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Article ; Online: Optic neuritis as sign presentation of acute disseminated encephalomyelitis following Mycoplasma pneumoniae infection.

González-Rodríguez, B / González-Rodríguez, M / Bejarano Ramírez, N / Redondo Calvo, F J

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2022 Volume 35, Issue 2, Page(s) 223–224

MeSH term(s)	Encephalomyelitis, Acute Disseminated/diagnostic imaging ; Encephalomyelitis, Acute Disseminated/drug therapy ; Humans ; Magnetic Resonance Imaging ; Mycoplasma pneumoniae ; Optic Neuritis/diagnostic imaging ; Optic Neuritis/drug therapy ; Optic Neuritis/etiology ; Pneumonia, Mycoplasma/complications ; Pneumonia, Mycoplasma/diagnosis ; Pneumonia, Mycoplasma/drug therapy
Language	English
Publishing date	2022-02-25
Publishing country	Spain
Document type	Letter
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/112.2021
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Article: Crosslinked Bifunctional Particles for the Removal of Bilirubin in Hyperbilirubinemia Cases.

Garrido, María Del Prado / Borreguero, Ana Maria / Ramos, Maria Jesús / Carmona, Manuel / Redondo Calvo, Francisco Javier / Rodriguez, Juan Francisco

Materials (Basel, Switzerland)

2023 Volume 16, Issue 8

Abstract: This work describes the development of styrene-divinylbenzene (St-DVB) particles with polyethylene glycol methacrylate (PEGMA) and/or glycidyl methacrylate (GMA) brushes for the removal of bilirubin from blood in haemodialyzed patients. Bovine serum ... ...

Abstract	This work describes the development of styrene-divinylbenzene (St-DVB) particles with polyethylene glycol methacrylate (PEGMA) and/or glycidyl methacrylate (GMA) brushes for the removal of bilirubin from blood in haemodialyzed patients. Bovine serum albumin (BSA) was immobilized onto the particles using ethyl lactate as a biocompatible solvent, which allowed the immobilization of up to 2 mg BSA/g of particles. The presence of albumin on the particles increased their capacity for bilirubin removal from phosphate-buffered saline (PBS) by 43% compared to particles without albumin. The particles were tested in plasma, finding that St-DVB-GMA-PEGMA particles that had been wetted in ethyl lactate with BSA reduced the concentration of bilirubin in plasma by 53% in less than 30 min. This effect was not observed in particles without BSA. Therefore, the presence of albumin on the particles enabled quick and selective removal of bilirubin from plasma. Overall, the study highlights the potential use of St-DVB particles with PEGMA and/or GMA brushes for bilirubin removal in haemodialyzed patients. The immobilization of albumin onto the particles using ethyl lactate increased their capacity for bilirubin removal and enabled quick and selective removal from plasma.
Language	English
Publishing date	2023-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16082999
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Article ; Online: Paclitaxel as HIPEC-Drug after Surgical Cytoreduction for Ovarian Peritoneal Metastases: A Randomized Phase III Clinical Trial (HIPECOVA).

Villarejo Campos, Pedro / Sánchez García, Susana / Amo-Salas, Mariano / García Santos, Esther / López de la Manzanara, Carlos / Alberca, Ana / Padilla-Valverde, David / Redondo Calvo, Francisco Javier / Martín, Jesús

Current oncology (Toronto, Ont.)

2024 Volume 31, Issue 2, Page(s) 660–671

Abstract: Multidisciplinary strategies have transformed the management of advanced ovarian cancer. We aimed to evaluate the effectiveness of paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical cytoreduction for ovarian peritoneal ... ...

Abstract	Multidisciplinary strategies have transformed the management of advanced ovarian cancer. We aimed to evaluate the effectiveness of paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical cytoreduction for ovarian peritoneal metastases in a randomized phase III trial conducted between August 2012 and December 2019. Seventy-six patients were randomized to either the HIPEC or no HIPEC group. Although median values for the primary endpoints (recurrence-free survival (RFS) and overall survival (OS)) revealed superior outcomes for the HIPEC (RFS: 23 months, OS: 48 months) over the control group (RFS: 19 months, OS: 46 months), these differences were not statistically significant (
MeSH term(s)	Female ; Humans ; Paclitaxel/therapeutic use ; Hyperthermic Intraperitoneal Chemotherapy ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/surgery ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Follow-Up Studies ; Hyperthermia, Induced ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31020048
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Article ; Online: The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer.

Bodoque-Villar, Raquel / Padilla-Valverde, David / González-López, Lucía María / Muñoz-Rodríguez, José Ramón / Arias-Pardilla, Javier / Villar-Rodríguez, Clara / Gómez-Romero, Francisco Javier / Verdugo-Moreno, Gema / Redondo-Calvo, Francisco Javier / Serrano-Oviedo, Leticia

World journal of surgical oncology

2023 Volume 21, Issue 1, Page(s) 287

Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer is that a large part of the tumor volume is composed of a stroma with different cells and factors. ... ...

Abstract	Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer is that a large part of the tumor volume is composed of a stroma with different cells and factors. Among these, we can highlight the cytokines, which perform their function through binding to their receptors. Given the impact of the CXCR4 receptor in the interactions between tumor cells and their microenvironment and its involvement in important signaling pathways in cancer, it is proposed as a very promising prognostic biomarker and as a goal for new targeted therapies. Numerous studies analyze the expression of CXCR4 but we suggest focusing on the expression of CXCR4 in the stroma. Methods: Expression of CXCR4 in specimens from 33 patients with PDAC was evaluated by immunohistochemistry techniques and matched with clinicopathological parameters, overall and disease-free survival rates. Results: The percentage of stroma was lower in non-tumor tissue (32.4 ± 5.2) than in tumor pancreatic tissue (67.4 ± 4.8), P-value = 0.001. The level of CXCR4 expression in stromal cells was diminished in non-tumor tissue (8.7 ± 4.6) and higher in tumor pancreatic tissue (23.5 ± 6.1), P-value = 0.022. No significant differences were identified in total cell count and inflammatory cells between non-tumor tissue and pancreatic tumor tissue. No association was observed between CXCR4 expression and any of the clinical or pathological data, overall and disease-free survival rates. Analyzing exclusively the stroma of tumor samples, the CXCR4 expression was associated with tumor differentiation, P-value = 0.05. Conclusions: In this study, we reflect the importance of CXCR4 expression in the stroma of patients diagnosed with PDAC. Our results revealed a high CXCR4 expression in the tumor stroma, which is related to a poor tumor differentiation. On the contrary, we could not find an association between CXCR4 expression and survival and the rest of the clinicopathological variables. Focusing the study on the CXCR4 expression in the tumor stroma could generate more robust results. Therefore, we consider it key to develop more studies to enlighten the role of this receptor in PDAC and its implication as a possible biomarker.
MeSH term(s)	Humans ; Carcinoma, Pancreatic Ductal ; Pancreatic Neoplasms ; Receptors, CXCR4 ; Tumor Microenvironment ; Biomarkers, Tumor ; Pancreatic Neoplasms
Chemical Substances	CXCR4 protein, human ; Receptors, CXCR4 ; Biomarkers, Tumor
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-023-03168-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

2023 Volume 24, Issue 7

Abstract: Garlic ( ...

Abstract	Garlic (
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Garlic/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Monocytes/metabolism ; Sepsis/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Antioxidants ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; HIF1A protein, human
Language	English
Publishing date	2023-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076234
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Article ; Online: Complications related to Turner syndrome.

Bejarano Ramírez, Natalia / Redondo Calvo, Francisco Javier / Galán Gómez, Enrique

Medicina clinica

2017 Volume 149, Issue 1, Page(s) 39–40

Title translation	Complicaciones asociadas a niñas con síndrome de Turner.
MeSH term(s)	Female ; Humans ; Turner Syndrome/complications ; Turner Syndrome/diagnosis ; Turner Syndrome/genetics
Language	Spanish
Publishing date	2017-04-04
Publishing country	Spain
Document type	Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.02.016
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Article ; Online: Clinical features and mortality of COVID-19 patients admitted to ICU according to SOFA score.

Gómez-Romero, Francisco Javier / Muñoz-Rodríguez, José Ramón / Serrano-Oviedo, Leticia / García-Jabalera, Inmaculada / López-Juárez, Pilar / Pérez-Ortiz, José Manuel / Redondo-Calvo, Francisco Javier

Medicine

2022 Volume 101, Issue 28, Page(s) e29206

Abstract: The Sequential Organ Failure Assessment (SOFA) could function as an effective risk stratification tool in the admission of critically ill patients with COVID-19 and would allow stratification based on a risk assessment. We aimed to examine whether the ... ...

Abstract	The Sequential Organ Failure Assessment (SOFA) could function as an effective risk stratification tool in the admission of critically ill patients with COVID-19 and would allow stratification based on a risk assessment. We aimed to examine whether the SOFA score is useful to define 2 severity profiles in COVID-19 patients admitted to ICU: mild with SOFA < 5, and severe with SOFA ≥ 5. A retrospective cohort, multicenter study was conducted from February 11 to May 11, 2020. We analyzed patients admitted to all ICUs of the 14 public hospitals of the Castilla-La Mancha Health Service at the beginning of the pandemic and with SARS-CoV-2 infection. Patients were divided in 2 groups according to the level of severity by SOFA at admission to the ICU. Cox regression was used to evaluate factors associated with survival and Kaplan-Meier test to examine survival probability. In total, 405 patients with a complete SOFA panel were recruited in the 14 participating ICUs. SOFA <5 group showed that age above 60 years and D-dimer above 1000 ng/mL were risk factors associated with lower survival. In SOFA ≥ 5 it was found that high blood pressure was a risk factor associated with shorter survival. Kaplan-Meier showed lower survival in SOFA ≥ 5 in combination with high blood pressure, time since viral symptom onset to admission in ICU < 7 days, D-dimer ≥1000 ng/mL and respiratory pathology. However, SOFA < 5 showed only higher age (≥60 years) associated with lower survival. Age over 60 years and D-dimer over 1000 ng/mL were risk factors reflecting lower survival in patients with SOFA < 5. Moreover, SOFA ≥ 5 patients within a week after COVID-19 onset and comorbidities such as high blood pressure and previous respiratory pathology showed lower survival.
MeSH term(s)	COVID-19 ; Humans ; Hypertension ; Intensive Care Units ; Middle Aged ; Organ Dysfunction Scores ; Prognosis ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029206
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Article ; Online: Pediatric patients with suspected COVID-19 in an emergency department: analysis of characteristics and transmission to contacts.

Pérez-Ortiz, José Manuel / García-Jabalera, Inmaculada / Gómez-Romero, Francisco Javier / Muñoz-Rodríguez, José Ramón / Serrano-Oviedo, Leticia / Bejarano-Ramírez, Natalia / Redondo-Calvo, Francisco Javier

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

2022 Volume 34, Issue 1, Page(s) 73–75

Title translation	Análisis de los pacientes menores de edad con sospecha de COVID-19 en un servicio de urgencias y su impacto en el estudio de contactos.
MeSH term(s)	COVID-19 ; Child ; Emergency Service, Hospital ; Humans ; SARS-CoV-2
Language	Spanish
Publishing date	2022-01-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2127173-2
ISSN	2386-5857 ; 2386-5857
ISSN (online)	2386-5857
ISSN	2386-5857
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Article: Black Garlic and Thiosulfinate-Enriched Extracts as Adjuvants to Ceftriaxone Treatment in a Rat Peritonitis Model of Sepsis.

Redondo-Calvo, Francisco Javier / Bejarano-Ramírez, Natalia / Baladrón, Víctor / Montenegro, Omar / Gómez, Luis Antonio / Velasco, Rubén / Villasanti, Natalia / Illescas, Soledad / Franco-Sereno, María Teresa / Gracia, Ignacio / Rodríguez, Juan Francisco / Muñoz-Rodríguez, José Ramón / Pérez-Ortiz, José Manuel

Biomedicines

2022 Volume 10, Issue 12

Abstract: To date, there have been no new drugs or adjuvants able to decrease both morbidity and mortality in the context of sepsis and septic shock. Our objective was to evaluate the use of thiosulfinate- ... ...

Abstract	To date, there have been no new drugs or adjuvants able to decrease both morbidity and mortality in the context of sepsis and septic shock. Our objective was to evaluate the use of thiosulfinate-enriched
Language	English
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10123095
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Article: Characterization of Permeability Barrier Dysfunction in a Murine Model of Cutaneous Field Cancerization Following Chronic UV-B Irradiation: Implications for the Pathogenesis of Skin Cancer.

Santiago, Juan Luis / Muñoz-Rodriguez, Jose Ramon / Cruz-Morcillo, Miguel Angel de la / Villar-Rodriguez, Clara / Gonzalez-Lopez, Lucia / Aguado, Carolina / Nuncia-Cantarero, Miriam / Redondo-Calvo, Francisco Javier / Perez-Ortiz, Jose Manuel / Galan-Moya, Eva Maria

Cancers

2021 Volume 13, Issue 16

Abstract: Chronic ultraviolet B (UV-B) irradiation is known to be one of the most important hazards acting on the skin and poses a risk of developing photoaging, skin with cutaneous field cancerization (CFC), actinic keratosis (AKs), and squamous cell carcinomas ( ... ...

Abstract	Chronic ultraviolet B (UV-B) irradiation is known to be one of the most important hazards acting on the skin and poses a risk of developing photoaging, skin with cutaneous field cancerization (CFC), actinic keratosis (AKs), and squamous cell carcinomas (SCCs). Most of the UV-B light is absorbed in the epidermis, affecting the outermost cell layers, the stratum corneum, and the stratum granulosum, which protects against this radiation and tries to maintain the permeability barrier. In the present work, we show an impairment in the transepidermal water loss, stratum corneum hydration, and surface pH after chronic UV-B light exposure in an immunologically intact mouse model (SKH1 aged mice) of skin with CFC. Macroscopic lesions of AKs and SCCs may develop synchronically or over time on the same cutaneous surface due to both the presence of subclinical AKs and in situ SCC, but also the accumulation of different mutations in keratinocytes. Focusing on skin with CFC, yet without the pathological criteria of AKs or SCC, the presence of p53 immunopositive patches (PIPs) within the epidermis is associated with these UV-B-induced mutations. Reactive epidermis to chronic UV-B exposure correlated with a marked hyperkeratotic hyperplasia, hypergranulosis, and induction of keratinocyte hyperproliferation, while expressing an upregulation of filaggrin, loricrin, and involucrin immunostaining. However, incidental AKs and in situ SCC might show neither hypergranulosis nor upregulation of differentiation markers in the upper epidermis. Despite the overexpression of filaggrin, loricrin, involucrin, lipid enzymes, and ATP-binding cassette subfamily A member 12 (ABCA12) after chronic UV-B irradiation, the permeability barrier, stratum corneum hydration, and surface pH were severely compromised in the skin with CFC. We interpret these results as an attempt to restore the permeability barrier homeostasis by the reactive epidermis, which fails due to ultrastructural losses in stratum corneum integrity, higher pH on skin surface, abundant mast cells in the dermis, and the common presence of incidental AKs and in situ SCC. As far as we know, this is the first time that the permeability barrier has been studied in the skin with CFC in a murine model of SCC induced after chronic UV-B irradiation at high doses. The impairment in the permeability barrier and the consequent keratinocyte hyperproliferation in the skin of CFC might play a role in the physiopathology of AKs and SCCs.
Language	English
Publishing date	2021-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13163935
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