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Article: Vitenskapelig merittering og kompetansevurdering.

Reed, R K

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

1996 Volume 116, Issue 30, Page(s) 3690–3691

Title translation	Scientific qualification and competence assessment.
MeSH term(s)	Clinical Competence ; Humans ; Periodicals as Topic ; Publishing ; Research
Language	Norwegian
Publishing date	1996-12-10
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
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Article: Anders Jahre-prisen for yngre forskere 1993. Løse bindevev og vaeskebalanse. Fra statiske til dynamiske vev.

Reed, R K

Nordisk medicin

1994 Volume 109, Issue 4, Page(s) 104–6, 125

Abstract: Rolf K Reed, recipient of the 1993 Anders Jahre Prize for younger medical researchers, describes some newer aspects of loose (areolar) connective tissue physiology and shows how research in recent years has changed our understanding of the involvement of ...

Title translation	Anders Jahre-Award for young researchers 1993. Loose connective tissue and fluid balance. From static to dynamic tissue.
Abstract	Rolf K Reed, recipient of the 1993 Anders Jahre Prize for younger medical researchers, describes some newer aspects of loose (areolar) connective tissue physiology and shows how research in recent years has changed our understanding of the involvement of these tissues in the regulation of fluid balance. There is a dynamic relationship between loose connective tissue and fluid balance, as a result of which the development of oedema is normally inhibited. However, certain inflammatory reactions are accompanied by changes in the activity of these tissues which then "absorb" fluid from the capillaries. This feature seems to be partly related to hyaluronidase+, the metabolism of which is also dependent on connective tissue fluid balance.
MeSH term(s)	Awards and Prizes ; Burns/physiopathology ; Connective Tissue/physiology ; Edema/physiopathology ; Extracellular Space/physiology ; Humans ; Hyaluronoglucosaminidase/metabolism ; Inflammation/physiopathology ; Norway ; Water-Electrolyte Balance
Chemical Substances	Hyaluronoglucosaminidase (EC 3.2.1.35)
Language	Norwegian
Publishing date	1994
Publishing country	Sweden
Document type	English Abstract ; Journal Article
ZDB-ID	80188-4
ISSN	0029-1420
ISSN	0029-1420
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Book ; Conference proceedings: Interstitium, connective tissue, and lymphatics

Reed, R. K

proceedings of the XXXII Congress of the International Union of Physiological Sciences, Glasgow, U.K

(Portland Press proceedings, ; 9)

1995

Institution	International Union of Physiological Sciences. / Congress
Author's details	editors R.K. Reed ... [et al.]
Series title	Portland Press proceedings, ; 9
MeSH term(s)	Biological Transport/physiology ; Connective Tissue/chemistry ; Connective Tissue/physiology ; Lymphatic System/physiology
Language	English
Size	xiv, 341 p. :, ill.
Publisher	Portland Press ; Distributor in North America, Ashgate Pub
Publishing place	London, U.K ; Brookfield, VT, U.S.A
Document type	Book ; Conference proceedings
ISBN	9781855780736 ; 1855780739
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Intra-family wealth flows and strategies for upward mobility in the Philippines

Reed, R. K

1995

Abstract: The author examined ever-married women's expectations of support from their children and the role those expectations play in parental strategies for the accumulation of resources and achieving upward mobility. Study data are from 11,320 ever-married ... ...

Author's details	R.K. Reed
Abstract	The author examined ever-married women's expectations of support from their children and the role those expectations play in parental strategies for the accumulation of resources and achieving upward mobility. Study data are from 11,320 ever-married women aged 15-49 years sampled in the 1983 Philippines National Demographic Survey. 5095 of the respondents were from Luzon, 2136 were from the Visayas, and 3724 from Mindanao. It is concluded that the expectation of support by parents from their children is related to the rural to urban migration system, there is little indication that parents invested in their children's education in order to produce affluent children who could better support them in the future, a threshold of poverty exists below which the expectation of support from children and dim prospects for upward mobility go hand in hand, households with sufficient resources to maintain children in school past primary school may take advantage of differing strategies for upward mobility involving their children, and female labor is important in achieving upward social mobility.
MeSH term(s)	Data Collection ; Economics ; Family Characteristics ; Investments ; Old Age Assistance ; Social Mobility ; Developing Countries ; Financial Management ; Health Manpower ; Research ; Sampling Studies ; Social Class ; Socioeconomic Factors
Keywords	Asia ; Asia, Southeastern ; Philippines ; Southeastern Asia ; Family And Household ; Human Capital ; Old Age Security ; Research Report ; Surveys ; Economic Factors ; Financial Activities ; Human Resources ; Microeconomic Factors ; Research Methodology ; Socioeconomic Status ; Studies
Language	English
Size	15, [9] p.
Document type	Book
Note	Presented at the Annual Meeting of the Population Association of America, San Francisco, California, April 6-8, 1995.
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: PGE1 induced transcapillary transport of 51Cr-EDTA in rat skin measured by microdialysis.

Iversen, V V / Reed, R K

Acta physiologica Scandinavica

2002 Volume 176, Issue 4, Page(s) 269–274

Abstract: Interstitial fluid pressure (P(if)) is a key determinant in increasing the transcapillary driving pressure, pulling fluid from the microcirculation into the interstitial space at the onset of acute inflammatory reactions and the oedema formation ... ...

Abstract	Interstitial fluid pressure (P(if)) is a key determinant in increasing the transcapillary driving pressure, pulling fluid from the microcirculation into the interstitial space at the onset of acute inflammatory reactions and the oedema formation associated with these. Prostaglandin E1 (PGE1) induces lowering of P(if) in rat skin which increases transcapillary transport of 51Cr-EDTA into the center of a tumor as measured by microdialysis. The aim of this study was twofold: First, to evaluate and develop the microdialysis technique thoroughly with regard to its suitability for investigating transcapillary water transport in rat skin using 51Cr-EDTA as a tracer. Secondly, to evaluate the effect of PGE1 on transcapillary transport of 51Cr-EDTA. This study demonstrates that PGE1 increases transcapillary transport of 51Cr-EDTA into skin interstitium. There were no significant differences between the experimental probe and the control probe when calculations from the entire experiment (90 min) were compared. On the other hand, significant differences were observed by examining the experiment in smaller time intervals. PGE1 increased transcapillary transport of 51Cr-EDTA during the first 15 min when administered through the microdialysis probe. This observation suggests that increased blood flow and/or permeability-surface area product are responsible for raising the transcapillary transport of 51Cr-EDTA, i.e. the transport is diffusion limited. Administration of PGE1 through the probe rather than around the probe resulted in less scatter between experiments than when PGE1 was injected subcutaneously around the probe.
MeSH term(s)	Alprostadil/pharmacology ; Animals ; Biological Transport, Active/drug effects ; Biological Transport, Active/physiology ; Blood Pressure/physiology ; Chromium Radioisotopes ; Edetic Acid ; Extracellular Space/physiology ; Female ; Microdialysis/methods ; Pressure ; Rats ; Rats, Sprague-Dawley ; Skin Physiological Phenomena/drug effects
Chemical Substances	Chromium Radioisotopes ; Edetic Acid (9G34HU7RV0) ; Alprostadil (F5TD010360)
Language	English
Publishing date	2002-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	101-6
ISSN	0001-6772
ISSN	0001-6772
DOI	10.1046/j.1365-201X.2002.01038.x
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Book: Connective tissue biology

Reed, R. K / Rubin, K

integration and reductionism

(Wenner-Gren international series ; v. 71)

1998

Author's details	edited by R.K. Reed, K. Rubin
Series title	Wenner-Gren international series ; v. 71
MeSH term(s)	Connective Tissue/physiology
Language	English
Size	xiv, 299 p. :, ill.
Publisher	Portland Press
Publishing place	London ; Miami
Document type	Book
ISBN	9781855781184 ; 1855781182
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Conference proceedings: Connective tissue biology

Reed, R. K / Rubin, K

integration and reductionism

(Wenner-Gren international series ; 71)

1998

Event/congress	Wenner-Gren Symposium "Connective Tissue Biology: Integration and Reductionism" (Stockholm1996.06)
Author's details	ed. by R.K. Reed, K. Rubin
Series title	Wenner-Gren international series ; 71
Language	English
Size	XIV, 299 S, Ill., graph. Darst, 25 cm
Publisher	Portland Press
Publishing place	London u.a.
Document type	Book ; Conference proceedings
ISBN	1855781182 ; 9781855781184
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Lowered albumin extravasation rate in heart but not in other organs in beta3-integrin-deficient mice.

Svendsen, O S / Lidén, A / Rubin, K / Reed, R K

Acta physiologica (Oxford, England)

2009 Volume 197, Issue 4, Page(s) 305–311

Abstract: Aim: The vascular protein permeability is dependent on the integrity of the vascular wall. The heart capillaries in male mice lacking beta3 integrins have an immature phenotype. Previously, we have demonstrated a role for alphavbeta3 integrins in ... ...

Abstract	Aim: The vascular protein permeability is dependent on the integrity of the vascular wall. The heart capillaries in male mice lacking beta3 integrins have an immature phenotype. Previously, we have demonstrated a role for alphavbeta3 integrins in control of interstitial fluid pressure (Pif) and thereby in the fluid flux during inflammation. We wanted to explore a possible role for alphavbeta3 integrins in controlling capillary protein permeability during control situation and inflammation. Methods: We performed double-tracer and microdialysis experiments on beta3-integrin-deficient mice and wild type control mice. We also measured blood pressure and heart rate in the two mice strains. Results: We found reduced albumin extravasation (during 25 min) in the heart capillaries (0.053 +/- 0.003 vs. 0.087 +/- 0.009 mL g(-1) dw, P < 0.05), and an increased cardiac mass/body weight (5.3 x 10(-3) +/- 0.3 x 10(-3) vs. 3.8 x 10(-3) +/- 0.1 x 10(-3), P < 0.01) in the beta3-integrin-deficient mice (n = 6) compared with the controls (n = 6). Heart rate and blood pressure were the same in mice with and without beta3-integrins. No difference in permeability was found in other tissues studied, or under local inflammation. Conclusion: These results show a function for the alphavbeta3 integrin in the regulation of protein permeability, selective for the heart capillaries.
MeSH term(s)	Albumins/metabolism ; Animals ; Capillary Permeability/physiology ; Extracellular Fluid/chemistry ; Extracellular Fluid/metabolism ; Heart/anatomy & histology ; Hemodynamics ; Humans ; Inflammation/metabolism ; Integrin beta3/genetics ; Integrin beta3/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Microdialysis ; Myocardium/cytology ; Myocardium/metabolism
Chemical Substances	Albumins ; Integrin beta3
Language	English
Publishing date	2009-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218636-0
ISSN	1748-1716 ; 1748-1708
ISSN (online)	1748-1716
ISSN	1748-1708
DOI	10.1111/j.1748-1716.2009.02025.x
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Article: Transcapillary albumin extravasation in rat skin and skeletal muscle: effect of increased venous pressure.

Reed, R K

Acta physiologica Scandinavica

1988 Volume 134, Issue 3, Page(s) 375–382

Abstract: Plasma-to-tissue transport of radioactively labelled albumin has been used to study the effect of increased venous pressure on transcapillary albumin transport. Venous pressure was increased by inflating a balloon catheter in the inferior caval vein. ... ...

Abstract	Plasma-to-tissue transport of radioactively labelled albumin has been used to study the effect of increased venous pressure on transcapillary albumin transport. Venous pressure was increased by inflating a balloon catheter in the inferior caval vein. Plasma-to-tissue transport of albumin was taken as the extravascular distribution space (EValb) for 125I-labelled human serum albumin (I-HSA) after 1 h. Venous pressure was increased from 2 to 20 mmHg in the experimental group. Interstitial fluid volume (IFV) was measured as the extravascular distribution space for 51Cr-EDTA. In control EValb was 9.24 X 10(-3) ml g-1 d. wt (SD = 1.28, n = 8) and 3.67 X 10(-3) ml g-1 d.wt (SD = 0.94, n = 8) in skin and skeletal muscle, respectively. Increasing venous pressure raised EValb and IFV in skin and skeletal muscle, but the increase in EValb was about 3 and 5% of the rise in IFV, resulting in capillary reflection coefficients for albumin of 0.94 in skin and 0.98 in skeletal muscle. The low transcapillary albumin transport relative to water transport is compatible with a two-pore model of transcapillary exchange where large pores (250 A) accounts for less than 5.5 and 2.5% of the total capillary filtrate of fluid in skin and skeletal muscle, respectively.
MeSH term(s)	Animals ; Capillary Permeability ; Intracellular Fluid ; Male ; Muscles/blood supply ; Plasma Volume ; Rats ; Rats, Inbred Strains ; Serum Albumin, Radio-Iodinated/pharmacokinetics ; Skin/blood supply ; Venous Pressure
Chemical Substances	Serum Albumin, Radio-Iodinated
Language	English
Publishing date	1988-11
Publishing country	England
Document type	Journal Article
ZDB-ID	101-6
ISSN	0001-6772
ISSN	0001-6772
DOI	10.1111/j.1748-1716.1988.tb08504.x
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Article: Changes in plasma protein extravasation in rat skin during inflammatory challenges evaluated by microdialysis.

Borge, B A / Iversen, V V / Reed, R K

American journal of physiology. Heart and circulatory physiology

2005 Volume 290, Issue 5, Page(s) H2108–15

Abstract: Docetaxel and prostaglandin E1 (PGE1) increase transcapillary albumin extravasation and reduce interstitial fluid pressure in the skin. In this study the microdialysate concentration (Cm) of 125I-labeled human serum albumin (125I-HSA) and different-sized ...

Abstract	Docetaxel and prostaglandin E1 (PGE1) increase transcapillary albumin extravasation and reduce interstitial fluid pressure in the skin. In this study the microdialysate concentration (Cm) of 125I-labeled human serum albumin (125I-HSA) and different-sized endogenous plasma proteins (EPP) was compared to evaluate changes in transcapillary extravasation of plasma proteins. 125I-HSA was also used to estimate changes in the specific activity of albumin. Extravasation of 125I-HSA and EPP from plasma to interstitium in the rat skin was compared during continuous administration of docetaxel and PGE1 by using microdialysis in anesthetized rats. Also, 20 ml of Ringer solution (RS) were injected intravenously during 10 min in a separate group. Two hollow plasmapheresis fibers (3 cm, cut off 3,000 kDa), one acting as control, were placed subcutaneously on the back skin and perfused with RS (5 microl/min, 140 min, collected every 10 min). The size of the different EPP was estimated to be 73, 65, 56, 47, and 39 A, separated by a size-exclusion high-performance liquid chromatography column and quantified by UV detection (280 nm). Docetaxel (0.5 mg/ml, n = 5) increased Cm of 125I-HSA and EPP of sizes 73, 65, 56, and 39 A significantly (P < 0.05) compared with control. PGE1 (20 microg/ml, n = 6) increased Cm of 125I-HSA significantly (P < 0.05) but none of the different-sized EPP was increased compared with control. Intravenous RS (20 ml, n = 6) increased Cm of 125I-HSA and increased all the different-sized EPP significantly (P < 0.05) compared with control. Although the microdialysis method is able to monitor qualitative changes in capillary permeability, a quantitative determination of the capillary reflection coefficient or permeability-surface area product was not possible, because steady state between plasma and dialysate was not achieved during the measurement period. The different pattern of extravasation of EPP and 125I-HSA after docetaxel, PGE1, and RS indicates increased interstitial transport rate and/or increased capillary permeability after docetaxel and RS, whereas PGE1 seems to increase transcapillary fluid flux without altering the permeability.
MeSH term(s)	Alprostadil/administration & dosage ; Animals ; Blood Proteins/metabolism ; Capillary Permeability/drug effects ; Capillary Permeability/immunology ; Docetaxel ; Dose-Response Relationship, Drug ; Female ; Microdialysis/methods ; Rats ; Rats, Wistar ; Skin/blood supply ; Skin/drug effects ; Skin/immunology ; Taxoids/administration & dosage
Chemical Substances	Blood Proteins ; Taxoids ; Docetaxel (15H5577CQD) ; Alprostadil (F5TD010360)
Language	English
Publishing date	2005-12-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00395.2005
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