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Article: Are Kidneys Affected by SARS-CoV-2 Infection? An Updated Review on COVID-19-Associated AKI.

Fabrizi, Fabrizio / Nardelli, Luca / Regalia, Anna / Zanoni, Francesca / Castellano, Giuseppe

2024 Volume 13, Issue 4

Abstract: Background: Human kidneys are an important target of SARS-CoV-2 infection, and many renal abnormalities have been found in patients with SARS-CoV-2 infection, including proteinuria, hematuria, and acute kidney injury. Acute kidney injury is now ... ...

Abstract	Background: Human kidneys are an important target of SARS-CoV-2 infection, and many renal abnormalities have been found in patients with SARS-CoV-2 infection, including proteinuria, hematuria, and acute kidney injury. Acute kidney injury is now considered a common complication of COVID-19, and the epidemiology of AKI in SARS-CoV-2-infected patients continues to be controversial. Aim and methods: We have carried out a narrative review to evaluate the frequency and risk factors for AKI among patients hospitalized due to COVID-19, and the latest surveys on this topic have been included. The mechanisms by which AKI occurs in COVID-19 patients have also been reviewed. Results: Multiple risk factors for the development of AKI in patients with SARS-CoV-2 infection have been identified; these have been classified in various groups (management and background factors, among others). SARS-CoV-2 targets the kidneys by indirect activity, but SARS-CoV-2 infects tubular epithelial cells and podocytes. We retrieved 24 reports ( Conclusions: AKI is a common complication of hospitalized SARS-CoV-2-infected patients, and some comorbidities are important risk factors for it. The direct activity of the virus on the kidneys has been mentioned in the pathogenesis of AKI in SARS-CoV-2 patients. Further studies are ongoing in order to identify the mechanisms underlying the kidney injury in this population. The role of AKI on survival in SARS-CoV-2-infected patients is another area of active investigation.
Language	English
Publishing date	2024-04-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens13040325
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Impact of Antiviral Treatment of Hepatitis B Virus after Kidney Transplant and the Latest Insights.

Fabrizi, Fabrizio / Donato, Maria Francesca / Tripodi, Federica / Regalia, Anna / Lampertico, Pietro / Castellano, Giuseppe

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract: Background: The current frequency of hepatitis B virus infection in patients with advanced chronic kidney disease (CKD) (including patients on maintenance dialysis and kidney transplant recipients) is low but not negligible worldwide. HBV has a ... ...

Abstract	Background: The current frequency of hepatitis B virus infection in patients with advanced chronic kidney disease (CKD) (including patients on maintenance dialysis and kidney transplant recipients) is low but not negligible worldwide. HBV has a deleterious effect on survival after a kidney transplant; antiviral treatments improved the short-term outcomes of kidney transplant recipients, but their long-term impact remains uncertain. Aim: The aim of this review is to assess the role of antiviral therapy for HBV in improving survival after a kidney transplant. The recent publication of large surveys has prompted us to update the available evidence on the impact of HBV on patient and graft survival after a kidney transplant. Methods: We have conducted an extensive review of the medical literature, and various research engines have been used. Results: We retrieved several studies ( Conclusions: The recent availability of safe and effective antiviral drugs for the treatment of HBV has meant that the survival curves of HBsAg-positive patients on antiviral therapy and HBsAg-negative patients after a kidney transplant can be comparable. Antiviral therapy should be systematically proposed to HBV-positive kidney transplant recipients and candidates to avoid the deleterious hepatic and extra-hepatic effects of chronic HBV replication.
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12020340
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Corrigendum: Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study.

Molinari, Paolo / Regalia, Anna / Leoni, Alessandro / Campise, Mariarosaria / Cresseri, Donata / Cicero, Elisa / Vettoretti, Simone / Nardelli, Luca / Brigati, Emilietta / Favi, Evaldo / Messa, Piergiorgio / Castellano, Giuseppe / Alfieri, Carlo M

Frontiers in medicine

2024 Volume 11, Page(s) 1362741

Abstract: This corrects the article DOI: 10.3389/fmed.2023.1221086.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmed.2023.1221086.].
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1362741
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Rate and predictors of chronic organ damage accrual in active lupus nephritis: a single centre experience over 18 years of observation.

Frontini, Giulia / Tamborini, Francesco / Porata, Giulia / Regalia, Anna / Binda, Valentina / Moroni, Gabriella

Clinical and experimental rheumatology

2021 Volume 40, Issue 5, Page(s) 872–881

Abstract: Objectives: We aimed to identify the rates and predictors of chronic damage accrual and mortality in lupus nephritis (LN).: Methods: We retrospectively measured SLICC/ACR Damage Index (SDI) in biopsy proven active LN with at least 5 years follow-up. ... ...

Abstract	Objectives: We aimed to identify the rates and predictors of chronic damage accrual and mortality in lupus nephritis (LN). Methods: We retrospectively measured SLICC/ACR Damage Index (SDI) in biopsy proven active LN with at least 5 years follow-up. We searched for the predictors of first SDI increase and death at univariate and multivariate regression analysis. Then, we considered clinical/biochemical/histological features at diagnosis, corticosteroids dose and proportion of follow-up in complete renal remission. Results: 187 patients (91.4% females, age 28.1 years, 95.7% Caucasians) were included. After a median follow-up of 18.6 years, 26 patients (13.9%) died, 116 (62%) accrued damage. SDI annual rate has significantly reduced over the last decades (from a mean of 0.14±0.17 in 1970-1985, to 0.09±0.21 in 1986-2001, to 0.07±0.1 in 2002-2019; p=0.0032). SDI increases occurred more frequently in renal (22.5%), ocular (18.2%), cardiovascular, neuropsychiatric (13.4% both) and malignancy (12.8%) domains. First SDI increase free survival was 73.3%, 59.8%, 49.9% and 38% at 5,10,15 and 20 years. At multivariate analysis, hypertension (HR:1.699, CI:1.126-2.457, p=0.011), presentation with acute renal dysfunction (HR:1.587,CI:1.082-2.327, p=0.018) and average prednisone dose >5mg/day (HR:3.378, CI:1.984-5.751, p<0.0001) independently predicted damage. Achievement of complete renal remission (HR:0.993, CI:0.987-0.999, p<0.039) reduced the risk of damage. Age (HR:1.063, CI:1.027-1.099, p=0.0004), hypertension (HR:3.096, CI:1.211-7.912, p=0.019), and no immunosuppressors as maintenance therapy (HR:4.168, CI:1.212-14.336, p=0.024) predicted mortality at multivariate analysis. Conclusions: Besides arterial hypertension, presentation with acute renal dysfunction and corticosteroids dose predict SDI increase in LN, while achieving renal remission prevents damage. Aggressive therapy to induce remission in the acute phases of LN and low corticosteroids dose in maintenance therapy may prevent the increase of chronic damage.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Female ; Humans ; Hypertension ; Kidney/pathology ; Lupus Erythematosus, Systemic ; Lupus Nephritis/diagnosis ; Lupus Nephritis/drug therapy ; Lupus Nephritis/pathology ; Male ; Retrospective Studies ; Severity of Illness Index
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2021-09-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/ig0lu0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients

Regalia, Anna / Benedetti, Matteo / Malvica, Silvia / Alfieri, Carlo / Campise, Mariarosaria / Cresseri, Donata / Gandolfo, Maria Teresa / Tripodi, Federica / Castellano, Giuseppe / Messa, Piergiorgio

Nutrients. 2022 Jan. 13, v. 14, no. 2

2022

Abstract: Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney ... ...

Abstract	Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney transplanted patients (KTxp). Methods: A total of 61 KTxp with SARS-CoV-2 infection (COV+) were matched with 122 healthy KTxp controls (COV−). Main biochemical parameters at 1, 6, and 12 months before SARS-CoV-2 infection were recorded. Vitamin D status was considered as the mean of two 25(OH)D measures obtained 6 ± 2 months apart during the last year. The severity of SARS-CoV-2 infection was based on the need for hospitalization (HOSP+) and death (D+). Results: 25(OH)D levels were lower in COV+ than in controls [19(12–26) vs. 23(17–31) ng/mL, p = 0.01]. No differences among the other biochemical parameters were found. The SARS-CoV-2 infection discriminative power of 25(OH)D was evaluated by ROC-curve (AUC 0.61, 95% CI 0.5–0.7, p = 0.01). 25(OH)D was not significantly different between HOSP+ and HOSP− [17(8–25) vs. 20(15–26) ng/mL, p = 0.19] and between D+ and D− [14(6–23) vs. 20(14–26) ng/mL, p = 0.22] and had no significant correlation with disease length. Conclusions: During the year preceding the infection, 25(OH)D levels were lower in COV+ KTxp in comparison with controls matched for demographic features and comorbidities. No significant association between vitamin D status and SARS-CoV-2 infection related outcomes was found.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; death ; kidneys ; protective effect
Language	English
Dates of publication	2022-0113
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14020317
Database	NAL-Catalogue (AGRICOLA)

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Article: Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality

Messa, Piergiorgio / Regalia, Anna / Alfieri, Carlo Maria

Nutrients. 2017 May 27, v. 9, no. 6

2017

Abstract: Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a ... ...

Abstract	Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects.
Keywords	bone metabolism ; kidney diseases ; kidney transplant ; patients ; pleiotropy ; vitamin D ; vitamin D deficiency
Language	English
Dates of publication	2017-0527
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu9060550
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.

Messa, Piergiorgio / Regalia, Anna / Alfieri, Carlo Maria

Nutrients

2017 Volume 9, Issue 6

Abstract	Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects.
Language	English
Publishing date	2017-05-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu9060550
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Article: Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study.

Frontiers in medicine

2023 Volume 10, Page(s) 1221086

Abstract: Purpose: We studied the association between parathormone (PTH) levels and long-term graft loss in RTx patients (RTx-p).: Methods: We retrospectively evaluated 871 RTx-p, transplanted in our unit from Jan-2004 to Dec-2020 assessing renal function and ... ...

Abstract	Purpose: We studied the association between parathormone (PTH) levels and long-term graft loss in RTx patients (RTx-p). Methods: We retrospectively evaluated 871 RTx-p, transplanted in our unit from Jan-2004 to Dec-2020 assessing renal function and mineral metabolism parameters at 1, 6, and 12 months after RTx. Graft loss and death with functioning graft during follow-up (FU, 8.3[5.4-11.4] years) were checked. Results: At month-1, 79% had HPT, of which 63% with secondary HPT (SHPT) and 16% tertiary HPT (THPT); at month-6, HPT prevalence was 80% of which SHPT 64% and THPT 16%; at month-12 HPT prevalence was 77% of which SHPT 62% and THPT 15%. A strong significant correlation was found between HPT type, PTH levels and graft loss at every time point. Mean PTH exposure remained strongly and independently associated to long term graft loss (OR 3.1 [1.4-7.1], Conclusion: High PTH levels during 1st year of RTx seem to be associated with long term graft loss.
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1221086
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Migalastat Treatment in a Kidney-Transplanted Patient with Fabry Disease and N215S Mutation: The First Case Report.

Di Stefano, Valeria / Mancarella, Marta / Camporeale, Antonia / Regalia, Anna / Ferraresi, Marta / Pisaniello, Marco / Cassinerio, Elena / Pieruzzi, Federico / Motta, Irene

Pharmaceuticals (Basel, Switzerland)

2021 Volume 14, Issue 12

Abstract: Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the GLA gene, leading to deficient α-galactosidase A activity and, consequently, to glycosphingolipid accumulation in a wide variety of cells. Fabry disease due to N215S ( ... ...

Abstract	Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the GLA gene, leading to deficient α-galactosidase A activity and, consequently, to glycosphingolipid accumulation in a wide variety of cells. Fabry disease due to N215S (c.644A>G, p.Asn215Ser) missense mutation usually results in a late-onset phenotype presenting with isolated cardiac involvement. We herein present the case of a patient with N215S mutation with cardiac involvement, namely left ventricular hypertrophy and ventricular arrhythmias, and end-stage renal disease requiring kidney transplantation. To the best of our knowledge, this is the first report of a kidney-transplanted Fabry patient treated with oral pharmacologic chaperone migalastat.
Language	English
Publishing date	2021-12-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph14121304
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 Infection in Kidney Transplant Patients: An Italian One Year Single Centre Experience.

Campise, Mariarosaria / Alfieri, Carlo Maria / Perego, Marta / Tamborini, Francesco / Cresseri, Donata / Gandolfo, Maria Teresa / Binda, Valentina / Regalia, Anna / Messa, Piergiorgio

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 8

Abstract: COVID-19 is a life-threatening infection among elderly patients, comorbid patients, or transplanted patients. Lombardy (region of Italy), accounts for 786,324 cases as of 21 April 2021. We retrospectively describe our single Centre experience in 82 adult ...

Abstract	COVID-19 is a life-threatening infection among elderly patients, comorbid patients, or transplanted patients. Lombardy (region of Italy), accounts for 786,324 cases as of 21 April 2021. We retrospectively describe our single Centre experience in 82 adult kidney-transplant patients with COVID-19 infection during two pandemic outbreaks: 27 (first outbreak) and 65 (second outbreak). Thirty-seven patients were hospitalized (HP) and sixty-five were home managed (HM). Infection presented with fever (80%), cough (51%), and dyspnea (33%). HP were older (60 ± 11 vs. 50 ± 14 years,
Language	English
Publishing date	2021-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10080964
Database	MEDical Literature Analysis and Retrieval System OnLINE

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