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  1. Article ; Online: Correlation between diabetic nephropathy and diabetic retinopathy as a long term complications of diabetes mellitus

    Dervišević Muamer / Rebić Damir / Dervišević Emina

    Acta Marisiensis - Seria Medica, Vol 69, Iss 3, Pp 176-

    2023  Volume 181

    Abstract: Background/aim: Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by a lack of insulin, with a consequent disordered metabolism of glucose, fats, and proteins. A number of complications, such as diabetic nephropathy and ... ...

    Abstract Background/aim: Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by a lack of insulin, with a consequent disordered metabolism of glucose, fats, and proteins. A number of complications, such as diabetic nephropathy and retinopathy, may develop as a result of long-term diabetes. The aim of this study aimed to determine the correlation between diabetic nephropathy and diabetic retinopathy as long-term complications of diabetes mellitus.
    Keywords diabetes mellitus ; microvascular ; retinopathy ; diabetic nephropathy ; Medicine ; R
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Acute Kidney Injury Classifications in the Prediction of In-hospital Mortality and Renal Function Non-recovery.

    Hamzic-Mehmedbasic, Aida / Mackic, Melina / Rebic, Damir / Spahovic, Hajrudin / Arnautovic-Halimic, Ajla / Jakirlic, Nadina

    Materia socio-medica

    2023  Volume 35, Issue 4, Page(s) 304–308

    Abstract: Background: In the last two decades diagnostic criteria for acute kidney injury (AKI) were developed: Risk, Injury, Failure, Loss of Kidney Function, End-Stage Kidney Disease (RIFLE), Acute Kidney Injury Network (AKIN), and Kidney Disease: Improving ... ...

    Abstract Background: In the last two decades diagnostic criteria for acute kidney injury (AKI) were developed: Risk, Injury, Failure, Loss of Kidney Function, End-Stage Kidney Disease (RIFLE), Acute Kidney Injury Network (AKIN), and Kidney Disease: Improving Global Outcomes (KDIGO) classifications.
    Objective: The study aimed to determine the incidence of AKI based on the RIFLE, AKIN, and KDIGO criteria, as well as analyze their predictive value for mortality and renal function outcome.
    Methods: This was a single-center prospective study of patients diagnosed with AKI. Acute kidney injury was defined and classified according to the RIFLE, AKIN, and KDIGO criteria. The outcomes were renal function outcome and in-hospital mortality.
    Results: The incidence rates of AKI based on the RIFLE, AKIN, and KDIGO criteria were 13.4%, 14-36%, and 14.64%, respectively. Multiple regression analysis showed that higher stages of AKI according to the KDIGO criteria were independently associated with non-recovery of renal function (p=0.011). However, the predictive ability of RIFLE, AKIN and KDIGO classifications for renal function recovery was poor (Area Under the Receiver Operating Characteristics-AUROC=0.599, AUROC=0.637, AUROC=0.659, respectively). According to the RIFLE and AKIN criteria, in-hospital mortality was statistically significantly higher in stage Failure/3 (p=0.0403 and p=0.0329, respectively) compared to stages Risk/1 and Injury/2. Receiver Operating Characteristics (ROC) analysis showed that all three classifications had poor predictive ability for in-hospital mortality (AUROC=0.675, AUROC=0.66, AUROC=0.681).
    Conclusions: KDIGO classification is an independent predictor of renal function non-recovery. However, by ROC analysis, all three classifications have poor predictive ability for renal function outcome and mortality.
    Language English
    Publishing date 2023-10-11
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 1512-7680
    ISSN 1512-7680
    DOI 10.5455/msm.2023.35.304-308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lipid status and carotid intima-media thickness in patients with end-stage renal disease.

    Rebić, Damir / Begić, Edin / Šljivo, Armin / Granov, Nermir / Hasanspahić, Senad / Džubur, Alen / Durak-Nalbantić, Azra

    Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

    2023  Volume 20, Issue 2

    Abstract: Aim To assess morphological characteristics of carotid blood vessels in uremic patients before to the initiation of the dialysis treatment, and corelate data with various dialysis therapy modules. Methods The study included 30 patients with end-stage ... ...

    Abstract Aim To assess morphological characteristics of carotid blood vessels in uremic patients before to the initiation of the dialysis treatment, and corelate data with various dialysis therapy modules. Methods The study included 30 patients with end-stage renal disease (ERDS) prior to commencing dialysis, 30 patients treated with haemodialysis and 30 patients treated with continuous ambulatory peritoneal dialysis. The control group consisted of 15 subjects with normal kidney function (eGFR>60ml/min). Carotid intima-media thickness (CIMT), as well as lipid status values (cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), apolipoprotein A, apolipoprotein B) were evaluated. Results The significant difference in CIMT was detected between the control and haemodialysis groups (p<0.001), and between the control and the peritoneal dialysis group (p=0.004). In patients in the predialysis group, CIMT was influenced by cholesterol (p=0.013), HDL (p=0.044), LDL (p=0.001) and ApoB (p=0.042) values. A significant difference in CIMT was proved between the haemodialysis and predialysis group of patients (p<0.001). The only variable from the patient's lipometabolic profile significantly associated with the change in IMT in uremic patients was HDL. A significant difference was found in the average value for systolic blood pressure (p<0.001) and diastolic blood pressure (p=0.018) in patients before starting the dialysis treatment compared to patients treated with other dialysis methods. Conclusion Patients on haemodialysis treatment had a significantly greater CIMT, which is in relation with a higher cardiovascular risk.
    Language English
    Publishing date 2023-08-01
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 2378942-6
    ISSN 1840-2445 ; 1840-2445
    ISSN (online) 1840-2445
    ISSN 1840-2445
    DOI 10.17392/1570-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Role of Dyslipidemia in Atherogenesis in Peritoneal Dialysis Patients.

    Rebić, Damir / Begić, Edin / Aziri, Buena / Džubur, Alen / Gogić, Ena / Durak-Nalbantić, Azra / Hamzić-Mehmedbašić, Aida / Hasanspahić, Senad / Granov, Nermir

    Advanced biomedical research

    2023  Volume 12, Page(s) 135

    Abstract: Background: To evaluate atherosclerotic changes in carotid arteries (CCA) in uremic patients before and after 18 months of continuous ambulatory peritoneal dialysis (CAPD) treatment, and to evaluate the impact of dyslipidemia and CAPD treatment on ... ...

    Abstract Background: To evaluate atherosclerotic changes in carotid arteries (CCA) in uremic patients before and after 18 months of continuous ambulatory peritoneal dialysis (CAPD) treatment, and to evaluate the impact of dyslipidemia and CAPD treatment on vascular remodeling.
    Materials and methods: We conducted a longitudinal, prospective study during 2020 and 2021 at the Clinic for Nephrology, Clinical Center University of Sarajevo. Patients with end-stage renal disease were included and were followed during 18 months of CAPD treatment. All patients were treated using commercially prepared biocompatible balanced dialysis solutions. Carotid intima-media thickness (IMT) and atherosclerotic plaques on the common carotid artery (CCA) were measured by echotomography.
    Results: A total of 50 patients were included and were followed during 18 months of CAPD treatment. Lipid values in the serum of patients with CAPD were significantly lower after 18 months of CAPD treatment compared to the values before treatment, while the value of high-density lipoprotein (HDL) was significantly increased after 18 months of CAPD treatment. The values of IMT and the diameter of the CCA compared to the basal values were significantly lower (
    Conclusion: We demonstrated significantly lower lipid values and higher HDL levels following CAPD treatment. Correct selection of the targeted pharmacological intervention can substantially impact the regression of vascular changes in patients on peritoneal dialysis.
    Language English
    Publishing date 2023-05-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 2672524-1
    ISSN 2277-9175
    ISSN 2277-9175
    DOI 10.4103/abr.abr_1_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assessment of Retinal Microangiopathy in Chronic Kidney Disease Patients.

    Kasumovic, Aida / Matoc, Ines / Rebic, Damir / Avdagic, Nesina / Halimic, Tarik

    Medical archives (Sarajevo, Bosnia and Herzegovina)

    2020  Volume 74, Issue 3, Page(s) 191–194

    Abstract: Introduction: Optical coherence tomography angiography (OCT-A) is a useful diagnostic tool for assessing eyes' health in patients with chronic diseases, such as diabetes, hypertension, Parkinson's disease and chronic kidney disease (CKD).: Aim: To ... ...

    Abstract Introduction: Optical coherence tomography angiography (OCT-A) is a useful diagnostic tool for assessing eyes' health in patients with chronic diseases, such as diabetes, hypertension, Parkinson's disease and chronic kidney disease (CKD).
    Aim: To detect changes in macular structure and retinal vascular meshwork in the macular area and peripapillary in patients with chronic kidney disease (CKD).
    Methods: This cross-sectional study included 80 eyes of patients with CKD in stages 2, 3 or 4, who were followed-up in the Nephrology Clinic of University Clinical Center Sarajevo. All patients were categorized according to the stage of CKD. All patients were scanned by a high-speed 840-nm-wavelength spectral-domain optical coherence tomography instrument (RTVue XR Avanti; Optovue, Inc, Fremont, California, USA). Blood flow was detected using a split-spectrum amplitude-decorrelation angiography algorithm. A fully automated microstructural analysis of the foveal avascular zone (FAZ), FAZ perimeter, foveal vessel density in a 300-μm area around the FAZ (FD), nonflow area, flow index in superficial and deep vascular plexus, choriocapillary flow, vascular density, radial peripapillary capillary density was performed.
    Results: When comparing patients with CKD stage 2 and stage 3 there were no statistically significant changes in microvascular parameters on OCT angiography, as well as when comparing patients with CKD stage 3 and stage 4. But in the comparison between patients with less developed CKD (stage 2) and terminal CKD (stage 4) there was a significant difference between some microvascular parameters such as FAZ area, FAZ perimeter, choriocapillary flow.
    Conclusion: Many studies demonstrated that evaluation of the microvascular changes in different retinal layers using SS-OCTA may be considered as a key to assessing the systemic perfusion status. Evaluation of retinal microvasculature may ease the management and approach of patients with CKD, having in mind that the retinal and the kidney vascular network are, concerning structure, development and the function, very similar.
    MeSH term(s) Aged ; Aged, 80 and over ; Angiography ; Cross-Sectional Studies ; Female ; Fovea Centralis/blood supply ; Fovea Centralis/diagnostic imaging ; Humans ; Male ; Microcirculation ; Microvessels/diagnostic imaging ; Microvessels/physiopathology ; Middle Aged ; Regional Blood Flow ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/physiopathology ; Retinal Diseases/complications ; Retinal Diseases/diagnostic imaging ; Retinal Vessels/diagnostic imaging ; Retinal Vessels/physiopathology ; Tomography, Optical Coherence
    Language English
    Publishing date 2020-08-14
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 128782-5
    ISSN 1986-5961 ; 0025-8083 ; 0350-199X
    ISSN (online) 1986-5961
    ISSN 0025-8083 ; 0350-199X
    DOI 10.5455/medarh.2020.74.191-194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Serum malondialdehyde (MDA) level as a potential biomarker of cancer progression for patients with bladder cancer

    Lepara Zahid / Lepara Orhan / Fajkić Almir / Rebić Damir / Alić Jasmin / Spahović Hajrudin

    Romanian Journal of Internal Medicine, Vol 58, Iss 3, Pp 146-

    2020  Volume 152

    Abstract: Introduction. Bladder cancer is the most common malignancy involving the urinary system. Recent research tends to emphasize the role of oxidative stress products in the carcinogenesis of bladder cancer. The level of oxidative stress can be measured by ... ...

    Abstract Introduction. Bladder cancer is the most common malignancy involving the urinary system. Recent research tends to emphasize the role of oxidative stress products in the carcinogenesis of bladder cancer. The level of oxidative stress can be measured by assessing the MDA levels. This study aimed to evaluate serum MDA levels in patients with bladder cancer, as well as to determine its potential role as a biomarker in the diagnosis of the disease and progression risk considerations.
    Keywords bladder cancer ; biomarker ; oxidative stress ; cancer progression ; malondialdehyde ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Serum Creatinine versus Corrected Cockcroft-Gault Equation According to Poggio Reference Values in Patients with Arterial Hypertension.

    Šečić, Damir / Turohan, Adnan / Begić, Edin / Rebić, Damir / Pepić, Esad / Begić, Zijo / Iglica, Amer / Begić, Nedim / Metović, Azra / Mušanović, Jasmin

    International journal of applied & basic medical research

    2022  Volume 12, Issue 1, Page(s) 9–13

    Abstract: Introduction: Serum creatinine is not enough sensitive marker for the evaluation of glomerular filtration rate (GFR). Cockcroft-Gault (CG) formula is often used to assess GFR, but it is necessary to correct original one for body surface area (BSA), ... ...

    Abstract Introduction: Serum creatinine is not enough sensitive marker for the evaluation of glomerular filtration rate (GFR). Cockcroft-Gault (CG) formula is often used to assess GFR, but it is necessary to correct original one for body surface area (BSA), adipositas, and the creatinine tubular secretion. The values of the estimated creatinine clearance and GFR are considered to Poggio reference ones according to biological parameters (age and gender). The aim of the study was to determine the difference in renal function estimation between serum creatinine and corrected CG equation according to the Poggio reference values in the arterial hypertension patients.
    Materials and methods: The research included 124 patients of both gender with arterial hypertension, excluding ones with the already verified chronic kidney disease. We estimated creatinine clearance and GFR by CG method corrected for the BSA, body mass index (BMI), and the creatinine tubular secretion according to Poggio reference values.
    Results: There was no significant difference in both age and gender groups among patients with physiological and pathological values of the renal function determined by the serum creatinine and estimated creatinine clearance by CG equation corrected for BMI, BSA. In both age and gender groups there was significant difference among subjects with physiological and pathological values of the renal function determined by serum creatinine and estimated GFR by CG method corrected for BMI, BSA, and creatinine tubular secretion.
    Conclusion: There is the most striking difference in the assessment of renal function between serum creatinine and estimated GFR by CG method with three corrections (BSA, BMI, the creatinine tubular secretion). Estimated GFR by CG method with three corrections can help in the early diagnosis of renal dysfunction and optimal treatment in patients with arterial hypertension.
    Language English
    Publishing date 2022-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2645750-7
    ISSN 2248-9606 ; 2229-516X
    ISSN (online) 2248-9606
    ISSN 2229-516X
    DOI 10.4103/ijabmr.ijabmr_301_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hemodialysis Parameters and Pulse Wave Velocity.

    Miseljic, Sanja / Aziri, Buena / Begic, Edin / Rebic, Damir / Džubur, Alen / Miseljic, Nenad / Mekic, Mevludin / Resic, Halima / Begic, Nedim / Zukic, Fuad

    International journal of applied & basic medical research

    2022  Volume 12, Issue 4, Page(s) 269–276

    Abstract: Aim: The study aimed to evaluate the acute effect of ultrafiltration on the mechanical properties of the aorta using brachial-ankle pulse wave velocity (PWV) before and after hemodialysis (HD).: Patients and methods: This study included 80 patients ... ...

    Abstract Aim: The study aimed to evaluate the acute effect of ultrafiltration on the mechanical properties of the aorta using brachial-ankle pulse wave velocity (PWV) before and after hemodialysis (HD).
    Patients and methods: This study included 80 patients who were on a long-term HD program. The input variables were anamnestic data, body composition monitor (BCM) parameters, and echocardiography findings. The assessment of hydration status was determined by BCM, whose work is based on the principle of multifrequency bioimpedance spectroscopy. Another diagnostic procedure was the use of an arteriograph apparatus to assess PWV and Augmentation Index (AIx). All measurements were performed before and after dialysis on the middle dialysis day of the week.
    Results: The participants were divided into two groups based on hydration status: the experimental group consisted of 40 overhydrated participants and the control group consisted of 40 normovolemic participants. Statistically, the following BCM parameters correlated significantly positively with PWV: total body fat (
    Conclusion: Overhydration showed an effect on brachial-ankle PWV before and after HD, and brachial-ankle PWV should be followed in HD patients.
    Language English
    Publishing date 2022-12-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 2645750-7
    ISSN 2248-9606 ; 2229-516X
    ISSN (online) 2248-9606
    ISSN 2229-516X
    DOI 10.4103/ijabmr.ijabmr_197_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Serum malondialdehyde (MDA) level as a potential biomarker of cancer progression for patients with bladder cancer.

    Lepara, Zahid / Lepara, Orhan / Fajkić, Almir / Rebić, Damir / Alić, Jasmin / Spahović, Hajrudin

    Romanian journal of internal medicine = Revue roumaine de medecine interne

    2020  Volume 58, Issue 3, Page(s) 146–152

    Abstract: Introduction: Bladder cancer is the most common malignancy involving the urinary system. Recent research tends to emphasize the role of oxidative stress products in the carcinogenesis of bladder cancer. The level of oxidative stress can be measured by ... ...

    Abstract Introduction: Bladder cancer is the most common malignancy involving the urinary system. Recent research tends to emphasize the role of oxidative stress products in the carcinogenesis of bladder cancer. The level of oxidative stress can be measured by assessing the MDA levels. This study aimed to evaluate serum MDA levels in patients with bladder cancer, as well as to determine its potential role as a biomarker in the diagnosis of the disease and progression risk considerations.
    Methods: The study was designed as a cross-sectional study and included 90 patients, divided into three groups with 30 patients each: Ta, T1and T2-T4 group, based on histopathological findings after transurethral resection of the tumor. The control group included 30 healthy volunteers. MDA level was determined using the spectrophotometric method.
    Results: Serum MDA level in patients with bladder cancer [0.86 (0.78-1.05) μmol/L] was significantly higher than the serum MDA level in control group [0.70 (0.69-0.72) μmol/L] (p < 0.001). Serum MDA level in Ta group [0.73 (0.70-1.05) μmol/L], T1 group [0.85 (0.80-1.12) μmol/L] and in T2-T4 group [0.91 (0.84-1.04) μmol/L] was significantly higher than the serum MDA level in control group [0.70 (0.69-0.72) μmol/L] (p < 0.01). MDA level in T1 and T2-T4 group was significantly higher than the MDA level in Ta group (p < 0.01). No significant difference was observed in MDA level between T1 and T2-T4 group (p = NS). A statistically significant positive correlation was found between tumor size and serum MDA level in patients with bladder cancer (rho = 0.254 p < 0.01).
    Conclusions: The results of the present study suggest that MDA serum level might play a significant role as a biomarker in the diagnosis of bladder cancer, as well as in the monitoring of its progression.
    MeSH term(s) Aged ; Area Under Curve ; Biomarkers, Tumor ; Case-Control Studies ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Male ; Malondialdehyde/blood ; Middle Aged ; ROC Curve ; Tumor Burden ; Urinary Bladder Neoplasms/blood ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor ; Malondialdehyde (4Y8F71G49Q)
    Language English
    Publishing date 2020-05-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2015966-3
    ISSN 2501-062X ; 0035-3973 ; 1582-3296
    ISSN (online) 2501-062X
    ISSN 0035-3973 ; 1582-3296
    DOI 10.2478/rjim-2020-0008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Minimally invasive coronary artery bypass (MICS CABG) in Bosnia and Herzegovina: a single centre, single surgeon cohort experience.

    Granov, Nermir / Šljivo, Armin / Mujičić, Ermina / Rebić, Damir / Džubur, Alen / Begić, Edin / Selimović, Tarik / Zvizdić, Zlatan / Fajkić, Almir / Jonuzi, Asmir / Kabil, Edin / Štraus, Slavenka

    Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

    2023  Volume 20, Issue 2

    Abstract: Aim This is the first research in Bosnia and Herzegovina presenting minimally invasive coronary artery bypass grafting surgery (MICS CABG) experience, advantages, and outcomes as compared to conventional surgery (OPEN CABG). Methods This retrospective ... ...

    Abstract Aim This is the first research in Bosnia and Herzegovina presenting minimally invasive coronary artery bypass grafting surgery (MICS CABG) experience, advantages, and outcomes as compared to conventional surgery (OPEN CABG). Methods This retrospective cross-sectional study was conducted between January 2019 and November 2022 and included patients with indication for surgical revascularization. Results Among 237 patients, males predominated, 182 (76.7%), with a mean body mass index (BMI) of 28.4±3.9, median The Society of Thoracic Surgery Risk (STS) score of 1.55 (0.8, 4.0), short term STS score of 11.2 (6.8, 23.7), mean age of 64.8±8.7 (ranging 41-83) years, 122 (51.4%) underwent OPEN CABG and 115 (48.6%) MICS CABG. MICS CABG took less time (p<0.001; OPEN 3.5±0.8h; MICS 2.8±0.8h) and needed less mechanical ventilation (p<0.001, OPEN 17.3±11.9h; MICS 13.0±12.5h) than OPEN CABG. Even though there was no difference in hospitalization length between groups (OPEN (7.5±3.2), MICS (7.1±4.0)), patients receiving MICS (2.9±1.5) spent less time in the ICU (p=0.0013) than OPEN CABG (3.6±2.8). OPEN CABG used also more blood derivatives, red blood cells (OPEN 292 vs MICS 55), plasma (OPEN 270 vs MICS 86) and platelets (OPEN 71 vs MICS 28). Conclusion Patients undergoing MICS CABG in Bosnia and Herzegovina had less mechanical ventilation hours and less ICU duration compared to OPEN CABG even though the hospitalization duration was very similar. MICS CABG takes less time to be conducted, has fewer CPRs postoperatively, uses less blood derivatives including red blood cells, plasma and platelets.
    Language English
    Publishing date 2023-08-01
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 2378942-6
    ISSN 1840-2445 ; 1840-2445
    ISSN (online) 1840-2445
    ISSN 1840-2445
    DOI 10.17392/1571-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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