LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 203

Search options

  1. Book ; Conference proceedings: Paraoxonases in inflammation, infection, and toxicology

    Reddy, Srinivasa T.

    [3. International Conference on Paraoxonases held at University of California Los Angels, Los Angeles, CA from September 1-10-2008]

    (Advances in experimental medicine and biology ; 660)

    2010  

    Event/congress International Conference on Paraoxonases (3, 2008, LosAngelesCalif.)
    Author's details ed. by Srinivasa T. Reddy
    Series title Advances in experimental medicine and biology ; 660
    Collection
    Language English
    Size XIV, 211 S. : Ill., graph. Darst., 24 cm
    Publisher Humana ; Springer distributor
    Publishing place Totowa, N.J ; New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016213287
    ISBN 978-1-607-61349-7 ; 978-1-60761-349-7 ; 1-60761-349-2 ; 1-607-61349-2 ; 9781607613503 ; 1607613506
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -660- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Editorial: Pathogenesis in progenitor cells: epigenetics and external influences.

    Koka, Prasad S / Reddy, Srinivasa T

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1205372

    Language English
    Publishing date 2023-04-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1205372
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis.

    Chattopadhyay, Arnab / Reddy, Srinivasa T / Fogelman, Alan M

    Current opinion in lipidology

    2023  Volume 34, Issue 5, Page(s) 196–200

    Abstract: Purpose of review: To explore the multiple roles that lysophosphatidic acid (LPA) plays in vascular disease and atherosclerosis.: Recent findings: A high-fat high-cholesterol diet decreases antimicrobial activity in the small intestine, which leads ... ...

    Abstract Purpose of review: To explore the multiple roles that lysophosphatidic acid (LPA) plays in vascular disease and atherosclerosis.
    Recent findings: A high-fat high-cholesterol diet decreases antimicrobial activity in the small intestine, which leads to increased levels of bacterial lipopolysaccharide in the mucus of the small intestine and in plasma that increase systemic inflammation, and enhance dyslipidemia and aortic atherosclerosis. Decreasing LPA production in enterocytes reduces the impact of the diet. LPA signaling inhibits glucagon-like peptide 1 secretion, promotes atherosclerosis, increases vessel permeability and infarct volume in stroke, but protects against abdominal aortic aneurysm formation and rupture. Acting through the calpain system in lymphatic endothelial cells, LPA reduces the trafficking of anti-inflammatory Treg lymphocytes, which enhances atherosclerosis. Acting through LPA receptor 1 in cardiac lymphatic endothelial cells and fibroblasts, LPA enhances hypertrophic cardiomyopathy.
    Summary: LPA plays multiple roles in vascular disease and atherosclerosis that is cell and context dependent. In some settings LPA promotes these disease processes and in others it inhibits the disease process. Because LPA is so ubiquitous, therapeutic approaches targeting LPA must be as specific as possible for the cells and the context in which the disease process occurs.
    MeSH term(s) Humans ; Endothelial Cells ; Lysophospholipids ; Atherosclerosis ; Intestine, Small
    Chemical Substances lysophosphatidic acid (PG6M3969SG) ; Lysophospholipids
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1045394-5
    ISSN 1473-6535 ; 0957-9672
    ISSN (online) 1473-6535
    ISSN 0957-9672
    DOI 10.1097/MOL.0000000000000890
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The role of gut-derived oxidized lipids and bacterial lipopolysaccharide in systemic inflammation and atherosclerosis.

    Wang, Huan / Reddy, Srinivasa T / Fogelman, Alan M

    Current opinion in lipidology

    2022  Volume 33, Issue 5, Page(s) 277–282

    Abstract: Purpose of review: This review explores mechanisms by which gut-derived bacteriallipopolysaccharide (LPS) and oxidized phospholipids contribute to chronic systemic inflammation and atherosclerosis.: Recent findings: Gut-derived LPS enters through the ...

    Abstract Purpose of review: This review explores mechanisms by which gut-derived bacteriallipopolysaccharide (LPS) and oxidized phospholipids contribute to chronic systemic inflammation and atherosclerosis.
    Recent findings: Gut-derived LPS enters through the small intestine via two distinct pathways that involve high density lipoproteins (HDL) and chylomicrons. Gut-derived LPS can bind to the LPS-binding protein (LBP) and to HDL 3 in the small intestine and travel through the portal vein to the liver where it does not elicit an inflammatory reaction, and is inactivated or it can bind to HDL 2 and travel through the portal vein to the liver where it elicits an inflammatory reaction. Alternatively, in the small intestine, LPS can bind to LBP and chylomicrons and travel through the lymphatics to the systemic circulation and enhance inflammatory processes including atherosclerosis. Oxidized phospholipids formed in the small intestine regulate the levels and uptake of LPS in small intestine by regulating antimicrobial proteins such as intestinal alkaline phosphatase. Gut-derived LPS and oxidized phospholipids may be responsible for the persistent inflammation seen in some persons with human immunodeficiency virus on potent antiretroviral therapy with undetectable virus levels.
    Summary: By targeting gut-derived oxidized phospholipids, the uptake of gut-derived LPS may be reduced to decrease systemic inflammation and atherosclerosis.
    MeSH term(s) Atherosclerosis/metabolism ; Chylomicrons ; Humans ; Inflammation/metabolism ; Lipopolysaccharides/metabolism ; Lipoproteins, HDL/metabolism ; Phospholipids/metabolism
    Chemical Substances Chylomicrons ; Lipopolysaccharides ; Lipoproteins, HDL ; Phospholipids
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1045394-5
    ISSN 1473-6535 ; 0957-9672
    ISSN (online) 1473-6535
    ISSN 0957-9672
    DOI 10.1097/MOL.0000000000000841
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders.

    Pervin, Shehla / Reddy, Srinivasa T / Singh, Rajan

    Frontiers in endocrinology

    2021  Volume 12, Page(s) 653179

    Abstract: Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases. Obesity develops from chronic imbalance between energy intake and energy ... ...

    Abstract Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases. Obesity develops from chronic imbalance between energy intake and energy expenditure. Stimulation of cellular energy burning process has the potential to dissipate excess calories in the form of heat
    MeSH term(s) Adipose Tissue, Beige/metabolism ; Adipose Tissue, Brown/metabolism ; Animals ; Energy Metabolism ; Fibronectins/biosynthesis ; Follistatin/biosynthesis ; Follistatin/metabolism ; Follistatin-Related Proteins/biosynthesis ; Humans ; Ligands ; Metabolic Diseases/metabolism ; Mice ; Myostatin/biosynthesis ; Obesity/metabolism ; Signal Transduction ; Thermogenesis/drug effects ; Transforming Growth Factor beta1/metabolism ; Uncoupling Protein 1/metabolism
    Chemical Substances FNDC5 protein, human ; Fibronectins ; Follistatin ; Follistatin-Related Proteins ; Ligands ; MSTN protein, human ; Myostatin ; TGFB1 protein, human ; Transforming Growth Factor beta1 ; UCP1 protein, human ; Uncoupling Protein 1
    Language English
    Publishing date 2021-04-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.653179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD.

    Sreekumar, Parameswaran G / Reddy, Srinivasa T / Hinton, David R / Kannan, Ram

    Experimental eye research

    2022  Volume 215, Page(s) 108918

    Abstract: Oxidative stress in the retinal pigment epithelium (RPE) can cause mitochondrial dysfunction and is likely a causative factor in the pathogenesis of age-related macular degeneration (AMD). Under oxidative stress conditions, some of the RPE cells become ... ...

    Abstract Oxidative stress in the retinal pigment epithelium (RPE) can cause mitochondrial dysfunction and is likely a causative factor in the pathogenesis of age-related macular degeneration (AMD). Under oxidative stress conditions, some of the RPE cells become senescent and a contributory role for RPE senescence in AMD pathology has been proposed. The purpose of this study is to 1) characterize senescence in human RPE; 2) investigate the effect of an αB Crystallin chaperone peptide (mini Cry) in controlling senescence, in particular by regulating mitochondrial function and senescence-associated secretory phenotype (SASP) production and 3) develop mouse models for studying the role of RPE senescence in dry and nAMD. Senescence was induced in human RPE cells in two ways. First, subconfluent cells were treated with 0.2 μg/ml doxorubicin (DOX); second, subconfluent cells were treated with 500 μM H
    MeSH term(s) Animals ; Cellular Senescence ; Disease Models, Animal ; Fibrosis ; Hydrogen Peroxide/pharmacology ; Macular Degeneration/metabolism ; Mice ; Oxidative Stress ; Peptides/pharmacology ; Retinal Degeneration/metabolism ; Retinal Pigment Epithelium/metabolism ; alpha-Crystallin B Chain/genetics
    Chemical Substances Peptides ; alpha-Crystallin B Chain ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-01-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2021.108918
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Lipidomic changes in a novel sepsis outcome-based analysis reveals potent pro-inflammatory and pro-resolving signaling lipids.

    Sulaiman, Dawoud / Wu, Dongyuan / Black, Lauren Page / Williams, Kevin J / Graim, Kiley / Datta, Susmita / Reddy, Srinivasa T / Guirgis, Faheem W

    Clinical and translational science

    2024  Volume 17, Issue 3, Page(s) e13745

    Abstract: The purpose of this study was to investigate changes in the lipidome of patients with sepsis to identify signaling lipids associated with poor outcomes that could be linked to future therapies. Adult patients with sepsis were enrolled within 24h of ... ...

    Abstract The purpose of this study was to investigate changes in the lipidome of patients with sepsis to identify signaling lipids associated with poor outcomes that could be linked to future therapies. Adult patients with sepsis were enrolled within 24h of sepsis recognition. Patients meeting Sepsis-3 criteria were enrolled from the emergency department or intensive care unit and blood samples were obtained. Clinical data were collected and outcomes of rapid recovery, chronic critical illness (CCI), or early death were adjudicated by clinicians. Lipidomic analysis was performed on two platforms, the Sciex™ 5500 device to perform a lipidomic screen of 1450 lipid species and a targeted signaling lipid panel using liquid-chromatography tandem mass spectrometry. For the lipidomic screen, there were 274 patients with sepsis: 192 with rapid recovery, 47 with CCI, and 35 with early deaths. CCI and early death patients were grouped together for analysis. Fatty acid (FA) 12:0 was decreased in CCI/early death, whereas FA 17:0 and 20:1 were elevated in CCI/early death, compared to rapid recovery patients. For the signaling lipid panel analysis, there were 262 patients with sepsis: 189 with rapid recovery, 45 with CCI, and 28 with early death. Pro-inflammatory signaling lipids from ω-6 poly-unsaturated fatty acids (PUFAs), including 15-hydroxyeicosatetraenoic (HETE), 12-HETE, and 11-HETE (oxidation products of arachidonic acid [AA]) were elevated in CCI/early death patients compared to rapid recovery. The pro-resolving lipid mediator from ω-3 PUFAs, 14(S)-hydroxy docosahexaenoic acid (14S-HDHA), was also elevated in CCI/early death compared to rapid recovery. Signaling lipids of the AA pathway were elevated in poor-outcome patients with sepsis and may serve as targets for future therapies.
    MeSH term(s) Adult ; Humans ; Lipidomics ; Fatty Acids, Omega-3 ; Sepsis ; Fatty Acids ; Mass Spectrometry
    Chemical Substances Fatty Acids, Omega-3 ; Fatty Acids
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13745
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Ramatroban as a Novel Immunotherapy for COVID-19.

    Gupta, Ajay / Kalantar-Zadeh, Kamyar / Reddy, Srinivasa T

    Journal of molecular and genetic medicine : an international journal of biomedical research

    2020  Volume 14, Issue 3

    Abstract: SARS-CoV-2 virus suppresses host innate and adaptive immune responses, thereby allowing the virus to proliferate, and cause multiorgan failure, especially in the elderly. Respiratory viruses stimulate cyclooxygenase-2 (COX-2) to generate prostanoids ... ...

    Abstract SARS-CoV-2 virus suppresses host innate and adaptive immune responses, thereby allowing the virus to proliferate, and cause multiorgan failure, especially in the elderly. Respiratory viruses stimulate cyclooxygenase-2 (COX-2) to generate prostanoids including Prostaglandin D
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2202415-3
    ISSN 1747-0862
    ISSN 1747-0862
    DOI 10.37421/jmgm.2020.14.457
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice.

    Sreekumar, Parameswaran Gangadharan / Su, Feng / Spee, Christine / Hong, Elise / Komirisetty, Ravikiran / Araujo, Eduardo / Nusinowitz, Steven / Reddy, Srinivasa T / Kannan, Ram

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant protein that is ...

    Abstract Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant protein that is found intracellularly associated with mitochondrial membranes and modulates mitochondrial ROS production and function. The contribution of PON2 to AMD has not been studied to date. In this study, we examined the role of PON2 in AMD utilizing both in vitro and in vivo models of AMD with emphasis on mitochondrial function. Mitochondrial localization and regulation of PON2 following oxidative stress were determined in human primary cultured retinal pigment epithelium (hRPE) cells. PON2 was knocked down in RPE cells using siRNA and mitochondrial bioenergetics were measured. To investigate the function of PON2 in the retina, WT and PON2-deficient mice were administered NaIO
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12101820
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Making sense of a seemingly odd connection.

    Fogelman, Alan M / Reddy, Srinivasa T

    European heart journal

    2017  Volume 38, Issue 48, Page(s) 3588–3589

    MeSH term(s) ATP Binding Cassette Transporter 1/metabolism ; Carrier Proteins/metabolism ; Cholesterol ; Humans ; Nerve Tissue Proteins/metabolism
    Chemical Substances ABCA1 protein, human ; ATP Binding Cassette Transporter 1 ; Carrier Proteins ; Nerve Tissue Proteins ; TRAK2 protein, human ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2017-10-10
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx506
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top