid spectral measures, called SID-JM-TAN(SAM) and SID-JM-TAN(SCA). We analyzed spectral signatures obtained from 13 different human tissue types and two different materials (gauze, instruments), collected from HS images of 100 patients during surgeries.
    Results: The quantitative results showed the reliable performance of the different similarity measures and the proposed hybrid measures for tissue discrimination purposes. The latter produced higher discrimination values, up to 6.7 times more than the classical spectral similarity measures. Moreover, an application of the similarity measures was presented to support the annotations of the HS images. We showed that the automatic checking of tissue-annotated thyroid and colon tissues was successful in 73% and 60% of the total spectra, respectively. The hybrid measures showed the highest performance. Furthermore, the automatic labeling of wrongly annotated tissues was similar for all measures, with an accuracy of up to 90%.
    Conclusion: In future work, the proposed spectral similarity measures will be integrated with tools to support physicians in annotations and tissue labeling of HS images.
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13020195
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  7. Article ; Online: Adrenal Crisis - Definition, Prevention and Treatment: Results from a Delphi Survey.

    Kienitz, Tina / Bechmann, Nicole / Deutschbein, Timo / Hahner, Stefanie / Honegger, Jürgen / Kroiss, Matthias / Quinkler, Marcus / Rayes, Nada / Reisch, Nicole / Willenberg, Holger Sven / Meyer, Gesine

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2023  Volume 56, Issue 1, Page(s) 10–15

    Abstract: Based on recent data, a total number of about 29 000 patients with adrenal insufficiency can be calculated for Germany, and about 1500 fatalities due to adrenal crises have to be expected within the next decade. Management of adrenal crises is still ... ...

    Abstract Based on recent data, a total number of about 29 000 patients with adrenal insufficiency can be calculated for Germany, and about 1500 fatalities due to adrenal crises have to be expected within the next decade. Management of adrenal crises is still unsatisfactory. The objectives of this study were to establish consensus for diagnostic criteria, prevention strategies, and treatment recommendations for adrenal crises. The study was conducted from January 2022 to April 2023, using Delphi technique. Four rounds of questionnaires were sent to 45 experts, selected by a coordinating group on behalf of the adrenal section of the German Society of Endocrinology. The survey was implemented online using the REDCap web application. Responses were captured anonymously. During the Delphi process the expert panel developed diagnostic criteria to identify patients likely to have an adrenal crisis. Education about adrenal insufficiency among patients as well as non-endocrine medical personnel were regarded as highly important. It was suggested that recommendations for the management of adrenal insufficiency have to be simplified and made widely available. This study provides pragmatic strategies to identify and treat patients prone to adrenal crisis, thereby highlighting the need for an improved management of patients with adrenal insufficiency.
    MeSH term(s) Humans ; Adrenal Insufficiency/diagnosis ; Adrenal Insufficiency/prevention & control ; Surveys and Questionnaires ; Endocrinology ; Germany/epidemiology
    Language English
    Publishing date 2023-08-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-2130-1938
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    Zs.A 681: Show issues Location:
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  8. Article: John M. Kinney International Award for Nutrition and Metabolism. Lactobacilli and fibers--a strong couple against bacterial infections in patients with major abdominal surgery.

    Rayes, Nada

    Nutrition (Burbank, Los Angeles County, Calif.)

    2004  Volume 20, Issue 6, Page(s) 579–580

    MeSH term(s) Abdomen/surgery ; Avena/physiology ; Awards and Prizes ; Bacterial Infections/prevention & control ; Dietary Fiber/therapeutic use ; Germany ; Humans ; Lactobacillus/physiology ; Nutritional Support/methods ; Postoperative Complications/prevention & control ; Randomized Controlled Trials as Topic/statistics & numerical data
    Language English
    Publishing date 2004-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2004.03.005
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    Zs.A 2290: Show issues Location:
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  9. Article ; Online: Adrenal Metastasis of Hepatocellular Carcinoma in Patients following Liver Resection or Liver Transplantation: Experience from a Tertiary Referral Center.

    Teegen, Eva M / Mogl, Martina T / Pratschke, Johann / Rayes, Nada

    International journal of surgical oncology

    2018  Volume 2018, Page(s) 4195076

    Abstract: Introduction: Adrenal metastasis of hepatocellular carcinoma (HCC) is a rare entity and can be treated by resection, local ablative therapy, or systemic therapy. Unfortunately, data about treatment outcome, especially in liver transplant recipients, are ...

    Abstract Introduction: Adrenal metastasis of hepatocellular carcinoma (HCC) is a rare entity and can be treated by resection, local ablative therapy, or systemic therapy. Unfortunately, data about treatment outcome, especially in liver transplant recipients, are rare.
    Patients and methods: From 2005 to 2015, 990 liver resections and 303 liver transplantations because of HCC were performed at our clinic. We retrospectively analyzed treatment outcome of the patients with metachronous adrenal metastasis of HCC, who received either resection, local ablation, or surveillance only.
    Results: 10 patients were identified (0.8%). 7 patients received liver transplantation for primary HCC therapy, 3 liver resection, and 1 a local ablative therapy. 8 patients underwent adrenalectomy (one via retroperitoneoscopy), one was treated with local ablation, and one had surveillance only. Seven out of eight patients had no surgical complications and one experienced a pancreatic fistula, treated conservatively. 37.5% of the resected patients had recurrence 1 year after adrenalectomy and 75% after 2 years. The mean survival time after primary diagnosis of HCC was 96.6±22.4 months. After adrenalectomy, the mean survival time was 112.4±25.2 months. The mean time until tumor recurrence was 13.2±3.8 in the total cohort and 15.8±3.8 months in patients after adrenalectomy. The estimated overall survival after adrenalectomy was 77.2±17.4 months.
    Conclusion: Metachronous adrenal metastasis occured in less than 1% of HCC patients. Adrenalectomy is a safe procedure and leads to acceptable survival rates even after liver transplantion. Therefore, it should be performed whenever the primary tumor is well controlled and the patient is in adequate physical condition.
    MeSH term(s) Adrenal Gland Neoplasms/etiology ; Adrenal Gland Neoplasms/secondary ; Adrenal Gland Neoplasms/surgery ; Adrenalectomy/methods ; Adult ; Aged ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/surgery ; Female ; Germany/epidemiology ; Hepatectomy/adverse effects ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Neoplasm Metastasis ; Retrospective Studies ; Survival Rate/trends ; Tertiary Care Centers ; Transplant Recipients ; Treatment Outcome
    Language English
    Publishing date 2018-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2584964-5
    ISSN 2090-1410 ; 2090-1410
    ISSN (online) 2090-1410
    ISSN 2090-1410
    DOI 10.1155/2018/4195076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: Experimentelle und klinische Untersuchung des Einflusses von Prä- und Probiotika auf bakterielle Translokation und postoperative Infektionen nach abdominalchirurgischen Eingriffen

    Rayes, Nada

    2004  

    Author's details von Nada Rayes
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Humboldt-Univ., Habil--Berlin, 2004
    Database Former special subject collection: coastal and deep sea fishing

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