LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells.

    Lockhart, Ainsley / Reed, Aubrey / Rezende de Castro, Tiago / Herman, Calvin / Campos Canesso, Maria Cecilia / Mucida, Daniel

    The Journal of experimental medicine

    2023  Volume 220, Issue 8

    Abstract: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell ... ...

    Abstract The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4+ T cells. Independent of the microbiota, dietary proteins contributed to accumulation and clonal selection of antigen-experienced CD4+ T cells at the intestinal epithelium, imprinting a tissue-specialized transcriptional program including cytotoxic genes on both conventional and regulatory CD4+ T cells (Tregs). This steady state CD4+ T cell response to food was disrupted by inflammatory challenge, and protection against food allergy in this context was associated with Treg clonal expansion and decreased proinflammatory gene expression. Finally, we identified both steady-state epithelium-adapted CD4+ T cells and tolerance-induced Tregs that recognize dietary antigens, suggesting that both cell types may be critical for preventing inappropriate immune responses to food.
    MeSH term(s) CD4-Positive T-Lymphocytes ; Intestines ; T-Lymphocytes, Regulatory ; Immune Tolerance ; Antigens/metabolism ; Dietary Proteins/metabolism
    Chemical Substances Antigens ; Dietary Proteins
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221816
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 45: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Dietary protein shapes the profile and repertoire of intestinal CD4

    Lockhart, Ainsley / Reed, Aubrey / de Castro, Tiago Rezende / Herman, Calvin / Canesso, Maria Cecilia Campos / Mucida, Daniel

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring ... ...

    Abstract The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.11.536475
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets.

    Reis, Bernardo S / Darcy, Patrick W / Khan, Iasha Z / Moon, Christine S / Kornberg, Adam E / Schneider, Vanessa S / Alvarez, Yelina / Eleso, Olawale / Zhu, Caixia / Schernthanner, Marina / Lockhart, Ainsley / Reed, Aubrey / Bortolatto, Juliana / Castro, Tiago B R / Bilate, Angelina M / Grivennikov, Sergei / Han, Arnold S / Mucida, Daniel

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6603, Page(s) 276–284

    Abstract: γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression ... ...

    Abstract γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression remains unclear. Using human CRC samples and murine CRC models, we found that most γδ T cells in premalignant or nontumor colons exhibit cytotoxic markers, whereas tumor-infiltrating γδ T cells express a protumorigenic profile. These contrasting T cell profiles were associated with distinct T cell receptor (TCR)-Vγδ gene usage in both humans and mice. Longitudinal intersectional genetics and antibody-dependent strategies targeting murine γδ T cells enriched in the epithelium at steady state led to heightened tumor development, whereas targeting γδ subsets that accumulate during CRC resulted in reduced tumor growth. Our results uncover temporal pro- and antitumor roles for γδ T cell subsets.
    MeSH term(s) Animals ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Cytotoxicity, Immunologic ; Humans ; Intestines/immunology ; Intraepithelial Lymphocytes/immunology ; Mice ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/physiology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abj8695
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top