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  1. Article ; Online: Spontaneous Coronary Artery Dissection in a Healthy Man With Non-ST Elevation Myocardial Infarction.

    Krittanawong, Chayakrit / Rao, Sunil V / Razzouk, Louai

    JAMA cardiology

    2024  

    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2024.0381
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  2. Article ; Online: Workflow for Percutaneous Coronary Intervention With Optical Coherence Tomography-Guidance: MAXing the MLD?

    Razzouk, Louai / Attubato, Michael J

    Circulation. Cardiovascular interventions

    2022  Volume 15, Issue 11, Page(s) 882–883

    MeSH term(s) Humans ; Tomography, Optical Coherence ; Workflow ; Treatment Outcome ; Percutaneous Coronary Intervention/adverse effects ; Coronary Angiography ; Ultrasonography, Interventional ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.122.012608
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    Zs.A 6746: Show issues Location:
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  3. Article ; Online: Editorial commentary: The need for a streamlined approach to STEMI management during the COVID-19 pandemic.

    Razzouk, Louai / Farkouh, Michael E

    Trends in cardiovascular medicine

    2021  Volume 31, Issue 3, Page(s) 141–142

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Percutaneous Coronary Intervention/adverse effects ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/epidemiology ; ST Elevation Myocardial Infarction/therapy
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2021.01.001
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    Zs.A 3419: Show issues Location:
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  4. Article ; Online: Revascularization in patients with diabetes and chronic total occlusion: The journey or the destination?

    Razzouk, Louai / Jneid, Hani

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2021  Volume 97, Issue 3, Page(s) 384–385

    MeSH term(s) Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/surgery ; Diabetes Mellitus ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.29532
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    Zs.A 1226: Show issues Location:
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  5. Article ; Online: Letter by Sherrid et al Regarding Article, "Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock".

    Sherrid, Mark V / Razzouk, Louai / Massera, Daniele

    Circulation. Cardiovascular interventions

    2019  Volume 12, Issue 4, Page(s) e007977

    MeSH term(s) Cardiac Surgical Procedures ; Cardiomyopathy, Hypertrophic ; Heart Septum ; Humans ; Shock, Cardiogenic ; Takotsubo Cardiomyopathy
    Language English
    Publishing date 2019-04-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.119.007977
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    Zs.A 6746: Show issues Location:
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  6. Article ; Online: Optimal approaches to diabetic patients with multivessel disease.

    Razzouk, Louai / Farkouh, Michael E

    Trends in cardiovascular medicine

    2015  Volume 25, Issue 7, Page(s) 625–631

    Abstract: The pathophysiology of diabetes and systemic insulin resistance contributes to the nature of diffuse atherosclerosis and a high prevalence of multivessel coronary artery disease (CAD) in diabetic patients. The optimal approach to this patient population ... ...

    Abstract The pathophysiology of diabetes and systemic insulin resistance contributes to the nature of diffuse atherosclerosis and a high prevalence of multivessel coronary artery disease (CAD) in diabetic patients. The optimal approach to this patient population remains a subject of an ongoing discussion. In this review, we give an overview of the unique pathophysiology of CAD in patients with diabetes, summarize the current state of therapies available, and compare modalities of revascularization that have been investigated in recent clinical trials. We conclude by highlighting the importance of a comprehensive heart team approach to every patient while accommodating both patient preference and quality-of-life decisions.
    MeSH term(s) Biomarkers/blood ; Blood Glucose/metabolism ; Cardiovascular Agents/therapeutic use ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/economics ; Coronary Artery Bypass/mortality ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/economics ; Coronary Artery Disease/mortality ; Coronary Artery Disease/therapy ; Cost-Benefit Analysis ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/economics ; Diabetic Angiopathies/mortality ; Diabetic Angiopathies/therapy ; Health Care Costs ; Humans ; Insulin Resistance ; Patient Selection ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/economics ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/mortality ; Quality of Life ; Risk Factors ; Risk Reduction Behavior ; Stents ; Time Factors ; Treatment Outcome
    Chemical Substances Biomarkers ; Blood Glucose ; Cardiovascular Agents
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2015.02.004
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    Zs.A 3419: Show issues Location:
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  7. Article ; Online: Cardiac allograft vasculopathy in heart transplant recipients from hepatitis C viremic donors.

    Kadosh, Bernard S / Birs, Antoinette S / Flattery, Erin / Stachel, Maxine / Hong, Kimberly N / Xia, Yuhe / Gidea, Claudia / Aslam, Saima / Razzouk, Louai / Saraon, Tajinderpal / Goldberg, Randal / Rao, Shaline / Pretorius, Victor / Moazami, Nader / Smith, Deane E / Adler, Eric D / Reyentovich, Alex

    Clinical transplantation

    2024  Volume 38, Issue 4, Page(s) e15294

    Abstract: Background: Recent studies suggest the transplantation of Hepatitis C (HCV) hearts from viremic donors is associated with comparable 1 year survival to nonviremic donors. Though HCV viremia is a known risk factor for accelerated atherosclerosis, data on ...

    Abstract Background: Recent studies suggest the transplantation of Hepatitis C (HCV) hearts from viremic donors is associated with comparable 1 year survival to nonviremic donors. Though HCV viremia is a known risk factor for accelerated atherosclerosis, data on cardiac allograft vasculopathy (CAV) outcomes are limited. We compared the incidence of CAV in heart transplant recipients from HCV viremic donors (nucleic acid amplification test positive; NAT+) compared to non-HCV infected donors (NAT-).
    Methods: We retrospectively reviewed annual coronary angiograms with intravascular ultrasound from April 2017 to August 2020 at two large cardiac transplant centers. CAV was graded according to ISHLT guidelines. Maximal intimal thickness (MIT) ≥ 0.5 mm was considered significant for subclinical disease.
    Results: Among 270 heart transplant recipients (mean age 54; 77% male), 62 patients were transplanted from NAT+ donors. CAV ≥ grade 1 was present in 8.8% of the NAT+ versus 16.8% of the NAT- group at 1 year, 20% versus 28.8% at 2 years, and 33.3% versus 41.5% at 3 years. After adjusting for donor age, donor smoking history, recipient BMI, recipient, hypertension, and recipient diabetes, NAT+ status did not confer increased risk of CAV (HR.80; 95% CI.45-1.40, p = 0.43) or subclinical IVUS disease (HR.87; 95% CI.58-1.30, p = 0.49). Additionally, there was no difference in the presence of rapidly progressive lesions on IVUS.
    Conclusion: Our data show that NAT+ donors conferred no increased risk for early CAV or subclinical IVUS disease following transplantation in a cohort of heart transplant patients who were treated for HCV, suggesting the short-term safety of this strategy to maximize the pool of available donor hearts.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Tissue Donors ; Retrospective Studies ; Heart Transplantation/adverse effects ; Viremia/epidemiology ; Viremia/etiology ; Follow-Up Studies ; Hepatitis C/etiology ; Hepacivirus ; Allografts ; Transplant Recipients
    Language English
    Publishing date 2024-03-28
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15294
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    Zs.A 2204: Show issues Location:
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  8. Article ; Online: Posterior Descending Coronary Artery Arising From a Septal Branch of the Left Anterior Descending Coronary Artery.

    Smilowitz, Nathaniel R / Razzouk, Louai / Slater, James N

    The Journal of invasive cardiology

    2017  Volume 29, Issue 2, Page(s) E26–E27

    Abstract: A 48-year-old man with hypertension presented with heart failure and reduced left ventricular systolic function. Coronary angiography revealed a non-dominant right coronary artery and a long anomalous branch of the proximal left anterior descending ... ...

    Abstract A 48-year-old man with hypertension presented with heart failure and reduced left ventricular systolic function. Coronary angiography revealed a non-dominant right coronary artery and a long anomalous branch of the proximal left anterior descending coronary artery that coursed inferiorly to give rise to the posterior descending artery. No epicardial coronary artery disease was visualized. The highly unusual anomalous branch was considered to be an incidental finding, with no pathological contribution to the clinical presentation.
    MeSH term(s) Cardiac Catheterization/methods ; Coronary Angiography/methods ; Coronary Vessel Anomalies/diagnosis ; Coronary Vessel Anomalies/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
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    Zs.A 3701: Show issues Location:
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    Zs.MO 272: Show issues
    Zs.MG 31: Show issues

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  9. Article ; Online: Revascularization for Advanced Coronary Artery Disease in Type 2 Diabetic Patients: Choosing Wisely Between PCI and Surgery.

    Razzouk, Louai / Feit, Frederick / Farkouh, Michael E

    Current cardiology reports

    2017  Volume 19, Issue 5, Page(s) 37

    Abstract: Purpose of review: Patients with type 2 diabetes mellitus (T2DM) are at an increased risk of systemic atherosclerosis and advanced coronary artery disease (CAD). Herein, we review clinical trials comparing surgical to percutaneous revascularization in ... ...

    Abstract Purpose of review: Patients with type 2 diabetes mellitus (T2DM) are at an increased risk of systemic atherosclerosis and advanced coronary artery disease (CAD). Herein, we review clinical trials comparing surgical to percutaneous revascularization in the context of the unique pathophysiology in this patient population, and seek to answer the question of optimal strategy of revascularization.
    Recent findings: Early studies showed a signal towards benefit of surgical revascularization over percutaneous revascularization in this group, but there was a paucity of randomized clinical trials (RCT) to directly support this finding. The Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease (FREEDOM), a large-scale international RCT, was then undertaken and established the benefit of coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI) in terms of mortality, myocardial infarction and repeat revascularization; CABG was inferior to PCI with regards to stroke. The quality of life and cost effectiveness also demonstrated a long-term benefit for surgery. The decision as to choice of mode of revascularization in patients with T2DM and advanced CAD depends upon a multitude of factors, including the coronary anatomy, co-morbidities and the patient's surgical risk. These factors influence the recommendation of the cardiovascular team, which should result in a balanced presentation of the short and long-term risks and benefits of either mode of revascularization to the patient and his/her family.
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-017-0849-7
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    Zs.A 5524: Show issues Location:
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  10. Article ; Online: Long-term follow-up of acute and chronic rejection in heart transplant recipients from hepatitis C viremic (NAT+) donors.

    Stachel, Maxine W / Alimi, Marjan / Narula, Navneet / Flattery, Erin E / Xia, Yuhe / Ramachandran, Abhinay / Saraon, Tajinderpal / Smith, Deane / Reyentovich, Alex / Goldberg, Randal / Kadosh, Bernard S / Razzouk, Louai / Katz, Stuart / Moazami, Nader / Gidea, Claudia G

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2022  Volume 22, Issue 12, Page(s) 2951–2960

    Abstract: The long-term safety of heart transplants from hepatitis C viremic (NAT+) donors remains uncertain. We conducted a prospective study of all patients who underwent heart transplantation at our center from January 2018 through August 2020. Routine testing ... ...

    Abstract The long-term safety of heart transplants from hepatitis C viremic (NAT+) donors remains uncertain. We conducted a prospective study of all patients who underwent heart transplantation at our center from January 2018 through August 2020. Routine testing was performed to assess for donor-derived cell-free DNA, acute cellular rejection (ACR), antibody-mediated rejection (AMR), and cardiac allograft vasculopathy (CAV). Allograft dysfunction and mortality were also monitored. Seventy-five NAT- recipients and 32 NAT+ recipients were enrolled in the study. All NAT+ recipients developed viremia detected by PCR, were treated with glecaprevir/pibrentasvir at the time of viremia detection, and cleared the virus by 59 days post-transplant. Patients who underwent NAT testing starting on post-operative day 7 (NAT+ Group 1) had significantly higher viral loads and were viremic for a longer period compared with patients tested on post-operative day 1 (NAT+ Group 2). Through 3.5 years of follow-up, there were no statistically significant differences in timing, severity, or frequency of ACR in NAT+ recipients compared with the NAT- cohort, nor were there differences in noninvasive measures of graft injury, incidence or severity of CAV, graft dysfunction, or mortality. There were five episodes of AMR, all in the NAT- group. There were no statistically significant differences between Group 1 and Group 2 NAT+ cohorts. Overall, these findings underscore the safety of heart transplantation from NAT+ donors.
    MeSH term(s) Humans ; Follow-Up Studies ; Heart Transplantation/adverse effects ; Hepacivirus ; Hepatitis C ; Prospective Studies ; Tissue Donors ; Transplant Recipients ; Viremia/etiology
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.17190
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    Zs.A 5542: Show issues Location:
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