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Article: Development and Characterisation of Joints with Novel Densified and Wood/Cork Composite Substrates.

Corte-Real, Luis M R M / Jalali, Shahin / Borges, Catarina S P / Marques, Eduardo A S / Carbas, Ricardo J C / da Silva, Lucas F M

Materials (Basel, Switzerland)

2022 Volume 15, Issue 20

Abstract: The automotive industry, driven by the desire to decrease the environmental impact of vehicles, is permanently seeking to develop lightweight structural components, which lead to lower gas emissions and energy consumption, reducing their carbon footprint. ...

Abstract	The automotive industry, driven by the desire to decrease the environmental impact of vehicles, is permanently seeking to develop lightweight structural components, which lead to lower gas emissions and energy consumption, reducing their carbon footprint. In parallel, adopting innovative, constructive solutions, which dispense non-recyclable and energy-intensive materials, can increase the footprint reduction. Thus, an increase in the use of renewable materials for structural applications, including wood and its by-products, has been observed over the last few decades. Furthermore, composite materials are often joined by using petroleum-based synthetic adhesives, which should be progressively replaced by eco-friendly bio-adhesives. In this study, novel densified wood and wood/cork composites, joined with a bio-adhesive, are proposed and characterised. The densification of the wood aims to enhance the mechanical properties of the natural material, with the purpose of improving the energy absorption of the wood/bio-adhesive joint. To mitigate delamination and the brittle behaviour of wood/cork agglomerates were introduced between the wood substrate and the bio-adhesive. Different configurations of single lap joints (SLJ) were manufactured to study the effect of the overlap length and loading rate on the performance of the joints, both in terms of failure load and energy absorption. Afterward, the joints were numerically simulated. The densification process was successful, although it represents an additional challenge in terms of surface flatness, because the bio-adhesive requires zero bondline thickness. The increase of the overlap had a positive impact on the energy absorption of the joint, and the addition of cork resulted in a more consistent failure mode and higher strain to failure. The numerical models developed had a good correlation with the experimental results.
Language	English
Publishing date	2022-10-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15207163
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lower probability of persistence of total anti-SARS-CoV-2 antibodies after COVID-19 among people living with HIV.

Macías, Juan / Fernández-Fuertes, Marta / Oliver, Noemí / Corma-Gómez, Anaïs / Real, Luis M / Pineda, Juan A

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2022 Volume 28, Issue 5, Page(s) 755–756

MeSH term(s)	Antibodies, Viral ; COVID-19 ; HIV Infections/complications ; Humans ; Neutralization Tests ; Probability
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2022.01.028
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Article ; Online: Low rate of vaccination and risk of incident hepatitis A among HIV-infected men who have sex with men in Seville, Southern Spain.

Fernandez-Fuertes, Marta / Macias, Juan / Corma-Gomez, Anaïs / Salazar-Gonzalez, Adolfo / Gonzalez-Serna, Alejandro / Rincon, Pilar / Arriaza-Estevez, Maria J / Fuentes-Lopez, Ana / Real, Luis M / Pineda, Juan A

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023

Abstract: Background: Periodic outbreaks of hepatitis A (HAV) infection in men who have sex with men (MSM) have been reported. Low vaccination uptake in HIV-infected individuals could drive new outbreaks. We aimed at evaluating the incidence of and risk factors ... ...

Abstract	Background: Periodic outbreaks of hepatitis A (HAV) infection in men who have sex with men (MSM) have been reported. Low vaccination uptake in HIV-infected individuals could drive new outbreaks. We aimed at evaluating the incidence of and risk factors for HAV infection in people living with HIV (PLWH) in our area. We also assessed the rates of HAV vaccination. Methods: This was a prospective cohort study. 915 patients were included, 272 (30%) of them were anti-HAV seronegative at baseline. Results: Twenty-six (9.6%) susceptible individuals became infected. Incident cases peaked in 2009-2010 and 2017-2018. Incident HAV infection was independently associated with MSM [adjusted odds ratio (95% confidence ratio): 4.39 (1.35-14.27), p=0.014]. One hundred and five (38.6%) HAV seronegative patients were vaccinated, 21 (20%) of them did not respond, and one (1%) patient lost immunity against HAV. Four (29%) non-responders to vaccination showed incident HAV 5-9 years afterwards. Conclusions: The incidence of HAV infection in a cohort of well-controlled PLWH remains low and stable, with intermittent outbreaks involving mainly non-immunized MSM. A significant proportion of PLWH remain susceptible to HAV infection due to insufficient vaccine uptake and limited response to vaccination. Importantly, patients not responding to HAV vaccination continue at risk of infection.
Language	English
Publishing date	2023-05-23
Publishing country	Spain
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2023.03.007
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Article ; Online: Poor increase on HAV vaccination coverage among people living with HIV after an immunization-based intervention.

Corma-Gómez, Anaïs / Real, Luis M / Fernández-Fuertes, Marta / González-Serna, Alejandro / Oliver, Noemi / Ortega, Jesús / Rincón, Pilar / Rodríguez-Pineda, Elena / Santos, Marta / Trigo-Rodríguez, Marta / Macías, Juan / Pineda, Juan A

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 3, Page(s) 144–148

Abstract: Objectives: To assess HAV serologic and vaccination status among people who live with HIV (PLWH), and to evaluate the impact of a vaccination-based strategy on HAV-negative patients in Seville, Spain.: Methods: Study with two time-overlapping phases: ...

Abstract	Objectives: To assess HAV serologic and vaccination status among people who live with HIV (PLWH), and to evaluate the impact of a vaccination-based strategy on HAV-negative patients in Seville, Spain. Methods: Study with two time-overlapping phases: (i) cross-sectional study of HAV immunity prevalence among PLWH followed at a Spanish hospital between August 2019 and March 2020. (ii) Patients seronegative for HAV, reliably unvaccinated were included in a before-and-after quasi-experimental study, with an intervention focused on HAV vaccination according to national recommendations in force. Results: Six hundred and fifty-six patients were included, of which 111 [17%, 95% confidence interval (95% CI) 14-20%] were seronegative for HAV. Of these, 48 [43% (95% CI, 34-53%)] individuals were MSM. The absence of HAV immunity was attributed in 69 [62% (95% CI, 52-71%)] patients to non-referral to vaccination, followed by lack of achievement of a correct vaccination scheme [n=26; 23% (95% CI, 16-32%)]. After the program implementation, 96 [15% (95% CI, 12-18%)] individuals were seronegative (17% vs. 15%, p=0.256), of whom 42 [41% (95% CI, 32-51%)] were MSM. The absence of immunity after the intervention was mainly attributed to: adherence failure in 23 [24.0% (95% CI, 15.8-33.7%)] patients, on-course immunization scheme in 34 [33% (95% CI, 24-43%)] individuals and pending appointment at the vaccine delivery unit in 20 [20.8% (95% CI, 13.2-30.3%)] patients. Conclusions: A sizeable proportion of PLWH remains susceptible for HAV infection in future outbreaks. A program based on referral to the vaccine delivery unit yields poor results, largely due to program adherence failures. New strategies are needed to increase HAV vaccination coverage.
MeSH term(s)	Humans ; HIV ; Vaccination Coverage ; Cross-Sectional Studies ; HIV Infections ; Immunization
Language	English
Publishing date	2023-03-02
Publishing country	Spain
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.01.006
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Article ; Online: Non-Alcoholic Fatty Liver Disease in HIV Infection.

Macías, Juan / Pineda, Juan A / Real, Luis M

AIDS reviews

2017 Volume 19, Issue 1, Page(s) 35–46

Abstract: Non-alcoholic fatty liver disease is one of the most frequent chronic hepatic conditions worldwide. The spectrum of non-alcoholic fatty liver disease goes from hepatic steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Risk factors ... ...

Abstract	Non-alcoholic fatty liver disease is one of the most frequent chronic hepatic conditions worldwide. The spectrum of non-alcoholic fatty liver disease goes from hepatic steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Risk factors for non-alcoholic fatty liver disease are metabolic, mainly obesity and the accompanying consequences. Treatment and prevention of non-alcoholic fatty liver disease should target those metabolic abnormalities. The frequency of and the factors associated with hepatic steatosis in HIV infection seem to be similar to those reported in the general population, though direct comparisons are lacking. Hepatic steatosis in HIV infection may also be secondary to antiretroviral drugs or HCV-related factors in HCV-coinfected subjects. However, more recent data suggest that hepatic steatosis in HIV infection represents true non-alcoholic fatty liver disease. As such, management of non-alcoholic fatty liver disease in HIV infection should follow the same principles as in the general population.
MeSH term(s)	Coinfection/complications ; Disease Progression ; HIV Infections/complications ; HIV Infections/drug therapy ; Hepatitis C/complications ; Humans ; Liver Cirrhosis/diagnosis ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/therapy
Language	English
Publishing date	2017-01
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	2086783-9
ISSN	1698-6997 ; 1139-6121
ISSN (online)	1698-6997
ISSN	1139-6121
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Zs.A 5711: Show issues

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Article ; Online: Reduced neutralizing antibody response to SARS-CoV-2 vaccine booster dose in people living with HIV with severe immunosuppression.

Corma-Gómez, Anaïs / Fernández-Fuertes, Marta / Viñuela, Laura / Domínguez, Carmen / Santos, Marta / Fuentes-López, Ana / Rojas, Almudena / Fernández-Pérez, Nieves / Martín-Carmona, Jessica / Serrano-Conde, Esther / Real, Luis M / Mendoza, Joaquín / Macías, Juan / Pineda, Juan A / García, Federico

Journal of medical virology

2023 Volume 95, Issue 3, Page(s) e28602

Abstract: The aim of this study was to assess the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines among people living with HIV (PLWH) with severe immunosuppression, after a booster dose. The design was a case-control study ... ...

Abstract	The aim of this study was to assess the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines among people living with HIV (PLWH) with severe immunosuppression, after a booster dose. The design was a case-control study nested in a prospective cohort of PLWH. All patients with CD4 cell count <200 cells/mm
MeSH term(s)	Humans ; COVID-19 Vaccines ; Antibodies, Neutralizing ; Antibody Formation ; Case-Control Studies ; Prospective Studies ; COVID-19/prevention & control ; SARS-CoV-2 ; Immunosuppression Therapy ; RNA, Messenger ; HIV Infections ; Antibodies, Viral
Chemical Substances	COVID-19 Vaccines ; Antibodies, Neutralizing ; RNA, Messenger ; Antibodies, Viral
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28602
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Zs.A 1320: Show issues

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Article: Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic

Fernandez‐Fuertes, Marta / Corma‐Gomez, Anaïs / Torres, Eva / Rodriguez‐Pineda, Elena / Fuentes‐Lopez, Ana / Rincon, Pilar / Fernandez, Nieves / Garcia, Federico / Bernal, Samuel / Real, Luis M. / Macias, Juan / Pineda, Juan A.

Transboundary and emerging diseases. 2022 July, v. 69, no. 4

2022

Abstract: Whether people living with HIV (PLWH) are at greater risk of acquiring SARS‐CoV‐2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we ... ...

Abstract	Whether people living with HIV (PLWH) are at greater risk of acquiring SARS‐CoV‐2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we evaluated the incidence of associated factors with and the clinical outcome of SARS‐CoV‐2 infection in PLWH in Southern Spain. This prospective cohort study included PLWH from a Tertiary University Hospital in Southern Spain. Patients were enrolled in the study if (1) they had attended as outpatients our Unit from 1 August 2019 to 8 February 2020 and (2) had two subsequent evaluations from 9 February 2020 to 4 March 2021. SARS‐CoV‐2 infections were diagnosed by PCR, antigen detection or serology. Seven hundred and nine PLWH were included in the study. Of them, 55 [7.8%, 95% confidence interval (95% CI) 5.9%–9.9%] patients developed SARS‐CoV‐2 infection. Between 18 May and 29 November 2020, the rate of seroconversion was 5.3% (95% CI: 3.1%–9.0%) for the general population in the area of Seville and 2.3% (95% CI: 1.3%–2.6%) for PLWH in this study (p = .001). After multivariable analysis, adjusted by age, sex, and risk factors for HIV infection, active tobacco use and CDC stage, active tobacco smoking was the only factor independently associated with lower risk of SARS‐Cov‐2 infection [Incidence rate ratio: 0.29 (95% CI 0.16–0.55) p < .001]. In conclusion, the incidence of SARS‐CoV‐2 infection among PLWH in Southern Spain during the ongoing pandemic was lower than that reported for the general population in the same area.
Keywords	HIV infections ; Severe acute respiratory syndrome coronavirus 2 ; antigen detection ; cohort studies ; confidence interval ; hospitals ; pandemic ; people ; seroconversion ; serology ; tobacco ; Spain
Language	English
Dates of publication	2022-07
Size	p. e267-e275.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14293
Database	NAL-Catalogue (AGRICOLA)

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Article: The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients.

Alonso-Bellido, Isabel M / Bachiller, Sara / Vázquez, Guillermo / Cruz-Hernández, Luis / Martínez, Emilio / Ruiz-Mateos, Ezequiel / Deierborg, Tomas / Venero, José L / Real, Luis M / Ruiz, Rocío

Frontiers in aging neuroscience

2021 Volume 13, Page(s) 632673

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation.
Language	English
Publishing date	2021-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2021.632673
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Article ; Online: Similar incidence of coronavirus disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxychloroquine therapy.

Macías, Juan / González-Moreno, Paz / Sánchez-García, Esther / Morillo-Verdugo, Ramón / Pérez-Venegas, José J / Pinilla, Ana / Macho, MªMar / Martínez, MªVictoria / González-Serna, Alejandro / Corma, Anaïs / Real, Luis M / Pineda, Juan A

PloS one

2021 Volume 16, Issue 4, Page(s) e0249036

Abstract: Background: Hydroxychloroquine is not efficacious as post-exposure prophylaxis against coronavirus disease 2019 (COVID-19). It is not known whether as pre-exposure prophylaxis it may prevent COVID-19.: Objective: To compare the incidence of COVID-19 ... ...

Abstract	Background: Hydroxychloroquine is not efficacious as post-exposure prophylaxis against coronavirus disease 2019 (COVID-19). It is not known whether as pre-exposure prophylaxis it may prevent COVID-19. Objective: To compare the incidence of COVID-19 in Spanish patients with autoimmune rheumatic diseases treated with and without hydroxychloroquine. Patients and methods: Retrospective electronic record review, from February 27th to June 21st, 2020, of patients with autoimmune inflammatory diseases followed at two academic tertiary care hospitals in Seville, Spain. The cumulative incidence of confirmed COVID-19, by PCR or serology, was compared between patients with and without hydroxychloroquine as part of their treatment of autoimmune inflammatory diseases. Results: Among 722 included patients, 290 (40%) were receiving hydroxychloroquine. During the seventeen-week study period, 10 (3.4% [95% CI: 1.7%-6.7%] cases of COVID-19 were registered among patients with hydroxychloroquine and 13 (3.0% [1.6%-5.1%]) (p = 0.565) in those without hydroxychloroquine. COVID-19 was diagnosed by PCR in four (1.4%, 95% CI 0.38%-3.5%) subject with hydroxychloroquine and six (1.4%, 95% CI 0.5%-3.0%) without hydroxychloroquine (p = 0.697). Three patients on hydroxychloroquine and four patients without hydroxychloroquine were admitted to the hospital, none of them required to be transferred to the intensive care unit and no patient died during the episode. Conclusions: The incidence and severity of COVID-19 among patients with autoimmune rheumatic diseases with and without hydroxychloroquine was not significantly different.
MeSH term(s)	Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Female ; Humans ; Hydroxychloroquine/administration & dosage ; Incidence ; Male ; Middle Aged ; Post-Exposure Prophylaxis ; Pre-Exposure Prophylaxis ; Retrospective Studies ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/epidemiology ; Risk Factors ; SARS-CoV-2 ; Spain/epidemiology
Chemical Substances	Hydroxychloroquine (4QWG6N8QKH)
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0249036
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Article ; Online: Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIV.

Corma-Gómez, Anaïs / Fernández-Fuertes, Marta / García, Estefanía / Fuentes-López, Ana / Gómez-Ayerbe, Cristina / Rivero-Juárez, Antonio / Domínguez, Carmen / Santos, Marta / Viñuela, Laura / Palacios, Rosario / Real, Luis M / Rivero, Antonio / Macías, Juan / Pineda, Juan A / García, Federico

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2022 Volume 28, Issue 11, Page(s) 1492–1498

Abstract: Objectives: The aim of this study was to assess the immunogenicity of SARS-CoV-2 available vaccines among people living with HIV (PLWH) after a complete vaccination scheme, and determine predictors of seroconversion.: Methods: This multicentre ... ...

Abstract	Objectives: The aim of this study was to assess the immunogenicity of SARS-CoV-2 available vaccines among people living with HIV (PLWH) after a complete vaccination scheme, and determine predictors of seroconversion. Methods: This multicentre prospective cohort study included 420 PLWH who had received a standard immunization, either with mRNA or adenoviral-vectored COVID-19 vaccines. Antibody response was evaluated within 1 to 2 months after the last dose of the vaccine with a quantitative determination of antitrimeric spike protein-specific IgG antibodies and IgG neutralizing antibodies. Results: Overall, 384 of 420 PLWH (91%) showed antibody response to vaccination. Seroconversion was observed in 308 of 326 individuals with cluster of differentiation 4 (CD4) counts ≥350 cells/mm Discussion: HIV-related immunosuppression impairs the antibody response to SARS-CoV-2 vaccines. Specific vaccination schemes should be urgently tailored in this setting, particularly in patients with CD4 cell counts <200 cells/μL. Adenoviral-vectored vaccines should be avoided in PLWH whenever possible.
MeSH term(s)	Humans ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; SARS-CoV-2 ; Prospective Studies ; Antibodies, Viral ; COVID-19/prevention & control ; Antibodies, Neutralizing ; Immunoglobulin G ; Immunosuppression Therapy ; Vaccination ; Immunologic Deficiency Syndromes ; HIV Infections ; RNA, Messenger
Chemical Substances	COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; Antibodies, Neutralizing ; Immunoglobulin G ; RNA, Messenger ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-05-28
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2022.05.018
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