Artikel ; Online: C-Peptide effects on renal physiology and diabetes.
Experimental diabetes research
2008 Band 2008, Seite(n) 281536
Abstract: The C-peptide of proinsulin is important for the biosynthesis of insulin and has for a long time been considered to be biologically inert. Animal studies have shown that some of the renal effects of the C-peptide may in part be explained by its ability ... ...
Abstract | The C-peptide of proinsulin is important for the biosynthesis of insulin and has for a long time been considered to be biologically inert. Animal studies have shown that some of the renal effects of the C-peptide may in part be explained by its ability to stimulate the Na,K-ATPase activity. Precisely, the C-peptide reduces diabetes-induced glomerular hyperfiltration both in animals and humans, therefore, resulting in regression of fibrosis. The tubular function is also concerned as diabetic animals supplemented with C-peptide exhibit better renal function resulting in reduced urinary sodium waste and protein excretion together with the reduction of the diabetes-induced glomerular hyperfiltration. The tubular effectors of C-peptide were considered to be tubule transporters, but recent studies have shown that biochemical pathways involving cellular kinases and inflammatory pathways may also be important. The matter theory concerning the C-peptide effects is a metabolic one involving the effects of the C-peptide on lipidic metabolic status. This review concentrates on the most convincing data which indicate that the C-peptide is a biologically active hormone for renal physiology. |
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Mesh-Begriff(e) | Animals ; C-Peptide/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/physiopathology ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/physiopathology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/physiopathology ; Glomerular Filtration Rate ; Humans ; Inflammation/metabolism ; Inflammation/physiopathology ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/physiopathology ; Kidney Tubules/metabolism ; Kidney Tubules/physiopathology ; Lipid Metabolism ; Signal Transduction ; Sodium-Potassium-Exchanging ATPase/metabolism |
Chemische Substanzen | C-Peptide ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) |
Sprache | Englisch |
Erscheinungsdatum | 2008-05-20 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 2465179-5 |
ISSN | 1687-5303 ; 1687-5214 |
ISSN (online) | 1687-5303 |
ISSN | 1687-5214 |
DOI | 10.1155/2008/281536 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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