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  1. Article ; Online: Nanocomposites of iron oxide, sodium alginate, and eugenol induce apoptosis via PI3K/Akt/mTOR signaling in Hep3 cells and in vivo hepatotoxicity in the zebrafish model.

    Elderdery, Abozer Y / Alzerwi, Nasser A N / Alzahrani, Badr / Alsrhani, Abdullah / Alsultan, Afnan / Rayzah, Musaed / Idrees, Bandar / Rayzah, Fares / Baksh, Yaser / Alzahrani, Ahmed M / Alabdulsalam, Abdulrahim A / Mohamedain, A / Subbiah, Suresh Kumar / Mok, Pooi Ling

    International journal of biological macromolecules

    2023  Volume 256, Issue Pt 2, Page(s) 127490

    Abstract: Hepatic cancer is among the most recurrently detected malignancies worldwide and one of the main contributors to cancer-associated mortality. With few available therapeutic choices, there is an instant necessity to explore suitable options. In this ... ...

    Abstract Hepatic cancer is among the most recurrently detected malignancies worldwide and one of the main contributors to cancer-associated mortality. With few available therapeutic choices, there is an instant necessity to explore suitable options. In this aspect, Nanotechnology has been employed to explore prospective chemotherapeutic approaches, especially for cancer treatment. Nanotechnology is concerned with the biological and physical properties of nanoparticles in the therapeutic use of drugs. In the current work, formulation, and characterization of α-Fe
    MeSH term(s) Animals ; Zebrafish/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Eugenol/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Alginates/pharmacology ; Prospective Studies ; TOR Serine-Threonine Kinases/metabolism ; Apoptosis ; Nanocomposites/chemistry ; Chemical and Drug Induced Liver Injury ; Cell Line, Tumor ; Ferric Compounds
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Eugenol (3T8H1794QW) ; ferric oxide (1K09F3G675) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Alginates ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Ferric Compounds
    Language English
    Publishing date 2023-11-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Syzygium cumini

    Rayzah, Musaed / Elderdery, Abozer Y / Alzerwi, Nasser A N / Alzahrani, Badr / Alsrhani, Abdullah / Alsultan, Afnan / Idrees, Bandar / Rayzah, Fares / Bakhsh, Yaser / Alzahrani, Ahmed M / Subbiah, Suresh K / Mok, Pooi Ling

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 18

    Abstract: An aqueous extract ... ...

    Abstract An aqueous extract of
    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12183174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pluronic-F-127-Passivated SnO

    Alzahrani, Badr / Elderdery, Abozer Y / Alzerwi, Nasser A N / Alsrhani, Abdullah / Alsultan, Afnan / Rayzah, Musaed / Idrees, Bandar / Rayzah, Fares / Baksh, Yaser / Alzahrani, Ahmed M / Subbiah, Suresh K / Mok, Pooi Ling

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Nanotechnology has emerged as the most popular research topic with revolutionary applications across all scientific disciplines. Tin oxide ( ... ...

    Abstract Nanotechnology has emerged as the most popular research topic with revolutionary applications across all scientific disciplines. Tin oxide (SnO
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12091760
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  4. Article: Prevalence of Obstructed Defecation among Patients Who Underwent Hemorrhoidectomy and Correlation between Preoperative Constipation Score and Postoperative Patients' Satisfaction: A Prospective Study in Two Centers.

    Abd El Maksoud, Walid M / Abbas, Khaled S / Bawahab, Mohammed A / Rayzah, Fares / Alkorbi, Sultan M / Alfaifi, Abdulelah G / Alqahtani, Abdulrahman N / Alahmari, Abdullah F / Alotaibi, Turki B

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 5

    Abstract: Background and objectives: obstructed defecation syndrome (ODS) is a common but underestimated condition that may affect the outcomes after hemorrhoidectomy. Therefore, the aim of this study was to determine the prevalence of obstructed defecation ... ...

    Abstract Background and objectives: obstructed defecation syndrome (ODS) is a common but underestimated condition that may affect the outcomes after hemorrhoidectomy. Therefore, the aim of this study was to determine the prevalence of obstructed defecation syndrome (ODS) among patients who underwent hemorrhoidectomy and to assess the correlation between preoperative constipation score and postoperative patients' satisfaction.
    Materials and methods: This prospective study included adult patients who underwent hemorrhoidectomy for 3rd and 4th-grade hemorrhoidal diseases. All participant patients underwent an assessment of functional OD severity by the Agachan-Wexner Constipation Scoring System. All patients were subjected to conventional hemorrhoidectomy. At 6 months postoperatively, patients were assessed again for their constipation score and postoperative patients' satisfaction.
    Results: The study included 120 patients (62 males and 58 females) with a mean age of 38.7 ± 12.1 years. About one-quarter of patients (24.2%) had obstructed defecation (constipation score ≥12). ODS (constipation score ≥12) was found to be significantly more among older patients, female patients, especially those with multiple pregnancies and multiple labors, and those with perineal descent. The postoperative constipation score (5.6 ± 3.3 mean ± SD) showed significant improvement (
    Conclusions: The prevalence of obstructed defecation among patients with hemorrhoids was higher than reported among the general population. High preoperative constipation scores had a negative correlation with postoperative patients' satisfaction. Routine preoperative measurement of ODS can allow the detection of this particular group of patients who require a more physical and psychological evaluation, in addition to special preoperative counseling.
    Language English
    Publishing date 2023-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11050759
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  5. Article: Modulation of immune cum inflammatory pathway by earthworm granulation tissue extract in wound healing of diabetic rabbit model.

    M E Elkhalifa, Ahmed / Ali, Sofi Imtiyaz / Nabi, Showkat Ul / Bashir, Imran / Taifa, Syed / Rakhshan, Rabia / Shah, Iqra Hussain / Mir, Muzafar Ahmad / Malik, Masood / Ramzan, Zahid / Nazar, Mehak / Bashir, Nusrat / Ahad, Shubeena / Khursheed, Ibraq / Elamin, Elham / Bazie, Elsharif A / Alzerwi, Nasser A N / Rayzah, Musaed / Idrees, Bandar /
    Rayzah, Fares / Baksh, Yaser / Alsultan, Afnan / Alzahrani, Ahmed M

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e24909

    Abstract: Regeneration is a rare occurrence in the animal kingdom, but the earthworm stands out as a remarkable example of this phenomenon. Recent research has highlighted the promising wound healing properties of extracts derived from earthworms. Therefore, we ... ...

    Abstract Regeneration is a rare occurrence in the animal kingdom, but the earthworm stands out as a remarkable example of this phenomenon. Recent research has highlighted the promising wound healing properties of extracts derived from earthworms. Therefore, we propose that earthworm granulation tissue extract (EGTE) may facilitate wound healing by regulating immune responses in a rabbit diabetic wound model. Electron microscopy reveals that 70 % EGTE possesses noteworthy porosity with spherical to irregularly oval configuration. Gas chromatography-mass spectrometry (GC-MS) Characterization of EGTE revealed higher levels of ergosta-5,7,22-trien-3-ol, (3. beta.,22E).
    Language English
    Publishing date 2024-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24909
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  6. Article ; Online: A disseminated variant of pancreatic serous cystadenoma causing obstructive jaundice, a very rare entity: a case report and review of the literature.

    Al-Jiffry, Bilal O / Rayzah, Fares / Khayat, Samah H

    BMC research notes

    2014  Volume 7, Page(s) 749

    Abstract: Background: Microcystic adenoma or serous cystadenoma (SCA) is an uncommon tumor type, accounting for only 1-2% of pancreatic exocrine neoplasms. Usually unifocal, SCAs present as single, large, well-demarcated, multiloculated, cystic tumors, 1-25 cm in ...

    Abstract Background: Microcystic adenoma or serous cystadenoma (SCA) is an uncommon tumor type, accounting for only 1-2% of pancreatic exocrine neoplasms. Usually unifocal, SCAs present as single, large, well-demarcated, multiloculated, cystic tumors, 1-25 cm in size.
    Case presentation: A 73-year-old man initially presented with epigastric abdominal pain and was diagnosed with SCA involving the whole pancreas. Eleven months later, he presented with obstructive jaundice, and total pancreatectomy was performed. The removed tissue allowed histological verification of pancreatic SCA. Histopathological examination showed both microcysts and macrocysts, lined by cuboidal epithelium, with optically clear cytoplasm and the absence of detectable mitosis or necrosis.
    Conclusions: Thus, although relatively rare, pancreatic SCA is one of the differential diagnoses of epigastric abdominal pain; we recommend early surgical intervention for symptomatic pancreatic SCA.
    MeSH term(s) Abdominal Pain/etiology ; Aged ; Cholangiopancreatography, Magnetic Resonance ; Cystadenoma, Serous/complications ; Cystadenoma, Serous/pathology ; Cystadenoma, Serous/surgery ; Humans ; Jaundice, Obstructive/diagnosis ; Jaundice, Obstructive/etiology ; Jaundice, Obstructive/surgery ; Male ; Pancreatectomy ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Predictive Value of Tests ; Risk Factors ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2014-10-22
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/1756-0500-7-749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Presentation and outcomes of acute appendicitis during COVID-19 pandemic: lessons learned from the Middle East-a multicentre prospective cohort study.

    El Nakeeb, Ayman / Emile, Sameh Hany / AbdelMawla, Ahmed / Attia, Mohamed / Alzahrani, Mohamed / ElGamdi, Ayman / Nouh, Abd Elwahab / Alshahrani, Abdulaziz / AlAreef, Riyadh / Kayed, Taha / Hamza, Hosam Mohamad / AlMalki, Ahmad / Rayzah, Fares / Alsharif, Motaz / Alsharif, Fares / Mohammed, Mohammed M

    International journal of colorectal disease

    2022  Volume 37, Issue 4, Page(s) 777–789

    Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic had a striking impact on healthcare services in the world. The present study aimed to investigate the impact of the COVID-19 pandemic on the presentation management and outcomes of acute ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic had a striking impact on healthcare services in the world. The present study aimed to investigate the impact of the COVID-19 pandemic on the presentation management and outcomes of acute appendicitis (AA) in different centers in the Middle East.
    Methods: This multicenter cohort study compared the presentation and outcomes of patients with AA who presented during the COVID-19 pandemic in comparison to patients who presented before the onset of the pandemic. Demographic data, clinical presentation, management strategy, and outcomes were prospectively collected and compared.
    Results: Seven hundred seventy-one patients presented with AA during the COVID pandemic versus 1174 in the pre-COVID period. Delayed and complex presentation of AA was significantly more observed during the pandemic period. Seventy-six percent of patients underwent CT scanning to confirm the diagnosis of AA during the pandemic period, compared to 62.7% in the pre-COVID period. Non-operative management (NOM) was more frequently employed in the pandemic period. Postoperative complications were higher amid the pandemic as compared to before its onset. Reoperation and readmission rates were significantly higher in the COVID period, whereas the negative appendicectomy rate was significantly lower in the pandemic period (p = 0.0001).
    Conclusion: During the COVID-19 pandemic, a remarkable decrease in the number of patients with AA was seen along with a higher incidence of complex AA, greater use of CT scanning, and more application of NOM. The rates of postoperative complications, reoperation, and readmission were significantly higher during the COVID period.
    MeSH term(s) Appendectomy ; Appendicitis/epidemiology ; Appendicitis/surgery ; COVID-19/epidemiology ; Cohort Studies ; Humans ; Middle East/epidemiology ; Pandemics ; Prospective Studies ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2022-02-13
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-022-04108-8
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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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