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  1. Article ; Online: A Systematic Review of Imaging Studies in Olfactory Dysfunction Secondary to COVID-19.

    Keshavarz, Pedram / Haseli, Sara / Yazdanpanah, Fereshteh / Bagheri, Fateme / Raygani, Negar / Karimi-Galougahi, Mahboobeh

    Academic radiology

    2021  Volume 28, Issue 11, Page(s) 1530–1540

    Abstract: Rationale and objectives: Hyposmia/anosmia is common among patients with coronavirus disease-2019 (COVID-19). Various imaging modalities have been used to assess olfactory dysfunction in COVID-19. In this systematic review, we sought to categorize and ... ...

    Abstract Rationale and objectives: Hyposmia/anosmia is common among patients with coronavirus disease-2019 (COVID-19). Various imaging modalities have been used to assess olfactory dysfunction in COVID-19. In this systematic review, we sought to categorize and summarize the imaging data in COVID-19-induced anosmia.
    Material and methods: Eligible articles were included after a comprehensive review using online databases including Google scholar, Scopus, PubMed, Web of science and Elsevier. Duplicate results, conference abstracts, reviews, and studies in languages other than English were excluded.
    Results: In total, 305 patients undergoing MRI/functional MRI (177), CT of paranasal sinuses (129), and PET/CT or PET/MRI scans (14) were included. Out of a total of 218 findings reported on MRI, 80 were reported on early (≤ 1 month) and 85 on late (>1 month) imaging in relation to the onset of anosmia. Overall, OB morphology and T2-weighted or FLAIR signal intensity were normal in 68/218 (31.2%), while partial or complete opacification of OC was observed in 60/218 (27.5%). T2 hyperintensity in OB was detected in 11/80 (13.75%) and 18/85 (21.17%) on early and late imaging, respectively. Moreover, OB atrophy was reported in 1/80 (1.25%) on early and in 9/85 (10.58%) on late imaging. Last, among a total of 129 CT scans included, paranasal sinuses were evalualted in 88 (68.21%), which were reported as normal in most cases (77/88, [87.5%]).
    Conclusion: In this systematic review, normal morphology and T2/FLAIR signal intensity in OB and OC obstruction were the most common findings in COVID-19-induced anosmia, while paranasal sinuses were normal in most cases. OC obstruction is the likely mechanism for olfactory dysfunction in COVID-19. Abnormalities in OB signal intensity and OB atrophy suggest that central mechanisms may also play a role in late stage in COVID-19-induced anosmia.
    MeSH term(s) COVID-19 ; Humans ; Magnetic Resonance Imaging ; Olfaction Disorders/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2021.08.010
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    Zs.A 4594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: 18

    Karimi-Galougahi, Mahboobeh / Yousefi-Koma, Abbas / Raygani, Negar / Bakhshayeshkaram, Mehrdad / Haseli, Sara

    Academic radiology

    2020  Volume 28, Issue 1, Page(s) 144–145

    Keywords covid19
    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2020.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Emergence and Evolution of Olfactory and Gustatory Symptoms in Patients with COVID-19 in the Outpatient Setting.

    Karimi-Galougahi, Mahboobeh / Safavi Naini, Ali / Ghorbani, Jahangir / Raad, Nasim / Raygani, Negar

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2020  Volume 74, Issue Suppl 2, Page(s) 2743–2749

    Abstract: The present study aimed at evaluating the prevalence of general and sinonasal symptoms in patients with olfactory symptoms and mild coronavirus disease-2019 (COVID-19) and determining the patterns in emergence and resolution of olfactory/gustatory ... ...

    Abstract The present study aimed at evaluating the prevalence of general and sinonasal symptoms in patients with olfactory symptoms and mild coronavirus disease-2019 (COVID-19) and determining the patterns in emergence and resolution of olfactory/gustatory symptoms relative to general and sinonassal symptoms. This was a prospective cross-sectional study conducted at the outpatient otorhinolaryngology clinic at a COVID-19-designated referral Hospital. We included consecutive patients with new-onset olfactory dysfunction and positive polymerase chain reaction (PCR) assay of COVID-19. We asked the patients to fill in a questionnaire about general and sinonasal symptoms in association with anosmia, hyposmia or hypogeusia, and recorded the time course of the olfactory/gustatory symptoms during 2-weeks of follow-up. 76 patients with average age of 38.5 ± 10.6 years were included. Majority of participants (94.7%) had general or sinonasal symptom. There was anosmia in 60.5% and hyposmia in 39.5%, with sudden onset of olfactory symptoms reported in 63.2% of patients. During the follow-up, 30.3% of patients completely and 44.7% partially recovered from anosmia/hyposmia. Regardless of whether the general or olfactory symptoms appeared initially, the general symptoms resolved first while a degree of olfactory dysfunction persisted during the follow-up. Our study showed that hyposmia and anosmia in mild COVID-19 are frequently associated with general and sinonasal symptoms and tend to persist longer than the general and sinonasal symptoms during the course of the disease.
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-020-02166-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5300: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Emergence and Evolution of Olfactory and Gustatory Symptoms in Patients with COVID-19 in the Outpatient Setting

    Karimi-Galougahi, Mahboobeh / Safavi Naini, Ali / Ghorbani, Jahangir / Raad, Nasim / Raygani, Negar

    Indian Journal of Otolaryngology and Head & Neck Surgery ; ISSN 2231-3796 0973-7707

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s12070-020-02166-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: 18FDG-PET/CT Assessment of COVID-19-Induced Bell's Palsy

    Karimi-Galougahi, Mahboobeh / Yousefi-Koma, Abbas / Raygani, Negar / Bakhshayeshkaram, Mehrdad / Haseli, Sara

    Academic Radiology ; ISSN 1076-6332

    2020  

    Keywords Radiology Nuclear Medicine and imaging ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.acra.2020.11.001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: The Effect of Correlation of Laboratory-Developed Test and Initial Symptoms and False Negatives in RT-PCR Strategies for COVID-19 Patients with Beta Variants

    Ghasemi, Shohreh / Nadji, Seyed Alireza / Dashti, Mahmood / Karimi-Galougahi, Mahboobeh / Raygani, Negar / Nabi, Mahla / Mohammadi, Ghazal / Kandez, Niyoosha / Ebrahimi, Amirali / Askari, Elaheh

    European Dental Research and Biomaterials Journal

    2022  Volume 03, Issue 01/02, Page(s) 21–25

    Abstract: Objective: Reverse transcription-polymerase chain reaction (RT-PCR) assays detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The number of viruses in the sample varies between patients; it depends on sample location, nasal or throat, ... ...

    Abstract Objective: Reverse transcription-polymerase chain reaction (RT-PCR) assays detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The number of viruses in the sample varies between patients; it depends on sample location, nasal or throat, and with time infection spreads. Previous studies showed that the viral load of coronavirus disease 2019 (COVID-19) infection is the peak just before symptoms onset. Furthermore, positive and negative results depend on test site, sampling, and timing method; RT-PCR can be 1 to 30% false-negative result.
    Materials and Methods: Within this study, we took RT-PCR test from COVID-19 positive patients who already had the confirmation of the disease either by lung computed tomography (CT)-scan or the symptoms such as dyspnea. The study was explained to all the patients, and they confirmed to take the RT-PCR test. Negative samples from those patients were retested, and if the result came back negative, we included them as negative in the result.
    Result: A total number of 49 patients (25 females) and (24 males) with a mean age of 53.24 years (ranging from 32 to 77) were enrolled. About 32.3% of patients, despite having COVID-19 disease, had a negative RT-PCR test. There is a positive and significant relationship between weight ( r  = 0.253) and CT at the time of hospitalization of COVID-19 patients and a negative and significant relationship with O2 saturation without oxygen therapy ( r  =  − 0.296), the model can predict 67.7% of the disease due to the beta value, and the share of O2 saturation without oxygen therapy is more than weight.
    Conclusion: We show that a pragmatic model can be designed to predict which patients have a higher chance of getting false-negative result, and should be retested for COVID-19. Among the variables, weight had a negative and significant relationship, and O2 saturation without respiratory support had a negative and significant relationship with COVID-19 disease.
    Keywords SARS-Cov-2 ; COVID-19 ; saliva ; RT-PCR test ; laboratory-developed test
    Language English
    Publishing date 2022-01-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2791-7452
    ISSN (online) 2791-7452
    DOI 10.1055/s-0043-1768174
    Database Thieme publisher's database

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  8. Article: Reduction in SARS-CoV-2 Oral Viral Load with Prophylactic Mouth Rinse

    Ghasemi, Shohreh / Nadji, Seyed Alireza / Heidari, Ali / James, Jeffrey N. / Karimi-Galougahi, Mahboobeh / Raygani, Negar / Khazaei, Salman / Mehri, Freshteh / Poormohammadi, Ali / Bashirian, Saeid / Mehrpooya, Maryam / Miresmaeili, Amirfarhang / Jalilian, Farid Azizi / Shirahmadi, Samaneh / Keramat, Fariba / Soltanian, Alireza / Ansari, Nastaran / Zeynalzadeh, Farhad / Ebrahimi, Amirali /
    Dashti, Amirreza / Bloomquist, Ryan F. / Dashti, Mahmood

    European Journal of General Dentistry

    2022  Volume 11, Issue 02, Page(s) 94–101

    Abstract: Objectives: The medical and health facilities are at high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study tested the preprocedural prophylactic mouthwash rinses to reduce the oral viral load. The findings from ... ...

    Abstract Objectives: The medical and health facilities are at high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study tested the preprocedural prophylactic mouthwash rinses to reduce the oral viral load. The findings from this study will help the practitioners to select the best mouthwash for the patients to mitigate the risk of transmission during aerosolizing. This study aimed to evaluate the effectiveness of four commonly used types of mouthwash in reducing intraoral viral load among hospitalized coronavirus disease 2019 patients.
    Materials and Methods: This prospective cohort study was conducted with 116 patients referred to the Masih Daneshvari Hospital in Tehran, Hamadan University of Medical Sciences of Hamadan City, and Mashhad University of Medical Sciences. Patients were randomized into four groups with each group rinsed their mouth with 20 mL of 2% povidone-iodine, 1% hydrogen peroxide, normal saline as a control study group, or 0.12% chlorhexidine, respectively, for 20 seconds. The standard reverse transcription polymerase chain reaction method evaluated the virus load before and at 1 hour, 2 hours, and 4 hours after using the mentioned mouthwash.
    Results: Our results revealed that chlorhexidine and H 2 O 2 showed the highest efficiency in reducing SARS-Co-2 load in the oral cavity and nasopharyngeal region of patients; they increased the Ct values by 9 to 10 (before: 25.84 vs. after 32. 4, p  < 0.455) (17.333 vs. after 26.497, p <0.097).
    Conclusion: Our findings suggest that chlorhexidine and H 2 O 2 could be used in dental clinics to reduce the risk of transmitting the SARS-CoV-2 virus from infected individuals to dentists before dental procedures.
    Keywords mouthwashes ; viral load ; COVID-19 ; chlorhexidine ; povidone-iodine ; hydrogen peroxide
    Language English
    Publishing date 2022-05-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2716867-0
    ISSN 2320-4753 ; 2278-9626 ; 2320-4753
    ISSN (online) 2320-4753
    ISSN 2278-9626 ; 2320-4753
    DOI 10.1055/s-0042-1747958
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