Article: The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer.
2018 Volume 2018, Page(s) 2830503
Abstract: Background: Tumor development and growth are driven in many cases by inflammatory cells, which can produce cytokines and other factors that can stimulate the development of the malignant process. The aim of this study was to evaluate interleukin-6 (IL-6) ...
Abstract | Background: Tumor development and growth are driven in many cases by inflammatory cells, which can produce cytokines and other factors that can stimulate the development of the malignant process. The aim of this study was to evaluate interleukin-6 (IL-6), C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9), serum levels in patients with colorectal cancer (CRC), and their association with the stage of CRC. Methods: IL-6, MMP-9, and CRP serum levels were measured in 75 patients with CRC just before surgical treatment, as well as in 20 healthy individuals as controls. Surgically obtained tissue material was subjected to pathological analysis. Results: Significant increase in CRP and IL-6 serum concentration is associated with increasing stage of CRC ( Conclusion: Combined quantification of IL-6, MMP-9, and CRP serum levels seems to be a reliable index of inflammation-related processes during colorectal carcinogenesis. |
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Language | English |
Publishing date | 2018-07-30 |
Publishing country | Egypt |
Document type | Journal Article |
ZDB-ID | 2461349-6 |
ISSN | 1687-8469 ; 1687-8450 |
ISSN (online) | 1687-8469 |
ISSN | 1687-8450 |
DOI | 10.1155/2018/2830503 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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