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Article ; Online: Primary hyperparathyroidism causing posterior reversible encephalopathy syndrome: a case report.

Cagney, D / Razzaq, Z / Majeed, M / O'Leary, D P / Redmond, H P

Annals of the Royal College of Surgeons of England

2021 Volume 103, Issue 10, Page(s) e341–e344

Abstract: Posterior reversible encephalopathy syndrome (PRES) is a reversible leukoencephalopathy characterised by subcortical vasogenic oedema and neurological signs. We present the case of a 64-year-old woman who presented to hospital with symptomatic primary ... ...

Abstract	Posterior reversible encephalopathy syndrome (PRES) is a reversible leukoencephalopathy characterised by subcortical vasogenic oedema and neurological signs. We present the case of a 64-year-old woman who presented to hospital with symptomatic primary hyperparathyroidism. Her parathyroid hormone (PTH) level on admission was elevated at 1,330ng/l (normal range15-68ng/l) and her serum calcium measured 4.83mmol/l (normal range 2.25-2.54mmol/l). Technectium-99m sestamibi scan demonstrated a focus of radiotracer uptake consistent with a right upper parathyroid adenoma or carcinoma. After commencing appropriate medical treatment, the patient developed intractable seizures necessitating endotracheal intubation. Magnetic resonance imaging of her brain revealed bilateral symmetrical T2 hyperintensities in the posterior circulation consistent with PRES. Following stabilisation and further medical treatment for hypercalcaemia, the patient underwent a parathyroidectomy. Preoperative rapid PTH assay measured 1,021ng/l. Following excision, PTH levels fell to just 10ng/l. She was extubated in the intensive care unit on postoperative day 1 and made an uneventful recovery. At her 6-week follow-up appointment, all neurological symptoms had resolved. PRES is a rare neurological entity more often seen in the setting of hypertension, immunosuppression and renal failure. The development of new neurological manifestations in the setting of known risk factors should raise suspicion for the underlying diagnosis.
MeSH term(s)	Female ; Humans ; Hypercalcemia/etiology ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/surgery ; Magnetic Resonance Imaging ; Middle Aged ; Neuroimaging ; Parathyroidectomy ; Posterior Leukoencephalopathy Syndrome/diagnostic imaging ; Posterior Leukoencephalopathy Syndrome/etiology ; Status Epilepticus/etiology
Language	English
Publishing date	2021-08-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2021.0062
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Readability and Quality of Online Health Information Regarding Parathyroidectomy.

Byrne, Jim / Keogh, Samuel / Cullinane, Carolyn / Razzaq, Zeeshan / Redmond, Henry Paul

OTO open

2022 Volume 6, Issue 4, Page(s) 2473974X221133308

Abstract: Objective: Assessment of the readability and quality of online health information regarding parathyroidectomy.: Study design: Cross-sectional analysis.: Setting: Websites providing patient-oriented health information regarding parathyroidectomy ... ...

Abstract	Objective: Assessment of the readability and quality of online health information regarding parathyroidectomy. Study design: Cross-sectional analysis. Setting: Websites providing patient-oriented health information regarding parathyroidectomy obtained via the Google search engine. Methods: The top 75 Google search results for "parathyroidectomy,""parathyroid surgery," and "parathyroid gland removal" were reviewed. Websites were categorized by website type and country of origin. Readability was assessed by Flesch-Kincaid Grade Level and Simple Measure of Gobbledygook. Website quality was assessed per JAMA benchmark criteria and the DISCERN instrument. Results: A total of 74 unique websites were evaluated. The mean readability of the assessed websites exceeded the recommended sixth-grade reading level on the Flesch-Kincaid Grade Level and Simple Measure of Gobbledygook ( Conclusion: Online health information regarding parathyroidectomy is largely of poor quality and is poorly readable for many patients. Institutions utilizing well-defined guidelines for development of patient educational resources may provide online health information of greater quality and readability.
Language	English
Publishing date	2022-10-20
Publishing country	United States
Document type	Journal Article
ISSN	2473-974X
ISSN (online)	2473-974X
DOI	10.1177/2473974X221133308
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Article ; Online: Removal of As(V) and Cr(VI) with Low-Cost Novel Virgin and Iron-Impregnated Banana Peduncle-Activated Carbons.

Razzaq, Zobia / Hamayun, Muhammad / Murtaza, Shahzad / Kausar, Samia / Altaf, Ataf Ali / Khan, Rizwan Ullah / Javaid, Tehzeen

ACS omega

2023 Volume 8, Issue 2, Page(s) 2098–2111

Abstract: This work reports the investigation of activated carbons from virgin banana peduncle ( ...

Abstract	This work reports the investigation of activated carbons from virgin banana peduncle (
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c05957
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Article: The moderating impact of emotions on customer equity drivers and loyality intentions

Razzaq, Zohaib / Yousaf, Salman / Zhao, Zhao

Asia Pacific journal of marketing and logistics Vol. 29, No. 2 , p. 239-264

evidence of within sector differences

2017 Volume 29, Issue 2, Page(s) 239–264

Author's details	Zohaib Razzaq, Salman Yousaf and Zhao Hong
Keywords	Emotions ; Brand equity ; Consumer loyalty ; Value equity ; Customer equity drivers ; Relationship equity
Language	English
Publisher	Emerald Group Publishing Limited
Publishing place	Bingley
Document type	Article
ZDB-ID	1174740-7 ; 2419238-7
ISSN	0954-7517
ISSN	0954-7517
Database	ECONomics Information System

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Article ; Online: Evolution of adrenal surgery in a tertiary referral centre.

Cagney, David / Hanrahan, Michael / Razzaq, Zeeshan / Majeed, Mudassar / O'Leary, Donal Peter / Redmond, Henry Paul

Irish journal of medical science

2020 Volume 189, Issue 4, Page(s) 1305–1310

Abstract: Background: Laparoscopic transperitoneal and retroperitoneoscopic adrenalectomy have largely replaced open adrenal surgery, particularly in benign disease. Laparoscopic surgery results in less post-operative pain, fewer surgical site complications and ... ...

Abstract	Background: Laparoscopic transperitoneal and retroperitoneoscopic adrenalectomy have largely replaced open adrenal surgery, particularly in benign disease. Laparoscopic surgery results in less post-operative pain, fewer surgical site complications and reduced length of hospital stay. The aim of this retrospective study was to analyse the characteristics of patients and evolution of surgical technique in adrenal surgery at Cork University Hospital over a 12-year period. Methods: All cases of adrenalectomy between January 1st, 2007 and December 31st, 2018 were retrospectively reviewed. Patient demographics, diagnosis, surgical approach, length of hospital stay, histology and complications were evaluated. Comparisons were made between open, laparoscopic transperitoneal and retroperitoneoscopic adrenalectomy cases. Results: There were 57 adrenalectomies performed on 55 patients over the 12-year period. Twenty-six patients (46%) were male, and the mean age was 49 years (range 14-84 years). Twenty-two (39%) right-sided adrenalectomies were performed, 33 (57%) left sided and 2 (4%) patients underwent bilateral surgery. Seventeen adrenalectomies were performed using an open transperitoneal approach, 30 via a laparoscopic transperitoneal approach and 10 using the retroperitoneoscopic technique. Adenoma and pheochromocytoma were the most common indications for surgery (42% and 40%, respectively). Seven percent were performed for malignancy and 5% for other benign indications. The complication rate for open adrenalectomy was 18% versus 10% in laparoscopic transperitoneal adrenalectomy and 0% for retroperitoneoscopic adrenalectomy. Two patients (7%) undergoing laparoscopic transperitoneal surgery required conversion to an open procedure. There were no 30-day mortalities and no disease recurrence within the study time frame. The mean length of hospital stay was 7.6 days in the open group, 5.8 days for the laparoscopic transperitoneal group and 3 days for the retroperitoneoscopic group (p = 0.03). Conclusions: Adrenalectomy is a safe procedure and in our setting was primarily performed for pheochromocytoma and non-functioning adenomas. Minimally invasive adrenalectomy has become the standard of care internationally and is associated with fewer complications, shorter hospital stay and a low conversion rate.
MeSH term(s)	Adolescent ; Adrenal Gland Neoplasms/surgery ; Adrenalectomy/methods ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Tertiary Care Centers ; Young Adult
Language	English
Publishing date	2020-03-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-020-02204-8
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Article: Viral load is associated with abnormal serum levels of micronutrients and glutathione and glutathione-dependent enzymes in genotype 3 HCV patients.

Razzaq, Zarish / Malik, Arif

BBA clinical

2014 Volume 2, Page(s) 72–78

Abstract: Background: Oxidative stress in hepatitis C patients has been linked to hepatitis C virus. We verified this assumption in HCV genotype 3 patients by detecting the relationship between viral load and certain specific oxidative stress markers like Cu, Mn, ...

Abstract	Background: Oxidative stress in hepatitis C patients has been linked to hepatitis C virus. We verified this assumption in HCV genotype 3 patients by detecting the relationship between viral load and certain specific oxidative stress markers like Cu, Mn, Fe, Se, Zn and glutathione and glutathione-dependent enzymes. Method: Subjects (n = 200, average age 24 years) with quantitative HCV RNA polymerase chain reaction-proven genotype 3 hepatitis C were simultaneously evaluated. Cu, Mn, Fe, Se and Zn serum levels were by using atomic absorption spectrophotometer. Internationally accepted methods were used for viral load quantification of glutathione, GR and Gpx serum levels. Result: There was a significant correlation between HCV viral load and studied parameters. With the increase of viral load from mild group (200,000-1,000,000 copies/ml) to severe group (5,000,000-25,000,000 copies/ml) the serum levels of Cu, Mn, Zn, and Fe and glutathione reductase were found to be abnormally high. However, in severe viral load group serum concentration of Se and glutathione was less than the healthy controls. Conclusion: As a significant correlation was detected between the study parameters in genotype 3 HCV patients, it is concluded that the studied micronutrients and glutathione and glutathione-dependent enzymes are the biomolecular targets of HCV to induce oxidative stress. General significance: Constant monitoring and regulation of the recommended biomolecular targets of HCV can improve the plight of more than 170 million patients suffering from hepatitis C virus around the globe.
Language	English
Publishing date	2014-10-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2777083-7
ISSN	2214-6474
ISSN	2214-6474
DOI	10.1016/j.bbacli.2014.09.006
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Article: Pharmacological screening and GC-MS analysis of vegetative/reproductive parts of Nigella sativa L.

Aftab, Arusa / Yousaf, Zubaida / Aftab, Zill-E-Huma / Younas, Afifa / Riaz, Nadia / Rashid, Madiha / Shamsheer, Hafiza Bushra / Razzaq, Zainab / Javaid, Arshad

Pakistan journal of pharmaceutical sciences

2021 Volume 33, Issue 5, Page(s) 2103–2111

Abstract: Nigella sativa is an extensively utilized herbal medicinal plant. Medicinal utilization of seeds and oil of N. sativa was common among all the ancient medicinal systems. Previously, the vegetative part of the plant was not utilized for pharmaceutical ... ...

Abstract	Nigella sativa is an extensively utilized herbal medicinal plant. Medicinal utilization of seeds and oil of N. sativa was common among all the ancient medicinal systems. Previously, the vegetative part of the plant was not utilized for pharmaceutical purposes. Therefore, the current study was aimed at determining the potential of the vegetative parts (leaves, branches and stem) of the plant to reduce the pressure on the reproductive part (seeds/oil) and to get a potential alternate source of pharmaceutical materials. The experiment was carried out in split block RCD design. The dried plant was extracted through partitioning method in a series of concentrations ranging from 200-1.562mg/ml in different solvents. Phyto-chemical screening, antibacterial and anti-oxidant assays and GC-MS analysis of the potent extracts were done. The green parts of N. sativa were shown to contain saponins, alkaloids, terpenoids, steroids, cardiac glycosides, tannins, and flavonoids, whereas phloba-tannins were absent. Evaluation of anti-aging properties through antioxidant assays yielded significant results in all the assays. Linoleic acid, palmitic acid, stearic acid, oleic acid and glyceryl linoleate were profiled through GC-MS analysis. Based on these results, it was concluded that the vegetative parts of N. sativa are effective alternatives to the reproductive part/seed for anti-aging and other phytochemicals needed to meet the present day requirements of the pharmaceutical industry.
MeSH term(s)	Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Bacteria/drug effects ; Bacteria/growth & development ; Gas Chromatography-Mass Spectrometry ; Nigella sativa/anatomy & histology ; Nigella sativa/chemistry ; Oxidative Stress/drug effects ; Pharmacognosy ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Components, Aerial/anatomy & histology ; Plant Components, Aerial/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Seeds/chemistry
Chemical Substances	Anti-Bacterial Agents ; Antioxidants ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2021-04-06
Publishing country	Pakistan
Document type	Comparative Study ; Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line.

Akhter, Naheed / Batool, Sidra / Khan, Samreen Gul / Rasool, Nasir / Anjum, Fozia / Rasul, Azhar / Adem, Şevki / Mahmood, Sadaf / Rehman, Aziz Ur / Nisa, Mehr Un / Razzaq, Zainib / Christensen, Jørn B / Abourehab, Mohammed A S / Shah, Syed Adnan Ali / Imran, Syahrul

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 2

Abstract: Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid ( ...

Abstract	Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16020211
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Article ; Online: Cytotoxic and photocatalytic studies of hexagonal boron nitride nanotubes: a potential candidate for wastewater and air treatment.

Khalid, Awais / Ahmad, Pervaiz / Khan, Abdulhameed / Khandaker, Mayeen Uddin / Kebaili, Imen / Alam, Md Mottahir / Din, Israf Ud / Muhammad, Saleh / Razzaq, Zohaib / Rehman, Ibad Ur / Abbasi, Habib Ahmad / Hayat, Danish

RSC advances

2022 Volume 12, Issue 11, Page(s) 6592–6600

Abstract: Boron nitride (BN) nanomaterials are rapidly being investigated for potential applications in biomedical sciences due to their exceptional physico-chemical characteristics. However, their safe use demands a thorough understanding of their possible ... ...

Abstract	Boron nitride (BN) nanomaterials are rapidly being investigated for potential applications in biomedical sciences due to their exceptional physico-chemical characteristics. However, their safe use demands a thorough understanding of their possible environmental and toxicological effects. The cytotoxicity of boron nitride nanotubes (BNNTs) was explored to see if they could be used in living cell imaging. It was observed that the cytotoxicity of BNNTs is higher in cancer cells (65 and 80%) than in normal cell lines (40 and 60%) for 24 h and 48 h respectively. The influence of multiple experimental parameters such as pH, time, amount of catalyst, and initial dye concentration on percentage degradation efficiency was also examined for both catalyst and dye. The degradation effectiveness decreases (92 to 25%) as the original concentration of dye increases (5-50 ppm) due to a decrease in the availability of adsorption sites. Similarly, the degradation efficiency improves up to 90% as the concentration of catalyst increases (0.01-0.05 g) due to an increase in the adsorption sites. The influence of pH was also investigated, the highest degradation efficiency for MO dye was observed at pH 4. Our results show that lower concentrations of BNNTs can be employed in biomedical applications. Dye degradation properties of BNNTs suggest that it can be a potential candidate as a wastewater and air treatment material.
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra00300g
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Article: PBL wrap up sessions: an approach to enhance generic skills in medical students.

Razzaq, Zubia / Ahsin, Sadia

Journal of Ayub Medical College, Abbottabad : JAMC

2011 Volume 23, Issue 2, Page(s) 162–165

Abstract: Background: Problem based learning (PBL) tutorials are being used in various medical schools world wide. Students' active participation is a must for the success of a teaching program. The objective of this study was to evaluate the effectiveness of PBL ...

Abstract	Background: Problem based learning (PBL) tutorials are being used in various medical schools world wide. Students' active participation is a must for the success of a teaching program. The objective of this study was to evaluate the effectiveness of PBL Wrap-up sessions in an integrated modular medical curriculum in enhancing the generic skills of medical students. Methodology: This study was conducted on 100 students of 2nd year MBBS who had been taking PBL sessions since 1 1/2 years. Each session concluded with a wrap-up session where students demonstrated their acquired knowledge in the form of PowerPoint presentations, concept maps, skits, models etc. A questionnaire based survey was conducted to find out overall effectiveness of PBL sessions including wrap-up sessions. The questionnaire comprised of 15 questions. Students were asked to rate all those sessions on a likert scale of 1 to 5. Results: Student's responses showed 'Moderate improvement' in 8 out of 15 skills like communication with peers and teachers, presentation skills, self confidence, application of acquired knowledge, using internet and other resources and understanding group dynamics. Improvement in abilities like problem solving, time management, creativity, motivation in studies and self-directed learning was 'Minimal'. In addition students recommended continuation of PBL in the same way for future classes. Conclusion: PBL with wrap-up sessions contributed in bringing moderate enhancement of generic learning skills in students which were not properly addressed in the traditional curriculum and are therefore recommended for future implementation.
MeSH term(s)	Curriculum ; Education, Medical, Undergraduate/methods ; Female ; Humans ; Learning ; Male ; Pakistan ; Problem-Based Learning ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2011-04
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2192473-9
ISSN	1025-9589
ISSN	1025-9589
Database	MEDical Literature Analysis and Retrieval System OnLINE

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