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  1. Article ; Online: Three neglected numbers in the CBC: The RDW, MPV, and NRBC count.

    May, Jori E / Marques, Marisa B / Reddy, Vishnu V B / Gangaraju, Radhika

    Cleveland Clinic journal of medicine

    2019  Volume 86, Issue 3, Page(s) 167–172

    Abstract: The complete blood cell count (CBC) is one of the most frequently ordered laboratory tests, but some values included in the test may be overlooked. This brief review discusses 3 potentially underutilized components of the CBC: the red blood cell ... ...

    Abstract The complete blood cell count (CBC) is one of the most frequently ordered laboratory tests, but some values included in the test may be overlooked. This brief review discusses 3 potentially underutilized components of the CBC: the red blood cell distribution width (RDW), the mean platelet volume (MPV), and the nucleated red blood cell (NRBC) count. These results have unique diagnostic applications and prognostic implications that can be incorporated into clinical practice. By understanding all components of the CBC, providers can learn more about the patient's condition.
    MeSH term(s) Blood Cell Count/methods ; Diagnosis, Differential ; Diagnostic Errors/prevention & control ; Erythroblasts ; Erythrocyte Indices ; Humans ; Mean Platelet Volume ; Prognosis
    Language English
    Publishing date 2019-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.86a.18072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In reply: Complete blood cell count.

    May, Jori E / Marques, Marisa B / Reddy, Vishnu V B / Gangaraju, Radhika

    Cleveland Clinic journal of medicine

    2019  Volume 86, Issue 6, Page(s) 368

    MeSH term(s) Blood Cell Count ; Humans
    Language English
    Publishing date 2019-08-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.86c.06002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fat Embolism Syndrome Secondary to Bone Marrow Necrosis in Patients with Hemoglobinopathies.

    Gangaraju, Radhika / Reddy, Vishnu V B / Marques, Marisa B

    Southern medical journal

    2016  Volume 109, Issue 9, Page(s) 549–553

    Abstract: Bone marrow necrosis with subsequent embolization of the fat and necrotic tissues into the systemic circulation causing fat embolism syndrome and multiorgan failure is a rare complication of patients with hemoglobinopathies. The exact etiology of this ... ...

    Abstract Bone marrow necrosis with subsequent embolization of the fat and necrotic tissues into the systemic circulation causing fat embolism syndrome and multiorgan failure is a rare complication of patients with hemoglobinopathies. The exact etiology of this condition is not known. Because it occurs more often in patients with compound heterozygous conditions than in sickle cell disease, some patients are unaware of their predisposition. The initial symptoms are nonspecific, such as back and/or abdominal pain, fever, and fatigue, which may rapidly progress to respiratory failure and severe neurologic compromise. Common laboratory tests reveal anemia without reticulocytosis, thrombocytopenia, leukoerythroblastic picture with immature white cells and nucleated red blood cells, increased lactate dehydrogenase, high ferritin, and, sometimes increased creatinine. The diagnosis can be delayed because of an apparent lack of awareness about bone marrow necrosis with fat embolism syndrome, its rarity, and its similarities with other conditions such as thrombotic thrombocytopenic purpura. Although a bone marrow biopsy is diagnostic, waiting for it delays definitive treatment, which appears to be essential for the recovery of end-organ damage, such as neurologic and pulmonary damage. In our experience, either multiple units of red blood cell transfusion or, preferably, red cell exchange initiated promptly, is lifesaving.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/pathology ; Bone Marrow/pathology ; Embolism, Fat/diagnosis ; Embolism, Fat/etiology ; Embolism, Fat/therapy ; Hemoglobinopathies/complications ; Hemoglobinopathies/pathology ; Humans ; Necrosis
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.14423/SMJ.0000000000000520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: B-cell lymphoma of the pericardium presenting with ventricular tachycardia with a successful catheter ablation.

    Yamada, Takumi / Siric, Franjo / Reddy, Vishnu V B / Neal Kay, G

    HeartRhythm case reports

    2016  Volume 2, Issue 5, Page(s) 384–387

    Language English
    Publishing date 2016-06-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2016.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Out with the bad and in with the good; red cell exchange, white cell reduction, and platelet reduction.

    Marques, Marisa B / Singh, Nirupama / Reddy, Vishnu V B

    Journal of clinical apheresis

    2014  Volume 29, Issue 4, Page(s) 220–227

    Abstract: Automated techniques for red cell [red blood cell (RBC)] exchange or depletion of malignant cells from the peripheral blood have allowed patients with life-threatening conditions to survive long enough to receive definitive treatment. Examples of such ... ...

    Abstract Automated techniques for red cell [red blood cell (RBC)] exchange or depletion of malignant cells from the peripheral blood have allowed patients with life-threatening conditions to survive long enough to receive definitive treatment. Examples of such conditions include acute chest syndrome in sickle cell disease (SCD) or acute respiratory insufficiency due to leukostasis in acute leukemia. Conversely, other patients with SCD undergo RBC exchanges on a chronic basis to maintain a reasonable quality of life and prevent another stroke. In this review, we will discuss the techniques as well as indications for RBC exchange, leukocytapheresis, and thrombocytapheresis. To illustrate the uses of these therapeutic apheresis procedures, the authors included a summary of the most common diagnoses that comprise their use.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/therapy ; Babesiosis/therapy ; Blood Component Removal/methods ; Blood Platelets ; Bone Marrow/pathology ; Erythrocyte Transfusion ; Hemoglobinopathies/genetics ; Hemoglobinopathies/therapy ; Heterozygote ; Humans ; Leukocyte Reduction Procedures ; Leukocytosis/therapy ; Malaria/therapy ; Multiple Organ Failure/etiology ; Multiple Organ Failure/prevention & control ; Necrosis ; Neoplastic Cells, Circulating ; Parasitemia/therapy ; Sickle Cell Trait/complications ; Sickle Cell Trait/therapy ; Thrombocytosis/therapy
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.21332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Selected case studies in hematopathology: application of current ancillary techniques in diagnosis.

    Reddy, Vishnu V B

    Advances in experimental medicine and biology

    2005  Volume 563, Page(s) 112–124

    MeSH term(s) Adult ; Diagnosis, Differential ; Female ; Germinal Center/pathology ; Humans ; Hyperplasia/pathology ; Immunohistochemistry ; Leukemia/pathology ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Lymphoma, B-Cell/metabolism ; Lymphoma, B-Cell/pathology ; Lymphoma, Follicular/pathology ; Lymphoproliferative Disorders/metabolism ; Lymphoproliferative Disorders/pathology ; Male ; Middle Aged ; Neoplasms, Second Primary/pathology ; Plasma Cells/metabolism ; Plasma Cells/pathology ; T-Lymphocytes/pathology
    Language English
    Publishing date 2005
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/0-387-32025-3_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An Unusual Presentation of Thrombotic Thrombocytopenic Purpura.

    Zhou, Yaolin / Reilly, Stephanie D / Gangaraju, Radhika / Reddy, Vishnu V B / Marques, Marisa B

    The American journal of medicine

    2017  Volume 130, Issue 8, Page(s) e323–e326

    MeSH term(s) Abdominal Pain/etiology ; Humans ; Male ; Middle Aged ; Purpura, Thrombotic Thrombocytopenic/complications ; Purpura, Thrombotic Thrombocytopenic/diagnosis
    Language English
    Publishing date 2017-05-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2017.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Best Practices in CD30 Immunohistochemistry Testing, Interpretation, and Reporting.

    Gru, Alejandro A / Lim, Megan S / Dogan, Ahmet / Horwitz, Steven M / Delabie, Jan / Fu, Kai / Peker, Deniz / Reddy, Vishnu V B / Xu, Mina L / Vij, Kiran / Slack, Graham W / Miranda, Roberto N / Jagadeesh, Deepa / Lisano, Julie M / Hsi, Eric D / Torlakovic, Emina

    Archives of pathology & laboratory medicine

    2022  

    Abstract: Context.—: Although CD30 testing is an established tool in the diagnostic workup of lymphomas, it is also emerging as a predictive biomarker that informs treatment. The current definition of CD30 positivity by immunohistochemistry is descriptive and ... ...

    Abstract Context.—: Although CD30 testing is an established tool in the diagnostic workup of lymphomas, it is also emerging as a predictive biomarker that informs treatment. The current definition of CD30 positivity by immunohistochemistry is descriptive and based on reactivity in lymphomas that are defined by their universal strong expression of CD30, rather than any established threshold. Challenges include inconsistencies with preanalytic variables, tissue processing, pathologist readout, and with the pathologist and oncologist interpretation of reported results.
    Objective.—: To develop and propose general best practice recommendations for reporting CD30 expression by immunohistochemistry in lymphoma biopsies to harmonize practices across institutions and facilitate assessment of its significance in clinical decision-making.
    Design.—: Following literature review and group discussion, the panel of 14 academic hematopathologists and 2 clinical/academic hematologists/oncologists divided into 3 working groups. Each working group was tasked with assessing CD30 testing by immunohistochemistry, CD30 expression readout, or CD30 expression interpretation.
    Results.—: Panel recommendations were reviewed and discussed. An online survey was conducted to confirm the consensus recommendations.
    Conclusions.—: CD30 immunohistochemistry is required for all patients in whom classic Hodgkin lymphoma and any lymphoma within the spectrum of peripheral T-cell lymphoma are differential diagnostic considerations. The panel reinforced and summarized that immunohistochemistry is the preferred methodology and any degree of CD30 expression should be reported. For diagnostic purposes, the interpretation of CD30 expression should follow published guidelines. To inform therapeutic decisions, report estimated percent positive expression in tumor cells (or total cells where applicable) and record descriptively if nontumor cells are positive.
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2021-0270-OA
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Extramedullary hematopoiesis: an unusual finding in subdural hematomas.

    Li, Rong / Reddy, Vishnu V B / Palmer, Cheryl Ann

    Case reports in pathology

    2011  Volume 2011, Page(s) 718585

    Abstract: We present a case of a 59-year-old man who was found to have clusters of hyperchromatic, small, round nucleated cells within a subdural hematoma removed after a skull fracture. Immunohistochemistry study confirmed that the cells were hematopoietic ... ...

    Abstract We present a case of a 59-year-old man who was found to have clusters of hyperchromatic, small, round nucleated cells within a subdural hematoma removed after a skull fracture. Immunohistochemistry study confirmed that the cells were hematopoietic components predominantly composed of normoblasts. In this paper, we describe the clinical and pathological findings. A brief review of published information on extramedullary hematopoiesis in subdural hematoma and the mechanisms of pathogenesis are also discussed. While extramedullary hematopoiesis is seen anecdotally by neuropathologists in chronic subdural hematomas, only a few cases are documented in the literature. Furthermore, extramedullary hematopoiesis in subdural hematoma can pose a diagnostic challenge for general pathologists who encounter subdural hematoma evacuations seldom in their surgical pathology practices.
    Language English
    Publishing date 2011-09-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648758-5
    ISSN 2090-679X ; 2090-6781
    ISSN (online) 2090-679X
    ISSN 2090-6781
    DOI 10.1155/2011/718585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transfusion medicine illustrated. Systemic neutrophilic aggregates in transfusion-related acute lung injury.

    Lima, Jose / Reddy, Vishnu V B / Marques, Marisa B

    Transfusion

    2010  Volume 50, Issue 7, Page(s) 1427–1428

    MeSH term(s) Acute Lung Injury/etiology ; Aged ; Cell Aggregation ; Humans ; Male ; Neutrophils/pathology ; Transfusion Reaction
    Language English
    Publishing date 2010-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/j.1537-2995.2010.02625.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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