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  1. Article ; Online: Left-sided portal hypertension due to retroperitoneal fibrosis treated with an oesophagus preserving, modified Sugiura procedure.

    Di Martino, M / de la Hoz Rodríguez, A / Real Martínez, Y / Martín-Pérez, E

    Annals of the Royal College of Surgeons of England

    2019  Volume 102, Issue 2, Page(s) e48–e50

    Abstract: Left-sided portal hypertension is a very uncommon condition and retroperitoneal fibrosis has rarely been reported as a cause. We present the case of a 77-year-old man with retroperitoneal fibrosis obstructing the splenic vein and causing recurrent ... ...

    Abstract Left-sided portal hypertension is a very uncommon condition and retroperitoneal fibrosis has rarely been reported as a cause. We present the case of a 77-year-old man with retroperitoneal fibrosis obstructing the splenic vein and causing recurrent episodes of upper gastrointestinal bleeding. Computed tomography showed a retroperitoneal mass as being responsible for the obstruction of the splenic vein, splenomegaly, and diffuse varices around the gastrosplenic and gastrohepatic ligaments. An oesophagus preserving, modified Sugiura procedure was performed with disconnection of the gastric vessels on the lesser curve of the stomach, preserving the pylorus branches of the nerves of Latarjet.
    MeSH term(s) Aged ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/surgery ; Esophagus/blood supply ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Humans ; Male ; Organ Sparing Treatments ; Retroperitoneal Fibrosis/complications ; Retroperitoneal Fibrosis/diagnosis ; Retroperitoneal Space/diagnostic imaging ; Splenectomy ; Stomach/blood supply ; Tomography, X-Ray Computed ; Treatment Outcome ; Vascular Surgical Procedures
    Language English
    Publishing date 2019-10-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2019.0138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hospital-based screening outperforms primary care screening as a means of achieving hepatitis C virus micro-elimination.

    Fernández-García, Carlos E / Gallego-Galiana, Juan / Solís-Muñoz, Pablo A / Del Pozo-Maroto, Elvira / Domínguez-Alcón, Lucía / Tobar-Izquierdo, Milagros / Sáez, Alicia / Rodríguez de Cía, Javier / Magaña-Sánchez, Amelia / Real-Martínez, Yolanda / García-Buey, Luisa / González-Moreno, Leticia / Caldas-Álvarez, María / Cardeñoso-Domingo, Laura M / González-Gamarra, Amelia / Salvador-Calvo, Antonio / González-Rodríguez, Águeda / García-Monzón, Carmelo

    Infectious diseases now

    2024  Volume 54, Issue 2, Page(s) 104855

    Abstract: Aim: To assess the respective performances of a HCV screening program in a hospital setting and a HCV screening model applied concomitantly in a primary care centre.: Methods: Adult patients consecutively admitted to hospital for ambulatory surgery ... ...

    Abstract Aim: To assess the respective performances of a HCV screening program in a hospital setting and a HCV screening model applied concomitantly in a primary care centre.
    Methods: Adult patients consecutively admitted to hospital for ambulatory surgery were screened for anti-HCV antibodies (hospital screening cohort, HPSC), as were patients receiving blood tests for medical reasons in a primary care centre (primary care screening cohort, PCSC). Serum anti-HCV and HCV RNA levels were tested by ELISA and real-time PCR, respectively.
    Results: Seroprevalence of HCV infection was 2.2 % in the HPSC and 1.4 % in the PCSC (p = 0.044). All viraemic patients (0.2 % in HPSC and 0.1 % in PCSC) were treated with direct-acting antivirals and 85.7 % experienced a sustained virological response.
    Conclusions: Hospital-based HCV screening outperformed primary care-centered screening, significantly increasing HCV case findings.
    MeSH term(s) Adult ; Humans ; Hepacivirus/genetics ; Antiviral Agents/therapeutic use ; Seroepidemiologic Studies ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hospitals ; Hepatitis C Antibodies/therapeutic use ; Primary Health Care
    Chemical Substances Antiviral Agents ; Hepatitis C Antibodies
    Language English
    Publishing date 2024-02-02
    Publishing country France
    Document type Journal Article
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2024.104855
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  3. Article: Hepatitis aguda y minociclina.

    Real Martínez, Y / Medina, S

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2003  Volume 95, Issue 10, Page(s) 741–742

    Title translation Acute hepatitis and minocycline.
    MeSH term(s) Acne Vulgaris/drug therapy ; Adolescent ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/therapy ; Humans ; Male ; Minocycline/administration & dosage ; Minocycline/adverse effects ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Minocycline (FYY3R43WGO)
    Language Spanish
    Publishing date 2003-10
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Megarrecto y anismo: causa de estreñimiento.

    Real Martínez, Y / Ibáñez Moya, M / Pérez Mota, A

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2007  Volume 99, Issue 6, Page(s) 352–353

    Title translation Megarectum and anismus: a cause of constipation.
    MeSH term(s) Adolescent ; Anal Canal/physiopathology ; Biofeedback, Psychology ; Cathartics/therapeutic use ; Chronic Disease ; Combined Modality Therapy ; Constipation/drug therapy ; Constipation/etiology ; Constipation/therapy ; Gastrointestinal Motility ; Humans ; Male ; Megacolon/complications ; Rectal Diseases/complications ; Rectal Diseases/physiopathology ; Reflex, Abnormal
    Chemical Substances Cathartics
    Language Spanish
    Publishing date 2007-09-14
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.4321/s1130-01082007000600009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Endoscopic extraction of a pig-tail catheter after urological surgery with Mainz II pouch urinary diversion.

    Lozano Maya, M / Campos Cantero, R / Plaza Santos, R / Alberdi Alonso, J M / Real Martínez, Y / Aldeguer Martínez, M

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2011  Volume 103, Issue 6, Page(s) 333–334

    MeSH term(s) Carcinoma, Transitional Cell/surgery ; Catheters/adverse effects ; Colon, Sigmoid/surgery ; Colonoscopy ; Cystectomy ; Device Removal/methods ; Emergencies ; Female ; Foreign-Body Migration/diagnostic imaging ; Foreign-Body Migration/etiology ; Foreign-Body Migration/surgery ; Humans ; Middle Aged ; Peritoneal Cavity ; Peritonitis/etiology ; Tomography, X-Ray Computed ; Ureter/surgery ; Urinary Bladder Neoplasms/surgery ; Urinary Diversion/instrumentation
    Language English
    Publishing date 2011-07-06
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.4321/s1130-01082011000600011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Reproducibility of ambulatory cutaneous electrogastrography in healthy volunteers.

    Real Martínez, Y / Ruiz de León, A / Díaz-Rubio, M

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2001  Volume 93, Issue 2, Page(s) 87–95

    Abstract: Objective: Cutaneous electrogastrography (cEGG) is a technique used for recording gastric electrical activity through electrodes placed on the abdominal skin. Given its increasing use for different pathologies, we decided to study its reliability (or ... ...

    Abstract Objective: Cutaneous electrogastrography (cEGG) is a technique used for recording gastric electrical activity through electrodes placed on the abdominal skin. Given its increasing use for different pathologies, we decided to study its reliability (or reproducibility), that had never been appropriately assessed before.
    Methods: Ambulatory cutaneous electrogastrogram was recorded after US location of the gastric antrum in 26 healthy volunteers with ages ranging from 20 to 60 years. cEGG was recorded during 60 minutes in fasting state and 60 minutes after a standard meal and it was repeated in a different day but under the same conditions.
    Results: ANOVA analysis showed significant individual differences regarding dominant frequency (DF) (p = 0.19) and power ratio (PR) (p = 0.11), and before and after the meal, except for DF (p = 0.12), dominant power (DP) (p = 0.59) and bradygastria (p = 0.09). No significant differences were found related to the day of the recording. The intra-observer agreement index showed a good agreement in the DF and the percentage of normogastria (0.91).
    Conclusions: Currently, DF and normogastria percentage are the most reliable variables for the non-invasive study of gastric electric activity.
    MeSH term(s) Adult ; Electrodiagnosis ; Electrophysiology ; Female ; Humans ; Male ; Monitoring, Ambulatory ; Reproducibility of Results ; Skin Physiological Phenomena ; Stomach/physiology
    Language Spanish
    Publishing date 2001-02
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
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  7. Article: Megacolon tóxico.

    Real Martínez, Y / Rey Díaz-Rubio, E / Díaz-Rubio, M

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    1997  Volume 89, Issue 3, Page(s) 206–211

    Title translation Toxic megacolon.
    MeSH term(s) Humans ; Megacolon, Toxic/etiology ; Megacolon, Toxic/therapy ; Prognosis
    Language Spanish
    Publishing date 1997-03
    Publishing country Spain
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
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  8. Article ; Online: Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C.

    Hernández-Bartolomé, Ángel / López-Rodríguez, Rosario / Borque, María Jesús / González-Moreno, Leticia / Real-Martínez, Yolanda / García-Buey, Luisa / Moreno-Otero, Ricardo / Sanz-Cameno, Paloma

    World journal of gastroenterology

    2016  Volume 22, Issue 44, Page(s) 9744–9751

    Abstract: Aim: To evaluate the efficacy of peripheral blood concentrations of angiopoietins (Ang) as cirrhosis biomarkers of chronic hepatitis C (CHC).: Methods: Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays (ELISA) in samples ... ...

    Abstract Aim: To evaluate the efficacy of peripheral blood concentrations of angiopoietins (Ang) as cirrhosis biomarkers of chronic hepatitis C (CHC).
    Methods: Ang1 and Ang2 serum levels were measured by enzyme-linked immunosorbent assays (ELISA) in samples from 179 cirrhotic and non-cirrhotic CHC patients, classified according to the METAVIR system. Groups were compared by non-parametric Mann-Whitney
    Results: Peripheral blood concentrations of Ang1 and Ang2 in CHC patients were significantly related to fibrosis. While Ang1 was decreased in cirrhotic subjects compared to non-cirrhotic (
    Conclusion: Ang2/Ang1 ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.
    MeSH term(s) Adult ; Aged ; Angiopoietin-1/blood ; Angiopoietin-2/blood ; Area Under Curve ; Biomarkers/blood ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/diagnosis ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Predictive Value of Tests ; ROC Curve ; Reproducibility of Results ; Severity of Illness Index ; Young Adult
    Chemical Substances ANGPT1 protein, human ; ANGPT2 protein, human ; Angiopoietin-1 ; Angiopoietin-2 ; Biomarkers
    Language English
    Publishing date 2016-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v22.i44.9744
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  9. Article: Normal values and influence of anthropometric and demographic factors on ambulatory cutaneous electrogastrography in healthy volunteers.

    Real Martínez, Y / Ruiz de León San Juan, A / Díaz-Rubio, M

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2001  Volume 93, Issue 1, Page(s) 29–38

    Abstract: Introduction: Cutaneous Electrogastrography (EGGc) is a technique used for recording the Gastric Electrical Activity by means of electrodes placed on the abdominal skin. The aim of the present study was to determine normal values in healthy volunteers ... ...

    Abstract Introduction: Cutaneous Electrogastrography (EGGc) is a technique used for recording the Gastric Electrical Activity by means of electrodes placed on the abdominal skin. The aim of the present study was to determine normal values in healthy volunteers as well as the influence of factors such as age, gender, Body Mass Index (BMI) and echographic location of the gastric antrum.
    Methods: An abdominal echography was initially performed in 35 of the 44 healthy volunteers in order to locate the gastric antrum and to place along its axis the skin electrodes, whereas in the other 9, the electrodes were placed according to anatomical references. Afterwards, the echography was also performed in those 9 volunteers in order to have all the 44 baseline echographic records. In every case, a record of ambulatory EGGc over 60 minutes was obtained, along with other record over the same period after eating a standard meal. The analysis of data was conducted through visual inspection and combined computer analysis.
    Results: Eighty per cent of the study subjects showed a dominant frequency ranging from 2 to 4 cpm during both periods. After the meal, the parameters showed a characteristic variation. A significant difference was found when comparing subjects under 40 years of age versus subjects between 40 and 60 years of age in terms of preprandial dominant frequency instability coefficient (DFIC) (p = 0.002) and bradygastria (p = 0.03). Subjects with BMI < 25 kg/m2 showed preprandially a smaller dominant power instability coefficient (DPIC) (p = 0.035) and a greater Dominant Power (DP) (p = 0.045). In subjects without echographic control, DFIC (p = 0.001), bradygastria (p = 0.016) and tachygastria (p = 0.02) were more frequent, with a shorter period of normogastria (p = 0.001) during the postprandial period.
    Conclusions: Normogastria is the predominant rhythm in healthy people, although brief dysarrhythmias can be recorded that do not have any pathological meaning. Age and BMI, but not sex, seem to influence the Gastric Electrical Activity. The percentage of gastric dysarrhythmias decreases when the electrodes are placed along the longitudinal axis of the gastric antrum through echographic control.
    MeSH term(s) Adult ; Anthropometry ; Demography ; Electrophysiology ; Female ; Humans ; Male ; Middle Aged ; Monitoring, Ambulatory ; Reference Values ; Stomach/physiology
    Language Spanish
    Publishing date 2001-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
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  10. Article ; Online: Intrahepatic angiopoietin-2 correlates with chronic hepatitis C progression and is induced in hepatitis C virus replicon systems.

    Hernández-Bartolomé, Ángel / López-Rodríguez, Rosario / García-Buey, Luisa / Martín-Vílchez, Samuel / Rodríguez-Muñoz, Yolanda / Borque, María Jesús / González-Moreno, Leticia / Real-Martínez, Yolanda / Mendoza-Ridruejo, Jorge / Martín-Pérez, Elena / Moreno-Otero, Ricardo / Sanz-Cameno, Paloma

    Liver international : official journal of the International Association for the Study of the Liver

    2017  Volume 37, Issue 8, Page(s) 1148–1156

    Abstract: Background & aims: Chronic hepatitis C (CHC) is a major cause of cirrhosis and hepatocellular carcinoma and angiogenesis is closely related to the pathogenesis and progression of different chronic liver diseases (CLD). Thus, the intrahepatic expression ... ...

    Abstract Background & aims: Chronic hepatitis C (CHC) is a major cause of cirrhosis and hepatocellular carcinoma and angiogenesis is closely related to the pathogenesis and progression of different chronic liver diseases (CLD). Thus, the intrahepatic expression of angiopoietins 1 and 2 (Ang1 and Ang2), as relevant mediators of pathological angiogenesis in several CLD, was investigated. In addition, the differential influence of structural and non-structural genomic regions of HCV on the expression of angiopoietins and the possible signalling involved were studied.
    Methods: Ang1 and Ang2 expression was evaluated by western blotting and enzyme-linked immunosorbent assay (ELISA) in liver homogenates of CHC patients (n=47) and uninfected subjects (n=8). Their association with disease progression (according to METAVIR classification) was assessed by Spearman's correlation. Statistical differences among the expression of angiopoietins at different CHC stages were calculated by Mann-Whitney U-test. Finally, the in vitro expression of Angiopoietins in HCV replicons (complete or non-structural subgenomic) and the main signalling pathways involved were also examined.
    Results: Ang2 levels were significantly higher in the liver of CHC patients compared to controls and significantly correlated with inflammation and fibrosis. Accordingly, an increased expression of Ang2 was found in all HCV replicons tested. Interestingly, the inhibition of MEK and PI3K signalling pathways exerted differential effects on Ang2 expression concerning to the genomic region of HCV.
    Conclusions: Hepatitis C virus induces Ang2 expression in hepatocytes through different signalling routes which may lead to the disregulation of vascular homeostasis in the liver. Thus, pharmacologic intervention on Ang2 signalling might constitute an important therapeutic tool.
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13352
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