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  1. Article ; Online: Recordkeeping Error or Strategic Seasonal Substitution?: The Seasonality of Occupational Injuries in SOII and MarketScan.

    Raymond, Benjamin

    Journal of occupational and environmental medicine

    2021  Volume 64, Issue 3, Page(s) e94–e102

    Abstract: Objective: I compare the seasonal patterns observed in the Survey of Occupational Injuries and Illnesses (SOII) to claims data from the IBM® MarketScan® Research Databases.: Methods: I construct monthly injury rates and claims rates by supplementing ... ...

    Abstract Objective: I compare the seasonal patterns observed in the Survey of Occupational Injuries and Illnesses (SOII) to claims data from the IBM® MarketScan® Research Databases.
    Methods: I construct monthly injury rates and claims rates by supplementing occupational injuries and other claims data with hours data from the Current Population Survey and estimate seasonal effects using an Unobservable Components Model.
    Results: While workers' compensation data and the SOII display similar seasonal patterns, the year-end decline in the MarketScan data is 1/3 to 1/2 the magnitude observed in the SOII. Short-term disability and private health insurance claims display seasonal patterns inversely related to occupational injuries.
    Conclusions: Part of the year-end decline in occupational injuries observed in the SOII is likely due to recordkeeping error. There is also some evidence of strategic seasonal substitution between various health-compensation alternatives.
    MeSH term(s) Humans ; Occupational Diseases/epidemiology ; Occupational Injuries/epidemiology ; Seasons ; Surveys and Questionnaires ; Workers' Compensation
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002457
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  2. Article ; Online: Bacterial macromolecular machineries.

    Raymond, Benjamin B A

    Molecular microbiology

    2022  Volume 118, Issue 1-2, Page(s) 1–2

    MeSH term(s) Bacteria/genetics
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Editorial
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14957
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Pathogen evasion strategies.

    Raymond, Benjamin B A

    Cellular microbiology

    2020  Volume 23, Issue 5, Page(s) e13300

    MeSH term(s) Animals ; Bacteria/metabolism ; Bacteria/pathogenicity ; Bacterial Infections/microbiology ; Host-Pathogen Interactions ; Humans ; Immune Evasion ; Virulence
    Language English
    Publishing date 2020-12-27
    Publishing country England
    Document type Editorial
    ZDB-ID 1468320-9
    ISSN 1462-5822 ; 1462-5814
    ISSN (online) 1462-5822
    ISSN 1462-5814
    DOI 10.1111/cmi.13300
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  4. Article ; Online: Isolation of Polystyrene Bead-Induced Phagosomes for Western Blotting.

    Raymond, Benjamin B A / Inns, Joseph / Frey, Andrew M / Trost, Matthias

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2692, Page(s) 237–246

    Abstract: The engulfment of "self" and "non-self" particles by immune and non-immune cells is crucial for maintaining homeostasis and combatting infection. Engulfed particles are contained within vesicles termed phagosomes that undergo dynamic fusion and fission ... ...

    Abstract The engulfment of "self" and "non-self" particles by immune and non-immune cells is crucial for maintaining homeostasis and combatting infection. Engulfed particles are contained within vesicles termed phagosomes that undergo dynamic fusion and fission events, which ultimately results in the formation of phagolysosomes that degrade the internalized cargo. This process is highly conserved and plays an important role in maintaining homeostasis, and disruptions in this are implicated in numerous inflammatory disorders. Given its broad role in innate immunity, it is important to understand how different stimuli or changes within the cell can shape the phagosome architecture. In this chapter, we describe a robust protocol for the isolation of polystyrene bead-induced phagosomes using sucrose density gradient centrifugation. This process results in a highly pure sample that can be used in downstream applications, namely, Western blotting.
    MeSH term(s) Polystyrenes ; Phagosomes/metabolism ; Phagocytosis ; Blotting, Western ; Immunity, Innate
    Chemical Substances Polystyrenes
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3338-0_16
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  5. Article: Sixty-One-Year-Old Female With Metastatic Poorly Differentiated Carcinoma of the Appendix With Omental Metastasis.

    McNamara, David / Raymond, Benjamin

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8688

    Abstract: Neuroendocrine tumors (NETs) are rare tumors that are often asymptomatic and were once considered benign. A specific subtype that we will dive into in this article is appendiceal neuroendocrine tumors (ANETS). ANETs are the most common tumors located ... ...

    Abstract Neuroendocrine tumors (NETs) are rare tumors that are often asymptomatic and were once considered benign. A specific subtype that we will dive into in this article is appendiceal neuroendocrine tumors (ANETS). ANETs are the most common tumors located within the appendix. Most often, they present as acute appendicitis and are found incidentally on pathology reports status post appendectomy. The objective of this article is to show that even though most of the ANETs are benign and fully treated via surgery, ANETs still have the potential to become malignant and metastasize. Our patient fits the common features seen in ANETS. She is a middle-aged woman with vague abdominal pain and no clear diagnosis on gastrointestinal (GI) workup. Computed tomography (CT) confirmed appendicitis, and pathology reports status post-surgery confirmed stage IV, pT4, Nx, M1 - poorly differentiated neuroendocrine carcinoma of the appendix with omental metastases.
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8688
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  6. Article ; Online: Telemedicine among Adults Living in America during the COVID-19 Pandemic.

    Hung, Man / Ocampo, Monica / Raymond, Benjamin / Mohajeri, Amir / Lipsky, Martin S

    International journal of environmental research and public health

    2023  Volume 20, Issue 9

    Abstract: Background and Objectives Telemedicine can expand healthcare access to populations, but relying on technology risks a digital divide. Therefore, it is important to understand who utilizes telemedicine. This study explores telemedicine usage across socio- ... ...

    Abstract Background and Objectives Telemedicine can expand healthcare access to populations, but relying on technology risks a digital divide. Therefore, it is important to understand who utilizes telemedicine. This study explores telemedicine usage across socio-demographic groups in the United States during COVID-19. Methods Data came from the Household Pulse Survey (HPS) between 14 April 2021, to 11 April 2022. HPS is a rapid online response survey that assesses household experiences during COVID-19. We calculated descriptive statistics and used cross-correlation to test each pair of the time series curves. Results High school graduates used the least telemedicine (20.58%), while those with some college (23.29%) or college graduates (22.61%) had similar levels, and those with less than a high school education fluctuated over time. Black people had higher levels of use (26.31%) than Asians (22.01%). Individuals with disabilities (35.40%) used telemedicine more than individuals without disabilities (20.21%). Individuals 80 years or over (27.63%) used telemedicine more than individuals 18 to 29 years old (18.44%). Cross-correlations for the time series pairs across demographics revealed significant differences in telemedicine use for all demographic groups over time. Conclusions Overall, elderly, Black people, individuals with some college, and persons with disabilities report higher levels of telemedicine use. Telemedicine may improve healthcare access post-pandemic, but more research is needed to understand factors that drive differences among groups.
    MeSH term(s) Adolescent ; Adult ; Aged ; Humans ; Young Adult ; Asian ; COVID-19/epidemiology ; Digital Divide ; Pandemics ; Telemedicine ; Black or African American
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20095680
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  7. Article ; Online: Bi-functional particles for real-time phagosome acidification and proteolysis multiplex assay in macrophages.

    Méndez-Alejandre, Alba / Raymond, Benjamin Bernard Armando / Trost, Matthias / Marín-Rubio, José Luis

    Frontiers in immunology

    2023  Volume 14, Page(s) 1204223

    Abstract: Phagosome acidification and proteolysis are essential processes in the immune response to contain and eliminate pathogens. In recent years, there has been an increased desire for a rapid and accurate method of assessing these processes in real-time. Here, ...

    Abstract Phagosome acidification and proteolysis are essential processes in the immune response to contain and eliminate pathogens. In recent years, there has been an increased desire for a rapid and accurate method of assessing these processes in real-time. Here, we outline the development of a multiplexed assay that allows simultaneous monitoring of phagosome acidification and proteolysis in the same sample using silica beads conjugated to pHrodo and DQ BSA. We describe in detail how to prepare the bi-functional particles and show proof of concept using differentially activated macrophages. This multiplexed spectrophotometric assay allows rapid and accurate assessment of phagosome acidification and proteolysis in real-time and could provide valuable information for understanding the immune response to pathogen invasion.
    MeSH term(s) Proteolysis ; Macrophages ; Biological Assay ; Hydrogen-Ion Concentration ; Phagosomes
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1204223
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  8. Article: C-type Lectins in Immunity to Lung Pathogens.

    Raymond, Benjamin B A / Neyrolles, Olivier / Rombouts, Yoann

    Current topics in microbiology and immunology

    2020  Volume 429, Page(s) 19–62

    Abstract: The respiratory tract is tasked with responding to a constant and vast influx of foreign agents. It acts as an important first line of defense in the innate immune system and as such plays a crucial role in preventing the entry of invading pathogens. ... ...

    Abstract The respiratory tract is tasked with responding to a constant and vast influx of foreign agents. It acts as an important first line of defense in the innate immune system and as such plays a crucial role in preventing the entry of invading pathogens. While physical barriers like the mucociliary escalator exert their effects through the clearance of these pathogens, diverse and dynamic cellular mechanisms exist for the activation of the innate immune response through the recognition of pathogen-associated molecular patterns (PAMPs). These PAMPs are recognized by pattern recognition receptors (PRRs) that are expressed on a number of myeloid cells such as dendritic cells, macrophages, and neutrophils found in the respiratory tract. C-type lectin receptors (CLRs) are PRRs that play a pivotal role in the innate immune response and its regulation to a variety of respiratory pathogens such as viruses, bacteria, and fungi. This chapter will describe the function of both activating and inhibiting myeloid CLRs in the recognition of a number of important respiratory pathogens as well as the signaling events initiated by these receptors.
    MeSH term(s) Immunity, Innate ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; Pathogen-Associated Molecular Pattern Molecules ; Receptors, Pattern Recognition/genetics ; Signal Transduction
    Chemical Substances Lectins, C-Type ; Pathogen-Associated Molecular Pattern Molecules ; Receptors, Pattern Recognition
    Language English
    Publishing date 2020-04-20
    Publishing country Germany
    Document type Journal Article
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/82_2020_197
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  9. Article: Pneumoperitoneum Secondary to Spontaneously Perforated Pyometra.

    Raymond, Benjamin A / Esper, Christopher

    Case reports in obstetrics and gynecology

    2017  Volume 2017, Page(s) 5213123

    Abstract: Pyometra, by definition, is a collection of purulent fluid within the uterine cavity. Incidence has been estimated to range from 0.1% to 0.5%. Typically, this is linked to postmenopausal women; however, it has been linked to premenopausal women with ... ...

    Abstract Pyometra, by definition, is a collection of purulent fluid within the uterine cavity. Incidence has been estimated to range from 0.1% to 0.5%. Typically, this is linked to postmenopausal women; however, it has been linked to premenopausal women with concordant use of intrauterine devices. Based on our knowledge, there have been less than 50 recorded cases reported in the English literature regarding perforation of pyometra resulting in acute abdomen and fewer than 25 resulting in pneumoperitoneum. We report a patient who was evaluated for diffuse peritonitis caused by perforated pyometra who was successfully treated with surgical intervention.
    Language English
    Publishing date 2017-03-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627654-9
    ISSN 2090-6692 ; 2090-6684
    ISSN (online) 2090-6692
    ISSN 2090-6684
    DOI 10.1155/2017/5213123
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  10. Article ; Online: Exploitation of plasmin(ogen) by bacterial pathogens of veterinary significance.

    Raymond, Benjamin B A / Djordjevic, Steven

    Veterinary microbiology

    2015  Volume 178, Issue 1-2, Page(s) 1–13

    Abstract: The plasminogen (Plg) system plays an important homeostatic role in the degradation of fibrin clots, extracellular matrices and tissue barriers important for cellular migration, as well as the promotion of neurotransmitter release. Plg circulates in ... ...

    Abstract The plasminogen (Plg) system plays an important homeostatic role in the degradation of fibrin clots, extracellular matrices and tissue barriers important for cellular migration, as well as the promotion of neurotransmitter release. Plg circulates in plasma at physiologically high concentrations (150-200μg ml(-1)) as an inactive proenzyme. Proteins enriched in lysine and other positively charged residues (histidine and arginine) as well as glycosaminoglycans and gangliosides bind Plg. The binding interaction initiates a structural adjustment to the bound Plg that facilitates cleavage by proteases (plasminogen activators tPA and uPA) that activate Plg to the active serine protease plasmin. Both pathogenic and commensal bacteria capture Plg onto their cell surface and promote its conversion to plasmin. Many microbial Plg-binding proteins have been described underpinning the importance this process plays in how bacteria interact with their hosts. Bacteria exploit the proteolytic capabilities of plasmin by (i) targeting the mammalian fibrinolytic system and degrading fibrin clots, (ii) remodeling the extracellular matrix and generating bioactive cleavage fragments of the ECM that influence signaling pathways, (iii) activating matrix metalloproteinases that assist in the destruction of tissue barriers and promote microbial metastasis and (iv) destroying immune effector molecules. There has been little focus on the exploitation of the fibrinolytic system by veterinary pathogens. Here we describe several pathogens of veterinary significance that possess adhesins that bind plasmin(ogen) onto their cell surface and promote its activation to plasmin. Cumulative data suggests that these attributes provide pathogenic and commensal bacteria with a means to colonize and persist within the host environment.
    MeSH term(s) Adhesins, Bacterial/metabolism ; Animals ; Bacteria/metabolism ; Enzyme Precursors/metabolism ; Fibrinolysin/metabolism ; Fibrinolysis/physiology ; Plasminogen/metabolism
    Chemical Substances Adhesins, Bacterial ; Enzyme Precursors ; Plasminogen (9001-91-6) ; Fibrinolysin (EC 3.4.21.7)
    Language English
    Publishing date 2015-07-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2015.04.008
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