Article ; Online: From Diagnostic-Therapeutic Pathways to Real-World Data: A Multicenter Prospective Study on Upfront Treatment for
2019 Volume 24, Issue 6, Page(s) e318–e326
Abstract: Introduction: Gefitinib, erlotinib, and afatinib represent the approved first-line options for epidermal growth factor receptor (: Methods: MOST is a multicenter observational study promoted by the Veneto Oncology Network, aiming at monitoring the ... ...
| Abstract | Introduction: Gefitinib, erlotinib, and afatinib represent the approved first-line options for epidermal growth factor receptor ( Methods: MOST is a multicenter observational study promoted by the Veneto Oncology Network, aiming at monitoring the diagnostic-therapeutic pathway of patients with nonsquamous Results: An Conclusion: Good regional adherence and compliance to the diagnostic-therapeutic pathway defined for patients with nonsquamous NSCLC was shown. mTTF did not significantly differ among the three targeted TKIs. Our budget impact analysis suggests the potential application of real-world data in the process of drug price negotiation. Implications for practice: The MOST study is a real-world data collection reporting a multicenter adherence and compliance to diagnostic-therapeutic pathways defined for patients with epidermal growth factor receptor-mutant non-small cell lung cancer. This represents an essential element of evidence-based medicine, providing information on patients and situations that may be challenging to assess using only data from randomized controlled trials, e.g., turn-around time of diagnostic tests, treatment compliance and persistence, guideline adherence, challenging-to-treat populations, drug safety, comparative effectiveness, and cost effectiveness. This study may be of interest to various stakeholders (patients, clinicians, and payers), providing a meaningful picture of the value of a given therapy in routine clinical practice. |
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| MeSH term(s) | Adult ; Afatinib/economics ; Afatinib/therapeutic use ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/economics ; Carcinoma, Non-Small-Cell Lung/genetics ; Cost-Benefit Analysis ; Critical Pathways/standards ; Critical Pathways/statistics & numerical data ; DNA Mutational Analysis/standards ; DNA Mutational Analysis/statistics & numerical data ; Disease Progression ; Disease-Free Survival ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Erlotinib Hydrochloride/economics ; Erlotinib Hydrochloride/therapeutic use ; Female ; Follow-Up Studies ; Gefitinib/economics ; Gefitinib/therapeutic use ; Guideline Adherence/standards ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/economics ; Lung Neoplasms/genetics ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Mutation ; Practice Guidelines as Topic ; Progression-Free Survival ; Prospective Studies ; Protein Kinase Inhibitors/economics ; Protein Kinase Inhibitors/therapeutic use ; Time Factors ; Treatment Failure |
| Chemical Substances | Protein Kinase Inhibitors ; Afatinib (41UD74L59M) ; Erlotinib Hydrochloride (DA87705X9K) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Gefitinib (S65743JHBS) |
| Language | English |
| Publishing date | 2019-03-07 |
| Publishing country | United States |
| Document type | Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1409038-7 |
| ISSN | 1549-490X ; 1083-7159 |
| ISSN (online) | 1549-490X |
| ISSN | 1083-7159 |
| DOI | 10.1634/theoncologist.2018-0712 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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