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  1. Article ; Online: Management of the Patient With Patent Foramen Ovale in 2021: A Spectrum of Cases.

    Reeder, Guy S / Taggart, Nathaniel W / Ammash, Naser M

    Mayo Clinic proceedings

    2021  Volume 96, Issue 5, Page(s) 1356–1362

    Abstract: Patients with patent foramen ovale can manifest in a variety of ways. These presentations and their resolution are discussed in this article. ...

    Abstract Patients with patent foramen ovale can manifest in a variety of ways. These presentations and their resolution are discussed in this article.
    MeSH term(s) Adult ; Aged ; Female ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnosis ; Foramen Ovale, Patent/therapy ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pulmonary Vein Flow Morphology After Transcatheter Mitral Valve Edge-to-Edge Repair as Predictor of Survival.

    El Shaer, Ahmed / Chavez Ponce, Alejandra A / Ali, Mays T / Oguz, Didem / Pislaru, Sorin V / Nkomo, Vuyisile T / Padang, Ratnasari / Eleid, Mackram F / Guerrero, Mayra / Reeder, Guy S / Rihal, Charanjit S / Alkhouli, Mohamad / Thaden, Jeremy J

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2024  Volume 37, Issue 5, Page(s) 530–537

    Abstract: Background: Data on the prognostic factors after mitral valve (MV) transcatheter edge-to-edge repair (TEER; MV-TEER) are limited. Pulsed-wave Doppler interrogation of pulmonary vein flow (PVF) is a convenient method to assess the hemodynamic burden of ... ...

    Abstract Background: Data on the prognostic factors after mitral valve (MV) transcatheter edge-to-edge repair (TEER; MV-TEER) are limited. Pulsed-wave Doppler interrogation of pulmonary vein flow (PVF) is a convenient method to assess the hemodynamic burden of residual mitral regurgitation (MR), which could be of utility as a predictor of outcomes.
    Methods: Patients that underwent MV-TEER between May 2014 and December 2021 at our institution were evaluated. Pulmonary vein flow patterns post-MV-TEER were reviewed on the procedural transesophageal echocardiogram and classified as normal (systolic dominant or codominant) or abnormal (systolic blunting or reversal). The PVF pattern was correlated with all-cause mortality at follow-up.
    Results: Two-hundred sixty-five patients had diagnostic PVF post-MV-TEER, with 73 (27.5%) categorized as normal and 192 (72.5%) categorized as abnormal. Patients with abnormal PVF morphology were more likely to have atrial fibrillation (70% vs 42%, P < .001) and greater than moderate residual MR (16% vs 3%, P = .01) and had higher mean left atrial pressure (18.1 ± 5.0 vs 15.9 ± 4.2 mm Hg, P = .002) and left atrial V wave (26.6 ± 8.5 vs 21.4 ± 7.3 mm Hg, P < .001) postprocedure. In multivariable analysis, abnormal PVF morphology post-MV-TEER was independently associated with mortality at follow-up (hazard ratio = 1.70; 95% CI, 1.06-2.74; P = .03) after correction for end-stage renal disease, atrial fibrillation, and residual MR. Results were similar in subgroups of patients with moderate or less and those with mild or less residual MR.
    Conclusions: Pulmonary vein flow morphology is a simple and objective tool to assess MR severity immediately post-MV-TEER and offers important prognostic information to optimize procedural results. Additional studies are needed to determine whether patients with abnormal PVF pattern post-MV-TEER would benefit from more intensive goal-directed medical therapy postprocedure.
    MeSH term(s) Humans ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Pulmonary Veins/physiopathology ; Male ; Female ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Aged ; Echocardiography, Transesophageal/methods ; Cardiac Catheterization/methods ; Retrospective Studies ; Survival Rate ; Prognosis ; Echocardiography, Doppler, Pulsed/methods
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2024.01.016
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  3. Article ; Online: Prominent Collateral Vessels in Pulmonary Vein Occlusion: Role of IVUS and a Staged Interventional Approach.

    Sarma, Dhruv / Gladden, James / Reeder, Guy S / Munger, Thomas M / Packer, Douglas L / Holmes, David R / Simard, Trevor

    JACC. Cardiovascular interventions

    2022  Volume 15, Issue 21, Page(s) e223–e224

    MeSH term(s) Humans ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Treatment Outcome ; Pulmonary Veno-Occlusive Disease ; Angioplasty, Balloon ; Ultrasonography, Interventional ; Stents
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2022.08.025
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  4. Article ; Online: Comparison of left atrial pressure monitoring with dedicated catheter versus steerable guiding catheter during transcatheter mitral valve repair.

    Eleid, Mackram F / Reeder, Guy S / Rihal, Charanjit S

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2017  Volume 92, Issue 2, Page(s) 374–378

    Abstract: Objective: The objective of this study was to determine the accuracy of left atrial pressure (LAP) measurement through the manufacturer provided steerable guiding catheter (SGC) during transcatheter mitral valve repair (TMVR).: Background: LAP ... ...

    Abstract Objective: The objective of this study was to determine the accuracy of left atrial pressure (LAP) measurement through the manufacturer provided steerable guiding catheter (SGC) during transcatheter mitral valve repair (TMVR).
    Background: LAP measurement during TMVR has been shown to be associated with clinical improvement when measured through a dedicated catheter.
    Methods: Simultaneous LAP was performed in consecutive patients using an independent fluid-filled 4F multipurpose catheter and compared to LAP waveforms measured through the manufacturer-provided MitraClip SGC during TMVR (Abbott, Santa Clara, CA).
    Results: Mean age of 10 consecutive subjects with primary mitral regurgitation undergoing TMVR was 83 ± 3 years (60% female). Left atrial v wave and mean pressures through the dedicated catheter were 42 ± 7 and 24 ± 3 mmHg vs. 35 ± 7 and 23 ± 3 mmHg through the SGC (P < 0.001 and P = 0.23, respectively). Mean differences in v wave and mean LAP were 8 ± 4 and 1.0 ± 2.4 mmHg (percent difference 19 and 3%), respectively. SGC waveform overdamping was observed in all cases.
    Conclusions: Left atrial v wave pressure measurement through a dedicated catheter with sideholes during TMVR has superior accuracy compared to the manufacturer provided SGC, which results in waveform overdamping and a significant underestimation of v wave pressure. These data have important implications for clinical practice.
    MeSH term(s) Aged, 80 and over ; Atrial Function, Left ; Atrial Pressure ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/instrumentation ; Cardiac Catheterization/methods ; Cardiac Catheters ; Equipment Design ; Female ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/methods ; Humans ; Male ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Monitoring, Intraoperative/instrumentation ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Severity of Illness Index ; Time Factors ; Transducers, Pressure ; Treatment Outcome
    Language English
    Publishing date 2017-11-24
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.27430
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  5. Article ; Online: Pathogenesis, Evaluation, and Management of Pulmonary Vein Stenosis: JACC Review Topic of the Week.

    Simard, Trevor / Sarma, Dhruv / Miranda, William R / Jain, C Charles / Anderson, Jason H / Collins, Jeremy D / El Sabbagh, Abdallah / Jhand, Aravdeep / Peikert, Tobias / Reeder, Guy S / Munger, Thomas M / Packer, Douglas L / Holmes, David R

    Journal of the American College of Cardiology

    2023  Volume 81, Issue 24, Page(s) 2361–2373

    Abstract: Pulmonary vein stenosis (PVS) can arise from several etiologies, including congenital, acquired, and iatrogenic sources. PVS presents insidiously, leading to significant delays in diagnosis. A high index of suspicion and dedicated noninvasive evaluation ... ...

    Abstract Pulmonary vein stenosis (PVS) can arise from several etiologies, including congenital, acquired, and iatrogenic sources. PVS presents insidiously, leading to significant delays in diagnosis. A high index of suspicion and dedicated noninvasive evaluation are key to diagnosis. Once diagnosed, both noninvasive and invasive evaluation may afford further insights into the relative contribution of PVS to symptoms. Treatment of underlying reversible pathologies coupled with transcatheter balloon angioplasty and stenting for persistent severe stenoses are established approaches. Ongoing refinements in diagnostic modalities, interventional approaches, postintervention monitoring, and medical therapies hold promise to further improve patient outcomes.
    MeSH term(s) Humans ; Stenosis, Pulmonary Vein/diagnosis ; Stenosis, Pulmonary Vein/etiology ; Stenosis, Pulmonary Vein/therapy ; Constriction, Pathologic/diagnosis ; Constriction, Pathologic/etiology ; Constriction, Pathologic/therapy ; Angioplasty, Balloon ; Stents
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.04.016
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  6. Article ; Online: Effect of saline administration on left atrial pressure during transcatheter mitral valve repair.

    Lloyd, James W / Reeder, Guy S / Rihal, Charanjit S / Eleid, Mackram F

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2018  Volume 92, Issue 7, Page(s) 1427–1432

    Abstract: Objectives: To measure the intraprocedural change in left atrial pressure (LAP) with saline administration during transcatheter mitral valve repair (TMVR).: Background: TMVR with MitraClip offers an alternative to surgery in select patients. During ... ...

    Abstract Objectives: To measure the intraprocedural change in left atrial pressure (LAP) with saline administration during transcatheter mitral valve repair (TMVR).
    Background: TMVR with MitraClip offers an alternative to surgery in select patients. During this procedure, large volumes of fluid are routinely administered with anesthesia and to facilitate transcatheter valve repair. LAP, a measure used to guide repair, may thereby change as a result of volume expansion, suggesting a need for continuous intracardiac pressure monitoring.
    Methods: Consecutive patients with severe mitral regurgitation underwent TMVR with MitraClip and continuous LAP monitoring through a dedicated sampling catheter. Specific LAP values were acquired immediately after transseptal access; before first clip deployment; and after deployment of the last clip.
    Results: 151 patients (age 80 ± 8 years, 64% male) underwent TMVR with MitraClip and continuous LAP monitoring. Mean LAP and v-wave pressure increased significantly from baseline to pre-MitraClip deployment (P < 0.0001) and decreased significantly from deployment to procedure end (P < 0.0001). Linear regression of v-wave pressure change (from procedure start to clip deployment) relative to volume administration yielded a significantly nonzero slope (0.28 mmHg/min, P < 0.0001, r = 0.30).
    Conclusion: Fluid administration during TMVR leads to time-dependent increases in LAP. Such intraprocedural change underscores the need for targeted, if not continuous, LAP measurement during TMVR to optimize MitraClip placement and mitral regurgitation reduction.
    MeSH term(s) Aged ; Aged, 80 and over ; Atrial Function, Left ; Atrial Pressure ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/instrumentation ; Female ; Fluid Therapy/adverse effects ; Humans ; Male ; Mitral Valve/physiopathology ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/therapy ; Prospective Studies ; Saline Solution/administration & dosage ; Saline Solution/adverse effects ; Severity of Illness Index ; Time Factors ; Treatment Outcome
    Chemical Substances Saline Solution
    Language English
    Publishing date 2018-08-05
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.27710
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  7. Article ; Online: Utility of Intracardiac Echocardiography in the Early Experience of Transcatheter Edge to Edge Tricuspid Valve Repair.

    Eleid, Mackram F / Alkhouli, Mohamad / Thaden, Jeremy J / Zahr, Firas / Chadderdon, Scott / Guerrero, Mayra / Reeder, Guy S / Rihal, Charanjit S

    Circulation. Cardiovascular interventions

    2021  Volume 14, Issue 10, Page(s) e011118

    Abstract: Figure: see text]. ...

    Abstract [Figure: see text].
    MeSH term(s) Cardiac Catheterization ; Echocardiography ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/surgery
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.121.011118
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  8. Article ; Online: Pulmonary Vein Stenosis-Balloon Angioplasty Versus Stenting: A Systematic Review and Meta-Analysis.

    Almakadma, Abdul Hakim / Sarma, Dhruv / Hassett, Leslie / Miranda, William / Alkhouli, Mohamad / Reeder, Guy S / Munger, Thomas M / Packer, Douglas L / Simard, Trevor / Holmes, David R

    JACC. Clinical electrophysiology

    2022  Volume 8, Issue 10, Page(s) 1323–1333

    Abstract: Pulmonary vein stenosis (PVS) may arise from a variety of conditions and result in major morbidity and mortality. In some patients, pharmacologic therapy may help, but more often in advanced stages, mechanical treatment must be considered. Transcatheter ... ...

    Abstract Pulmonary vein stenosis (PVS) may arise from a variety of conditions and result in major morbidity and mortality. In some patients, pharmacologic therapy may help, but more often in advanced stages, mechanical treatment must be considered. Transcatheter approaches, both balloon angioplasty (BA) and stent implantation, have been applied. Although both are effective, they continue to be limited by restenosis. In this systematic review and meta-analysis, Ovid MEDLINE, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus were searched for English-language studies in humans published between January 1, 2010, and August 2, 2021. Two independent reviewers screened for studies in which BA or stenting was performed for PVS with reporting of restenosis outcomes, and data were independently extracted. A systematic review was performed, and overall restenosis rates were reported across all 34 included studies. Meta-analysis was then performed using RevMan version 5.4, assessing rates of restenosis and restenosis requiring reintervention in those studies with available data reported. For restenosis rates, 4 studies treated a total of 340 patients with 579 pulmonary vein interventions (225 with BA and 354 with stenting, mean follow-up 13-69 months). Restenosis requiring repeat intervention was reported in 3 studies, including 301 patients with 495 pulmonary vein interventions (157 with BA and 338 with stenting). Compared with BA, stenting was associated with both a lower risk for restenosis (risk ratio: 0.36; 95% CI: 0.18-0.73; P = 0.005) and a lower risk for restenosis requiring reintervention (RR: 0.36; 95% CI: 0.15-0.86; P = 0.02). For PVS intervention, restenosis and reintervention rates may be improved by stent implantation compared with BA.
    MeSH term(s) Humans ; Stenosis, Pulmonary Vein/surgery ; Stenosis, Pulmonary Vein/etiology ; Angioplasty, Balloon/adverse effects ; Stents/adverse effects ; Pulmonary Veins/surgery ; Constriction, Pathologic/surgery
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2022.08.008
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  9. Article ; Online: Characteristics and outcomes of patients with normal left atrial pressure undergoing transcatheter mitral valve repair.

    Sims, Jason R / Reeder, Guy S / Guerrero, Mayra / Alkhouli, Mohamad / Nkomo, Vuyisile T / Nishimura, Rick A / Rihal, Charanjit S / Eleid, Mackram F

    Heart (British Cardiac Society)

    2020  Volume 106, Issue 12, Page(s) 898–903

    Abstract: Objective: A subset of patients at the time of transcatheter mitral valve repair (TMVR) will have normal left atrial pressure (LAP) (<13 mm Hg) despite having severe mitral regurgitation (MR). The goal of this study was to determine clinical ... ...

    Abstract Objective: A subset of patients at the time of transcatheter mitral valve repair (TMVR) will have normal left atrial pressure (LAP) (<13 mm Hg) despite having severe mitral regurgitation (MR). The goal of this study was to determine clinical characteristics and outcomes in patients with normal LAP undergoing TMVR.
    Methods: A single-centre retrospective cohort of consecutive patients who underwent transcatheter edge-to-edge mitral valve clip and continuous LAP monitoring between 5/1/2014 and 5/1/2018 was analysed. One-year mortality was compared by Kaplan-Meier survival curves. Multivariable analysis was performed to identify predictors of normal LAP and 1 year mortality.
    Results: Of the 204 patients undergoing TMVR, 65% were men and the mean age was 81. Of these patients, 31 (15%) had normal LAP (mean LAP 10.5 mm Hg, mean V wave 16.5 mm Hg) and 173 had elevated LAP (mean LAP 19 mm Hg, mean V wave 32.5 mm Hg). The prevalence of severe MR was not different between groups, although the normal LAP group had significantly lower effective regurgitant orifice area and regurgitant volume. Other notable baseline characteristics including prior cardiac surgery, atrial fibrillation, hypertension, diabetes, congestive heart failure, body mass index, mechanism of MR and ejection fraction were similar between groups. However, there was an increased prevalence of chronic lung disease (CLD) (45.2% vs 17.3%, p<0.001) in the normal LAP group. On multivariate analysis, the only significant predictor of normal LAP was the presence of CLD (OR 4.79 (1.83-12.36), p=0.001) and 1-year mortality was significantly higher in the normal LAP group (32.3% vs 12.7%, p=0.006). After adjustment for comorbidities, normal LAP was no longer a predictor of 1-year mortality (RR 1.62 (0.64-4.06), p=0.32); however, CLD (RR 3.44 (1.37-8.67), p=0.01) remained a statistically significant predictor.
    Conclusion: Normal LAP at the time of TMVR is associated with a higher incidence of CLD which independently predicts increased 1-year mortality. In patients with CLD and apparently severe MR, measurement of LAP may help identify those with lower likelihood of benefit from TMVR.
    MeSH term(s) Aged ; Aged, 80 and over ; Atrial Function, Left ; Atrial Pressure ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/instrumentation ; Cardiac Catheterization/mortality ; Female ; Humans ; Male ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/mortality ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/therapy ; Recovery of Function ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2019-316133
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  10. Article ; Online: Diastolic blood pressure predicts outcomes after aortic paravalvular leak closure.

    Vogt, Joshua C / Michelena, Hector I / Nishimura, Rick A / Nkomo, Vuyisile T / Pislaru, Sorin V / Reeder, Guy S / Rihal, Charanjit S / Eleid, Mackram F

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2020  Volume 97, Issue 1, Page(s) E79–E87

    Abstract: Objectives: We sought to determine hemodynamic effects of aortic paravalvular leak (PVL) and predictors of clinical outcomes after aortic PVL closure.: Background: The significance of hemodynamic alterations in PVL and relation to severity, ... ...

    Abstract Objectives: We sought to determine hemodynamic effects of aortic paravalvular leak (PVL) and predictors of clinical outcomes after aortic PVL closure.
    Background: The significance of hemodynamic alterations in PVL and relation to severity, procedural success of percutaneous closure and clinical outcomes have not been defined.
    Methods: Patients undergoing percutaneous PVL closure between July 21, 2004 and September 10, 2018 were included. PVL severity was assessed by echocardiography and aortic angiography. Hemodynamics were assessed by intra-arterial pressure tracings before and after PVL closure. The primary outcome was a composite of mortality, redo aortic valve replacement (AVR) and redo PVL closure.
    Results: One hundred and seventeen patients (mean age 70.3 ± 14.9 years, 79% surgical and 21% transcatheter prostheses) underwent PVL closure with 94% technical success. PVL was moderate or greater in 106 (91%) at baseline and 11 (11%) post-procedure. Diastolic BP for those with moderate or greater PVL was lower than for those with less PVL (50.3 ± 11.7 vs. 56.5 ± 12.4 mmHg, p < .001). Pulse pressure was similar between these groups (69.9 ± 20.3 vs. 67.4 ± 21.2 mmHg, p = .39). 35 patients (34%) had 40 events during a mean follow-up of 1.6 ± 1.9 years (23 deaths, 12 redo AVR, and five redo PVL closures). In a multivariate model, final diastolic BP <47 mmHg (HR 3.27 [1.45-7.36], p = .007) was a significant predictor of the composite endpoint.
    Conclusions: Diastolic BP was significantly associated with aortic PVL severity and clinical outcomes after PVL closure. In contrast, pulse pressure did not correlate with PVL severity or outcomes. These findings have implications for clinical management of patients with aortic PVL.
    MeSH term(s) Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Blood Pressure ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Retrospective Studies ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.28890
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