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  1. Article ; Online: Modulators of the Nrf2 Signaling Pathway Enhance the Cytotoxic Effect of Standard Chemotherapeutic Drugs on Organoids of Metastatic Colorectal Cancer.

    Razumovskaya, A V / Silkina, M O / Nikulin, S V / Tonevitsky, A G / Alekseev, B Ya

    Bulletin of experimental biology and medicine

    2024  

    Abstract: The activity of known modulators of the Nrf2 signaling pathway (bardoxolone and brusatol) was studied on cultures of tumor organoids of metastatic colorectal cancer previously obtained from three patients. The effect of modulators was studied both as ... ...

    Abstract The activity of known modulators of the Nrf2 signaling pathway (bardoxolone and brusatol) was studied on cultures of tumor organoids of metastatic colorectal cancer previously obtained from three patients. The effect of modulators was studied both as monotherapy and in combination with standard chemotherapy drugs used to treat colorectal cancer. The Nrf2 inhibitor brusatol and the Nrf2 activator bardoxolone have antitumor activity. Moreover, bardoxolone and brusatol also significantly enhance the effect of the chemotherapy drugs 5-fluorouracil, oxaliplatin, and irinotecan metabolite SN-38. Thus, bardoxolone and brusatol can be considered promising candidates for further preclinical and clinical studies in the treatment of colorectal cancer.
    Language English
    Publishing date 2024-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390407-6
    ISSN 1573-8221 ; 0007-4888 ; 0365-9615
    ISSN (online) 1573-8221
    ISSN 0007-4888 ; 0365-9615
    DOI 10.1007/s10517-024-06093-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessing the Efficacy of Anti-Cancer Drugs on Organoid Models Derived from Prostate Cancer.

    Silkina, M O / Razumovskaya, A V / Nikulin, S V / Tonevitsky, A G / Alekseev, B Ya

    Doklady. Biochemistry and biophysics

    2024  Volume 513, Issue Suppl 1, Page(s) S96–S99

    Abstract: It was proven that tumor organoids effectively mirror the phenotypic and genetic traits of the original biomaterial. It was reported that outcomes from drug testing in organoid cultures can accurately represent the clinical response observed in patients. ...

    Abstract It was proven that tumor organoids effectively mirror the phenotypic and genetic traits of the original biomaterial. It was reported that outcomes from drug testing in organoid cultures can accurately represent the clinical response observed in patients. In this study, an organoid culture was derived from biopsy material of prostate cancer (PC). Subsequently, clinical practice drugs, docetaxel and enzalutamide, were tested on this organoid culture. Various techniques for evaluating the efficacy of drugs in vitro were compared. The half-maximal inhibitory concentration of docetaxel was found to be markedly lower compared to that of enzalutamide. However, when tested at clinically relevant concentrations and incubation times, enzalutamide was more effective than docetaxel. Therefore, it is crucial to optimize the testing conditions for drugs on in vitro cultures for their subsequent application in clinical practice.
    MeSH term(s) Male ; Humans ; Docetaxel ; Antineoplastic Agents/pharmacology ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Nitriles ; Organoids/pathology ; Benzamides ; Phenylthiohydantoin
    Chemical Substances Docetaxel (15H5577CQD) ; enzalutamide (93T0T9GKNU) ; Antineoplastic Agents ; Nitriles ; Benzamides ; Phenylthiohydantoin (2010-15-3)
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062390-2
    ISSN 1608-3091 ; 1607-6729
    ISSN (online) 1608-3091
    ISSN 1607-6729
    DOI 10.1134/S1607672923700692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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