LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Rebecca A Butcher"
  2. AU="Kimberlyn Roosa"
  3. AU=Chian Ri-Cheng
  4. AU="Alzalzalah, Sayed"
  5. AU=Kaufman Jonathan J
  6. AU="Kim, Jin K"
  7. AU="Zevakov, S A"
  8. AU="Sui Phang"
  9. AU="Kolomeichuk, Lilia V"
  10. AU="Sabuj Kanti Mistry"
  11. AU="Basurto-Lozada, Daniela"
  12. AU="Takashima, Shin-Ichiro"
  13. AU="Teresinha Leal"
  14. AU="Angélique B van 't Wout"
  15. AU="Roberts, Nicholas J"
  16. AU="Chauhan, Gaurav B"
  17. AU=Hanjaya-Putra Donny
  18. AU=Powell James
  19. AU="Russell, Todd"
  20. AU=Forth Scott
  21. AU="Kreutzer, Susanne" AU="Kreutzer, Susanne"
  22. AU="St John, Maie"
  23. AU=Gerhardy A
  24. AU="Qi, Huixin"
  25. AU="Dobosiewicz, May"
  26. AU="Srivastava, Rakesh"
  27. AU="Grevtsov K.I."

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan

    Likui Feng / Matthew T. Gordon / Ying Liu / Kari B. Basso / Rebecca A. Butcher

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans. Here, the authors map the biosynthetic roles of individual megasynthetase domains and ... ...

    Abstract The only known animal polyketide-nonribosomal peptides, the nemamides, are biosynthesized by two megasynthetases in the canal-associated neurons (CANs) of C. elegans. Here, the authors map the biosynthetic roles of individual megasynthetase domains and identify additional enzymes in the CANs required for nemamide biosynthesis.
    Keywords Science ; Q
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans

    Yue Zhou / Yuting Wang / Xinxing Zhang / Subhradeep Bhar / Rachel A Jones Lipinski / Jungsoo Han / Likui Feng / Rebecca A Butcher

    eLife, Vol

    2018  Volume 7

    Abstract: Caenorhabditis elegans produces ascaroside pheromones to control its development and behavior. Even minor structural differences in the ascarosides have dramatic consequences for their biological activities. Here, we identify a mechanism that enables C. ... ...

    Abstract Caenorhabditis elegans produces ascaroside pheromones to control its development and behavior. Even minor structural differences in the ascarosides have dramatic consequences for their biological activities. Here, we identify a mechanism that enables C. elegans to dynamically tailor the fatty-acid side chains of the indole-3-carbonyl (IC)-modified ascarosides it has produced. In response to starvation, C. elegans uses the peroxisomal acyl-CoA synthetase ACS-7 to activate the side chains of medium-chain IC-ascarosides for β-oxidation involving the acyl-CoA oxidases ACOX-1.1 and ACOX-3. This pathway rapidly converts a favorable ascaroside pheromone that induces aggregation to an unfavorable one that induces the stress-resistant dauer larval stage. Thus, the pathway allows the worm to respond to changing environmental conditions and alter its chemical message without having to synthesize new ascarosides de novo. We establish a new model for biosynthesis of the IC-ascarosides in which side-chain β-oxidation is critical for controlling the type of IC-ascarosides produced.
    Keywords ascarosides ; dauer pheromone ; beta-oxidation ; acyl-CoA synthetase ; acyl-CoA oxidase ; peroxisome ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior

    Joshua S Greene / May Dobosiewicz / Rebecca A Butcher / Patrick T McGrath / Cornelia I Bargmann

    eLife, Vol

    2016  Volume 5

    Abstract: Natural isolates of C. elegans differ in their sensitivity to pheromones that inhibit exploratory behavior. Previous studies identified a QTL for pheromone sensitivity that includes alternative alleles of srx-43, a chemoreceptor that inhibits exploration ...

    Abstract Natural isolates of C. elegans differ in their sensitivity to pheromones that inhibit exploratory behavior. Previous studies identified a QTL for pheromone sensitivity that includes alternative alleles of srx-43, a chemoreceptor that inhibits exploration through its activity in ASI sensory neurons. Here we show that the QTL is multigenic and includes alternative alleles of srx-44, a second chemoreceptor gene that modifies pheromone sensitivity. srx-44 either promotes or inhibits exploration depending on its expression in the ASJ or ADL sensory neurons, respectively. Naturally occurring pheromone insensitivity results in part from previously described changes in srx-43 expression levels, and in part from increased srx-44 expression in ASJ, which antagonizes ASI and ADL. Antagonism between the sensory neurons results in cellular epistasis that is reflected in their transcription of insulin genes that regulate exploration. These results and genome-wide evidence suggest that chemoreceptor genes may be preferred sites of adaptive variation in C. elegans.
    Keywords pheromone receptor ; QTL analysis ; supergene ; insulin signaling ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Interspecific communication between pinewood nematode, its insect vector, and associated microbes

    Zhao, Lilin / Jianghua Sun / Manuel Mota / Paulo Vieira / Rebecca A. Butcher

    Trends in parasitology. 2014 June, v. 30, no. 6

    2014  

    Abstract: Pine wilt disease (PWD) is perhaps the most serious threat to pine forests worldwide. The causative agent of PWD, the pinewood nematode (PWN), engages in a symbiotic partnership with its insect vector, the Monochamus beetle, as well as associated ... ...

    Abstract Pine wilt disease (PWD) is perhaps the most serious threat to pine forests worldwide. The causative agent of PWD, the pinewood nematode (PWN), engages in a symbiotic partnership with its insect vector, the Monochamus beetle, as well as associated bacteria and ophiostomatoid fungi, in order to successfully infect and kill its host pine tree. This review focuses on the interspecific communication between PWN and its associated partners, and the potential role of this communication in promoting pathogenicity and invasiveness of PWN. We describe the chemical and molecular signals positively influencing the survival, reproduction, and spread of PWN. Knowledge of these signals could potentially be used to interfere with the proliferation and dispersal of PWN.
    Keywords bacteria ; Bursaphelenchus xylophilus ; coniferous forests ; fungi ; insect vectors ; Monochamus ; pathogenicity ; Pinus ; reproduction ; vascular wilt
    Language English
    Dates of publication 2014-06
    Size p. 299-308.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2014.04.007
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: A sexually conditioned switch of chemosensory behavior in C. elegans.

    Naoko Sakai / Ryo Iwata / Saori Yokoi / Rebecca A Butcher / Jon Clardy / Masahiro Tomioka / Yuichi Iino

    PLoS ONE, Vol 8, Iss 7, p e

    2013  Volume 68676

    Abstract: In sexually reproducing animals, mating is essential for transmitting genetic information to the next generation and therefore animals have evolved mechanisms for optimizing the chance of successful mate location. In the soil nematode C. elegans, males ... ...

    Abstract In sexually reproducing animals, mating is essential for transmitting genetic information to the next generation and therefore animals have evolved mechanisms for optimizing the chance of successful mate location. In the soil nematode C. elegans, males approach hermaphrodites via the ascaroside pheromones, recognize hermaphrodites when their tails contact the hermaphrodites' body, and eventually mate with them. These processes are mediated by sensory signals specialized for sexual communication, but other mechanisms may also be used to optimize mate location. Here we describe associative learning whereby males use sodium chloride as a cue for hermaphrodite location. Both males and hermaphrodites normally avoid sodium chloride after associative conditioning with salt and starvation. However, we found that males become attracted to sodium chloride after conditioning with salt and starvation if hermaphrodites are present during conditioning. For this conditioning, which we call sexual conditioning, hermaphrodites are detected by males through pheromonal signaling and additional cue(s). Sex transformation experiments suggest that neuronal sex of males is essential for sexual conditioning. Altogether, these results suggest that C. elegans males integrate environmental, internal and social signals to determine the optimal strategy for mate location.
    Keywords Medicine ; R ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans

    Scott J. Neal / JiSoo Park / Danielle DiTirro / Jason Yoon / Mayumi Shibuya / Woochan Choi / Frank C. Schroeder / Rebecca A. Butcher / Kyuhyung Kim / Piali Sengupta

    G3 : Genes, Genomes, Genetics, Vol 6, Iss 5, Pp 1475-

    2016  Volume 1487

    Abstract: Animals must constantly assess their surroundings and integrate sensory cues to make appropriate behavioral and developmental decisions. Pheromones produced by conspecific individuals provide critical information regarding environmental conditions. ... ...

    Abstract Animals must constantly assess their surroundings and integrate sensory cues to make appropriate behavioral and developmental decisions. Pheromones produced by conspecific individuals provide critical information regarding environmental conditions. Ascaroside pheromone concentration and composition are instructive in the decision of Caenorhabditis elegans to either develop into a reproductive adult or enter into the stress-resistant alternate dauer developmental stage. Pheromones are sensed by a small set of sensory neurons, and integrated with additional environmental cues, to regulate neuroendocrine signaling and dauer formation. To identify molecules required for pheromone-induced dauer formation, we performed an unbiased forward genetic screen and identified phd (pheromone response-defective dauer) mutants. Here, we describe new roles in dauer formation for previously identified neuronal molecules such as the WD40 domain protein QUI-1 and MACO-1 Macoilin, report new roles for nociceptive neurons in modulating pheromone-induced dauer formation, and identify tau tubulin kinases as new genes involved in dauer formation. Thus, phd mutants define loci required for the detection, transmission, or integration of pheromone signals in the regulation of dauer formation.
    Keywords C. elegans ; dauer ; pheromone ; che-12 ; maco-1 ; qui-1 ; ttbk ; Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2016-05-01T00:00:00Z
    Publisher Genetics Society of America
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Ascarosides coordinate the dispersal of a plant-parasitic nematode with the metamorphosis of its vector beetle

    Lilin Zhao / Xinxing Zhang / Yanan Wei / Jiao Zhou / Wei Zhang / Peijun Qin / Satya Chinta / Xiangbo Kong / Yunpeng Liu / Haiying Yu / Songnian Hu / Zhen Zou / Rebecca A. Butcher / Jianghua Sun

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Volume 8

    Abstract: Many species of nematodes use pheromones called ascarosides to coordinate their behaviour and development. Here, Zhao et al. demonstrate that the beetle vector of the pinewood nematode (Bursaphelenchus xylophilus) also uses and responds to ascarosides in ...

    Abstract Many species of nematodes use pheromones called ascarosides to coordinate their behaviour and development. Here, Zhao et al. demonstrate that the beetle vector of the pinewood nematode (Bursaphelenchus xylophilus) also uses and responds to ascarosides in its interactions with the nematodes.
    Keywords Science ; Q
    Language English
    Publishing date 2016-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Correction

    Scott J Neal / Asuka Takeishi / Michael P O'Donnell / JiSoo Park / Myeongjin Hong / Rebecca A Butcher / Kyuhyung Kim / Piali Sengupta

    eLife, Vol

    Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    2015  Volume 4

    Keywords Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2015-09-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

    Scott J Neal / Asuka Takeishi / Michael P O'Donnell / JiSoo Park / Myeongjin Hong / Rebecca A Butcher / Kyuhyung Kim / Piali Sengupta

    eLife, Vol

    2015  Volume 4

    Abstract: Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae to enter into the reproductive cycle or the dauer stage. In this study, we show ... ...

    Abstract Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae to enter into the reproductive cycle or the dauer stage. In this study, we show that CMK-1 CaMKI regulates the dauer decision as a function of feeding state. CMK-1 acts cell-autonomously in the ASI, and non cell-autonomously in the AWC, sensory neurons to regulate expression of the growth promoting daf-7 TGF-β and daf-28 insulin-like peptide (ILP) genes, respectively. Feeding state regulates dynamic subcellular localization of CMK-1, and CMK-1-dependent expression of anti-dauer ILP genes, in AWC. A food-regulated balance between anti-dauer ILP signals from AWC and pro-dauer signals regulates neuroendocrine signaling and dauer entry; disruption of this balance in cmk-1 mutants drives inappropriate dauer formation under well-fed conditions. These results identify mechanisms by which nutrient information is integrated in a small neuronal network to modulate neuroendocrine signaling and developmental plasticity.
    Keywords caMKI ; neuroendocrine ; dauer ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2015-09-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top