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  1. AU="Rayya, W."
  2. AU="Bleher, Jana"
  3. AU="Fong, Fuk-Kei"
  4. AU="Bouvier, Nicolas"
  5. AU="Mims, Catherine"
  6. AU="Abbasi, Ardeshir"
  7. AU="Gailey, Samantha" AU="Gailey, Samantha"
  8. AU="Yano, Shuya"
  9. AU="Balaur, Eugeniu"
  10. AU="Ağaçfidan, Ali"
  11. AU="Perkins, James A."
  12. AU="Arkoun, Brahim"

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  1. Artikel: Selektive Indikation zur neoadjuvanten Radiochemotherapie beim Rektumkarzinom. Selective indication for neoadjuvant chemoradiation therapy for rectal cancer

    Lauscher, J. C. / Rayya, W. / Kreis, M. E. / Schineis, C.

    Chirurgische Praxis

    2020  Band 87, Heft 3, Seite(n) 406

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 500633-8
    ISSN 0009-4846
    Datenquelle Current Contents Medizin

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    Verfügbar in ZB MED Köln/Königswinter

    Uk I Zs.210: Hefte anzeigen Standort:
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  2. Artikel ; Online: The Immune Checkpoint Landscape in Tumor Cells of Pancreatic Ductal Adenocarcinoma.

    Loch, Florian N / Kamphues, Carsten / Beyer, Katharina / Schineis, Christian / Rayya, Wael / Lauscher, Johannes C / Horst, David / Dragomir, Mihnea P / Schallenberg, Simon

    International journal of molecular sciences

    2023  Band 24, Heft 3

    Abstract: Immune checkpoint therapy (ICT) has shown promising potential in the treatment of multiple solid tumors. However, the role of ICT in pancreatic ductal adenocarcinoma (PDAC) remains limited. Patterns of immune checkpoints (ICs) in PDAC represent the basis ...

    Abstract Immune checkpoint therapy (ICT) has shown promising potential in the treatment of multiple solid tumors. However, the role of ICT in pancreatic ductal adenocarcinoma (PDAC) remains limited. Patterns of immune checkpoints (ICs) in PDAC represent the basis for establishing a potent ICT. The aim of this study is to create a profile of IC expression and its prognostic relevance in cancer cells of PDAC. Therefore, tumor cells from peripheral and central tissue microarray (TMA) spots from histologically confirmed PDAC of 68 patients after tumor resection were investigated in terms of expressions of TIM3, IDO, B7H4, LAG3, VISTA, and PD-L1 using immunohistochemistry. The presence of the respective ICs was compared to overall survival (OS). The presence of VISTA and PD-L1 significantly correlates with shorter OS (median OS: 22 months vs. 7 months and 22 months vs. 11 months, respectively,
    Mesh-Begriff(e) Humans ; B7-H1 Antigen/metabolism ; Hepatitis A Virus Cellular Receptor 2 ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/pathology ; Biomarkers, Tumor/metabolism ; Pancreatic Neoplasms
    Chemische Substanzen B7-H1 Antigen ; Hepatitis A Virus Cellular Receptor 2 ; Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2023-01-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032160
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Stepwise Analysis of Resection Margin Impact on Survival and Distant Metastasis in Pancreatic Head Ductal Adenocarcinoma.

    Loch, Florian N / Kamphues, Carsten / Rieger, Freschta / Beyer, Katharina / Rayya, Wael / Schineis, Christian / Klauschen, Frederick / Horst, David / Schallenberg, Simon / Dragomir, Mihnea P

    International journal of surgical pathology

    2024  , Seite(n) 10668969241229342

    Abstract: The prognostic role of tumor cells in pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head with direct microscopic infiltration (DMI) or in close proximity (≤1 mm) to the resection margin (RM) remains unclear. This single-center, retrospective ... ...

    Abstract The prognostic role of tumor cells in pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head with direct microscopic infiltration (DMI) or in close proximity (≤1 mm) to the resection margin (RM) remains unclear. This single-center, retrospective study included specimens from 75 patients who underwent oncological resection of pancreatic head PDAC between February 2013 and July 2020. Two pathologists independently re-measured the distance between tumors and the multiple RMs. The impact of RM involvement for DMI, tumor cells within ≤1 mm, in general, and for individual RMs on overall survival (OS) and development of distant pulmonary (PM) and hepatic (HM) metastasis was analyzed. DMI of RMs was significantly associated with a shorter OS (median 5 vs 19 months,
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969241229342
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4500: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Artikel ; Online: Diagnostic performance of Node Reporting and Data System (Node-RADS) for regional lymph node staging of gastric cancer by CT.

    Loch, Florian N / Beyer, Katharina / Kreis, Martin E / Kamphues, Carsten / Rayya, Wael / Schineis, Christian / Jahn, Janosch / Tronser, Moritz / Elsholtz, Fabian H J / Hamm, Bernd / Reiter, Rolf

    European radiology

    2023  

    Abstract: Objectives: Diagnostic performance of imaging for regional lymph node assessment in gastric cancer is still limited, and there is a lack of consensus on radiological evaluation. At the same time, there is an increasing demand for structured reporting ... ...

    Abstract Objectives: Diagnostic performance of imaging for regional lymph node assessment in gastric cancer is still limited, and there is a lack of consensus on radiological evaluation. At the same time, there is an increasing demand for structured reporting using Reporting and Data Systems (RADS) to standardize oncological imaging. We aimed at investigating the diagnostic performance of Node-RADS compared to the use of various individual criteria for assessing regional lymph nodes in gastric cancer using histopathology as reference.
    Methods: In this retrospective single-center study, consecutive 91 patients (median age, 66 years, range 33-91 years, 54 men) with CT scans and histologically proven gastric adenocarcinoma were assessed using Node-RADS assigning scores from 1 to 5 for the likelihood of regional lymph node metastases. Additionally, different Node-RADS criteria as well as subcategories of altered border contour (lobulated, spiculated, indistinct) were assessed individually. Sensitivity, specificity, and Youden's index were calculated for Node-RADS scores, and all criteria investigated. Interreader agreement was calculated using Cohen's kappa.
    Results: Among all criteria, best performance was found for Node-RADS scores ≥ 3 and ≥ 4 with a sensitivity/specificity/Youden's index of 56.8%/90.7%/0.48 and 48.6%/98.1%/0.47, respectively, both with substantial interreader agreement (κ = 0.73 and 0.67, p < 0.01). Among individual criteria, the best performance was found for short-axis diameter of 10 mm with sensitivity/specificity/Youden's index of 56.8%/87.0%/0.44 (κ = 0.65, p < 0.01).
    Conclusion: This study shows that structured reporting of combined size and configuration criteria of regional lymph nodes in gastric cancer slightly improves overall diagnostic performance compared to individual criteria including short-axis diameter alone. The results show an increase in specificity and unchanged sensitivity.
    Clinical relevance statement: The results of this study suggest that Node-RADS may be a suitable tool for structured reporting of regional lymph nodes in gastric cancer.
    Key points: • Assessment of lymph nodes in gastric cancer is still limited, and there is a lack of consensus on radiological evaluation. • Node-RADS in gastric cancer improves overall diagnostic performance compared to individual criteria including short-axis diameter. • Node-RADS may be a suitable tool for structured reporting of regional lymph nodes in gastric cancer.
    Sprache Englisch
    Erscheinungsdatum 2023-10-24
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10352-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3300: Hefte anzeigen Standort:
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  5. Artikel: Peptide Signatures for Prognostic Markers of Pancreatic Cancer by MALDI Mass Spectrometry Imaging.

    Loch, Florian N / Klein, Oliver / Beyer, Katharina / Klauschen, Frederick / Schineis, Christian / Lauscher, Johannes C / Margonis, Georgios A / Degro, Claudius E / Rayya, Wael / Kamphues, Carsten

    Biology

    2021  Band 10, Heft 10

    Abstract: Despite the overall poor prognosis of pancreatic cancer there is heterogeneity in clinical courses of tumors not assessed by conventional risk stratification. This yields the need of additional markers for proper assessment of prognosis and multimodal ... ...

    Abstract Despite the overall poor prognosis of pancreatic cancer there is heterogeneity in clinical courses of tumors not assessed by conventional risk stratification. This yields the need of additional markers for proper assessment of prognosis and multimodal clinical management. We provide a proof of concept study evaluating the feasibility of Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) to identify specific peptide signatures linked to prognostic parameters of pancreatic cancer. On 18 patients with exocrine pancreatic cancer after tumor resection, MALDI imaging analysis was performed additional to histopathological assessment. Principal component analysis (PCA) was used to explore discrimination of peptide signatures of prognostic histopathological features and receiver operator characteristic (ROC) to identify which specific
    Sprache Englisch
    Erscheinungsdatum 2021-10-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10101033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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