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  1. Article ; Online: Bone mineral density fall during aromatase inhibitor treatment may predict lower breast cancer recurrence.

    Martin, Hilary / Redfern, Andrew

    Cancer medicine

    2024  

    Abstract: Purpose: Aromatase inhibitors (AIs) are associated with reduction in bone mineral density (BMD). The use of bone strengthening agents zoledronic acid and denosumab are associated with improved breast cancer outcomes for post-menopausal patients treated ... ...

    Abstract Purpose: Aromatase inhibitors (AIs) are associated with reduction in bone mineral density (BMD). The use of bone strengthening agents zoledronic acid and denosumab are associated with improved breast cancer outcomes for post-menopausal patients treated with AIs. This study investigates whether change in BMD with AI therapy is associated with breast cancer recurrence.
    Methods: A cohort of patients treated at a single institution diagnosed with hormone receptor-positive breast cancer with baseline BMD and subsequent BMD test while receiving adjuvant aromatase inhibitor therapy were studied. Demographic, treatment and outcome data was obtained. Simple and multiple linear regression analysis was performed to investigate predictors of annual percent BMD change at the LS and hip. Univariate and multivariate Cox proportional hazards modelling were undertaken to investigate predictors of breast cancer recurrence.
    Results: 353 patients eligible patients were identified. In multivariate analysis of lumbar spine BMD change, the difference between those in quartile 1, which showed the greatest reduction in BMD, and quartile 3, with substantially less reduction, was significant (HR = 3.02, 95% CI 1.15-7.90 p = 0.025). Hip BMD reduction was also not significantly associated with breast cancer recurrence. The two quartiles with the least reduction in hip BMD showing a non-significant reduced risk of recurrence relative to the quartile with the greatest (p = 0.10).
    Conclusions: The findings suggest an association may exist between lumbar spine BMD change and breast cancer recurrence for patients treated with adjuvant AI. Further research is required to determine whether BMD change can be utilised as a biomarker.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Evolving Role of Locally Delivered Checkpoint Inhibitors in Non-muscle-invasive Bladder Cancer.

    Hayne, Dickon / Redfern, Andrew

    European urology

    2022  Volume 82, Issue 6, Page(s) 611–612

    MeSH term(s) Humans ; Urinary Bladder Neoplasms/drug therapy ; Carcinoma, Transitional Cell ; Immunotherapy
    Language English
    Publishing date 2022-09-22
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.08.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  3. Article ; Online: Breast cancer metastasis: mapping long term outcomes in Australia.

    Redfern, Andrew / Martin, Hilary

    The Medical journal of Australia

    2022  Volume 217, Issue 8, Page(s) 398–399

    MeSH term(s) Humans ; Female ; Breast Neoplasms ; Australia/epidemiology ; Neoplasms, Second Primary ; Neoplasm Metastasis ; Prognosis
    Language English
    Publishing date 2022-09-18
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Competencies of junior medical doctors in managing seriously ill and injured children: time to rethink our current training approach?

    Erasmus, Louisa / Redfern, Andrew / Smit, Liezl

    Journal of tropical pediatrics

    2023  Volume 69, Issue 4

    Abstract: Background: The correct treatment of very ill and injured children is critical, yet little is known about the competencies of South African (SA) junior doctors in managing these children.: Methods: This survey documents SA junior doctors' reported ... ...

    Abstract Background: The correct treatment of very ill and injured children is critical, yet little is known about the competencies of South African (SA) junior doctors in managing these children.
    Methods: This survey documents SA junior doctors' reported resuscitation training opportunities, experience, skills and knowledge.
    Results: A total of 118 doctors (interns, medical officers and registrars) from paediatric departments affiliated with 7 medical schools, participated. Resuscitations were not rare events with 71% (84/118) reporting participation in >10 resuscitations during the preceding 2 years. Yet a third of doctors have not attended an accredited resuscitation training course within the last 2 years; 34% (12/35) medical officers and 29% (18/63) registrars, respectively, with 42% (49/118) of all participants never receiving any formal resuscitation training during employment. Feedback on performance is not standard practice with only 8% (10/118) reporting consistent debriefing after a resuscitation. Although 72% (85/118) reported their resuscitation knowledge as adequate, 56% (66/118) passed the knowledge test.
    Conclusion: This study recognized missed learning opportunities in junior doctors' training, assessment, debriefing and knowledge which may adversely affect the quality of care in managing paediatric emergencies. This has implications for departmental and post-graduate training programmes.
    MeSH term(s) Child ; Humans ; Health Personnel ; Medical Staff, Hospital ; Resuscitation ; South Africa ; Professional Competence
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 800065-7
    ISSN 1465-3664 ; 0449-3281 ; 0142-6338
    ISSN (online) 1465-3664
    ISSN 0449-3281 ; 0142-6338
    DOI 10.1093/tropej/fmad025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 932: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Stromal inflammation, fibrosis and cancer: An old intuition with promising potential.

    Oey, Oliver / Sunjaya, Angela Felicia / Khan, Yasir / Redfern, Andrew

    World journal of clinical oncology

    2023  Volume 14, Issue 7, Page(s) 230–246

    Abstract: It is now well established that the biology of cancer is influenced by not only malignant cells but also other components of the tumour microenvironment. Chronic inflammation and fibrosis have long been postulated to be involved in carcinogenesis. ... ...

    Abstract It is now well established that the biology of cancer is influenced by not only malignant cells but also other components of the tumour microenvironment. Chronic inflammation and fibrosis have long been postulated to be involved in carcinogenesis. Chronic inflammation can promote tumorigenesis
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2587357-X
    ISSN 2218-4333
    ISSN 2218-4333
    DOI 10.5306/wjco.v14.i7.230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling.

    Chi, Lap Hing / Redfern, Andrew D / Roslan, Suraya / Street, Ian P / Burrows, Allan D / Anderson, Robin L

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 248

    Abstract: Background: Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive.: Methods: To assess the requirement for ... ...

    Abstract Background: Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive.
    Methods: To assess the requirement for SMAD4 in BMP4-mediated suppression of metastasis, we knocked down SMAD4 in two different breast tumors and enforced SMAD4 expression in a third line with endogenous SMAD4 deletion. In addition, we assessed the requirement for SMAD4 in tumor cell-specific BMP signalling by expression of a constitutively active BMP receptor. Delineation of genes regulated by BMP4 in the presence or absence of SMAD4 was assessed by RNA sequencing and a BMP4-induced gene, MYO1F was assessed for its role in metastasis. Genes regulated by BMP4 and/or SMAD4 were assessed in a publicly available database of gene expression profiles of breast cancer patients.
    Results: In the absence of SMAD4, BMP4 promotes primary tumor growth that is accompanied by increased expression of genes associated with DNA replication, cell cycle, and MYC signalling pathways. Despite increased primary tumor growth, BMP4 suppresses metastasis in the absence of tumor cell expression of SMAD4. Consistent with the anti-metastatic activity of BMP4, enforced signalling through the constitutively active receptor in SMAD4 positive tumors that lacked BMP4 expression still suppressed metastasis, but in the absence of SMAD4, the suppression of metastasis was largely prevented. Thus BMP4 is required for suppression of metastasis regardless of tumor SMAD4 status. The BMP4 upregulated gene, MYO1F, was shown to be a potent suppressor of breast cancer metastasis. Gene signature upregulated by BMP4 in the absence of SMAD4 was associated with poor prognosis in breast cancer patients, whereas gene signature upregulated by BMP4 in the presence of SMAD4 was associated with improved prognosis.
    Conclusions: BMP4 expression is required for suppression of metastasis regardless of the SMAD4 status of the tumor cells. Since BMP4 is a secreted protein, we conclude that it can act both in an autocrine manner in SMAD4-expressing tumor cells and in a paracrine manner on stromal cells to suppress metastasis. Deletion of SMAD4 from tumor cells does not prevent BMP4 from suppressing metastasis via a paracrine mechanism.
    MeSH term(s) Smad4 Protein/genetics ; Smad4 Protein/metabolism ; Bone Morphogenetic Protein 4/genetics ; Bone Morphogenetic Protein 4/metabolism ; Humans ; Signal Transduction ; Animals ; Female ; Neoplasm Metastasis ; Cell Line, Tumor ; Breast Neoplasms/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Mice ; Cell Proliferation/genetics
    Chemical Substances Smad4 Protein ; Bone Morphogenetic Protein 4 ; SMAD4 protein, human
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-024-01559-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: The Essential Guide to Classroom Practice

    Redfern, Andrew

    200+ strategies for outstanding teaching and learning

    2015  

    Abstract: The Essential Guide to Classroom Practice has been written with two questions in mind. These are the questions that are most important to all practitioners who seek to improve the quality of learning in their classrooms - what strategies work? and, how ... ...

    Abstract The Essential Guide to Classroom Practice has been written with two questions in mind. These are the questions that are most important to all practitioners who seek to improve the quality of learning in their classrooms - what strategies work? and, how do we implement them?Covering all the areas that are key to effective teaching and learning, this text consists of over 200 practical strategies that secondary teachers can adopt and apply within their classroom. These strategies range from simple tools to improve the quality of questioning, to principles that can shape the whole approach to lea
    Language English
    Size Online-Ressource (225 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781138800281 ; 1138800287
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book: Teaching business and economics in secondary schools

    Redfern, Andrew / Hirst, Keith

    the essential guide

    2018  

    Author's details Andrew Redfern, Keith Hirst
    Keywords Business education/Study and teaching (Secondary) ; Economics/Study and teaching (Secondary)
    Language English
    Size 1 volume, 25 cm
    Publisher Routledge
    Publishing place London
    Document type Book
    ISBN 9781138675469 ; 9781138675544 ; 9781315560632 ; 9781317198833 ; 9781317198840 ; 9781317198840 ; 9781317198857 ; 1138675466 ; 1138675547 ; 1315560631 ; 1317198832 ; 1317198840 ; 1317198840 ; 1317198859
    Database ECONomics Information System

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  9. Article ; Online: Infants 21-90 days presenting with a possible serious bacterial infection - are evaluation algorithms from high income countries applicable in the South African public health sector?

    Lishman, Juanita / Smit, Liezl / Redfern, Andrew

    African journal of emergency medicine : Revue africaine de la medecine d'urgence

    2020  Volume 11, Issue 1, Page(s) 158–164

    Abstract: Background: Young infants with a possible serious bacterial infection (SBI) are a very common presentation to emergency centres (ECs). It is often difficult to distinguish clinically between self-limiting viral infections and an SBI. Available ... ...

    Abstract Background: Young infants with a possible serious bacterial infection (SBI) are a very common presentation to emergency centres (ECs). It is often difficult to distinguish clinically between self-limiting viral infections and an SBI. Available evaluation algorithms to assist clinicians are mostly from high-income countries. Data to inform clinical practice in low- and middle-income countries are lacking.
    Objectives: To determine the period prevalence of SBI and invasive bacterial infection (IBI) and describe current practice in the assessment and management of young infants aged 21-90 days presenting with a possible SBI to a Paediatric Emergency centre (PEC) in Cape Town, South Africa.
    Methods: A retrospective cross-sectional review of infants 21-90 days old presenting to the Tygerberg Hospital PED between 1 January 2016 and 31 May 2016.
    Results: A total of 248 infants 21-90 days were included in the study. Sixty-two patients (25%, 95% CI 20-30) had an SBI and 13 (5.2%, 95% CI 3-8) had an IBI. One hundred and sixty-five infants had a possible SBI based on WHO IMCI criteria. The sensitivity of the WHO IMCI criteria in detecting SBI was 82.3% (95% CI 70.5-90.8) and the specificity 38.7% (95% CI 31.7-46.1). More than half (51.2%) of the infants received antibiotics within the 48 h prior to presentation, of which 33.5% included intramuscular injection of Ceftriaxone. Only 20 (8.0%) patients in this age group were discharged home after initial evaluation. A significant relationship was noted between fever and the risk of SBI (p-value 0.010) and IBI (p-value 0.009). There also appeared to be a significant relationship between nutritional status and IBI (p-value 0.013).
    Conclusion: Period prevalence of SBI and IBI was higher compared to that published in the literature. Validated evaluation algorithms to stratify risk of SBI are needed to assist clinicians in diagnosing and managing infants appropriately in low- and middle-income settings.
    Language English
    Publishing date 2020-10-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-4203
    ISSN (online) 2211-4203
    DOI 10.1016/j.afjem.2020.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Association of Computed Tomography Measures of Muscle and Adipose Tissue and Progressive Changes throughout Treatment with Clinical Endpoints in Patients with Advanced Lung Cancer Treated with Immune Checkpoint Inhibitors.

    Khan, Azim / Welman, Christopher J / Abed, Afaf / O'Hanlon, Susan / Redfern, Andrew / Azim, Sara / Lopez, Pedro / Singh, Favil / Khattak, Adnan

    Cancers

    2023  Volume 15, Issue 5

    Abstract: To investigate the association between skeletal muscle mass and adiposity measures with disease-free progression (DFS) and overall survival (OS) in patients with advanced lung cancer receiving immunotherapy, we retrospectively analysed 97 patients (age: ... ...

    Abstract To investigate the association between skeletal muscle mass and adiposity measures with disease-free progression (DFS) and overall survival (OS) in patients with advanced lung cancer receiving immunotherapy, we retrospectively analysed 97 patients (age: 67.5 ± 10.2 years) with lung cancer who were treated with immunotherapy between March 2014 and June 2019. From computed tomography scans, we assessed the radiological measures of skeletal muscle mass, and intramuscular, subcutaneous and visceral adipose tissue at the third lumbar vertebra. Patients were divided into two groups based on specific or median values at baseline and changes throughout treatment. A total number of 96 patients (99.0%) had disease progression (median of 11.3 months) and died (median of 15.4 months) during follow-up. Increases of 10% in intramuscular adipose tissue were significantly associated with DFS (HR: 0.60, 95% CI: 0.38 to 0.95) and OS (HR: 0.60, 95% CI: 0.37 to 0.95), while increases of 10% in subcutaneous adipose tissue were associated with DFS (HR: 0.59, 95% CI: 0.36 to 0.95). These results indicate that, although muscle mass and visceral adipose tissue were not associated with DFS or OS, changes in intramuscular and subcutaneous adipose tissue can predict immunotherapy clinical outcomes in patients with advanced lung cancer.
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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