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  1. Article ; Online: Use of Chalazion Clamps in Oral Mucosa Surgery.

    Úbeda Clemente, M I / Cruañes Monferrer, J / Ramírez Andreo, A / Brufau Redondo, C

    Actas dermo-sifiliograficas

    2022  Volume 113, Issue 10, Page(s) T1003–T1004

    MeSH term(s) Humans ; Chalazion/surgery ; Mouth Mucosa
    Language Spanish
    Publishing date 2022-10-03
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2022.09.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluación de la expresión de PD-L1 e infiltración linfocitaria intratumoral en carcinoma de mama invasivo triple negativo.

    Barrios Barreto, Rina / Silvera Redondo, Carlos / Garavito, María Del Pilar / Ardila Pereira, Laura

    Medicina

    2024  Volume 84, Issue 2, Page(s) 227–235

    Abstract: Introduction: Triple negative breast cancer endophenotype (TNBC) is one of the least frequent and without therapeutic target; therefore we propose to study the correlation of PD-L1 immune checkpoint with the establishment of tumor microenvironment ... ...

    Title translation Evaluation of PD-L1 expression and intratumoral lymphocytic infiltration in triple-negative invasive breast carcinoma.
    Abstract Introduction: Triple negative breast cancer endophenotype (TNBC) is one of the least frequent and without therapeutic target; therefore we propose to study the correlation of PD-L1 immune checkpoint with the establishment of tumor microenvironment assessed by intratumoral stromal lymphocyte infiltration (TILS) and its importance in clinical practice.
    Methods: A retrospective case-control study was performed, with 31 cases of triple-negative infiltrating breast carcinoma and 57 unmatched controls of Luminal A, Luminal B and HER-2 endophenotype seen in one year. The following variables were evaluated: histologic type and grade, PD-L1 expression with clone 22C3, TILS, lymphovascular invasion, tumor size, lymph node involvement and metastasis. Statistical analysis was performed with the chi-square test and Spearman correlation coefficient test.
    Results: a statistically significant negative correlation was found between TILS and PD-L1 (rho - 0.106, p 0.025), indicating that the higher the expression of PD-L1, the lower the intratumoral lymphocytic infiltration. In the TILS B (10-40% TILS) and C (40-90% TILS) groups where there was a marked intratumoral inflammatory infiltrate, a greater number of patients were negative for PD-L1 (CPS <10) with 16 and 10 cases, respectively. For TNBC cases a negative association coefficient was identified (rho -0.378) with statistical significance (p 0.01).
    Discussion: The association between TNBC, TILS and PDL1 expression was established, which is important for the establishment of target therapies and the development of precision medicine.
    MeSH term(s) Humans ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/immunology ; B7-H1 Antigen/analysis ; B7-H1 Antigen/metabolism ; Female ; Retrospective Studies ; Lymphocytes, Tumor-Infiltrating/immunology ; Middle Aged ; Case-Control Studies ; Adult ; Aged ; Tumor Microenvironment/immunology
    Chemical Substances B7-H1 Antigen ; CD274 protein, human
    Language Spanish
    Publishing date 2024-04-29
    Publishing country Argentina
    Document type English Abstract ; Journal Article
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Use of Chalazion Clamps in Oral Mucosa Surgery.

    Úbeda Clemente, M I / Cruañes Monferrer, J / Ramírez Andreo, A / Brufau Redondo, C

    Actas dermo-sifiliograficas

    2021  Volume 113, Issue 10, Page(s) 1003–1004

    Title translation Empleo de pinza de chalazión en el tratamiento quirúrgico de la mucosa oral.
    MeSH term(s) Humans ; Mouth Mucosa ; Chalazion
    Language Spanish
    Publishing date 2021-09-17
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2021.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bioinformatic Analysis of Plus Gene Expression Related to Progression from Leukoplakia to Oral Squamous Cell Carcinoma.

    Guzman De Avila, Jaime / Silvera-Redondo, Carlos / Alviz-Amador, Antistio

    Asian Pacific journal of cancer prevention : APJCP

    2022  Volume 23, Issue 11, Page(s) 3833–3842

    Abstract: Introduction: Leukoplakia is one of the most frequently found lesions in the oral cavity, with a probability of 17 to 24% of becoming malignant cells in a period of 30 years.: Objective: To identify differentially expressed gene profiles of ... ...

    Abstract Introduction: Leukoplakia is one of the most frequently found lesions in the oral cavity, with a probability of 17 to 24% of becoming malignant cells in a period of 30 years.
    Objective: To identify differentially expressed gene profiles of leukoplakia and its progression to oral squamous cell carcinoma, essential for the discovery of new biomarkers to predict and prevent the presence of diseases in the oral cavity.
    Methods: Initially, gene profiles of GSE85514 and GSE160042 from the Gene Expression Omnibus database were used. Differentially expressed genes were identified using GEO2R. The CLUEGO plugin in Cytoscape was used for DEG functionality and enrichment analysis. Finally, a protein-protein interaction (PPI) network was constructed using Cytoscape from data collected online from the STRING server.
    Results: According to the MCC algorithm, the 10 most found gene sequences were HNRNPU, SMC1A, PAFAH1B1, EHMT1, SPTBN4, OLFM1, NCAM1, SF3B3, FGF2, and UBE2I; with HNRNPU, SMC1A, and PAFAH1B1 being the most representative of the modules.
    Conclusions: We were able to describe the gene sequences that promote the progression from leukoplakia to oral squamous cell carcinoma. Within these genes, the HNRNPU, SMC1A, and PAFAH1B1 constitute the main promising therapeutic targets to counteract the progression of oral cancer, they could also be important biomarkers for the diagnosis and classification of the disease.
    MeSH term(s) Humans ; Mouth Neoplasms/genetics ; Squamous Cell Carcinoma of Head and Neck ; Carcinoma, Squamous Cell/genetics ; Computational Biology ; Leukoplakia ; Head and Neck Neoplasms ; Gene Expression
    Language English
    Publishing date 2022-11-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2022.23.11.3833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Delving into the Role of lncRNAs in Papillary Thyroid Cancer: Upregulation of LINC00887 Promotes Cell Proliferation, Growth and Invasion.

    Tous, Cristina / Muñoz-Redondo, Carmen / Gavilán, Angela / Bravo-Gil, Nereida / Baco-Antón, Fátima / Navarro-González, Elena / Antiñolo, Guillermo / Borrego, Salud

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Papillary thyroid carcinoma (PTC) is the most common histological category of thyroid cancer. In recent years, there has been an increasing number of studies on lncRNAs in PTC. Long intergenic non-protein coding RNA 887 (LINC00887) is a critical oncogene ...

    Abstract Papillary thyroid carcinoma (PTC) is the most common histological category of thyroid cancer. In recent years, there has been an increasing number of studies on lncRNAs in PTC. Long intergenic non-protein coding RNA 887 (LINC00887) is a critical oncogene in developing other cancers. LINC00887 is upregulated in PTC samples but its role in PTC is currently unclear. This study aimed to investigate the impact the disruption of LINC00887 expression has on PTC progression. We performed a CRISPR/Cas9 strategy for the truncation of LINC00887 in BCPAP and TPC1 cell lines. Functional assays showed that LINC00887 knockdown in both TPC1 and BCPAP cells reduced cell proliferation, colony formation and migration, delayed the cell cycle, and increased apoptosis. These results strengthened the role of LINC00887 in cancer and showed for the first time that this lncRNA could be a potential oncogene in PTC, acting as a tumor promoter. Modulation of the immune system may be one of the etiopathogenic mechanisms of LINC00887 in PTC, as shown by the observed influence of this lncRNA on PD-L1 expression. In addition, the biological pathways of LINC00887 identified to date, such as EMT, the Wnt/β-catenin signaling pathway or the FRMD6-Hippo signaling pathway may also be relevant regulatory mechanisms operating in PTC.
    MeSH term(s) Humans ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; RNA, Long Noncoding/genetics ; Thyroid Cancer, Papillary/genetics ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Up-Regulation/genetics
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2024-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hybrid-APC treatment for gastric vascular ectasia of atypical location after failed radiofrequency ablation.

    Palma García, José Manuel / Honrubia López, Raúl / Fernández de Castro, Cristina / Comas Redondo, Carmen

    Revista espanola de enfermedades digestivas

    2023  

    Abstract: A 76-year-old woman was being followed up for chronic anemia secondary to bleeding from vascular ectasias at the gastric antrum and the cardial and subcardial region. On several occasions the patient required fulguration of these lesions with ... ...

    Abstract A 76-year-old woman was being followed up for chronic anemia secondary to bleeding from vascular ectasias at the gastric antrum and the cardial and subcardial region. On several occasions the patient required fulguration of these lesions with conventional APC, which resulted in no clear improvement. Radiofrequency ablation of these lesions was then attempted using a 90-degree probe, which was successful on antral angiodysplasias but failed to remove lesions in the cardial and subcardial region since anatomy there prevented proper apposition of the probe onto the target mucosa. Given the absence of any improvement, it was decided to use fulguration for angiectasias at the cardial and subcardial level by means of Hybrid-APC, which consists of lifting the mucosa with an injection through the APC probe and then fulgurating in the pulsedAPC® mode, thus achieving a broader ablation area in a shorter time. During the subsequent review a clear reduction of vascular ectasias was observed.
    Language English
    Publishing date 2023-06-14
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9709/2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Conference proceedings: Radiofrecuency as an alternative treatment for actinic proctitis instead of argon plasma

    Lopez, R. Honrubia / Portillo, E. Montiel / De Castro, C. Fernandez / Hernandez, L. Ciriano / Redondo, C. Comas

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783392
    Database Thieme publisher's database

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  8. Article ; Online: Optimal Frontier-Based Autonomous Exploration in Unconstructed Environment Using RGB-D Sensor.

    Lu, Liang / Redondo, Carlos / Campoy, Pascual

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 22

    Abstract: Aerial robots are widely used in search and rescue applications because of their small size and high maneuvering. However, designing an autonomous exploration algorithm is still a challenging and open task, because of the limited payload and computing ... ...

    Abstract Aerial robots are widely used in search and rescue applications because of their small size and high maneuvering. However, designing an autonomous exploration algorithm is still a challenging and open task, because of the limited payload and computing resources on board UAVs. This paper presents an autonomous exploration algorithm for the aerial robots that shows several improvements for being used in the search and rescue tasks. First of all, an RGB-D sensor is used to receive information from the environment and the OctoMap divides the environment into obstacles, free and unknown spaces. Then, a clustering algorithm is used to filter the frontiers extracted from the OctoMap, and an information gain based cost function is applied to choose the optimal frontier. At last, the feasible path is given by A* path planner and a safe corridor generation algorithm. The proposed algorithm has been tested and compared with baseline algorithms in three different environments with the map resolutions of 0.2 m, and 0.3 m. The experimental results show that the proposed algorithm has a shorter exploration path and can save more exploration time when compared with the state of the art. The algorithm has also been validated in the real flight experiments.
    Language English
    Publishing date 2020-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20226507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chemotactic Responses of

    Sena-Vélez, Marta / Ferragud, Elisa / Redondo, Cristina / Graham, James H / Cubero, Jaime

    Microorganisms

    2022  Volume 11, Issue 1

    Abstract: Xanthomonas ... ...

    Abstract Xanthomonas citri
    Language English
    Publishing date 2022-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11010043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Complete Genome Sequence Resources of Six Strains of the Most Virulent Pathovars of

    Cuesta-Morrondo, Sara / Redondo, Cristina / Palacio-Bielsa, Ana / Garita-Cambronero, Jerson / Cubero, Jaime

    Phytopathology

    2022  Volume 112, Issue 8, Page(s) 1808–1813

    MeSH term(s) High-Throughput Nucleotide Sequencing ; Plant Diseases ; Sequence Analysis, DNA ; Xanthomonas/genetics
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-10-21-0436-A
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