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  1. Book ; Online ; E-Book: Nolph and Gokal's textbook of peritoneal dialysis

    Khanna, Ramesh / Krediet, Raymond T.

    (Springer nature reference)

    2023  

    Title variant Textbook of peritoneal dialysis
    Author's details Ramesh Khanna, Raymond T. Krediet editors
    Series title Springer nature reference
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxii, 941 Seiten), Illustrationen, Diagramme
    Edition Fourth edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021871306
    ISBN 978-3-030-62087-5 ; 9783030620868 ; 3-030-62087-5 ; 3030620867
    DOI 10.1007/978-3-030-62087-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Hepatitis C Virus HIV co-infection

    Chung, Raymond T.

    (The journal of infectious diseases ; 207, Suppl. 1)

    2013  

    Title variant Hepatitis C Virus-HIV co-infection
    Author's details ed.: Raymond T. Chung
    Series title The journal of infectious diseases ; 207, Suppl. 1
    Collection
    Language English
    Size S44 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT017573253
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh II Zs 50 -207,Suppl.1- verfügbar in Königswinter Königswinter

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  3. Book: Lovell and Winter's pediatric orthopaedics / Volume 1 / editors Stuart L. Weinstein, MD, John M. (Jack) Flynn, MD, Haemish A. Crawford,FRACS

    Lovell, Wood W. / Winter, Robert B. / Crawford, Haemish A. / Morrissy, Raymond T. / Weinstein, Stuart L. / Flynn, John M.

    2021  

    Author's details ed. by Raymond T. Morrissy
    Collection Lovell and Winter's pediatric orthopaedics
    Language English
    Size xv, 884 Seiten, Seite I-1-I-41, Illustrationen
    Edition Eight edition
    Publishing country United States
    Document type Book
    Note Zugang zu Online-Ausgabe über Code
    HBZ-ID HT020485636
    ISBN 978-1-97510866-3 ; 1-97510866-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 902 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  4. Book: Lovell and Winter's pediatric orthopaedics / Volume 2 / editors Stuart L. Weinstein, MD, John M. (Jack) Flynn, MD, Haemish A. Crawford,FRACS

    Lovell, Wood W. / Winter, Robert B. / Crawford, Haemish A. / Morrissy, Raymond T. / Weinstein, Stuart L. / Flynn, John M.

    2021  

    Author's details ed. by Raymond T. Morrissy
    Collection Lovell and Winter's pediatric orthopaedics
    Language English
    Size xvi, Seite 885-1771, Seite I-1-I-41, Illustrationen
    Edition Eight edition
    Publishing country United States
    Document type Book
    HBZ-ID HT020485641
    ISBN 978-1-97510866-3 ; 1-97510866-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 903 available for loan (reading room) Lesesaal EG

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  5. Article: Corrigendum: Aging of the Peritoneal Dialysis Membrane.

    Krediet, Raymond T

    Frontiers in physiology

    2022  Volume 13, Page(s) 950933

    Abstract: This corrects the article DOI: 10.3389/fphys.2022.885802.]. ...

    Abstract [This corrects the article DOI: 10.3389/fphys.2022.885802.].
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.950933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Aging of the Peritoneal Dialysis Membrane.

    Krediet, Raymond T

    Frontiers in physiology

    2022  Volume 13, Page(s) 885802

    Abstract: Long-term peritoneal dialysis as currently performed, causes structural and functional alterations of the peritoneal dialysis membrane. This decay is brought about by the continuous exposure to commercially available glucose-based dialysis solutions. ... ...

    Abstract Long-term peritoneal dialysis as currently performed, causes structural and functional alterations of the peritoneal dialysis membrane. This decay is brought about by the continuous exposure to commercially available glucose-based dialysis solutions. This review summarizes our knowledge on the peritoneum in the initial phase of PD, during the first 2 years and the alterations in function and morphology in long-term PD patients. The pseudohypoxia hypothesis is discussed and how this glucose-induced condition can be used to explain all peritoneal alterations in long-term PD patients. Special attention is paid to the upregulation of hypoxia inducing factor-1 and the subsequent stimulation of the genes coding for glucose transporter-1 (GLUT-1) and the growth factors transforming growth factor-β (TGFβ), vascular endothelial growth factor (VEGF), plasminogen growth factor activator inhibitor-1 (PAI-1) and connective tissue growth factor (CTGF). It is argued that increased pseudohypoxia-induced expression of GLUT-1 in interstitial fibroblasts is the key factor in a vicious circle that augments ultrafiltration failure. The practical use of the protein transcripts of the upregulated growth factors in peritoneal dialysis effluent is considered. The available and developing options for prevention and treatment are examined. It is concluded that low glucose degradation products/neutral pH, bicarbonate buffered solutions with a combination of various osmotic agents all in low concentration, are currently the best achievable options, while other accompanying measures like the use of RAAS inhibitors and tamoxifen may be valuable. Emerging developments include the addition of alanyl glutamine to the dialysis solution and perhaps the use of nicotinamide mononucleotide, available as nutritional supplement.
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.885802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acquired Decline in Ultrafiltration in Peritoneal Dialysis: The Role of Glucose.

    Krediet, Raymond T

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 10, Page(s) 2408–2415

    Abstract: Ultrafiltration is essential in peritoneal dialysis (PD) for maintenance of euvolemia, making ultrafiltration insufficiency-preferably called ultrafiltration failure-an important complication. The mechanisms of ultrafiltration and ultrafiltration failure ...

    Abstract Ultrafiltration is essential in peritoneal dialysis (PD) for maintenance of euvolemia, making ultrafiltration insufficiency-preferably called ultrafiltration failure-an important complication. The mechanisms of ultrafiltration and ultrafiltration failure are more complex than generally assumed, especially after long-term treatment. Initially, ultrafiltration failure is mainly explained by a large number of perfused peritoneal microvessels, leading to a rapid decline of the crystalloid osmotic gradient, thereby decreasing aquaporin-mediated free water transport. The contribution of peritoneal interstitial tissue to ultrafiltration failure is limited during the first few years of PD, but becomes more important in long-term PD due to the development of interstitial fibrosis, which mainly consists of myofibroblasts. A dual hypothesis has been developed to explain why the continuous exposure of peritoneal tissues to the extremely high dialysate glucose concentrations causes progressive ultrafiltration decline. First, glucose absorption causes an increase of the intracellular NADH/NAD
    MeSH term(s) Biological Transport ; Cell Hypoxia/physiology ; Dialysis Solutions/adverse effects ; Dialysis Solutions/chemistry ; Fibrosis ; Glucose/adverse effects ; Glucose/analysis ; Glucose/metabolism ; Glucose Transporter Type 1/metabolism ; Hemodiafiltration ; Humans ; Myofibroblasts/metabolism ; Osmotic Pressure ; Peritoneal Dialysis ; Peritoneum/metabolism ; Peritoneum/pathology
    Chemical Substances Dialysis Solutions ; Glucose Transporter Type 1 ; SLC2A1 protein, human ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021010080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Systematic review: efficacy of therapies for cholestatic pruritus.

    Ebhohon, Ebehiwele / Chung, Raymond T

    Therapeutic advances in gastroenterology

    2023  Volume 16, Page(s) 17562848231172829

    Abstract: Background: Pruritus is a symptom of several cholestatic liver diseases (CLDs) that can impair health-related quality of life (HRQoL). Despite evidence-based guideline therapy, managing cholestatic pruritus (CP) remains challenging, thus making the need ...

    Abstract Background: Pruritus is a symptom of several cholestatic liver diseases (CLDs) that can impair health-related quality of life (HRQoL). Despite evidence-based guideline therapy, managing cholestatic pruritus (CP) remains challenging, thus making the need for newer, more effective therapeutic agents more evident.
    Objective: Our study evaluated the efficacy of existing CP therapies.
    Design: Systematic review.
    Data sources: From inception until March 2023, we conducted a comprehensive search of MEDLINE, Cochrane, EMBASE, Scopus, ClinicalTrial.gov, and other sources, including pharmaceutical webpages and conference proceedings published in English that reported on CP interventions.
    Methods: Two reviewers independently conducted screening and full-text review of articles with extraction conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The methodological quality of studies included in our qualitative synthesis was assessed by using the Cochrane ROBINS-I and ROBINS-II tools for interventional studies and the National Heart, Lung, and Blood Institute Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. The primary outcome assessed in our systematic review was the severity of CP after therapy.
    Results: Of 3293 screened articles, 92 studies were eligible for inclusion in the qualitative synthesis. Some patients' HRQoL improved with evidence-based standard therapy. Others, particularly those with severe and refractory CP, often required conversion to or addition of experimental noninvasive (e.g., ondansetron) or extracorporeal liver support to alleviate CP. In addition, studies investigating a newer class drug, the ileal bile acid transporter inhibitor (IBATi), demonstrate its effectiveness in reducing serum bile acid and alleviating CP with sustained improvement noted in patients with the inherited childhood cholestatic disorders - progressive familial intrahepatic cholestasis and Alagille syndrome.
    Conclusion: Our findings consolidate data on the efficacy of guideline-based approaches and newer therapies for CP. While the initial findings are promising, additional clinical trials will be needed to determine the full extent of IBATi's efficacy and potential use in treating other common CLDs. These results provide a foundation for future research and highlight the need for continued investigation into the management and treatment of CLDs.
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848231172829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Unmet Needs in the Post-Direct-Acting Antiviral Era: Hepatocarcinogenesis After Hepatitis C Virus Eradication.

    Przybyszewski, Eric M / Chung, Raymond T

    The Journal of infectious diseases

    2023  Volume 228, Issue Suppl 3, Page(s) S226–S231

    Abstract: Infection with chronic hepatitis C virus (HCV) is an important risk factor for hepatocellular carcinoma (HCC). Direct-acting antiviral therapy has transformed care for patients with HCV and reduces the risk of HCC. Despite HCV cure, a residual HCC risk ... ...

    Abstract Infection with chronic hepatitis C virus (HCV) is an important risk factor for hepatocellular carcinoma (HCC). Direct-acting antiviral therapy has transformed care for patients with HCV and reduces the risk of HCC. Despite HCV cure, a residual HCC risk remains in patients with advanced fibrosis and cirrhosis, with multiple mechanisms underlying subsequent hepatocarcinogenesis. Transcriptomic and proteomic signatures demonstrate the capacity for HCC risk stratification, and chemoprevention strategies are emerging. For now, pending more precise stratification, HCC surveillance of patients with cured HCV and advanced fibrosis or cirrhosis should continue.
    MeSH term(s) Humans ; Hepacivirus/genetics ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/prevention & control ; Proteomics ; Liver Neoplasms/epidemiology ; Liver Neoplasms/etiology ; Liver Neoplasms/prevention & control ; Hepatitis C ; Liver Cirrhosis ; Carcinogenesis
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  10. Article ; Online: Glucose-induced pseudohypoxia and advanced glycosylation end products explain peritoneal damage in long-term peritoneal dialysis.

    Krediet, Raymond T / Parikova, Alena

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2023  Volume 44, Issue 1, Page(s) 6–15

    Abstract: Long-term peritoneal dialysis is associated with the development of peritoneal membrane alterations, both in morphology and function. Impaired ultrafiltration (UF) is the most important functional change, and peritoneal fibrosis is the major ... ...

    Abstract Long-term peritoneal dialysis is associated with the development of peritoneal membrane alterations, both in morphology and function. Impaired ultrafiltration (UF) is the most important functional change, and peritoneal fibrosis is the major morphological alteration. Both are caused by the continuous exposure to dialysis solutions that are different from plasma water with regard to the buffer substance and the extremely high-glucose concentrations. Glucose has been incriminated as the major cause of long-term peritoneal membrane changes, but the precise mechanism has not been identified. We argue that glucose causes the membrane alterations by peritoneal pseudohypoxia and by the formation of advanced glycosylation end products (AGEs). After a summary of UF kinetics including the role of glucose transporters (GLUT), and a discussion on morphologic alterations, relationships between function and morphology and a survey of the pathogenesis of UF failure (UFF), it will be argued that impaired UF is partly caused by a reduction in small pore fluid transport as a consequence of AGE-related vasculopathy and - more importantly - in diminished free water transport due to pseudohypoxia, caused by increased peritoneal cellular expression of GLUT-1. The metabolism of intracellular glucose will be reviewed. This occurs in the glycolysis and in the polyol/sorbitol pathway, the latter is activated in case of a large supply. In both pathways the ratio between the reduced and oxidised form of nicotinamide dinucleotide (NADH/NAD
    MeSH term(s) Humans ; Peritoneal Dialysis/adverse effects ; Glucose/adverse effects ; Glucose/metabolism ; Glycosylation ; Peritoneum/metabolism ; Dialysis Solutions/adverse effects ; Dialysis Solutions/metabolism ; Water/metabolism ; Ultrafiltration
    Chemical Substances Glucose (IY9XDZ35W2) ; Dialysis Solutions ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608231196033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1936: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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