Article: Adverse reactions of drugs specifically used for treatment of SARS-CoV-2 infection
Medicina Clínica (English Edition)
Abstract: Currently, there is no treatment approved for COVID-19 Numerous drugs are being used in an empirical manner according to experience and availability Studies demonstrating their efficacy and safety are still to be published Thus, it is of vital importance ...
| Abstract | Currently, there is no treatment approved for COVID-19 Numerous drugs are being used in an empirical manner according to experience and availability Studies demonstrating their efficacy and safety are still to be published Thus, it is of vital importance for healthcare workers to be well informed and updated regarding possible immunological and non-immunological adverse effects regarding such treatments In this narrative revision, the rationale use of these treatments in the SARS-CoV-2 infection is emphasized as well as their most frequently described adverse drug reactions Drugs that are being essayed to counteract both clinical phases that are thought to take place in the severe stage of this disease are included;an initial phase where a viral infection prevails and a second phase where an inflammatory response takes over Adverse reactions registered in the Pharmacovigilance Program of our hospital before the onset of this pandemic have also been included Resumen Actualmente no hay ningún fármaco aprobado para el tratamiento de la COVID-19 Se emplean fármacos de manera empírica según experiencia y disponibilidad, pero no existen estudios controlados que demuestren su eficacia y seguridad En este contexto, es importante que los médicos dispongan de información de los posibles efectos adversos tanto inmunológicos como no inmunológicos de estos medicamentos En esta revisión se repasa el fundamento para su uso en la infección por SARS-Cov-2, así como las reacciones adversas más frecuentes;no se trata de una revisión sistemática sino narrativa Se han incluido aquellos fármacos que se utilizan con el fin de abordar adecuadamente las dos fases clínicas que parece tener la enfermedad en su manifestación más grave: una primera fase con predominio de infección viral y una segunda fase con predominio de una respuesta inflamatoria También se han repasado los casos de reacciones a dichos fármacos recogidas en el Programa de Farmacovigilancia del hospital antes del inicio de la pandemia |
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| Keywords | covid19 |
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #894118 |
| Database | COVID19 |
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