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  1. Article: Left Bundle Branch Pacing: A Perfect Compromise?

    Raymond-Paquin, Alexandre / Padala, Santosh K / Ellenbogen, Kenneth A

    Arrhythmia & electrophysiology review

    2022  Volume 10, Issue 4, Page(s) 241–243

    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2813970-7
    ISSN 2050-3377 ; 2050-3369
    ISSN (online) 2050-3377
    ISSN 2050-3369
    DOI 10.15420/aer.2021.60
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  2. Article ; Online: Multifaceted Left Bundle Branch Block: What Are the Mechanisms?

    Raymond-Paquin, Alexandre / Ellenbogen, Kenneth A / Padala, Santosh K

    JACC. Case reports

    2022  Volume 4, Issue 5, Page(s) 306–309

    Abstract: Understanding different mechanisms of aberrant conduction is critical to better evaluate the need for cardiac pacing. Aberrant conduction is caused by 4 distinct electrophysiologic mechanisms: phase 3 block, acceleration-dependent block, phase 4 block, ... ...

    Abstract Understanding different mechanisms of aberrant conduction is critical to better evaluate the need for cardiac pacing. Aberrant conduction is caused by 4 distinct electrophysiologic mechanisms: phase 3 block, acceleration-dependent block, phase 4 block, and concealed transseptal conduction. This case offers a unique opportunity to review all aberrant conduction mechanisms in the same patient. (
    Language English
    Publishing date 2022-03-02
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.01.010
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  3. Article: High-resolution mapping and successful ablation of Purkinje ectopy-triggered ventricular fibrillation storm.

    Raymond-Paquin, Alexandre / Lovejoy, Scott / Ellenbogen, Kenneth A / Padala, Santosh K

    HeartRhythm case reports

    2021  Volume 8, Issue 3, Page(s) 217–221

    Language English
    Publishing date 2021-12-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2021.12.015
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  4. Article ; Online: Atypical atrial flutter catheter ablation in the era of high-density mapping.

    Raymond-Paquin, Alexandre / Pillai, Ajay / Myadam, Rahul / Mankad, Pranav / Lovejoy, Scott / Koneru, Jayanthi N / Ellenbogen, Kenneth A

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2023  Volume 66, Issue 8, Page(s) 1807–1815

    Abstract: Background: Mapping and ablating atypical atrial flutters (AAFLs) have evolved greatly with advances in high-density 3D mapping systems over the last years.: Methods: The objectives are to evaluate the feasibility of AAFL catheter ablation based on ... ...

    Abstract Background: Mapping and ablating atypical atrial flutters (AAFLs) have evolved greatly with advances in high-density 3D mapping systems over the last years.
    Methods: The objectives are to evaluate the feasibility of AAFL catheter ablation based on high-density mapping and minimizing entrainment and to better characterize AAFL circuits. Consecutive patients who underwent AAFL ablation using the EnSite Precision™ system and HD Grid™ mapping catheter (Abbott, Chicago, IL) between 06/2018 and 1/2022 were included. Mitral isthmus-dependent and roof-dependent AAFLs were classified as conventional circuits. All other AAFL circuits were classified as non-conventional circuits and were defined based on the location of the critical isthmus.
    Results: Sixty-two patients underwent AAFL ablation (mean age 68±11 years). A total of 95 AAFLs were mapped and 92 (97%) were successfully ablated. Fifty-three (85%) patients had a previous AF/AFL ablation. Forty-four (46%) AAFL circuits were classified as conventional and 51 (54%) as non-conventional. Conventional AAFL circuits had longer critical isthmuses (19.0±9.0 vs 10.8±6.3mm, p<0.001), a lower prevalence of slow conduction at the critical isthmus (59% vs 86%, p=0.005), and a longer radiofrequency time to AAFL termination (117±119 vs 51±66 s, p=0.002). Entrainment was attempted in 19 (20%) flutters and its use declined significantly over the study period. Procedural success rates remained high whether entrainment was used or not. Freedom of any atrial tachycardia was 65% over a follow-up of 13.8±9.0 months.
    Conclusions: AAFL catheter ablation can be achieved with high procedural success rate using a contemporary strategy based on high-density mapping alone. Non-conventional circuits are frequent and present unique electrophysiological characteristics.
    Language English
    Publishing date 2023-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-023-01475-2
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  5. Article: Catheter ablation: an ongoing revolution.

    Raymond-Paquin, Alexandre / Andrade, Jason / Macle, Laurent

    Journal of thoracic disease

    2019  Volume 11, Issue Suppl 3, Page(s) S212–S215

    Language English
    Publishing date 2019-04-09
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.02.20
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  6. Article ; Online: The Prognostic Value of Intraventricular Conduction Disturbances: A Matter of Time?

    Marquis-Gravel, Guillaume / Raymond-Paquin, Alexandre / McIntyre, William F

    The Canadian journal of cardiology

    2020  Volume 36, Issue 8, Page(s) 1196–1198

    MeSH term(s) Bundle-Branch Block ; Cardiac Conduction System Disease ; Coronary Angiography ; Humans ; Prognosis
    Language English
    Publishing date 2020-01-24
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2020.01.014
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  7. Article ; Online: Mechanisms and Clinical Significance of Arrhythmia-Induced Cardiomyopathy.

    Raymond-Paquin, Alexandre / Nattel, Stanley / Wakili, Reza / Tadros, Rafik

    The Canadian journal of cardiology

    2018  Volume 34, Issue 11, Page(s) 1449–1460

    Abstract: Arrhythmia-induced cardiomyopathy (AIC) is characterized by left ventricular systolic dysfunction for which the primary cause is arrhythmia. The hallmark of AIC is its reversibility once the arrhythmia is properly controlled. Any tachyarrhythmia can ... ...

    Abstract Arrhythmia-induced cardiomyopathy (AIC) is characterized by left ventricular systolic dysfunction for which the primary cause is arrhythmia. The hallmark of AIC is its reversibility once the arrhythmia is properly controlled. Any tachyarrhythmia can potentially cause AIC (often called "tachycardiomyopathy"), with atrial fibrillation (AF) being by far the most common in clinical practice. The pathophysiological mechanisms underlying AIC need further clarification, but the available evidence, principally from animal models, implicates metabolic dysfunction due to increased oxygen requirements, neurohormonal adaptive mechanisms, and cellular Ca
    MeSH term(s) Animals ; Anti-Arrhythmia Agents/therapeutic use ; Asymptomatic Diseases ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy ; Calcium/metabolism ; Cardiomyopathies/physiopathology ; Cardiomyopathies/therapy ; Catheter Ablation ; Comorbidity ; Death, Sudden, Cardiac/prevention & control ; Electric Countershock ; Genetic Predisposition to Disease ; Heart Diseases/physiopathology ; Humans ; Myocytes, Cardiac/metabolism ; Stroke Volume/physiology ; Time-to-Treatment ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling/physiology
    Chemical Substances Anti-Arrhythmia Agents ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-08-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2018.07.475
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  8. Article ; Online: Left bundle branch area pacing in patients with atrioventricular conduction disease: A prospective multicenter study.

    Raymond-Paquin, Alexandre / Verma, Atul / Kolominsky, Jeffrey / Sanchez-Somonte, Paula / Gul, Enes Elvin / Pillai, Ajay / Kron, Jordana / Shepard, Richard / Kalahasty, Gautham / Tsang, Bernice / Khaykin, Yaariv / Pantano, Alfredo / Koneru, Jayanthi N / Ellenbogen, Kenneth A

    Heart rhythm

    2022  Volume 19, Issue 9, Page(s) 1484–1490

    Abstract: Background: The reported success rate of His-bundle pacing (HBP) in patients with infranodal atrioventricular (AV) conduction disease is only 52%-76%. The success rate of left bundle branch area pacing (LBBAP) in this cohort is not well studied.: ... ...

    Abstract Background: The reported success rate of His-bundle pacing (HBP) in patients with infranodal atrioventricular (AV) conduction disease is only 52%-76%. The success rate of left bundle branch area pacing (LBBAP) in this cohort is not well studied.
    Objective: The purpose of this study was to evaluate the feasibility, safety, and electrophysiological characteristics of LBBAP in patients with AV conduction disease.
    Methods: Patients with AV conduction disease referred for pacemaker implantation at 2 centers between February 2019 and June 2021 were considered for LBBAP. Baseline demographic characteristics, procedural success rates, electrophysiological parameters, and complications were assessed.
    Results: LBBAP was successful in 340 of 364 patients (93%). Mean age was 72 ± 13 years, and mean follow-up was 331 ± 244 days. Pacing indications were Mobitz I in 27 patients (7%), Mobitz II or 2:1 AV block or high-grade AV block in 94 patients (26%), complete heart block in 199 patients (55%), and sick sinus syndrome with isolated bundle branch block in 44 patients (12%). Left bundle branch block and right bundle branch block were present in 57 patients (16%) and 140 patients (38%), respectively. Procedural success rates did not differ between indications (92.6%, 93.6%, 92.9%, and 95%, respectively) or between patients with narrow (<120 ms) vs wide QRS (≥120 ms). Mean LBBAP threshold was 0.77 ± 0.34 V at 0.4 ms at implant and remained stable during follow-up. There were 4 (1.2%) acute LBBAP lead dislodgments.
    Conclusion: LBBAP is safe and feasible with high success rates for patients with AV conduction disease. In contrast to HBP, LBBAP success rates remain high over the entire spectrum of AV conduction disease, and lead parameters remain stable during follow-up.
    MeSH term(s) Aged ; Aged, 80 and over ; Atrioventricular Block/therapy ; Bundle of His ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/therapy ; Cardiac Pacing, Artificial ; Electrocardiography ; Humans ; Middle Aged ; Prospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2022.04.033
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  9. Article ; Online: Incidence of premature battery depletion in subcutaneous cardioverter-defibrillator patients: insights from a multicenter registry.

    Lüker, Jakob / Strik, Marc / Andrade, Jason G / Raymond-Paquin, Alexandre / Elrefai, Mohamed Hassan / Roberts, Paul R / Pérez, Óscar Cano / Kron, Jordana / Koneru, Jayanthi / Franqui-Rivera, Hilton / Sultan, Arian / Ernst, Angela / Schmitt, Jörn / Pott, Alexander / Veltmann, Christian / Srinivasan, Neil T / Collinson, Jason / van Stipdonk, Antonius M W / Linz, Dominik /
    Fluschnik, Nina / Tönnis, Tobias / Haeberlin, Andreas / Ploux, Sylvain / Steven, Daniel

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2023  

    Abstract: Background: The subcutaneous ICD established its role in the prevention of sudden cardiac death in recent years. The occurrence of premature battery depletion in a large subset of potentially affected devices has been a cause of concern. The incidence ... ...

    Abstract Background: The subcutaneous ICD established its role in the prevention of sudden cardiac death in recent years. The occurrence of premature battery depletion in a large subset of potentially affected devices has been a cause of concern. The incidence of premature battery depletion has not been studied systematically beyond manufacturer-reported data.
    Methods: Retrospective data and the most recent follow-up data on S-ICD devices from fourteen centers in Europe, the US, and Canada was studied. The incidence of generator removal or failure was reported to investigate the incidence of premature S-ICD battery depletion, defined as battery failure within 60 months or less.
    Results: Data from 1054 devices was analyzed. Premature battery depletion occurred in 3.5% of potentially affected devices over an observation period of 49 months.
    Conclusions: The incidence of premature battery depletion of S-ICD potentially affected by a battery advisory was around 3.5% after 4 years in this study. Premature depletion occurred exclusively in devices under advisory. This is in line with the most recently published reports from the manufacturer.
    Trial registration: ClinicalTrials.gov Identifier: NCT04767516 .
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-023-01468-1
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  10. Article ; Online: Rationale and Design of the Randomized Bayesian Multicenter COME-TAVI Trial in Patients With a New Onset Left Bundle Branch Block.

    Rivard, Lena / Nault, Isabelle / Krahn, Andrew D / Daneault, Benoit / Roux, Jean-Francois / Natarajan, Madhu / Healey, Jeffrey S / Quadros, Kenneth / Sandhu, Roopinder K / Kouz, Remi / Greiss, Isabelle / Leong-Sit, Peter / Gourraud, Jean Baptiste / Ben Ali, Walid / Asgar, Anita / Aguilar, Martin / Bonan, Raoul / Cadrin-Tourigny, Julia / Cartier, Raymond /
    Dorval, Jean-Francois / Dubuc, Marc / Dürrleman, Nicolas / Dyrda, Katia / Guerra, Peter / Ibrahim, Marina / Ibrahim, Reda / Macle, Laurent / Mondesert, Blandine / Moss, Emmanuel / Raymond-Paquin, Alexandre / Roy, Denis / Tadros, Rafik / Thibault, Bernard / Talajic, Mario / Nozza, Anna / Guertin, Marie-Claude / Khairy, Paul

    CJC open

    2023  Volume 5, Issue 8, Page(s) 611–618

    Abstract: Patients with new-onset left bundle branch block (LBBB) after transcatheter aortic valve implantation (TAVI) are at risk of developing delayed high-degree atrioventricular block. Management of new-onset LBBB post-TAVI remains controversial. In ... ...

    Abstract Patients with new-onset left bundle branch block (LBBB) after transcatheter aortic valve implantation (TAVI) are at risk of developing delayed high-degree atrioventricular block. Management of new-onset LBBB post-TAVI remains controversial. In the
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2023.05.009
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