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Article ; Online: Novel use of oral chloramphenicol for treatment-resistant

Goodfellow, Jonathan Joseph / Hughes, Stephen / Smith, Jo / Jones, Rachael / Moore, Luke S P / Rayment, Michael

2023 Volume 99, Issue 3, Page(s) 208–210

Abstract: We describe the novel use of oral chloramphenicol for treatment- ... ...

Abstract	We describe the novel use of oral chloramphenicol for treatment-resistant
MeSH term(s)	Humans ; Male ; Young Adult ; Adult ; Mycoplasma genitalium ; Urethritis/drug therapy ; Urethritis/microbiology ; Chloramphenicol/therapeutic use ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/microbiology ; Anti-Infective Agents/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial
Chemical Substances	Chloramphenicol (66974FR9Q1) ; Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1420303-0
ISSN	1472-3263 ; 1368-4973
ISSN (online)	1472-3263
ISSN	1368-4973
DOI	10.1136/sextrans-2022-055621
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Article: Nutcracker syndrome: A proposed ultrasound protocol.

Englund, Katherine M / Rayment, Michael

Australasian journal of ultrasound in medicine

2018 Volume 21, Issue 2, Page(s) 75–78

Abstract: Background: Nutcracker phenomenon (NCP) describes the compression of the left renal vein between the aorta and the superior mesenteric artery. Nutcracker Syndrome (NCS) refers to the clinical manifestations of NCP.: Aims: This paper aims to provide ... ...

Abstract	Background: Nutcracker phenomenon (NCP) describes the compression of the left renal vein between the aorta and the superior mesenteric artery. Nutcracker Syndrome (NCS) refers to the clinical manifestations of NCP. Aims: This paper aims to provide education and ultrasound protocol for Clinicians and Sonographers who encounter patients with the symptoms of NCS during their course of practice. Methods: The following report examines two case studies where a diagnosis of NCP was made from clinical history and ultrasound findings. Based on these case studies, we would like to propose an appropriate ultrasound scanning protocol for patients presenting with symptoms of gonadal vein incompetence. Results: The above case studies highlight the need for further assessment with ultrasound to help diagnose cases of NCP. Conclusion: The proposed ultrasound techniques are a valid protocol extension to the ultrasound examination to help diagnose NCP.
Language	English
Publishing date	2018-03-22
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2843953-3
ISSN	2205-0140 ; 1836-6864
ISSN (online)	2205-0140
ISSN	1836-6864
DOI	10.1002/ajum.12087
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Article ; Online: Acceptability of routine domestic abuse enquiry within sexual health services.

Platt, Elizabeth / Hepworth, Eleanor / Rayment, Michael / Melendez-Torres, G J / Duff, Fiona / Cohen, Charlotte

International journal of STD & AIDS

2022 Volume 33, Issue 6, Page(s) 608–612

Abstract: Background: Our sexual health services (SHS) introduced routine domestic abuse (DA) enquiry in April 2018 following targeted staff training. A survey was undertaken to ascertain attitudes towards the initiative.: Methods: Between October 2019 and ... ...

Abstract	Background: Our sexual health services (SHS) introduced routine domestic abuse (DA) enquiry in April 2018 following targeted staff training. A survey was undertaken to ascertain attitudes towards the initiative. Methods: Between October 2019 and March 2020, patients were invited to respond to an anonymous questionnaire by SMS. Clinical staff were emailed a separate survey. Results: The patient response rate was 40% (226/562): 72% (161/226) female, 80% (179/226) heterosexual, 19% (42) LGBT, 47% (106) aged 25-34 and 25% (57) aged 18-24. Almost all (97%, 220) recalled routine enquiry at their clinic appointment; 91% (206) felt comfortable when asked, and 95% (214) found this acceptable. Fifty-one staff responded (36% response rate), 67% (34) female, 55% (28) heterosexual, 35% (18) LGBT. 43% (22) were nurses, 31% (16) doctors, 12% (6) health advisers and 8% (4) healthcare assistants. The majority of staff 96% (49) were confident with conducting routine enquiry, 92% (47) agreed patients found it acceptable; 92% (47) felt routine enquiry was appropriate and 92% (47) had received targeted training. Conclusion: Respondents were overwhelmingly in favour of routine DA enquiry within SHS, and this initiative could be easily adapted in other specialties alongside staff training.
MeSH term(s)	Ambulatory Care Facilities ; Attitude of Health Personnel ; Domestic Violence ; Female ; Health Services ; Humans ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624221083183
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Article ; Online: Why sexual health clinics are important in the 2020s.

Medland, Nicholas A / Taylor, Ruth / Saunders, John / Rayment, Michael / Fox, Ashini / Sullivan, Ann

Sexual health

2022 Volume 19, Issue 4, Page(s) 329–335

Abstract: To make services more accessible, acceptable and affordable, sexual health service delivery models have embraced innovation, technology, outreach and decentralisation. In particular, some routine high-volume services, like asymptomatic testing for ... ...

Abstract	To make services more accessible, acceptable and affordable, sexual health service delivery models have embraced innovation, technology, outreach and decentralisation. In particular, some routine high-volume services, like asymptomatic testing for sexually transmitted infections (STIs), can be delivered in general practice, online or in non-clinical settings. On the surface, sexual health clinics, like hospitals or other primary care clinics, might appear to be operating on a model that has not changed significantly in recent times. However, globally sexual healthcare needs are rising both in volume and complexity, not all of which can be adequately met through decentralised care. Sexual health clinics themselves are the site of considerable innovation. The importance of sexual health clinics in the diagnosis and treatment of symptomatic STIs is likely to increase with the increasing burden of disease, the complexity of treatment guidelines and the emergence of new infections. Services essential to patient health such as immediate or complex clinical care, partner notification and safeguarding, and activities essential to the health system like research, training and supervision require expertise to be located where it can be accessed and maintained at reasonable cost. We do not know whether increasing some services outside existing models can safely compensate for reducing other services inside them.
MeSH term(s)	Ambulatory Care Facilities ; Contact Tracing ; Humans ; Sexual Behavior ; Sexual Health ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/therapy
Language	English
Publishing date	2022-07-31
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2256731-8
ISSN	1449-8987 ; 1448-5028
ISSN (online)	1449-8987
ISSN	1448-5028
DOI	10.1071/SH22078
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Zs.A 6421: Show issues

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Article ; Online: Investigating the cause of increased tetracycline-resistant Neisseria gonorrhoeae in England, 2016-20.

Pitt-Kendall, Rachel / Sun, Suzy / Hughes, Stephen / Merrick, Rachel / Donaldson, Hugo / Rayment, Michael / Ivanov, Zdravko / Day, Michaela / Bari, Aisha / Rebec, Monica / Callan, Emma / Mohammed, Hamish / Sinka, Katy / Cole, Michelle / Fifer, Helen

The Journal of antimicrobial chemotherapy

2024 Volume 79, Issue 5, Page(s) 1060–1068

Abstract: Background: Antimicrobial resistance in Neisseria gonorrhoeae is a global public health concern. Tetracycline resistance (TetR) increased from 39.4% to 75.2% between 2016 and 2021 in N. gonorrhoeae isolates collected through national surveillance in ... ...

Abstract	Background: Antimicrobial resistance in Neisseria gonorrhoeae is a global public health concern. Tetracycline resistance (TetR) increased from 39.4% to 75.2% between 2016 and 2021 in N. gonorrhoeae isolates collected through national surveillance in England, despite the absence of use of tetracyclines for the treatment of gonorrhoea. Objectives: We investigated whether there was correlation between bacterial sexually transmitted infection (STI) tests performed and treatment with antimicrobials, with increased TetR in N. gonorrhoeae. Methods: We examined correlations between bacterial STI tests, antimicrobial treatment and TetR in N. gonorrhoeae, using national surveillance data from three large sexual health services (SHS) in London during 2016-20. Doxycycline prescribing data and antibiograms of a non-STI pathogen from distinct patient groups (sexual health, obstetric and paediatric), at a large London hospital, were analysed to identify if doxycycline use in SHS was associated with resistance in a non-STI organism. Results: A substantial increase in TetR was observed, particularly in isolates from gay, bisexual and other MSM (GBMSM). Strong positive correlations were observed exclusively in GBMSM between N. gonorrhoeae TetR and both bacterial STI tests (r = 0.97, P = 0.01) and antimicrobial treatment (r = 0.87, P = 0.05). Doxycycline prescribing increased dramatically during the study period in SHS. Prevalence of TetR in Staphylococcus aureus was higher in isolates sourced from SHS attendees than those from other settings. Conclusions: Frequent screening of GBMSM at higher risk of STIs, such as those on pre-exposure prophylaxis (PrEP) leading to/and increased use of doxycycline for the treatment of diagnosed infections, may account for the increase in TetR in N. gonorrhoeae.
MeSH term(s)	Neisseria gonorrhoeae/drug effects ; Neisseria gonorrhoeae/isolation & purification ; Humans ; Gonorrhea/microbiology ; Gonorrhea/epidemiology ; Gonorrhea/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests ; England/epidemiology ; Male ; Female ; Doxycycline/therapeutic use ; Doxycycline/pharmacology ; Tetracycline Resistance ; Adult ; London/epidemiology ; Tetracycline/pharmacology ; Tetracycline/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Doxycycline (N12000U13O) ; Tetracycline (F8VB5M810T)
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkae073
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: HIV-indicator-condition-driven HIV testing: clinically effective but still rarely implemented.

Bull, Lauren / Rayment, Michael

Clinical medicine (London, England)

2016 Volume 16, Issue 2, Page(s) 175–179

Abstract: In the UK, outcomes for people living with HIV are excellent. However, a quarter of those living with HIV do not know their status, and almost half are diagnosed late. Strategies to broaden HIV testing are needed. HIV indicator conditions are those ... ...

Abstract	In the UK, outcomes for people living with HIV are excellent. However, a quarter of those living with HIV do not know their status, and almost half are diagnosed late. Strategies to broaden HIV testing are needed. HIV indicator conditions are those thought to be associated with HIV infection because they share risk factors (eg viral hepatitis) or because they arise as a result of early or late immunodeficiency (eg bacterial pneumonia, Kaposi's sarcoma). They comprise all AIDS-defining conditions, but also many non-AIDS-defining conditions spanning the spectrum of medicine. Patients presenting with indicator conditions should routinely be offered an HIV test. This approach is likely to be clinically effective, because knowledge of HIV status is essential in the management of many conditions. It is cost effective if the prevalence of HIV infection is greater than 0.1%. The strategy removes the need for risk assessment, and is acceptable to patients and healthcare practitioners. If broadly implemented, it is likely to be effective at a public health level, and will help to reduce both undiagnosed HIV and late diagnoses of HIV. Here we review the emerging evidence base that supports the value of routine HIV testing in indicator conditions.
MeSH term(s)	Delivery of Health Care ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/therapy ; Humans ; Risk Factors
Language	English
Publishing date	2016-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmedicine.16-2-175
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Article ; Online: Patients at a London integrated sexual health clinic are concerned at redirection of contraceptive prescriptions.

Bull, Lauren / Jones, Rachael / Rayment, Michael / Cohen, Charlotte

BMJ sexual & reproductive health

2018 Volume 44, Issue 2, Page(s) 146–147

Language	English
Publishing date	2018-04
Publishing country	England
Document type	Journal Article
ISSN	2515-2009
ISSN (online)	2515-2009
DOI	10.1136/bmjsrh-2018-200083
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Article ; Online: Non-invasive saliva specimens for the diagnosis of COVID-19: caution in mild outpatient cohorts with low prevalence.

Skolimowska, Keira / Rayment, Michael / Jones, Rachael / Madona, Pinglawathee / Moore, Luke S P / Randell, Paul

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2020 Volume 26, Issue 12, Page(s) 1711–1713

MeSH term(s)	Acute Disease ; Adult ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Oropharynx/virology ; Outpatients/statistics & numerical data ; Predictive Value of Tests ; Prevalence ; Prospective Studies ; SARS-CoV-2 ; Saliva/virology ; Sensitivity and Specificity ; United Kingdom ; Viral Load
Keywords	covid19
Language	English
Publishing date	2020-07-18
Publishing country	England
Document type	Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2020.07.015
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: "Sex without fear": exploring the psychosocial impact of oral HIV pre-exposure prophylaxis on gay men in England.

Hayes, Rosalie / Nutland, Will / Rayment, Michael / Wayal, Sonali / Apea, Vanesa / Clarke, Amanda / McOwan, Alan / Sullivan, Ann / Desai, Monica / Jajja, Andrew / Rice, Brian / Horne, Rob / McCormack, Sheena / Gafos, Mitzy

AIDS research and therapy

2023 Volume 20, Issue 1, Page(s) 81

Abstract: Gay, bisexual, and other men who have sex with men (GBMSM) experience a high prevalence of psychosocial health problems, such as harmful substance use and depression, as well as being disproportionately affected by HIV. HIV Pre-Exposure Prophylaxis (PrEP) ...

Abstract	Gay, bisexual, and other men who have sex with men (GBMSM) experience a high prevalence of psychosocial health problems, such as harmful substance use and depression, as well as being disproportionately affected by HIV. HIV Pre-Exposure Prophylaxis (PrEP) may provide psychosocial benefits beyond its intended purpose of reducing HIV infection. We explore the psychosocial impact of oral PrEP use on gay men in England using qualitative data from the PROUD study. From February 2014 to January 2016, semi-structured in-depth interviews were conducted with 40 gay men and one trans woman. Participants were purposively recruited based on trial arm allocation, adherence, and sexual risk behaviours. By removing HIV risk from sex, PrEP improves users' wellbeing by reducing HIV-related anxiety and internalised stigma and increasing HIV prevention self-efficacy, sexual pleasure, and intimacy. In turn, these psychological changes may influence behaviour in the form of greater sexual freedom, reduced harmful drug use, and more protective sexual health behaviours. However, PrEP may create internal conflict for some gay men, due to its disruption of social norms around condom use and its perceived influence on their sexual behaviour leading to reduced condom self-efficacy. These findings provide a baseline of PrEP's psychosocial impact amongst some of the first PrEP users in England and supports calls to consider the psychosocial impact of PrEP in prescribing guidelines.
MeSH term(s)	Female ; Humans ; Male ; England/epidemiology ; Fear ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Homosexuality, Male/psychology ; Pre-Exposure Prophylaxis ; Sexual and Gender Minorities ; Sexual Behavior/psychology ; Substance-Related Disorders ; Clinical Trials as Topic
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2173450-1
ISSN	1742-6405 ; 1742-6405
ISSN (online)	1742-6405
ISSN	1742-6405
DOI	10.1186/s12981-023-00568-2
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Article ; Online: United Kingdom British association for sexual health and HIV national guideline for the management of epididymo-orchitis, 2020.

Chirwa, Mimie / Davies, Olubanke / Castelino, Sheena / Mpenge, Mbiye / Nyatsanza, Farai / Sethi, Gulshan / Shabbir, Majid / Rayment, Michael

International journal of STD & AIDS

2021 Volume 32, Issue 10, Page(s) 884–895

Abstract: The British Association for Sexual Health and HIV (BASHH) UK guideline for the management of epididymo-orchitis has been updated in 2020. It offers advice on diagnostic tests, treatment and health promotion principles in the effective management of ... ...

Abstract	The British Association for Sexual Health and HIV (BASHH) UK guideline for the management of epididymo-orchitis has been updated in 2020. It offers advice on diagnostic tests, treatment and health promotion principles in the effective management of epididymo-orchitis. Empirical treatment should be started in patients with objective swelling and tenderness on testicular examination. First-line empirical treatment for sexually acquired epididymo-orchitis has changed to ceftriaxone 1g intramuscularly and doxycycline. Higher dose of ceftriaxone in line with the BASHH 2018 gonorrhoea guideline ensures effective treatment of strains with reduced susceptibility. Ofloxacin or doxycycline is recommended in patients with epididymo-orchitis probably due to non-gonococcal organisms (e.g. negative microscopy for gram-negative intracellular diplococci or no risk factors for gonorrhoea identified). Where
Language	English
Publishing date	2021-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624211003761
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