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  1. Article ; Online: A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins.

    Sudeep, H V / Venkatakrishna, K / Amritharaj / Gouthamchandra, K / Reethi, B / Naveen, P / Lingaraju, H B / Shyamprasad, K

    Journal of food biochemistry

    2021  Volume 45, Issue 12, Page(s) e13994

    Abstract: β-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using ... ...

    Abstract β-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using supercritical fluid extraction, standardized to contain 30% BCP (Viphyllin
    MeSH term(s) Amnesia/chemically induced ; Amnesia/drug therapy ; Animals ; Brain-Derived Neurotrophic Factor ; Cognition ; Male ; Mice ; Piper nigrum ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Polycyclic Sesquiterpenes ; Scopolamine/toxicity
    Chemical Substances Brain-Derived Neurotrophic Factor ; Plant Extracts ; Polycyclic Sesquiterpenes ; caryophyllene (BHW853AU9H) ; Scopolamine (DL48G20X8X)
    Language English
    Publishing date 2021-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13994
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  2. Article ; Online: Viphyllin™, a standardized extract from black pepper seeds, mitigates intestinal inflammation, oxidative stress, and anxiety-like behavior in DSS-induced colitis mice.

    Sudeep, Heggar Venkataramana / Venkatakrishna, Karempudi / Raj, Amritha / Reethi, Budanuru / Shyamprasad, Kodimule

    Journal of food biochemistry

    2022  Volume 46, Issue 10, Page(s) e14306

    Abstract: Inflammatory bowel diseases (IBD) are the common health concern in populations across the world. Clinical evidence suggests that IBD, characterized by intestinal inflammation, is associated with neuronal manifestations to a greater extent. In this study, ...

    Abstract Inflammatory bowel diseases (IBD) are the common health concern in populations across the world. Clinical evidence suggests that IBD, characterized by intestinal inflammation, is associated with neuronal manifestations to a greater extent. In this study, we have investigated the protective effects of Viphyllin™, a standardized black pepper (Piper nigrum) seed extract containing 30% β-caryophyllene against dextran sodium sulfate (DSS)-induced colitis in mice. Oral pretreatment of Viphyllin at the 50 mg and 100 mg/kg doses significantly reversed the clinical symptoms of colitis in mice. Viphyllin markedly inhibited NLRP3 inflammasome activation and improved barrier function in colon tissue. Viphyllin further mitigated the DSS-induced anxiety-like behavior in mice. Interestingly, Viphyllin improved brain antioxidant status and promoted neuronal cell survival in colitis model mice. In conclusion, our findings strongly support the health claims of Viphyllin as a functional ingredient to deal with IBD and related neuronal symptoms. PRACTICAL APPLICATIONS: Prevalence of inflammatory bowel diseases is not uncommon in the modern lifestyle. Gut health is associated with neurological disorders that contribute substantially to the deterioration of quality of life and socioeconomic development. In this research work, the protective action of a black pepper seed extract standardized to 30% β-caryophyllene (Viphyllin) is evaluated against Dextran sodium sulfate-induced experimental colitis model. Here we have demonstrated the beneficial role of Viphyllin in mitigating intestinal inflammation as a function of NLRP3 inflammasome inhibition. Further, the extract improves intestinal barrier function. In an important aspect of the study, we have provided the data on the effect of Viphyllin on neurological symptoms and brain health in colitis model mice.
    MeSH term(s) Animals ; Antioxidants ; Anxiety ; Colitis/chemically induced ; Colitis/drug therapy ; Dextran Sulfate/adverse effects ; Inflammasomes ; Inflammation/drug therapy ; Inflammatory Bowel Diseases/drug therapy ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nigella sativa/metabolism ; Oxidative Stress ; Piper nigrum/metabolism ; Plant Extracts ; Polycyclic Sesquiterpenes ; Quality of Life ; Seeds/metabolism ; Sulfates
    Chemical Substances Antioxidants ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Plant Extracts ; Polycyclic Sesquiterpenes ; Sulfates ; sodium sulfate (0YPR65R21J) ; Dextran Sulfate (9042-14-2) ; caryophyllene (BHW853AU9H)
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.14306
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

    Order via subito

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: A standardized black pepper seed extract containing β‐caryophyllene improves cognitive function in scopolamine‐induced amnesia model mice via regulation of brain‐derived neurotrophic factor and MAPK proteins

    Sudeep, H. V. / Venkatakrishna, K. / Amritharaj / Gouthamchandra, K. / Reethi, B. / Naveen, P. / Lingaraju, H. B. / Shyamprasad, K.

    Journal of food biochemistry. 2021 Dec., v. 45, no. 12

    2021  

    Abstract: β‐caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type‐2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using ... ...

    Abstract β‐caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type‐2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using supercritical fluid extraction, standardized to contain 30% BCP (Viphyllinᵀᴹ). The beneficial effects of prophylactic treatment with Viphyllin on cognitive functions were demonstrated in Scopolamine‐induced dementia model mice. Male Swiss albino mice (25–30 g) were administered with Viphyllin (50 mg and 100 mg/kg body weight p.o.) or donepezil (1.60 mg/kg) for 14 days. Subsequently, cognitive deficits were induced by treating the animals intraperitoneally with Scopolamine (0.75 mg/kg). The cognitive behavior of mice was evaluated using a novel object recognition test (NORT) and Morris water maze (MWM) test. The brain homogenates were studied for biochemical parameters including cholinesterase activities and antioxidant status. Western blot analysis was performed to investigate the mechanism of action. Viphyllin dose dependently improved the recognition and spatial memory and cholinergic functions in Scop‐treated mice. The extract was found protective against Scop‐induced oxidative damage and histopathologic changes in the brain. At 100 mg/kg Viphyllin markedly reduced the proBDNF/mBDNF ratio (p < .05) and augmented the TrkB expression (p < .01). Viphyllin (100 mg/kg) was found to be neuroprotective by reducing the Scop‐induced upregulation of p‐JNK and p‐p38 MAPK proteins, Bax/Bcl‐2 ratio, and caspase activation in the brain. Viphyllin also exerted anti‐inflammatory effects by downregulating Cox‐2, TNF‐α, and NOS‐2 in Scop‐induced mice (p < .05). To summarize, our data encourage Viphyllin as a functional ingredient/dietary supplement for brain health and cognition. PRACTICAL APPLICATIONS: Black pepper is a culinary spice having several medicinal attributes. Essential oils in the seeds of the plant give aroma and flavor to it. Here we have prepared an extract from the seeds of black pepper using supercritical fluid extraction, characterized for the presence of β‐caryophyllene (not <30%). This research work further validates the neuroprotective mechanism of the extract in Scopolamine‐induced cognitive impairment model mice. The findings from this study strongly suggest the beneficial neuroactive properties of black pepper seed extract having the presence of BCP, a CB2 receptor agonist. It can thus be used potentially as a functional food ingredient for cognition and brain function.
    Keywords Piper nigrum ; Western blotting ; agonists ; albino ; amnesia ; antioxidants ; black pepper ; body weight ; brain ; cannabinoid receptors ; cannabinoids ; caspases ; cholinesterase ; cognition ; cognitive disorders ; dementia ; dietary supplements ; disease prevention ; flavor ; food composition ; functional foods ; histopathology ; ingredients ; males ; mechanism of action ; odors ; scopolamine ; seed extracts ; spatial memory ; supercritical fluid extraction
    Language English
    Dates of publication 2021-12
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13994
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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