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  1. Article: PI3K Isoform Immunotherapy for Solid Tumours.

    Scott, Jake / Rees, Lauren / Gallimore, Awen / Lauder, Sarah N

    Current topics in microbiology and immunology

    2022  Volume 436, Page(s) 369–392

    Abstract: Improving the anti-tumour T cell response as a consequence of immunotherapy can result in eradication of tumour burden, however, the majority of patients fail with current treatment regimens and so novel immunotherapies with greater efficacy and improved ...

    Abstract Improving the anti-tumour T cell response as a consequence of immunotherapy can result in eradication of tumour burden, however, the majority of patients fail with current treatment regimens and so novel immunotherapies with greater efficacy and improved tolerability are needed. The phosphoinositide-3-kinase (PI3K) family members that are directly involved in cell signalling comprise PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, with the latter two isoforms expressed primarily by leukocytes. The survival and optimal function of regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs) is dependent on PI3Kδ, whereas tumour-associated macrophages (TAMs), use PI3Kγ. Blocking these signalling isoforms can boost development of effective anti-cancer immune responses and result in control of tumour burden. The dependence on different PI3K isoforms in immune cells makes targeting this pathway an attractive approach for tumour immunotherapy. Herein, we discuss how inhibiting specific PI3K isoforms in pro-tumoural Tregs, MDSCS and TAMs can unleash a powerful anti-tumour immune response, driven by CD8
    MeSH term(s) CD8-Positive T-Lymphocytes ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Neoplasms/drug therapy ; Phosphatidylinositol 3-Kinase ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositols/therapeutic use ; Phosphoinositide-3 Kinase Inhibitors ; Protein Isoforms/genetics ; Protein Isoforms/therapeutic use
    Chemical Substances Immune Checkpoint Inhibitors ; Phosphatidylinositols ; Phosphoinositide-3 Kinase Inhibitors ; Protein Isoforms ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137)
    Language English
    Publishing date 2022-09-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 210099-X
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-031-06566-8_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Orthographically sensitive treatment for dysprosody in children with childhood apraxia of speech using ReST intervention.

    McCabe, Patricia / Macdonald-D'Silva, Anita G / van Rees, Lauren J / Ballard, Kirrie J / Arciuli, Joanne

    Developmental neurorehabilitation

    2014  Volume 17, Issue 2, Page(s) 137–146

    Abstract: Objective: Impaired prosody is a core diagnostic feature of Childhood Apraxia of Speech (CAS) but there is limited evidence of effective prosodic intervention. This study reports the efficacy of the ReST intervention used in conjunction with bisyllabic ... ...

    Abstract Objective: Impaired prosody is a core diagnostic feature of Childhood Apraxia of Speech (CAS) but there is limited evidence of effective prosodic intervention. This study reports the efficacy of the ReST intervention used in conjunction with bisyllabic pseudo word stimuli containing orthographic cues that are strongly associated with either strong-weak or weak-strong patterns of lexical stress.
    Methods: Using a single case AB design with one follow-up and replication, four children with CAS received treatment of four one-hour sessions per week for three weeks. Sessions contained 100 randomized trials of pseudo word treatment stimuli. Baseline measures were taken of treated and untreated behaviors; retention was measured at one day and four weeks post-treatment.
    Results: Children's production of lexical stress improved from pre to post-treatment. Treatment effects and maintenance varied among participants.
    Conclusions: This study provides support for the treatment of prosodic deficits in CAS.
    MeSH term(s) Apraxias/therapy ; Child ; Child, Preschool ; Humans ; Male ; Reading ; Speech ; Speech Disorders/therapy ; Speech Therapy/methods
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2280007-4
    ISSN 1751-8431 ; 1751-8423
    ISSN (online) 1751-8431
    ISSN 1751-8423
    DOI 10.3109/17518423.2014.906002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5416: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Training production of lexical stress in typically developing children using orthographically biased stimuli and principles of motor learning.

    van Rees, Lauren J / Ballard, Kirrie J / McCabe, Patricia / Macdonald-D'Silva, Anita G / Arciuli, Joanne

    American journal of speech-language pathology

    2012  Volume 21, Issue 3, Page(s) 197–206

    Abstract: Purpose: Impaired lexical stress production characterizes multiple pediatric speech disorders. Effective remediation strategies are not available, and little is known about the normal process of learning to assign and produce lexical stress. This study ... ...

    Abstract Purpose: Impaired lexical stress production characterizes multiple pediatric speech disorders. Effective remediation strategies are not available, and little is known about the normal process of learning to assign and produce lexical stress. This study examined whether typically developing (TD) children can be trained to produce lexical stress on bisyllabic pseudowords that are orthographically biased to a strong-weak or weak-strong pattern (e.g., MAMbey or beDOON), in combination with the principles of motor learning (PML).
    Method: Fourteen TD children ages 5;0 (years;months) to 13;0 were randomly assigned to a training or control group using concealed allocation within blocks. A pre- to posttraining group design was used to examine the acquisition, retention, and generalization of lexical stress production.
    Results: The training group learned to produce appropriate lexical stress for the pseudowords with strong maintenance and generalization to related untrained stimuli. Accuracy of stress production did not change in the control group.
    Conclusion: TD children can learn to produce lexical stress patterns for orthographically biased pseudowords via explicit training methods. Findings have relevance for the study of languages other than English and for a range of prosodic disorders.
    MeSH term(s) Acoustic Stimulation/methods ; Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Male ; Motor Skills/physiology ; Phonetics ; Speech Disorders/physiopathology ; Speech Disorders/therapy ; Speech Production Measurement/methods ; Speech Therapy/methods ; Verbal Learning/physiology ; Vocal Cords/physiology ; Voice/physiology
    Language English
    Publishing date 2012-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1154406-5
    ISSN 1558-9110 ; 1058-0360
    ISSN (online) 1558-9110
    ISSN 1058-0360
    DOI 10.1044/1058-0360(2012/11-0008)
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3716: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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