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  1. Article ; Online: Sexual dimorphism in HIV-1 infection.

    Rechtien, Anne / Altfeld, Marcus

    Seminars in immunopathology

    2018  Volume 41, Issue 2, Page(s) 195–202

    Abstract: Sex-specific differences affecting various aspects of HIV-1 infection have been reported, including differences in susceptibility to infection, course of HIV-1 disease, and establishment of viral reservoirs. Once infected, initial plasma levels of HIV-1 ... ...

    Abstract Sex-specific differences affecting various aspects of HIV-1 infection have been reported, including differences in susceptibility to infection, course of HIV-1 disease, and establishment of viral reservoirs. Once infected, initial plasma levels of HIV-1 viremia in women are lower compared to men while the rates of progression to AIDS are similar. Factors contributing to these sex differences are poorly understood, and range from anatomical differences and differential expression of sex hormones to differences in immune responses, the microbiome and socio-economic discrepancies, all of which may impact HIV-1 acquisition and disease progression. Ongoing research efforts aiming at controlling HIV-1 disease or reducing viral reservoirs need to take these sex-based differences in HIV-1 pathogenesis into account. In this review, we discuss established knowledge and recent findings on immune pathways leading to sex differences in HIV-1 disease manifestations, with focus on HIV-1 latency and the effect of female sex hormones on HIV-1.
    MeSH term(s) Adult ; Female ; HIV Infections/immunology ; HIV Infections/pathology ; HIV-1/immunology ; Humans ; Male ; Sex Characteristics
    Language English
    Publishing date 2018-10-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-018-0704-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CXCR5

    Jordan-Paiz, Ana / Martrus, Glòria / Steinert, Fenja L / Kaufmann, Max / Sagebiel, Adrian F / Schreurs, Renée R C E / Rechtien, Anne / Baumdick, Martin E / Jung, Johannes M / Möller, Kimberly J / Wegner, Lucy / Grüttner, Cordula / Richert, Laura / Thünauer, Roland / Schroeder-Schwarz, Jennifer / van Goudoever, Johannes B / Geijtenbeek, Teunis B H / Altfeld, Marcus / Pals, Steven T /
    Perez, Daniel / Klarenbeek, Paul L / Tomuschat, Christian / Sauter, Guido / Königs, Ingo / Schumacher, Udo / Friese, Manuel A / Melling, Nathaniel / Reinshagen, Konrad / Bunders, Madeleine J

    Cellular & molecular immunology

    2023  Volume 20, Issue 2, Page(s) 201–213

    Abstract: Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires ... ...

    Abstract Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5
    MeSH term(s) Adult ; Child ; Humans ; Infant ; B-Lymphocytes ; Programmed Cell Death 1 Receptor ; Receptors, CXCR5 ; T-Lymphocytes, Helper-Inducer ; CD4-Positive T-Lymphocytes/immunology
    Chemical Substances CXCR5 protein, human ; Programmed Cell Death 1 Receptor ; Receptors, CXCR5
    Language English
    Publishing date 2023-01-05
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-022-00944-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stable Frequencies of HLA-C

    Ziegler, Maja Christiane / Grañana, Ferran Borràs / Garcia-Beltran, Wilfredo F / Schulze Zur Wiesch, Julian / Hoffmann, Christian / Rechtien, Anne / Lunemann, Sebastian / Altfeld, Marcus

    Frontiers in immunology

    2018  Volume 9, Page(s) 2361

    Abstract: Inhibitory KIRs play a central role in regulating NK cell activity. KIR2DL2/3 bind to HLA-C molecules, but the modulation of these interactions by viral infections and presentation of viral epitopes is not well-understood. We investigated whether the ... ...

    Abstract Inhibitory KIRs play a central role in regulating NK cell activity. KIR2DL2/3 bind to HLA-C molecules, but the modulation of these interactions by viral infections and presentation of viral epitopes is not well-understood. We investigated whether the frequencies of KIR2DL2/3
    MeSH term(s) Flow Cytometry ; HLA-C Antigens/chemistry ; HLA-C Antigens/immunology ; HLA-C Antigens/metabolism ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Multiprotein Complexes ; Peptides/chemistry ; Peptides/metabolism ; Protein Binding ; Receptors, KIR2DL2/metabolism ; Receptors, KIR2DL3/metabolism ; Vaccination ; Vaccines/immunology
    Chemical Substances HLA-C Antigens ; HLA-C*03:04 antigen ; KIR2DL2 protein, human ; KIR2DL3 protein, human ; Multiprotein Complexes ; Peptides ; Receptors, KIR2DL2 ; Receptors, KIR2DL3 ; Vaccines
    Language English
    Publishing date 2018-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV.

    Rechtien, Anne / Richert, Laura / Lorenzo, Hadrien / Martrus, Gloria / Hejblum, Boris / Dahlke, Christine / Kasonta, Rahel / Zinser, Madeleine / Stubbe, Hans / Matschl, Urte / Lohse, Ansgar / Krähling, Verena / Eickmann, Markus / Becker, Stephan / Thiébaut, Rodolphe / Altfeld, Marcus / Addo, Marylyn M

    Cell reports

    2017  Volume 20, Issue 9, Page(s) 2251–2261

    Abstract: Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were ... ...

    Abstract Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate immune cell subsets, and gene expression. Integrative statistical analyses with cross-validation identified a signature of 5 early innate markers correlating with antibody titers on day 28 and beyond. Among those, IP-10 on day 3 and MFI of CXCR6 on NK cells on day 1 were independent correlates. Consistently, we found an early gene expression signature linked to IP-10. This comprehensive characterization of early innate immune responses to the rVSV-ZEBOV vaccine in humans revealed immune signatures linked to IP-10. These results suggest correlates of vaccine-induced antibody induction and provide a rationale to explore strategies for augmenting the effectiveness of vaccines through manipulation of IP-10.
    MeSH term(s) Antibody Formation/immunology ; Biomarkers/metabolism ; Chemokine CXCL10/metabolism ; Cytokines/blood ; Ebola Vaccines/immunology ; Gene Expression Profiling ; Gene Expression Regulation ; Glycoproteins/immunology ; Hemorrhagic Fever, Ebola/blood ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunity, Innate ; Linear Models ; Multivariate Analysis ; Sequence Analysis, RNA ; Vaccination
    Chemical Substances Biomarkers ; Chemokine CXCL10 ; Cytokines ; Ebola Vaccines ; Glycoproteins
    Keywords covid19
    Language English
    Publishing date 2017-08-30
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2017.08.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans.

    Poetsch, Joseph H / Dahlke, Christine / Zinser, Madeleine E / Kasonta, Rahel / Lunemann, Sebastian / Rechtien, Anne / Ly, My L / Stubbe, Hans C / Krähling, Verena / Biedenkopf, Nadine / Eickmann, Markus / Fehling, Sarah K / Olearo, Flaminia / Strecker, Thomas / Sharma, Piyush / Lang, Karl S / Lohse, Ansgar W / Schmiedel, Stefan / Becker, Stephan /
    Addo, Marylyn M

    The Journal of infectious diseases

    2018  Volume 219, Issue 4, Page(s) 556–561

    Abstract: In response to the Ebola virus (EBOV) crisis of 2013-2016, a recombinant vesicular stomatitis virus (VSV)-based EBOV vaccine was clinically tested (NCT02283099). A single-dose regimen of VSV-EBOV revealed a safe and immunogenic profile and demonstrated ... ...

    Abstract In response to the Ebola virus (EBOV) crisis of 2013-2016, a recombinant vesicular stomatitis virus (VSV)-based EBOV vaccine was clinically tested (NCT02283099). A single-dose regimen of VSV-EBOV revealed a safe and immunogenic profile and demonstrated clinical efficacy. While EBOV-specific immune responses to this candidate vaccine have previously been investigated, limited human data on immunity to the VSV vector are available. Within the scope of a phase 1 study, we performed a comprehensive longitudinal analysis of adaptive immune responses to internal VSV proteins following VSV-EBOV immunization. While no preexisting immunity to the vector was observed, more than one-third of subjects developed VSV-specific cytotoxic T-lymphocyte responses and antibodies.
    MeSH term(s) Adult ; Antibody Formation ; Ebola Vaccines/administration & dosage ; Ebola Vaccines/immunology ; Humans ; Immunity, Cellular ; Longitudinal Studies ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/immunology ; Vesiculovirus/immunology
    Chemical Substances Ebola Vaccines ; Vaccines, Synthetic
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiy565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization.

    Dahlke, Christine / Kasonta, Rahel / Lunemann, Sebastian / Krähling, Verena / Zinser, Madeleine E / Biedenkopf, Nadine / Fehling, Sarah K / Ly, My L / Rechtien, Anne / Stubbe, Hans C / Olearo, Flaminia / Borregaard, Saskia / Jambrecina, Alen / Stahl, Felix / Strecker, Thomas / Eickmann, Markus / Lütgehetmann, Marc / Spohn, Michael / Schmiedel, Stefan /
    Lohse, Ansgar W / Becker, Stephan / Addo, Marylyn M

    EBioMedicine

    2017  Volume 19, Page(s) 107–118

    Abstract: Background: The recent West African Ebola epidemic led to accelerated efforts to test Ebola vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (VEBCON), we performed a phase I clinical trial investigating rVSV-ZEBOV (a ...

    Abstract Background: The recent West African Ebola epidemic led to accelerated efforts to test Ebola vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (VEBCON), we performed a phase I clinical trial investigating rVSV-ZEBOV (a recombinant vesicular stomatitis virus-vectored Ebola vaccine), which has recently demonstrated protection from Ebola virus disease (EVD) in phase III clinical trials and is currently in advanced stages of licensing. So far, correlates of immune protection are incompletely understood and the role of cell-mediated immune responses has not been comprehensively investigated to date.
    Methods: We recruited 30 healthy subjects aged 18-55 into an open-label, dose-escalation phase I trial testing three doses of rVSV-ZEBOV (3×10
    Findings: Immunization with rVSV-ZEBOV was well tolerated without serious vaccine-related adverse events. Ebola virus-specific neutralizing antibodies were induced in nearly all individuals. Additionally, vaccinees, particularly within the highest dose cohort, generated Ebola glycoprotein (GP)-specific T cells and initiated a cascade of signaling molecules following stimulation of peripheral blood mononuclear cells with Ebola GP peptides.
    Interpretation: In addition to a benign safety and robust humoral immunogenicity profile, subjects immunized with 2×10
    MeSH term(s) Adult ; Antibodies, Bacterial/blood ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; B-Lymphocytes/immunology ; Cytokines/immunology ; Ebola Vaccines/administration & dosage ; Ebola Vaccines/adverse effects ; Ebolavirus/immunology ; Female ; Glycoproteins/genetics ; Glycoproteins/immunology ; Hemorrhagic Fever, Ebola/prevention & control ; Humans ; Immunization ; Male ; Middle Aged ; Peptides/genetics ; Peptides/immunology ; T-Lymphocytes/immunology ; Vesicular stomatitis Indiana virus/genetics ; Viral Proteins/genetics ; Viral Proteins/immunology ; Young Adult
    Chemical Substances Antibodies, Bacterial ; Antibodies, Neutralizing ; Antibodies, Viral ; Cytokines ; Ebola Vaccines ; Glycoproteins ; Peptides ; Viral Proteins
    Language English
    Publishing date 2017-04-05
    Publishing country Netherlands
    Document type Clinical Trial, Phase I ; Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2017.03.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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